Sabiha Eddarkaoui
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View article: N-terminally acetylated Met11-Tau: a new pathological truncated Tau species with functional relevance in Alzheimer disease
N-terminally acetylated Met11-Tau: a new pathological truncated Tau species with functional relevance in Alzheimer disease Open
Neurodegenerative diseases like Alzheimer’s disease (AD) are characterized by progressive accumulation of pathological Tau proteins. Among the diverse Tau species, truncated variants are emerging as key contributors, yet their identity rem…
View article: Hampered AMPK-ULK1 cascade in Alzheimer’s disease (AD) instigates mitochondria dysfunctions and AD-related alterations which are alleviated by metformin
Hampered AMPK-ULK1 cascade in Alzheimer’s disease (AD) instigates mitochondria dysfunctions and AD-related alterations which are alleviated by metformin Open
The adenosine monophosphate-activated protein kinase (AMPK) and its downstream effector Unc-51 like autophagy activating kinase 1 (ULK1) represent a key cellular signaling node, the alteration of which likely contribute to AD development. …
View article: Neuronal A2A receptor exacerbates synapse loss and memory deficits in APP/PS1 mice
Neuronal A2A receptor exacerbates synapse loss and memory deficits in APP/PS1 mice Open
Early pathological upregulation of adenosine A2A receptors (A2ARs), one of the caffeine targets, by neurons is thought to be involved in the development of synaptic and memory deficits in Alzheimer’s disease (AD) but mechanisms remain ill-…
View article: The amyloid precursor protein and its derived fragments concomitantly contribute to the alterations of mitochondrial transport machinery in Alzheimer’s disease
The amyloid precursor protein and its derived fragments concomitantly contribute to the alterations of mitochondrial transport machinery in Alzheimer’s disease Open
View article: The amyloid precursor protein and its derived fragments concomitantly contribute to the alterations of mitochondrial transport machinery in Alzheimer’s disease
The amyloid precursor protein and its derived fragments concomitantly contribute to the alterations of mitochondrial transport machinery in Alzheimer’s disease Open
Mitochondria dysfunctions and mitophagy failure have been associated with several Alzheimer’s disease (AD) related molecular actors including amyloid beta (Aβ) and recently the amyloid precursor protein-C terminal fragments (APP-CTFs). The…
View article: GnRH replacement rescues cognition in Down syndrome
GnRH replacement rescues cognition in Down syndrome Open
At the present time, no viable treatment exists for cognitive and olfactory deficits in Down syndrome (DS). We show in a DS model (Ts65Dn mice) that these progressive nonreproductive neurological symptoms closely parallel a postpubertal de…
View article: Pathological changes induced by Alzheimer’s brain inoculation in amyloid-beta plaque-bearing mice
Pathological changes induced by Alzheimer’s brain inoculation in amyloid-beta plaque-bearing mice Open
Alzheimer's disease (AD) is characterized by intracerebral accumulations of extracellular amyloid-β (Aβ) plaques and intracellular tau pathology that spread in the brain. Three types of tau lesions occur in the form of neuropil threads, ne…
View article: Microtube Array Membrane Encapsulated Cell Therapy: A Novel Platform Technology Solution for Treatment of Alzheimer’s Disease
Microtube Array Membrane Encapsulated Cell Therapy: A Novel Platform Technology Solution for Treatment of Alzheimer’s Disease Open
Alzheimer’s disease is the most frequent form of dementia in aging population and is presently the world’s sixth largest cause of mortality. With the advancement of therapies, several solutions have been developed such as passive immunothe…
View article: Functional Analyses of Two Novel <scp><i>LRRK2</i></scp> Pathogenic Variants in Familial Parkinson′s Disease
Functional Analyses of Two Novel <span><i>LRRK2</i></span> Pathogenic Variants in Familial Parkinson′s Disease Open
Background Pathogenic variants in the LRRK2 gene are a common monogenic cause of Parkinson's disease. However, only seven variants have been confirmed to be pathogenic. Objectives We identified two novel LRRK2 variants (H230R and A1440P) a…
View article: Caffeine intake exerts dual genome-wide effects on hippocampal metabolism and learning-dependent transcription
Caffeine intake exerts dual genome-wide effects on hippocampal metabolism and learning-dependent transcription Open
Caffeine is the most consumed psychoactive substance worldwide. Strikingly, molecular pathways engaged by its regular consumption remain unclear. We herein addressed the mechanisms associated with habitual (chronic) caffeine consumption in…
View article: Impaired Glucose Homeostasis in a Tau Knock-In Mouse Model
Impaired Glucose Homeostasis in a Tau Knock-In Mouse Model Open
Alzheimer’s disease (AD) is the leading cause of dementia. While impaired glucose homeostasis has been shown to increase AD risk and pathological loss of tau function, the latter has been suggested to contribute to the emergence of the glu…
View article: Inhibition of Tau seeding by targeting Tau nucleation core within neurons with a single domain antibody fragment
Inhibition of Tau seeding by targeting Tau nucleation core within neurons with a single domain antibody fragment Open
View article: Functional analyses of two novel <i>LRRK2</i> pathogenic variants in familial Parkinson’s disease
Functional analyses of two novel <i>LRRK2</i> pathogenic variants in familial Parkinson’s disease Open
Background Pathogenic variants in the LRRK2 gene are a common monogenic cause of Parkinson’s disease. However, only seven variants have been confirmed to be pathogenic. Objectives We identified two novel LRRK2 variants (H230R and A1440P) a…
View article: Transmission of amyloid-beta and tau pathologies is associated with cognitive impairments in a primate
Transmission of amyloid-beta and tau pathologies is associated with cognitive impairments in a primate Open
Amyloid-β (Aβ) pathology transmission has been described in patients following iatrogenic exposure to compounds contaminated with Aβ proteins. It can induce cerebral Aβ angiopathy resulting in brain hemorrhages and devastating clinical imp…
View article: P2X7-deficiency improves plasticity and cognitive abilities in a mouse model of Tauopathy
P2X7-deficiency improves plasticity and cognitive abilities in a mouse model of Tauopathy Open
View article: A ß-Secretase Modulator Decreases Tau Pathology and Preserves Short-Term Memory in a Mouse Model of Neurofibrillary Degeneration
A ß-Secretase Modulator Decreases Tau Pathology and Preserves Short-Term Memory in a Mouse Model of Neurofibrillary Degeneration Open
Identifying which among several in cellulo pharmacological activities is necessary for the proper in vivo activity is essential for further drug development against Alzheimer’s disease pathophysiological processes. An in-depth structure–ac…
View article: Pathological changes induced by Alzheimer’s brain inoculation in amyloid-beta plaque-bearing mice
Pathological changes induced by Alzheimer’s brain inoculation in amyloid-beta plaque-bearing mice Open
Alzheimer’s disease (AD) is characterized by intracerebral accumulations of extracellular amyloid-β (Aβ) plaques and intracellular tau pathology that spread in the brain. Tau lesions occur in the form of neuropil threads, neurofibrillary t…
View article: A β-secretase modulator decreases Tau pathology and preserves short-term memory in a mouse model of neurofibrillary degeneration
A β-secretase modulator decreases Tau pathology and preserves short-term memory in a mouse model of neurofibrillary degeneration Open
A structure-activity relationship has enabled us to identify two molecules, MAGS02-14 and PEL24-199, sharing a β-secretase modulatory effect but having or not a lysosomotropic activity, respectively. More importantly, MAGS02-14 and PEL24-1…
View article: Iatrogenic transmission of Alzheimer's disease: Evidence based on experimental inoculation of Alzheimer's brains into a primate
Iatrogenic transmission of Alzheimer's disease: Evidence based on experimental inoculation of Alzheimer's brains into a primate Open
Background Epidemiologic data suggest that, in humans, iatrogenic administration of compounds (cadaver‐sourced human growth hormone, dura mater graft) or cerebral surgeries with tools contaminated with Aβ and tau induce aggregated Aβ and p…
View article: Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer’s disease
Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer’s disease Open
View article: A Novel Tau Antibody Detecting the First Amino-Terminal Insert Reveals Conformational Differences Among Tau Isoforms
A Novel Tau Antibody Detecting the First Amino-Terminal Insert Reveals Conformational Differences Among Tau Isoforms Open
As human Tau undergoes pathologically relevant post-translational modifications when expressed in yeast, the use of humanized yeast models for the generation of novel Tau monoclonal antibodies has previously been proven to be successful. I…
View article: Correction to: Gel electrophoresis of human sperm: a simple method for evaluating sperm protein quality
Correction to: Gel electrophoresis of human sperm: a simple method for evaluating sperm protein quality Open
Following publication of the original article [1], the authors reported that the author given names and family names had been transposed. The author names in this correction article are presented correctly.
View article: Exacerbation of C1q dysregulation, synaptic loss and memory deficits in tau pathology linked to neuronal adenosine A2A receptor
Exacerbation of C1q dysregulation, synaptic loss and memory deficits in tau pathology linked to neuronal adenosine A2A receptor Open
See Cunha (doi:10.1093/brain/awz335) for a scientific commentary on this article. Carvalho et al. provide clues to the onset of immune dysregulation underlying early synaptic loss in Alzheimer’s disease and tauopathies, by linking overacti…
View article: Encephalopathy induced by Alzheimer brain inoculation in a non-human primate
Encephalopathy induced by Alzheimer brain inoculation in a non-human primate Open
Alzheimer's disease is characterized by cognitive alterations, cerebral atrophy and neuropathological lesions including neuronal loss, accumulation of misfolded and aggregated β-amyloid peptides (Aβ) and tau proteins. Iatrogenic induction …
View article: New piperazine multi-effect drugs prevent neurofibrillary degeneration and amyloid deposition, and preserve memory in animal models of Alzheimer's disease
New piperazine multi-effect drugs prevent neurofibrillary degeneration and amyloid deposition, and preserve memory in animal models of Alzheimer's disease Open
View article: Brain insulin response and peripheral metabolic changes in a Tau transgenic mouse model
Brain insulin response and peripheral metabolic changes in a Tau transgenic mouse model Open
View article: A phenotypic approach to the discovery of compounds that promote non-amyloidogenic processing of the amyloid precursor protein: Toward a new profile of indirect β-secretase inhibitors
A phenotypic approach to the discovery of compounds that promote non-amyloidogenic processing of the amyloid precursor protein: Toward a new profile of indirect β-secretase inhibitors Open
View article: Gel electrophoresis of human sperm: a simple method for evaluating sperm protein quality
Gel electrophoresis of human sperm: a simple method for evaluating sperm protein quality Open
View article: Beneficial Effect of a Selective Adenosine A2A Receptor Antagonist in the APPswe/PS1dE9 Mouse Model of Alzheimer’s Disease
Beneficial Effect of a Selective Adenosine A2A Receptor Antagonist in the APPswe/PS1dE9 Mouse Model of Alzheimer’s Disease Open
Consumption of caffeine, a non-selective adenosine A2A receptor (A2AR) antagonist, reduces the risk of developing Alzheimer's disease (AD) and mitigates both amyloid and Tau lesions in transgenic mouse models of the d…
View article: Tau deletion promotes brain insulin resistance
Tau deletion promotes brain insulin resistance Open
The molecular pathways underlying tau pathology–induced synaptic/cognitive deficits and neurodegeneration are poorly understood. One prevalent hypothesis is that hyperphosphorylation, misfolding, and fibrillization of tau impair synaptic p…