Jacopo Sabbatinelli
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View article: High Torque teno virus viremia predicts long-term mortality and reflects chronic low-grade inflammation (inflammaging) in geriatric inpatients
High Torque teno virus viremia predicts long-term mortality and reflects chronic low-grade inflammation (inflammaging) in geriatric inpatients Open
View article: Is accelerated biological aging the hidden link between physical frailty, social deficits, cognitive impairment and risk of incident diseases?
Is accelerated biological aging the hidden link between physical frailty, social deficits, cognitive impairment and risk of incident diseases? Open
View article: Estimating the burden of dementia and parkinsonism through a novel identification algorithm based on healthcare administrative data
Estimating the burden of dementia and parkinsonism through a novel identification algorithm based on healthcare administrative data Open
Introduction Neurological disorders (ND), particularly dementia and parkinsonism, are major public health challenges in aging populations. Estimating their prevalence and incidence is essential for healthcare resource planning and targeted…
View article: Explainable artificial intelligence model predicting the risk of all-cause mortality in patients with type 2 diabetes mellitus
Explainable artificial intelligence model predicting the risk of all-cause mortality in patients with type 2 diabetes mellitus Open
Background Type 2 diabetes mellitus (T2DM) is a highly prevalent non-communicable chronic disease that substantially reduces life expectancy. Accurate estimation of all-cause mortality risk in T2DM patients is crucial for personalizing and…
View article: Explainable artificial intelligence model predicting the risk of all-cause mortality in patients with type 2 diabetes mellitus
Explainable artificial intelligence model predicting the risk of all-cause mortality in patients with type 2 diabetes mellitus Open
Objective. Type 2 diabetes mellitus (T2DM) is a highly prevalent non-communicable chronic disease that substantially reduces life expectancy. Accurate estimation of all-cause mortality risk in T2DM patients is crucial for personalizing and…
View article: Repeatome Analysis of Plasma Circulating DNA in Patients with Cardiovascular Disease: Variation with Cell-Free DNA Integrity/Length and Clinical Parameters
Repeatome Analysis of Plasma Circulating DNA in Patients with Cardiovascular Disease: Variation with Cell-Free DNA Integrity/Length and Clinical Parameters Open
Repetitive DNA represents over 50% of the human genome and is an abundant component of circulating cell-free DNA (cfDNA). We previously showed that cfDNA levels and integrity can predict survival in elderly patients with cardiovascular dis…
View article: A scoring model integrating CXCL9, GDF15, FGF21, and NfL, predicts long-term mortality in type 2 diabetes: a retrospective study
A scoring model integrating CXCL9, GDF15, FGF21, and NfL, predicts long-term mortality in type 2 diabetes: a retrospective study Open
View article: “Aging and epigenetic implications in radiotherapy: The promise of BNCT”
“Aging and epigenetic implications in radiotherapy: The promise of BNCT” Open
View article: miR-132–3p is down-regulated in plasma and CD171+ extracellular vesicles isolated from patients with mild Alzheimer’s disease
miR-132–3p is down-regulated in plasma and CD171+ extracellular vesicles isolated from patients with mild Alzheimer’s disease Open
Alzheimer's disease (AD), the most prevalent neurodegenerative disorder in aging populations, demands minimally invasive biomarkers for early diagnosis and monitoring. Circulating microRNAs (miRNAs) show promise as such biomarkers. In this…
View article: Triglyceride glucose index predicts long-term mortality and major adverse cardiovascular events in patients with type 2 diabetes
Triglyceride glucose index predicts long-term mortality and major adverse cardiovascular events in patients with type 2 diabetes Open
View article: Anticholinergic drug exposure is associated with prevalence, worsening and incidence of dysphagia among hospitalized older adults
Anticholinergic drug exposure is associated with prevalence, worsening and incidence of dysphagia among hospitalized older adults Open
View article: Analytical characteristics and performance of a new hs-cTnI method: a multicenter-study
Analytical characteristics and performance of a new hs-cTnI method: a multicenter-study Open
Objectives The present multicenter study was designed to evaluate the analytical performance and the 99th percentile value of the reference healthy population i.e., 99th percentile upper reference limit of the MAGLUMI ® CLIA high-sensitivi…
View article: Circulating MicroRNAs in Patients with Psoriasis Treated with Anti-IL-23: A Cohort Study
Circulating MicroRNAs in Patients with Psoriasis Treated with Anti-IL-23: A Cohort Study Open
View article: Correction: Inflammation scores based on C‑reactive protein and albumin predict mortality in hospitalized older patients independent of the admission diagnosis
Correction: Inflammation scores based on C‑reactive protein and albumin predict mortality in hospitalized older patients independent of the admission diagnosis Open
View article: Prediction of COVID-19 in-hospital mortality in older patients using artificial intelligence: a multicenter study
Prediction of COVID-19 in-hospital mortality in older patients using artificial intelligence: a multicenter study Open
Background Once the pandemic ended, SARS-CoV-2 became endemic, with flare-up phases. COVID-19 disease can still have a significant clinical impact, especially in older patients with multimorbidity and frailty. Objective This study aims at …
View article: Integrating cardiovascular risk biomarkers in the context of inflammaging
Integrating cardiovascular risk biomarkers in the context of inflammaging Open
View article: Inflammation scores based on C-reactive protein and albumin predict mortality in hospitalized older patients independent of the admission diagnosis
Inflammation scores based on C-reactive protein and albumin predict mortality in hospitalized older patients independent of the admission diagnosis Open
Systemic inflammation significantly increases the risk of short- and long-term mortality in geriatric hospitalized patients. To predict mortality in older patients with various age-related diseases and infections, including COVID-19, infla…
View article: Inflammatory Trajectory of Type 2 Diabetes: Novel Opportunities for Early and Late Treatment
Inflammatory Trajectory of Type 2 Diabetes: Novel Opportunities for Early and Late Treatment Open
Low-grade inflammation (LGI) represents a key driver of type 2 diabetes (T2D) and its associated cardiovascular diseases (CVDs). Indeed, inflammatory markers such as hs-CRP and IL-6 predict the development of T2D and its complications, sug…
View article: Heart rate variability and autonomic nervous system imbalance: Potential biomarkers and detectable hallmarks of aging and inflammaging
Heart rate variability and autonomic nervous system imbalance: Potential biomarkers and detectable hallmarks of aging and inflammaging Open
The most cutting-edge issue in the research on aging is the quest for biomarkers that transcend molecular and cellular domains to encompass organismal-level implications. We recently hypothesized the role of Autonomic Nervous System (ANS) …
View article: Syndecan 4 is a marker of endothelial inflammation in pathological aging and predicts long-term cardiovascular outcomes in type 2 diabetes
Syndecan 4 is a marker of endothelial inflammation in pathological aging and predicts long-term cardiovascular outcomes in type 2 diabetes Open
View article: Pro-Osteogenic Effect of the Nutraceutical BlastiMin Complex® in Women with Osteoporosis or Osteopenia: An Open Intervention Clinical Trial
Pro-Osteogenic Effect of the Nutraceutical BlastiMin Complex® in Women with Osteoporosis or Osteopenia: An Open Intervention Clinical Trial Open
Osteoporosis is a chronic disease that affects millions of patients worldwide and is characterized by low bone mineral density (BMD) and increased risk of fractures. Notably, natural molecules can increase BMD and exert pro-osteogenic effe…
View article: Relationship between imaging‐derived parameters and circulating <scp>microRNAs</scp> to study the degree of lung involvement in hospitalized geriatric patients with <scp>COVID</scp>‐19 pneumonia
Relationship between imaging‐derived parameters and circulating <span>microRNAs</span> to study the degree of lung involvement in hospitalized geriatric patients with <span>COVID</span>‐19 pneumonia Open
Aim Chest computed tomography (CT) scan is useful to evaluate the type and extent of lung lesions in coronavirus disease 2019 (COVID‐19) pneumonia. This study explored the association between radiological parameters and various circulating…
View article: DNA Methylation-derived biological age and long-term mortality risk in subjects with type 2 diabetes
DNA Methylation-derived biological age and long-term mortality risk in subjects with type 2 diabetes Open
View article: Age‐Related Reduction of D‐Dimer Cut‐Off Level Specificity: Diagnostic Relevance in Geriatric Patients
Age‐Related Reduction of D‐Dimer Cut‐Off Level Specificity: Diagnostic Relevance in Geriatric Patients Open
D-dimer testing in combination with clinical assessment is commonly used to diagnose suspected DVT and pulmonary embolism. However, as D-dimer levels are physiologically higher in elderly patients, this test loses clinical specificity in t…
View article: Physical performance strongly predicts all-cause mortality risk in a real-world population of older diabetic patients: machine learning approach for mortality risk stratification
Physical performance strongly predicts all-cause mortality risk in a real-world population of older diabetic patients: machine learning approach for mortality risk stratification Open
Background Prognostic risk stratification in older adults with type 2 diabetes (T2D) is important for guiding decisions concerning advance care planning. Materials and methods A retrospective longitudinal study was conducted in a real-worl…
View article: A study protocol for identifying aging trajectories toward chronic neurodegenerative diseases by means of Marche regional administrative databases – TREND project
A study protocol for identifying aging trajectories toward chronic neurodegenerative diseases by means of Marche regional administrative databases – TREND project Open
Background People are living longer but an increasing number of older people experience chronicity and disability in the latest years of their life. The Marche region is one of the Italian regions where people live the longest lives; there…
View article: Replicative senescence and high glucose induce the accrual of self-derived cytosolic nucleic acids in human endothelial cells
Replicative senescence and high glucose induce the accrual of self-derived cytosolic nucleic acids in human endothelial cells Open
View article: Circulating biomarkers of inflammaging and Alzheimer’s disease to track age-related trajectories of dementia: Can we develop a clinically relevant composite combination?
Circulating biomarkers of inflammaging and Alzheimer’s disease to track age-related trajectories of dementia: Can we develop a clinically relevant composite combination? Open
View article: Neutrophil-to-lymphocyte ratio (NLR) predicts mortality in hospitalized geriatric patients independent of the admission diagnosis: a multicenter prospective cohort study
Neutrophil-to-lymphocyte ratio (NLR) predicts mortality in hospitalized geriatric patients independent of the admission diagnosis: a multicenter prospective cohort study Open
View article: Senescent Endothelial Cells Sustain Their Senescence-Associated Secretory Phenotype (SASP) through Enhanced Fatty Acid Oxidation
Senescent Endothelial Cells Sustain Their Senescence-Associated Secretory Phenotype (SASP) through Enhanced Fatty Acid Oxidation Open
Cellular senescence is closely linked to endothelial dysfunction, a key factor in age-related vascular diseases. Senescent endothelial cells exhibit a proinflammatory phenotype known as SASP, leading to chronic inflammation (inflammaging) …