Sabrina Fasoli
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View article: Evaluation of the difference between mean corpuscular haemoglobin concentration and mean cellular haemoglobin concentration in canine complete blood count assessed with an automated haematology analyser
Evaluation of the difference between mean corpuscular haemoglobin concentration and mean cellular haemoglobin concentration in canine complete blood count assessed with an automated haematology analyser Open
Objectives The study aimed (a) to establish the reference interval for Δmean corpuscular haemoglobin concentration‐mean cellular haemoglobin concentration in healthy dogs by ADVIA 2120 haematology analyser, (b) to identify the causes of in…
View article: Spurious increase in automated optical platelet counts associated with lipemia in dogs
Spurious increase in automated optical platelet counts associated with lipemia in dogs Open
Spurious platelet counts (PLTCs) associated with lipemia are documented in humans and rarely in dogs. We retrospectively evaluated CBCs of dogs admitted to a veterinary hospital to assess the interference of lipemia with the automated PLTC…
View article: Neutrophil Gelatinase-Associated Lipocalin (NGAL) as a Biomarker of Acute Kidney Injury (AKI) in Dogs with Congestive Heart Failure (CHF) Due to Myxomatous Mitral Valve Disease (MMVD)
Neutrophil Gelatinase-Associated Lipocalin (NGAL) as a Biomarker of Acute Kidney Injury (AKI) in Dogs with Congestive Heart Failure (CHF) Due to Myxomatous Mitral Valve Disease (MMVD) Open
Dogs with acute congestive heart failure (CHF) can develop acute kidney injury (AKI); the prevalence of this condition has not been defined. This study aimed to assess the occurrence of AKI (increase in serum creatinine (sCr) ≥ 0.3 mg/dL) …
View article: Efficacy and safety of different antiarrhythmic protocols used for rate control in dogs with secondary atrial fibrillation
Efficacy and safety of different antiarrhythmic protocols used for rate control in dogs with secondary atrial fibrillation Open
View article: Efficacy and safety of antiarrhythmic therapy in dogs with naturally acquired tachyarrhythmias treated with amiodarone or sotalol: a retrospective analysis of 64 cases
Efficacy and safety of antiarrhythmic therapy in dogs with naturally acquired tachyarrhythmias treated with amiodarone or sotalol: a retrospective analysis of 64 cases Open
View article: Dimerization of Human Angiogenin and of Variants Involved in Neurodegenerative Diseases
Dimerization of Human Angiogenin and of Variants Involved in Neurodegenerative Diseases Open
Human Angiogenin (hANG, or ANG, 14.1 kDa) promotes vessel formation and is also called RNase 5 because it is included in the pancreatic-type ribonuclease (pt-RNase) super-family. Although low, its ribonucleolytic activity is crucial for an…
View article: RNase A Domain-Swapped Dimers Produced Through Different Methods: Structure–Catalytic Properties and Antitumor Activity
RNase A Domain-Swapped Dimers Produced Through Different Methods: Structure–Catalytic Properties and Antitumor Activity Open
Upon oligomerization, RNase A can acquire important properties, such as cytotoxicity against leukemic cells. When lyophilized from 40% acetic acid solutions, the enzyme self-associates through the so-called three-dimensional domain swappin…
View article: NMR Characterization of Angiogenin Variants and tRNAAla Products Impacting Aberrant Protein Oligomerization
NMR Characterization of Angiogenin Variants and tRNAAla Products Impacting Aberrant Protein Oligomerization Open
Protein oligomerization is key to countless physiological processes, but also to abnormal amyloid conformations implicated in over 25 mortal human diseases. Human Angiogenin (h-ANG), a ribonuclease A family member, produces RNA fragments t…
View article: NMR Characterization of Angiogenin Variants and tRNAAla Products Impacting Aberrant Protein Oligomerization
NMR Characterization of Angiogenin Variants and tRNAAla Products Impacting Aberrant Protein Oligomerization Open
Protein oligomerzation is key to countless physiological processes, but also to abnormal amyloid conformations implicated in over 25 mortal human diseases. Angiogenin (h-ANG), a ribonuclease A family member, produces RNA fragments that reg…
View article: Giraffe’s urine: from urinalysis to proteomics and metabolomics
Giraffe’s urine: from urinalysis to proteomics and metabolomics Open
This thesis focused on defining the urinary reference values and investigating the urinary proteome and metabolome of captive giraffes (Giraffa camelopardalis) by using a non-invasive sampling method. Urine samples were collected with a sy…
View article: Noninvasive sampling method for urinalysis and urine protein profile in captive giraffes
Noninvasive sampling method for urinalysis and urine protein profile in captive giraffes Open
Urinalysis could be helpful to investigate the health status of giraffes held in captivity using noninvasive methods to avoid animal handling or anesthesia. We collected 52 voided urine samples from 20 giraffes of different ages, sexes, an…
View article: Urinary Reference Values and First Insight into the Urinary Proteome of Captive Giraffes
Urinary Reference Values and First Insight into the Urinary Proteome of Captive Giraffes Open
Urinalysis is widely recognized to be a useful tool in routine health investigations, since it can diagnose numerous pathologies. Considering the paucity of knowledge concerning giraffes, urine from 44 giraffes (Giraffa camelopardalis) (18…
View article: First Insights into the Urinary Metabolome of Captive Giraffes by Proton Nuclear Magnetic Resonance Spectroscopy
First Insights into the Urinary Metabolome of Captive Giraffes by Proton Nuclear Magnetic Resonance Spectroscopy Open
The urine from 35 giraffes was studied by untargeted 1H-NMR, with the purpose of obtaining, for the first time, a fingerprint of its metabolome. The metabolome, as downstream of the transcriptome and proteome, has been considered as the mo…
View article: Onconase Restores Cytotoxicity in Dabrafenib-Resistant A375 Human Melanoma Cells and Affects Cell Migration, Invasion and Colony Formation Capability
Onconase Restores Cytotoxicity in Dabrafenib-Resistant A375 Human Melanoma Cells and Affects Cell Migration, Invasion and Colony Formation Capability Open
Melanoma is a lethal tumor because of its severe metastatic potential, and serine/threonine-protein kinase B-raf inhibitors (BRAFi) are used in patients harboring BRAF-mutation. Unfortunately, BRAFi induce resistance. Therefore, we tested …
View article: Human alpha-Thrombin Binds to and Potently Inhibits Leukocyte Myeloperoxidase: A Novel Biochemical Link Between Inflammation and Coagulation
Human alpha-Thrombin Binds to and Potently Inhibits Leukocyte Myeloperoxidase: A Novel Biochemical Link Between Inflammation and Coagulation Open
Human alpha-Thrombin (aT) is a serine protease that plays a pivotal role at the interface between inflammation and coagulation. aT displays both pro-coagulant (i.e., fibrin generation and platelets activation) and anti-coagulant (generatio…