Sabina Sahanic
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View article: The common genetic variant rs1278960 determining expression of Interferon-lambda predicts inflammatory response in critically ill COVID-19 patients
The common genetic variant rs1278960 determining expression of Interferon-lambda predicts inflammatory response in critically ill COVID-19 patients Open
View article: Machine Learning Based Multi-Parameter Modeling for Prediction of Post-Inflammatory Lung Changes
Machine Learning Based Multi-Parameter Modeling for Prediction of Post-Inflammatory Lung Changes Open
Objectives: Prediction of lung function deficits following pulmonary infection is challenging and suffers from inaccuracy. We sought to develop machine-learning models for prediction of post-inflammatory lung changes based on COVID-19 reco…
View article: Laboratory parameters related to disease severity and physical performance after reconvalescence of acute COVID-19 infection
Laboratory parameters related to disease severity and physical performance after reconvalescence of acute COVID-19 infection Open
Research into the molecular basis of disease trajectory and Long-COVID is important to get insights toward underlying pathophysiological processes. The objective of this study was to investigate inflammation-mediated changes of metabolism …
View article: Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children
Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children Open
We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients: IFN-α2 only in three, IFN-α2 plus IFN-ω in five, and IFN-α2, IFN-ω plu…
View article: SARS-CoV-2 activates the TLR4/MyD88 pathway in human macrophages: A possible correlation with strong pro-inflammatory responses in severe COVID-19
SARS-CoV-2 activates the TLR4/MyD88 pathway in human macrophages: A possible correlation with strong pro-inflammatory responses in severe COVID-19 Open
View article: Distinct smell and taste disorder phenotype of post-acute COVID-19 sequelae
Distinct smell and taste disorder phenotype of post-acute COVID-19 sequelae Open
View article: Persistent Symptoms and IFN-γ-Mediated Pathways after COVID-19
Persistent Symptoms and IFN-γ-Mediated Pathways after COVID-19 Open
After COVID-19, patients have reported various complaints such as fatigue, neurological symptoms, and insomnia. Immune-mediated changes in amino acid metabolism might contribute to the development of these symptoms. Patients who had had ac…
View article: Persistent somatic symptoms are key to individual illness perception at one year after COVID-19 in a cross-sectional analysis of a prospective cohort study
Persistent somatic symptoms are key to individual illness perception at one year after COVID-19 in a cross-sectional analysis of a prospective cohort study Open
View article: Immunity of Heterologously and Homologously Boosted or Convalescent Individuals Against Omicron BA.1, BA.2, and BA.4/5 Variants
Immunity of Heterologously and Homologously Boosted or Convalescent Individuals Against Omicron BA.1, BA.2, and BA.4/5 Variants Open
Background The emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variants BA.1, BA.2, and BA.4/5 demonstrate higher transmission and infection rates than previous variants of concern. To evaluate effectiveness of…
View article: COVID-19 and its continuing burden after 12 months: a longitudinal observational prospective multicentre trial
COVID-19 and its continuing burden after 12 months: a longitudinal observational prospective multicentre trial Open
Background Recovery trajectories from coronavirus disease 2019 (COVID-19) call for longitudinal investigation. We aimed to characterise the kinetics and status of clinical, cardiopulmonary and mental health recovery up to 1 year following …
View article: Pulmonary recovery from COVID-19 in patients with metabolic diseases: a longitudinal prospective cohort study
Pulmonary recovery from COVID-19 in patients with metabolic diseases: a longitudinal prospective cohort study Open
The severity of coronavirus disease 2019 (COVID-19) is related to the presence of comorbidities including metabolic diseases. We herein present data from the longitudinal prospective CovILD trial, and investigate the recovery from COVID-19…
View article: Interferon-gamma Mediated Metabolic Pathways in Hospitalized Patients During Acute and Reconvalescent COVID-19
Interferon-gamma Mediated Metabolic Pathways in Hospitalized Patients During Acute and Reconvalescent COVID-19 Open
Background: Fatigue, sleep disturbance, and neurological symptoms during and after COVID-19 are common and might be associated with inflammation-induced changes in tryptophan (Trp) and phenylalanine (Phe) metabolism. Aim: This pilot study …
View article: Correlation between structural heart disease and cardiac SARS-CoV-2 manifestations
Correlation between structural heart disease and cardiac SARS-CoV-2 manifestations Open
View article: Enhancing Clinical Diagnosis for Patients With Persistent Pulmonary Abnormalities After COVID-19 Infection
Enhancing Clinical Diagnosis for Patients With Persistent Pulmonary Abnormalities After COVID-19 Infection Open
Coronavirus disease 2019 (COVID-19)–related pneumonia challenges clinical practice. We explore the potential diagnostic benefit of PET/CT to establish the underlying inflammatory or fibrotic repair processes in prolonged structural lung ab…
View article: One-Year Follow-Up of COVID-19 Patients Indicates Substantial Assay-Dependent Differences in the Kinetics of SARS-CoV-2 Antibodies
One-Year Follow-Up of COVID-19 Patients Indicates Substantial Assay-Dependent Differences in the Kinetics of SARS-CoV-2 Antibodies Open
Determination of antibodies against SARS-CoV-2 will play an important role in detecting a sufficient immune response. Although all the manufacturers expressed antibody levels in binding antibody units per milliliter, thus suggesting compar…
View article: Persistent somatic symptoms are key to individual illness perception at one year after COVID-19
Persistent somatic symptoms are key to individual illness perception at one year after COVID-19 Open
Background Sequelae of Coronavirus disease 2019 (COVID-19) were investigated by both patient-initiated and academic initiatives. Patient’s subjective illness perceptions might differ from physician’s clinical assessment results. Herein, we…
View article: Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs
Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs Open
Life-threatening “breakthrough” cases of critical COVID-19 are attributed to poor or waning antibody (Ab) response to SARS-CoV-2 vaccines in individuals already at risk. Preexisting auto-Abs neutralizing type I IFNs underlie at least 15% o…
View article: The Impact of Iron Dyshomeostasis and Anaemia on Long-Term Pulmonary Recovery and Persisting Symptom Burden after COVID-19: A Prospective Observational Cohort Study
The Impact of Iron Dyshomeostasis and Anaemia on Long-Term Pulmonary Recovery and Persisting Symptom Burden after COVID-19: A Prospective Observational Cohort Study Open
Coronavirus disease 2019 (COVID-19) is frequently associated with iron dyshomeostasis. The latter is related to acute disease severity and COVID-19 convalescence. We herein describe iron dyshomeostasis at COVID-19 follow-up and its associa…
View article: Distinct smell and taste disorder phenotype of post-acute COVID-19 sequelae
Distinct smell and taste disorder phenotype of post-acute COVID-19 sequelae Open
Background Olfactory dysfunction (OD) often accompanies acute coronavirus disease 2019 (COVID-19) and its sequelae. Herein, we investigated OD during COVID-19 recovery in the context of other symptoms, quality of life, physical and mental …
View article: The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies Open
Significance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19…
View article: Diagnostic guidance for patients with persistent pulmonary abnormalities after COVID-19 infection: the potential benefit of 68Ga-FAPI PET/CT
Diagnostic guidance for patients with persistent pulmonary abnormalities after COVID-19 infection: the potential benefit of 68Ga-FAPI PET/CT Open
Coronavirus disease 2019 (COVID-19)-related pneumonia challenges clinical practice. We explore the potential diagnostic benefit of positron emission tomography/computed tomography (PET/CT) in order to establish the underlying inflammatory …
View article: Chest CT of Lung Injury 1 Year after COVID-19 Pneumonia: The CovILD Study
Chest CT of Lung Injury 1 Year after COVID-19 Pneumonia: The CovILD Study Open
Background The long-term pulmonary sequelae of COVID-19 is not well known. Purpose To characterize patterns and rates of improvement of chest CT abnormalities 1 year after COVID-19 pneumonia. Materials and Methods This was a secondary anal…
View article: Who Is at Risk of Poor Mental Health Following Coronavirus Disease-19 Outpatient Management?
Who Is at Risk of Poor Mental Health Following Coronavirus Disease-19 Outpatient Management? Open
Background Coronavirus Disease-19 (COVID-19) convalescents are at risk of developing a de novo mental health disorder or worsening of a pre-existing one. COVID-19 outpatients have been less well characterized than their hospitalized counte…
View article: Quantity of IgG response to SARS-CoV-2 spike glycoprotein predicts pulmonary recovery from COVID-19
Quantity of IgG response to SARS-CoV-2 spike glycoprotein predicts pulmonary recovery from COVID-19 Open
View article: Neurological outcomes 1 year after COVID‐19 diagnosis: A prospective longitudinal cohort study
Neurological outcomes 1 year after COVID‐19 diagnosis: A prospective longitudinal cohort study Open
Background and purpose Neurological sequelae from coronavirus disease 2019 (COVID‐19) may persist after recovery from acute infection. Here, the aim was to describe the natural history of neurological manifestations over 1 year after COVID…
View article: Investigating phenotypes of pulmonary COVID-19 recovery: A longitudinal observational prospective multicenter trial
Investigating phenotypes of pulmonary COVID-19 recovery: A longitudinal observational prospective multicenter trial Open
Background: The optimal procedures to prevent, identify, monitor, and treat long-term pulmonary sequelae of COVID-19 are elusive. Here, we characterized the kinetics of respiratory and symptom recovery following COVID-19. Methods: We condu…
View article: A proteomic survival predictor for COVID-19 patients in intensive care
A proteomic survival predictor for COVID-19 patients in intensive care Open
Global healthcare systems are challenged by the COVID-19 pandemic. There is a need to optimize allocation of treatment and resources in intensive care, as clinically established risk assessments such as SOFA and APACHE II scores show only …
View article: The risk of COVID-19 death is much greater and age-dependent with type I IFN autoantibodies
The risk of COVID-19 death is much greater and age-dependent with type I IFN autoantibodies Open
SARS-CoV-2 infection fatality rate (IFR) doubles with every five years of age from childhood onward. Circulating autoantibodies neutralizing IFN-α, IFN-ω, and/or IFN-β are found in ~20% of deceased patients across age groups. In the genera…
View article: Author response: Investigating phenotypes of pulmonary COVID-19 recovery: A longitudinal observational prospective multicenter trial
Author response: Investigating phenotypes of pulmonary COVID-19 recovery: A longitudinal observational prospective multicenter trial Open
Article Figures and data Abstract Editor's evaluation Introduction Methods Results Discussion Appendix 1 Data availability References Decision letter Author response Article and author information Metrics Abstract Background: The optimal p…
View article: Phenotyping of Acute and Persistent Coronavirus Disease 2019 Features in the Outpatient Setting: Exploratory Analysis of an International Cross-sectional Online Survey
Phenotyping of Acute and Persistent Coronavirus Disease 2019 Features in the Outpatient Setting: Exploratory Analysis of an International Cross-sectional Online Survey Open
Background Long COVID, defined as the presence of coronavirus disease 2019 (COVID-19) symptoms ≥28 days after clinical onset, is an emerging challenge to healthcare systems. The objective of the current study was to explore recovery phenot…