Sabina Halappanavar
YOU?
Author Swipe
View article: Comparison of Lung Inflammatory and Transcriptional Responses in Mice and Rats Following Pulmonary Exposure to a Fiber Paradigm-Compatible and Non-Compatible MWCNT
Comparison of Lung Inflammatory and Transcriptional Responses in Mice and Rats Following Pulmonary Exposure to a Fiber Paradigm-Compatible and Non-Compatible MWCNT Open
Inhalation of multi-walled carbon nanotubes (MWCNTs) poses potential health risks due to their structural similarity to asbestos and their ability to induce chronic lung inflammation, fibrosis, and lung cancer in animal models. This study …
View article: Acute Toxicity of Metal Oxide Nanoparticles—Role of Intracellular Localization In Vitro in Lung Epithelial Cells
Acute Toxicity of Metal Oxide Nanoparticles—Role of Intracellular Localization In Vitro in Lung Epithelial Cells Open
Endocytic uptake and lysosomal localization are suggested to be the key mechanisms underlying the toxicity of metal oxide nanoparticles (MONPs), with dissolution in the acidic milieu driving the response. In this study, we aimed to investi…
View article: The Impact of Carbon Nanotube Properties on Lung Pathologies and Atherosclerosis Through Acute Inflammation: a New AOP‐Anchored <i>in Silico</i> NAM
The Impact of Carbon Nanotube Properties on Lung Pathologies and Atherosclerosis Through Acute Inflammation: a New AOP‐Anchored <i>in Silico</i> NAM Open
In this study, a previously developed approach for creating a quantitative structure‐activity relationship model anchored in an Adverse Outcome Pathway framework (AOP‐anchored Nano‐QSAR) is employed to develop a novel model capable of pred…
View article: Polyethylene Terephthalate Microplastics Generated from Disposable Water Bottles Induce Interferon Signaling Pathways in Mouse Lung Epithelial Cells
Polyethylene Terephthalate Microplastics Generated from Disposable Water Bottles Induce Interferon Signaling Pathways in Mouse Lung Epithelial Cells Open
Microplastics (MPs) are present in ambient air in a respirable size fraction; however, their potential impact on human health via inhalation routes is not well documented. In the present study, methods for a lab-scale generation of MPs fro…
View article: Next Generation Risk Assessment approaches for advanced nanomaterials: Current status and future perspectives
Next Generation Risk Assessment approaches for advanced nanomaterials: Current status and future perspectives Open
View article: Building an Adverse Outcome Pathway network for COVID-19
Building an Adverse Outcome Pathway network for COVID-19 Open
The COVID-19 pandemic generated large amounts of data on the disease pathogenesis leading to a need for organizing the vast knowledge in a succinct manner. Between April 2020 and February 2023, the CIAO consortium exploited the Adverse Out…
View article: Particulate contamination of human placenta: Plastic and non-plastic
Particulate contamination of human placenta: Plastic and non-plastic Open
Recent evidence indicates that the human womb is contaminated with a variety of particulate contaminants. Microplastics (MPs, tiny plastic particles, 0.1 – 5000 µm) generated by the breakdown of larger plastic products in the environment) …
View article: Bioinformatics and machine learning to support nanomaterial grouping
Bioinformatics and machine learning to support nanomaterial grouping Open
Nanomaterials (NMs) offer plenty of novel functionalities. Moreover, their physicochemical properties can be fine-tuned to meet the needs of specific applications, leading to virtually unlimited numbers of NM variants. Hence, efficient haz…
View article: A Systematic Genotoxicity Assessment of a Suite of Metal Oxide Nanoparticles Reveals Their DNA Damaging and Clastogenic Potential
A Systematic Genotoxicity Assessment of a Suite of Metal Oxide Nanoparticles Reveals Their DNA Damaging and Clastogenic Potential Open
Metal oxide nanoparticles (MONP/s) induce DNA damage, which is influenced by their physicochemical properties. In this study, the high-throughput CometChip and micronucleus (MicroFlow) assays were used to investigate DNA and chromosomal da…
View article: Particulate Contamination of Human Placenta: Plastic and non-plastic
Particulate Contamination of Human Placenta: Plastic and non-plastic Open
Recent evidence indicates that the human womb is contaminated with a variety of particulate contaminants. Microplastics (MPs, tiny plastic particles ( < 5 mm) generated by the breakdown of larger plastic products in the environment) accumu…
View article: Toxicity of Metal Oxide Nanoparticles: Looking through the Lens of Toxicogenomics
Toxicity of Metal Oxide Nanoparticles: Looking through the Lens of Toxicogenomics Open
The impact of solubility on the toxicity of metal oxide nanoparticles (MONPs) requires further exploration to ascertain the impact of the dissolved and particulate species on response. In this study, FE1 mouse lung epithelial cells were ex…
View article: Single-Walled vs. Multi-Walled Carbon Nanotubes: Influence of Physico-Chemical Properties on Toxicogenomics Responses in Mouse Lungs
Single-Walled vs. Multi-Walled Carbon Nanotubes: Influence of Physico-Chemical Properties on Toxicogenomics Responses in Mouse Lungs Open
Single-walled carbon nanotubes (SWCNTs) and multi-walled carbon nanotubes (MWCNTs) are nanomaterials with one or multiple layers of carbon sheets. While it is suggested that various properties influence their toxicity, the specific mechani…
View article: Characterization of ENM Dynamic Dose-Dependent MOA in Lung with Respect to Immune Cells Infiltration
Characterization of ENM Dynamic Dose-Dependent MOA in Lung with Respect to Immune Cells Infiltration Open
The molecular effects of exposures to engineered nanomaterials (ENMs) are still largely unknown. In classical inhalation toxicology, cell composition of bronchoalveolar lavage (BAL) is a toxicity indicator at the lung tissue level that can…
View article: The High-Throughput In Vitro CometChip Assay for the Analysis of Metal Oxide Nanomaterial Induced DNA Damage
The High-Throughput In Vitro CometChip Assay for the Analysis of Metal Oxide Nanomaterial Induced DNA Damage Open
Metal oxide nanomaterials (MONMs) are among the most highly utilized classes of nanomaterials worldwide, though their potential to induce DNA damage in living organisms is known. High-throughput in vitro assays have the potential to greatl…
View article: The Road to Achieving the European Commission's Chemicals Strategy for Nanomaterial Sustainability—A PATROLS Perspective on New Approach Methodologies
The Road to Achieving the European Commission's Chemicals Strategy for Nanomaterial Sustainability—A PATROLS Perspective on New Approach Methodologies Open
The European Green Deal outlines ambitions to build a more sustainable, climate neutral, and circular economy by 2050. To achieve this, the European Commission has published the Chemicals Strategy for Sustainability: Towards a Toxic‐Free E…
View article: Adverse outcome pathways and in vitro toxicology strategies for microplastics hazard testing
Adverse outcome pathways and in vitro toxicology strategies for microplastics hazard testing Open
The human health impacts of microplastics exposure remain uncertain, though they are of growing global concern. The strategic use of the adverse outcome pathways (AOPs) framework will permit leveraging of existing knowledge on disease mech…
View article: Toxicity screening of air extracts representing different source sectors in the Greater Toronto and Hamilton areas: In vitro oxidative stress, pro-inflammatory response, and toxicogenomic analysis
Toxicity screening of air extracts representing different source sectors in the Greater Toronto and Hamilton areas: In vitro oxidative stress, pro-inflammatory response, and toxicogenomic analysis Open
In the present study, the suitability and sensitivity of different in vitro toxicity endpoints were determined to evaluate and distinguish the specific contributions of polycyclic aromatic carbon (PAC) mixtures from various sites in Toront…
View article: Adverse Outcome Pathway Development for Assessment of Lung Carcinogenicity by Nanoparticles
Adverse Outcome Pathway Development for Assessment of Lung Carcinogenicity by Nanoparticles Open
Lung cancer, one of the most common and deadly forms of cancer, is in some cases associated with exposure to certain types of particles. With the rise of nanotechnology, there is concern that some engineered nanoparticles may be among such…
View article: Pulmonary toxicity and gene expression changes after short-term inhalation exposure to surface-modified copper oxide nanoparticles
Pulmonary toxicity and gene expression changes after short-term inhalation exposure to surface-modified copper oxide nanoparticles Open
View article: Non‐Animal Strategies for Toxicity Assessment of Nanoscale Materials: Role of Adverse Outcome Pathways in the Selection of Endpoints
Non‐Animal Strategies for Toxicity Assessment of Nanoscale Materials: Role of Adverse Outcome Pathways in the Selection of Endpoints Open
Faster, cheaper, sensitive, and mechanisms‐based animal alternatives are needed to address the safety assessment needs of the growing number of nanomaterials (NM) and their sophisticated property variants. Specifically, strategies that hel…
View article: Bringing together scientific disciplines for collaborative undertakings: a vision for advancing the adverse outcome pathway framework
Bringing together scientific disciplines for collaborative undertakings: a vision for advancing the adverse outcome pathway framework Open
A joint chemical and radiological expert group was proposed as a means to encourage cooperation between risk assessors and an initial vision was discussed on a path forward. A global survey was suggested as a way to identify priority healt…
View article: Impact of copper oxide particle dissolution on lung epithelial cell toxicity: response characterization using global transcriptional analysis
Impact of copper oxide particle dissolution on lung epithelial cell toxicity: response characterization using global transcriptional analysis Open
The in vitro and in vivo toxicity of copper oxide nanoparticles (CuO NPs) is attributed to both particle and dissolved copper ion species. However, a clear understanding of (1) the specific cellular responses that are modulat…
View article: A methodology for developing key events to advance nanomaterial-relevant adverse outcome pathways to inform risk assessment
A methodology for developing key events to advance nanomaterial-relevant adverse outcome pathways to inform risk assessment Open
Significant advances have been made in the development of Adverse Outcome Pathways (AOPs) over the last decade, mainly focused on the toxicity mechanisms of chemicals. These AOPs, although relevant to manufactured nanomaterials (MNs), do n…
View article: A transcriptomic overview of lung and liver changes one day after pulmonary exposure to graphene and graphene oxide
A transcriptomic overview of lung and liver changes one day after pulmonary exposure to graphene and graphene oxide Open
View article: Disease Prediction: Prediction of Chronic Inflammation for Inhaled Particles: the Impact of Material Cycling and Quarantining in the Lung Epithelium (Adv. Mater. 47/2020)
Disease Prediction: Prediction of Chronic Inflammation for Inhaled Particles: the Impact of Material Cycling and Quarantining in the Lung Epithelium (Adv. Mater. 47/2020) Open
The prediction of diseases associated with nanomaterials is currently hampered by an incomplete understanding of the underlying mechanisms. Newly discovered nanomaterial quarantining and counteracting nanomaterial cycling fill that gap all…
View article: Prediction of Chronic Inflammation for Inhaled Particles: the Impact of Material Cycling and Quarantining in the Lung Epithelium
Prediction of Chronic Inflammation for Inhaled Particles: the Impact of Material Cycling and Quarantining in the Lung Epithelium Open
On a daily basis, people are exposed to a multitude of health‐hazardous airborne particulate matter with notable deposition in the fragile alveolar region of the lungs. Hence, there is a great need for identification and prediction of mate…
View article: Risk Governance of Emerging Technologies Demonstrated in Terms of its Applicability to Nanomaterials
Risk Governance of Emerging Technologies Demonstrated in Terms of its Applicability to Nanomaterials Open
Nanotechnologies have reached maturity and market penetration that require nano‐specific changes in legislation and harmonization among legislation domains, such as the amendments to REACH for nanomaterials (NMs) which came into force in 2…
View article: Translating Scientific Advances in the AOP Framework to Decision Making for Nanomaterials
Translating Scientific Advances in the AOP Framework to Decision Making for Nanomaterials Open
Much of the current innovation in advanced materials is occurring at the nanoscale, specifically in manufactured nanomaterials (MNs). MNs display unique attributes and behaviors, and may be biologically and physically unique, making them v…
View article: Adverse outcome pathways as a tool for the design of testing strategies to support the safety assessment of emerging advanced materials at the nanoscale
Adverse outcome pathways as a tool for the design of testing strategies to support the safety assessment of emerging advanced materials at the nanoscale Open
View article: 21st Century Tools for Nanotoxicology: Transcriptomic Biomarker Panel and Precision‐Cut Lung Slice Organ Mimic System for the Assessment of Nanomaterial‐Induced Lung Fibrosis
21st Century Tools for Nanotoxicology: Transcriptomic Biomarker Panel and Precision‐Cut Lung Slice Organ Mimic System for the Assessment of Nanomaterial‐Induced Lung Fibrosis Open
There is an urgent need for reliable toxicity assays to support the human health risk assessment of an ever increasing number of engineered nanomaterials (ENMs). Animal testing is not a suitable option for ENMs. Sensitive in vitro models a…