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View article: Enteropathogenic Escherichia Coli Revisited - New Insights into Old Epec Isolates Using Whole Genome Sequencing
Enteropathogenic Escherichia Coli Revisited - New Insights into Old Epec Isolates Using Whole Genome Sequencing Open
View article: Infection and antibiotic-associated changes in the fecal microbiota of<i>C. rodentium</i>ϕ<i>stx2<sub>dact</sub></i>-infected C57BL/6 mice
Infection and antibiotic-associated changes in the fecal microbiota of<i>C. rodentium</i>ϕ<i>stx2<sub>dact</sub></i>-infected C57BL/6 mice Open
Enterohemorrhagic E. coli causes watery to bloody diarrhea, which may progress to hemorrhagic colitis and hemolytic-uremic syndrome. While early studies suggested that antibiotic treatment may worsen the pathology of an EHEC infection, rec…
View article: An innate immune sensor wandering around – <scp>NOD1</scp> promotes cell migration via non‐canonical signaling
An innate immune sensor wandering around – <span>NOD1</span> promotes cell migration via non‐canonical signaling Open
NOD1 is a cytosolic immune receptor well known for recognizing intracellular bacteria and inducing innate immune responses. Upon ligand binding, it usually forms a complex with the serine/threonine kinase RIPK2 to activate the transcriptio…
View article: Targeting bacterial pathogenesis by inhibiting virulence-associated Type III and Type IV secretion systems
Targeting bacterial pathogenesis by inhibiting virulence-associated Type III and Type IV secretion systems Open
Infections caused by Gram-negative pathogens pose a major health burden. Both respiratory and gastrointestinal infections are commonly associated with these pathogens. With the increase in antimicrobial resistance (AMR) over the last decad…
View article: Identification of translocation inhibitors targeting the type III secretion system of enteropathogenic <i>Escherichia coli</i>
Identification of translocation inhibitors targeting the type III secretion system of enteropathogenic <i>Escherichia coli</i> Open
Infections with enteropathogenic E. coli (EPEC) cause severe diarrhea in children. The non-invasive bacteria adhere to enterocytes of the small intestine and use a type III secretion system (T3SS) to inject effector proteins into host cell…
View article: Attaching and Effacing Pathogens: The Effector ABC of Immune Subversion
Attaching and Effacing Pathogens: The Effector ABC of Immune Subversion Open
The innate immune response resembles an essential barrier to bacterial infection. Many bacterial pathogens have, therefore, evolved mechanisms to evade from or subvert the host immune response in order to colonize, survive and multiply. Th…
View article: Treatment Strategies for Infections With Shiga Toxin-Producing Escherichia coli
Treatment Strategies for Infections With Shiga Toxin-Producing Escherichia coli Open
Infections with Shiga toxin-producing Escherichia coli (STEC) cause outbreaks of severe diarrheal disease in children and the elderly around the world. The severe complications associated with toxin production and release range from…
View article: Crystal structure of full-length cytotoxic necrotizing factor CNF<sub>Y</sub>reveals molecular building blocks for intoxication
Crystal structure of full-length cytotoxic necrotizing factor CNF<sub>Y</sub>reveals molecular building blocks for intoxication Open
Cytotoxic necrotizing factors (CNFs) are bacterial single-chain exotoxins that modulate cytokinetic/oncogenic and inflammatory processes through activation of host cell Rho GTPases. To achieve this, they are secreted, bind surface receptor…
View article: Variations in microbiota composition of laboratory mice influence Citrobacter rodentium infection via variable short-chain fatty acid production
Variations in microbiota composition of laboratory mice influence Citrobacter rodentium infection via variable short-chain fatty acid production Open
The composition of the intestinal microbiota influences the outcome of enteric infections in human and mice. However, the role of specific members and their metabolites contributing to disease severity is largely unknown. Using isogenic mo…
View article: Identification of Antibiotics That Diminish Disease in a Murine Model of Enterohemorrhagic Escherichia coli Infection
Identification of Antibiotics That Diminish Disease in a Murine Model of Enterohemorrhagic Escherichia coli Infection Open
Infections with enterohemorrhagic Escherichia coli (EHEC) cause disease ranging from mild diarrhea to hemolytic-uremic syndrome (HUS) and are the most common cause of renal failure in children in high-income countries. The severity of the …
View article: Novel type of pilus associated with a Shiga-toxigenic <i>E. coli</i> hybrid pathovar conveys aggregative adherence and bacterial virulence
Novel type of pilus associated with a Shiga-toxigenic <i>E. coli</i> hybrid pathovar conveys aggregative adherence and bacterial virulence Open
A large German outbreak in 2011 was caused by a locus of enterocyte effacement (LEE)-negative enterohemorrhagic E. coli (EHEC) strain of the serotype O104:H4. This strain harbors markers that are characteristic of both EHEC and ente…
View article: Novel type of pilus associated with a Shiga-toxigenic <i>E. coli</i> hybrid pathovar conveys aggregative adherence and bacterial virulence
Novel type of pilus associated with a Shiga-toxigenic <i>E. coli</i> hybrid pathovar conveys aggregative adherence and bacterial virulence Open
A large German outbreak in 2011 was caused by a locus of enterocyte effacement (LEE)-negative enterohemorrhagic E. coli (EHEC) strain of the serotype O104:H4. This strain harbors markers that are characteristic of both EHEC and enteroaggre…
View article: Erratum: EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation
Erratum: EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation Open
View article: EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation
EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation Open
View article: The Type III Effector NleD from Enteropathogenic Escherichia coli Differentiates between Host Substrates p38 and JNK
The Type III Effector NleD from Enteropathogenic Escherichia coli Differentiates between Host Substrates p38 and JNK Open
Enteropathogenic Escherichia coli (EPEC) is a gastrointestinal pathogen that utilizes a type III secretion system (T3SS) to inject an array of virulence effector proteins into host enterocytes to subvert numerous cellular processes for suc…
View article: Substrate recognition by the zinc metalloprotease effector NleC from enteropathogenic<i>E</i><i>scherichia coli</i>
Substrate recognition by the zinc metalloprotease effector NleC from enteropathogenic<i>E</i><i>scherichia coli</i> Open
Upon infection of epithelial cells, enteropathogenic Escherichia coli suppresses host cell inflammatory signalling in a type III secretion system (T3SS) dependent manner. Two key T3SS effector proteins involved in this response are NleE an…
View article: A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production
A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production Open
Intracellular nucleotide binding and oligomerization domain (NOD) receptors recognize antigens including bacterial peptidoglycans and initiate immune responses by triggering the production of pro-inflammatory cytokines through activating N…
View article: Anti-virulence Strategies to Target Bacterial Infections
Anti-virulence Strategies to Target Bacterial Infections Open