Sabrina Blumer
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View article: Characteristics of ectopic alveolar basal cells relative to airway basal cells in fibrosis
Characteristics of ectopic alveolar basal cells relative to airway basal cells in fibrosis Open
Rationale Basal cells (BC) appear ectopically within the lung parenchyma of interstitial lung disease (ILD) patients, potentially through migration of airway BC or though trans-differentiation of alveolar epithelial type 2 (AT2) cells. The…
View article: Characteristics of ectopic alveolar basal cells relative to airway basal cells in fibrosis
Characteristics of ectopic alveolar basal cells relative to airway basal cells in fibrosis Open
Rationale Basal cells (BC) appear ectopically within the lung parenchyma of interstitial lung disease (ILD) patients, potentially through migration of airway BC or though trans-differentiation of alveolar epithelial type 2 (AT2) cells. The…
View article: The use of cultured human alveolar basal cells to mimic honeycomb formation in idiopathic pulmonary fibrosis
The use of cultured human alveolar basal cells to mimic honeycomb formation in idiopathic pulmonary fibrosis Open
Background Honeycomb cysts (HC) within the alveolar region are distinct histopathological features in the lungs of idiopathic pulmonary fibrosis (IPF) patients. HC are lined with a single-or stratified layer of basal cells (BC), or with a …
View article: The use of cultured human alveolar basal cells to mimic honeycomb formation in idiopathic pulmonary fibrosis
The use of cultured human alveolar basal cells to mimic honeycomb formation in idiopathic pulmonary fibrosis Open
Summary Honeycomb cysts (HC) within the alveolar region are distinct histopathological features in the lungs of idiopathic pulmonary fibrosis (IPF) patients. HC are lined with basal cells (BC), or with a bronchiolar-like epithelium compose…
View article: SSC/SSCS – SSP/SSTS Joint Annual Meeting 2023 - Abstracts
SSC/SSCS – SSP/SSTS Joint Annual Meeting 2023 - Abstracts Open
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View article: Alveolar Basal Cells Differentiate towards Secretory Epithelial- and Aberrant Basaloid-like Cells In Vitro
Alveolar Basal Cells Differentiate towards Secretory Epithelial- and Aberrant Basaloid-like Cells In Vitro Open
In idiopathic pulmonary fibrosis (IPF), keratin (KRT)17+/KRT5+ basal and KRT17+/KRT5− aberrant basaloid cells are atypically present within the alveolar space. We previously described the fibrosis-enriched outgrowth of alveolar basal cells…
View article: Basal-Like Cell-Conditioned Medium Exerts Anti-Fibrotic Effects In Vitro and In Vivo
Basal-Like Cell-Conditioned Medium Exerts Anti-Fibrotic Effects In Vitro and In Vivo Open
In idiopathic pulmonary fibrosis (IPF), basal-like cells are atypically present in the alveolar region, where they may affect adjacent stromal cells by paracrine mechanisms. We here aimed to confirm the presence of basal-like cells in peri…
View article: IPF-Fibroblast Erk1/2 Activity Is Independent from microRNA Cluster 17-92 but Can Be Inhibited by Treprostinil through DUSP1
IPF-Fibroblast Erk1/2 Activity Is Independent from microRNA Cluster 17-92 but Can Be Inhibited by Treprostinil through DUSP1 Open
Idiopathic pulmonary fibrosis (IPF) is a progressive terminal lung disease, and therapies aim to block fibrosis. Fibroblast proliferation is controlled by C/EBP-β, microRNA cluster 17-92 (miR17-92), and Erk1/2 mitogen-activated protein kin…
View article: In vitro culture of aberrant basal-like cells from fibrotic lung tissue
In vitro culture of aberrant basal-like cells from fibrotic lung tissue Open
Rationale In idiopathic pulmonary fibrosis (IPF) atypical epithelial cells are present in the alveolar compartment. Their origin and contribution to IPF pathogenesis is unknown. We recently cultured a distinct population of cells, which re…