Sabitha Joseph
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View article: Loss of the parkinsonism‐associated protein <scp>FBXO7</scp> in glutamatergic forebrain neurons in mice leads to abnormal motor behavior and synaptic defects
Loss of the parkinsonism‐associated protein <span>FBXO7</span> in glutamatergic forebrain neurons in mice leads to abnormal motor behavior and synaptic defects Open
Mutations in PARK15 , which encodes for the F‐box protein FBXO7 have been associated with Parkinsonian Pyramidal syndrome, a rare and complex movement disorder with Parkinsonian symptoms, pyramidal tract signs and juvenile onset. Our previ…
View article: Myelinating Glia-Specific Deletion of Fbxo7 in Mice Triggers Axonal Degeneration in the Central Nervous System Together with Peripheral Neuropathy
Myelinating Glia-Specific Deletion of Fbxo7 in Mice Triggers Axonal Degeneration in the Central Nervous System Together with Peripheral Neuropathy Open
Myelination of axons facilitates the rapid propagation of electrical signals and the long-term integrity of axons. The ubiquitin-proteasome system is essential for proper protein homeostasis, which is particularly crucial for interactions …
View article: A novel role for the E3 ubiquitin ligase FBXO7 in axon-myelin interaction
A novel role for the E3 ubiquitin ligase FBXO7 in axon-myelin interaction Open
The regulated turnover of proteins is an essential aspect of every cell. Cells must be able to respond to environmental changes or undergo different developmental stages, while still maintaining a balanced protein homeostasis. The ubiquiti…
View article: Mechanistic contributions of FBXO7 to Parkinson disease
Mechanistic contributions of FBXO7 to Parkinson disease Open
Parkinson disease (PD) is, without doubt, a burden on modern society as the prevalence increases significantly with age. Owing to this growing number of PD cases, it is more critical than ever to understand the pathogenic mechanisms underl…