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View article: Determination of the miRNA profile of extracellular vesicles from equine mesenchymal stem cells after different treatments
Determination of the miRNA profile of extracellular vesicles from equine mesenchymal stem cells after different treatments Open
Background Osteoarthritis (OA) is a common and incurable disease in humans and animals. To gain a better understanding of the pathogenesis and identify potential treatments, miRNAs will be extracted and analysed from extracellular vesicles…
View article: CRISPR/Cas9-Targeted Myostatin Deletion Improves the Myogenic Differentiation Parameters for Muscle-Derived Stem Cells in Mice
CRISPR/Cas9-Targeted Myostatin Deletion Improves the Myogenic Differentiation Parameters for Muscle-Derived Stem Cells in Mice Open
Skeletal muscle plays a pivotal role in physical activity, protein storage and energy utilization. Skeletal muscle wasting due to immobilization, aging, muscular dystrophy and cancer cachexia has negative impacts on the quality of life. Th…
View article: Phenotyping the Sheep Tail: Histological Depiction of Caudal Spine Structures in Sheep
Phenotyping the Sheep Tail: Histological Depiction of Caudal Spine Structures in Sheep Open
The morphology of sheep tails remains relatively understudied. Given the escalating discourse on routine removal of the caudal spine in sheep, a thorough exploration of the anatomical structures within this region is imperative. To examine…
View article: Correction: Bortezomib-releasing silica-collagen xerogels for local treatment of osteolytic bone- and minimal residual disease in multiple myeloma
Correction: Bortezomib-releasing silica-collagen xerogels for local treatment of osteolytic bone- and minimal residual disease in multiple myeloma Open
View article: Bortezomib-releasing silica-collagen xerogels for local treatment of osteolytic bone- and minimal residual disease in multiple myeloma
Bortezomib-releasing silica-collagen xerogels for local treatment of osteolytic bone- and minimal residual disease in multiple myeloma Open
View article: Extracellular Vesicles: A Novel Diagnostic Tool and Potential Therapeutic Approach for Equine Osteoarthritis
Extracellular Vesicles: A Novel Diagnostic Tool and Potential Therapeutic Approach for Equine Osteoarthritis Open
Osteoarthritis (OA) is a chronic progressive degenerative joint disease that affects a significant portion of the equine population and humans worldwide. Current treatment options for equine OA are limited and incompletely curative. Horses…
View article: Effect of storage conditions on the quality of equine and canine mesenchymal stem cell derived nanoparticles including extracellular vesicles for research and therapy
Effect of storage conditions on the quality of equine and canine mesenchymal stem cell derived nanoparticles including extracellular vesicles for research and therapy Open
Nanoparticles including extracellular vesicles derived from mesenchymal stem cells are of increasing interest for research and clinical use in regenerative medicine. Extracellular vesicles (EVs), including also previously named exosomes, p…
View article: Morphological and Immunohistochemical Characterization of Bone Structure and Cell–Cell Communication in a Rat Osteoporosis Model
Morphological and Immunohistochemical Characterization of Bone Structure and Cell–Cell Communication in a Rat Osteoporosis Model Open
Bone remodeling is essential for maintaining bone health. The imbalance between bone formation and bone resorption leads to bone diseases such as osteoporosis. Connexin43 (Cx43) is a gap junction molecule that plays an important role in bo…
View article: Modulation of the Cellular Microenvironment by Mechanical Fluid Shear Stress and Hypoxia Alters the Differentiation Capacity of Skeletal Muscle-Derived Stem Cells
Modulation of the Cellular Microenvironment by Mechanical Fluid Shear Stress and Hypoxia Alters the Differentiation Capacity of Skeletal Muscle-Derived Stem Cells Open
Skeletal muscle-derived stem cells (MDSCs) are the key modulators of muscle regeneration. An inappropriate cellular microenvironment can reduce the regenerative capacity of MDSCs. This study evaluates the effect of microenvironmental alter…
View article: Optimizing the Adipogenic Induction Protocol Using Rosiglitazone Improves the Physiological Parameters and Differentiation Capacity of Adipose Tissue-Derived Mesenchymal Stem Cells for Horses, Sheep, Dogs, Murines, and Humans
Optimizing the Adipogenic Induction Protocol Using Rosiglitazone Improves the Physiological Parameters and Differentiation Capacity of Adipose Tissue-Derived Mesenchymal Stem Cells for Horses, Sheep, Dogs, Murines, and Humans Open
The investigation of adipose tissue-derived mesenchymal stem cells (ASCs) has received considerable interest in regenerative medicine. A nontoxic adipogenic induction protocol valid for cells of different mammalian species has not been des…
View article: Frequency and Characterisation of Anomalies and Fractures of the Caudal Spine in Sheep with Undocked Tails
Frequency and Characterisation of Anomalies and Fractures of the Caudal Spine in Sheep with Undocked Tails Open
As tails are often docked within the first days of life, studies investigating tail malformations and injuries in sheep do not exist thus far. To address this gap in the literature, this research aimed to analyse the occurrence of vertebra…
View article: The effect of hypoxia on myogenic differentiation and multipotency of the skeletal muscle-derived stem cells in mice
The effect of hypoxia on myogenic differentiation and multipotency of the skeletal muscle-derived stem cells in mice Open
Background Skeletal muscle-derived stem cells (SC) have become a promising approach for investigating myogenic differentiation and optimizing tissue regeneration. Muscle regeneration is performed by SC, a self-renewal cell population under…
View article: Distribution pattern of local immune cells within the lower urinary tract of male sheep lambs
Distribution pattern of local immune cells within the lower urinary tract of male sheep lambs Open
The local immunity of the lower urinary tract (LUT) is often presumed to influence the development of ascending infections and local inflammation. Due to small ruminants being at a higher risk of developing obstructive urolithiasis after e…
View article: Podosome-Driven Defect Development in Lamellar Bone under the Conditions of Senile Osteoporosis Observed at the Nanometer Scale
Podosome-Driven Defect Development in Lamellar Bone under the Conditions of Senile Osteoporosis Observed at the Nanometer Scale Open
The degradation mechanism of human trabecular bone harvested from the central part of the femoral head of a patient with a fragility fracture of the femoral neck under conditions of senile osteoporosis was investigated by high-resolution e…
View article: Characterisation of stemness and multipotency of ovine muscle‐derived stem cells from various muscle sources
Characterisation of stemness and multipotency of ovine muscle‐derived stem cells from various muscle sources Open
Muscle stem cells (MSCs) are a promising tool for cell‐based therapy and tissue regeneration in veterinary medicine. Evaluation of MSCs from muscles of different origins improves our understanding of their regenerative potential. The prese…
View article: Combined macromolecule biomaterials together with fluid shear stress promote the osteogenic differentiation capacity of equine adipose-derived mesenchymal stem cells
Combined macromolecule biomaterials together with fluid shear stress promote the osteogenic differentiation capacity of equine adipose-derived mesenchymal stem cells Open
Background Combination of mesenchymal stem cells (MSCs) and biomaterials is a rapidly growing approach in regenerative medicine particularly for chronic degenerative disorders including osteoarthritis and osteoporosis. The present study ex…
View article: Combined Macromolecule biomaterials together with fluid shear stress promote the osteogenic differentiation capacity of equine adipose -derived mesenchymal stem cells
Combined Macromolecule biomaterials together with fluid shear stress promote the osteogenic differentiation capacity of equine adipose -derived mesenchymal stem cells Open
Background: Combination of mesenchymal stem cells (MSCs) and biomaterials is a rapidly growing approach in regenerative medicine particularly for chronic degenerative disorders including osteoarthritis and osteoporosis. The present study e…
View article: An in-depth diagnostic exploration of an inflammation and necrosis syndrome in a population of newborn piglets
An in-depth diagnostic exploration of an inflammation and necrosis syndrome in a population of newborn piglets Open
Inflammation and loss of tail integrity can be reasons for serious impairment of animal welfare and one of the major challenges facing modern pig farming. Evidence from practice increasingly suggests that tail lesions might be caused not o…
View article: Combined Macromolecule biomaterials together with fluid shear stress promote the osteogenic differentiation capacity of equine adipose -derived mesenchymal stem cells
Combined Macromolecule biomaterials together with fluid shear stress promote the osteogenic differentiation capacity of equine adipose -derived mesenchymal stem cells Open
Background: Combination of stem cells and biomaterials is a rapidly growing approach in regenerative medicine particularly for chronic degenerative disorders including osteoarthritis and osteoporosis. The present study examined the effect …
View article: Neuropeptides in the urinary tract of male sheep lambs
Neuropeptides in the urinary tract of male sheep lambs Open
Small ruminants are often presumed to be at a higher risk of developing obstructive urolithiasis after early castration. However, the underlying pathophysiology and histological correlation of this assumption is unknown. This study examine…
View article: Effect of long term palmitate treatment on osteogenic differentiation of human mesenchymal stromal cells - Impact of albumin
Effect of long term palmitate treatment on osteogenic differentiation of human mesenchymal stromal cells - Impact of albumin Open
View article: In Vitro and In Vivo Biocompatibility Studies of a Cast and Coated Titanium Alloy
In Vitro and In Vivo Biocompatibility Studies of a Cast and Coated Titanium Alloy Open
The biocompatibility of a cast porous and with a calcium titanate reaction layer functionalized titanium alloy (Ti-6Al-7Nb) was tested by means of cell culture, and a small (rat) and large animal (sheep) model. The uncoated titanium materi…
View article: Macromolecule Biomaterials Promote the Osteogenic Differentiation Capacity of Equine Adipose -Derived Mesenchymal Stem Cells
Macromolecule Biomaterials Promote the Osteogenic Differentiation Capacity of Equine Adipose -Derived Mesenchymal Stem Cells Open
Background: Combination of mesenchymal stem cells (MSCs) and biomaterials is a rapidly growing approach in regenerative medicine particularly for chronic degenerative disorders including osteoarthritis and osteoporosis. In the present stud…
View article: Effects of testosterone and 17β-estradiol on osteogenic and adipogenic differentiation capacity of human bone-derived mesenchymal stromal cells of postmenopausal women
Effects of testosterone and 17β-estradiol on osteogenic and adipogenic differentiation capacity of human bone-derived mesenchymal stromal cells of postmenopausal women Open
Progressive bone loss is a predominant symptom of aging and osteoporosis. Therefore, the effects of sex steroids (i.e. testosterone and 17β-estradiol) on the differentiation capacity of human bone-derived mesenchymal stromal cells (hMSCs),…
View article: The effect of high‐fat diet on the morphological properties of the forelimb musculature in hypertrophic myostatin null mice
The effect of high‐fat diet on the morphological properties of the forelimb musculature in hypertrophic myostatin null mice Open
Obesity is a worldwide nutritional disorder affecting body performance, including skeletal muscle. Inhibition of myostatin not only increases the muscle mass but also it reduces body fat accumulation. We examined the effect of high‐fat die…
View article: FRI0525 DURING ADIPOGENIC DIFFERENTIATION OF MSC ON MINERALIZED BONE FRAGMENTS
FRI0525 DURING ADIPOGENIC DIFFERENTIATION OF MSC ON MINERALIZED BONE FRAGMENTS Open
View article: The Addition of High Doses of Hyaluronic Acid to a Biphasic Bone Substitute Decreases the Proinflammatory Tissue Response
The Addition of High Doses of Hyaluronic Acid to a Biphasic Bone Substitute Decreases the Proinflammatory Tissue Response Open
Biphasic bone substitutes (BBS) are currently well-established biomaterials. Through their constant development, even natural components like hyaluronic acid (HY) have been added to improve both their handling and also their regenerative p…
View article: THE EFFECT OF TEMPERATURE TREATMENT OF XENOGENEIC BONE SUBSTITUTE ON THE TISSUE RESPONSE –A MINI REVIEW
THE EFFECT OF TEMPERATURE TREATMENT OF XENOGENEIC BONE SUBSTITUTE ON THE TISSUE RESPONSE –A MINI REVIEW Open
In general, it has been revealed that interaction of bone substitute material with the host immune system is dependent upon their physico-chemical properties.In the case of xeno-grafts, different purification methods are applied to process…
View article: P123 Extracellular matrix attenuated matrix-degrading effects of visfatin during adipogenic MSC differentiation
P123 Extracellular matrix attenuated matrix-degrading effects of visfatin during adipogenic MSC differentiation Open
View article: Exosomes isolation and identification from equine mesenchymal stem cells
Exosomes isolation and identification from equine mesenchymal stem cells Open
Exosomes generated by equine mesenchymal stem cells can be obtained by ultrafiltration and ultracentrifugation in an equal quality for in vitro experiments. Especially for later therapeutic usage we recommend ultrafiltration due to a highe…