Sabrina M. Heman-Ackah
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View article: Radiation-induced cavernous malformation within a vestibular schwannoma: A case report
Radiation-induced cavernous malformation within a vestibular schwannoma: A case report Open
Cavernous malformations are a well-described complication of intracranial radiation; however, have only once previously been described within a vestibular schwannoma following radiotherapy. We report a case of a 78-year-old woman presentin…
View article: A multi-institutional machine learning algorithm for prognosticating facial nerve injury following microsurgical resection of vestibular schwannoma
A multi-institutional machine learning algorithm for prognosticating facial nerve injury following microsurgical resection of vestibular schwannoma Open
Vestibular schwannomas (VS) are the most common tumor of the skull base with available treatment options that carry a risk of iatrogenic injury to the facial nerve, which can significantly impact patients’ quality of life. As facial nerve …
View article: Idiopathic Intracranial Hypertension Is Associated with Recurrent CSF Leak and Reoperation for Spontaneous Temporal Encephalocele
Idiopathic Intracranial Hypertension Is Associated with Recurrent CSF Leak and Reoperation for Spontaneous Temporal Encephalocele Open
Objective Spontaneous temporal encephaloceles (STEs) are increasingly recognized as sequelae of idiopathic intracranial hypertension (IIH), which in turn may further complicate their management. We endeavored to review the University of Pe…
View article: Phenotypic manifestation of α-synuclein strains derived from Parkinson’s disease and multiple system atrophy in human dopaminergic neurons
Phenotypic manifestation of α-synuclein strains derived from Parkinson’s disease and multiple system atrophy in human dopaminergic neurons Open
View article: Neurologically Devastating Intraparenchymal Hemorrhage in COVID-19 Patients on Extracorporeal Membrane Oxygenation: A Case Series
Neurologically Devastating Intraparenchymal Hemorrhage in COVID-19 Patients on Extracorporeal Membrane Oxygenation: A Case Series Open
BACKGROUND AND IMPORTANCE Extracorporeal membrane oxygenation (ECMO) represents a life-saving therapy in cases of refractory hypoxia and has been utilized in patients suffering from the most severe forms of coronavirus disease 2019 (COVID-…
View article: Precision Modulation of Neurodegenerative Disease-Related Gene Expression in Human iPSC-Derived Neurons
Precision Modulation of Neurodegenerative Disease-Related Gene Expression in Human iPSC-Derived Neurons Open
The ability to reprogram adult somatic cells into induced pluripotent stem cells (iPSCs) and the subsequent development of protocols for their differentiation into disease-relevant cell types have enabled in-depth molecular analyses of mul…
View article: Thalamic Deep Brain Stimulation for Essential Tremor: Relation of the Dentatorubrothalamic Tract with Stimulation Parameters
Thalamic Deep Brain Stimulation for Essential Tremor: Relation of the Dentatorubrothalamic Tract with Stimulation Parameters Open
View article: Doublecortin-like Kinase 1 Regulates α-Synuclein Levels and Toxicity
Doublecortin-like Kinase 1 Regulates α-Synuclein Levels and Toxicity Open
α-Synuclein (α-Syn) accumulation is a pathological hallmark of Parkinson's disease. Duplications and triplications of SNCA , the gene coding for α-Syn, cause genetic forms of the disease, which suggests that increased α-Syn dosage can driv…
View article: 347 Alpha-Synuclein Induces the Unfolded Protein Response in Parkinson's Disease Patient-Specific SNCA Triplication iPSC-Derived Neurons
347 Alpha-Synuclein Induces the Unfolded Protein Response in Parkinson's Disease Patient-Specific SNCA Triplication iPSC-Derived Neurons Open
Online date: August 16, 2018 This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard…
View article: Alpha-synuclein induces the unfolded protein response in Parkinson’s disease SNCA triplication iPSC-derived neurons
Alpha-synuclein induces the unfolded protein response in Parkinson’s disease SNCA triplication iPSC-derived neurons Open
The recent generation of induced pluripotent stem cells (iPSCs) from a patient with Parkinson's disease (PD) resulting from triplication of the α-synuclein (SNCA) gene locus allows unprecedented opportunities to explore its contribution to…
View article: Precision Modulation of Neurodegenerative Disease-Related Gene Expression in Human iPSC-Derived Neurons
Precision Modulation of Neurodegenerative Disease-Related Gene Expression in Human iPSC-Derived Neurons Open
View article: Chemogenomic Profiling of Endogenous <i>PARK2</i> Expression Using a Genome-Edited Coincidence Reporter
Chemogenomic Profiling of Endogenous <i>PARK2</i> Expression Using a Genome-Edited Coincidence Reporter Open
Parkin, an E3 ubiquitin ligase, is a central mediator of mitochondrial quality control and is linked to familial forms of Parkinson's disease (PD). Removal of dysfunctional mitochondria from the cell by Parkin is thought to be neuroprotect…
View article: Alpha-synuclein in Parkinson's disease: molecular pathogenesis and development of genome engineering-based silencing approaches
Alpha-synuclein in Parkinson's disease: molecular pathogenesis and development of genome engineering-based silencing approaches Open
The ability to reprogram adult somatic cells into induced pluripotent stem cells (iPSCs) and subsequent development of protocols for their differentiation into disease-relevant cell types have enabled in-depth molecular analyses of multipl…