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View article: Dynamic modeling of mortality risk factors in Ebola virus disease using logistic regression on unbalanced panel data from a randomized controlled trial in the Democratic Republic of Congo
Dynamic modeling of mortality risk factors in Ebola virus disease using logistic regression on unbalanced panel data from a randomized controlled trial in the Democratic Republic of Congo Open
Ebola Virus Disease (EVD) remains a significant public health threat, particularly in sub-Saharan Africa. During the 10th Ebola outbreak in the Democratic Republic of Congo (DRC), the Pamoja Tulinde Maisha clinical trial (PALM-RCT) provide…
View article: Hematologic Disorders in Ebola-Infected Patients During the Tenth Outbreak in Butembo, Democratic Republic of Congo: Hemogram Analysis of Ebola Virus Disease Patients During the Outbreak in Butembo 2019–2020
Hematologic Disorders in Ebola-Infected Patients During the Tenth Outbreak in Butembo, Democratic Republic of Congo: Hemogram Analysis of Ebola Virus Disease Patients During the Outbreak in Butembo 2019–2020 Open
Background: Hematologic disorders occur frequently in patients with Ebola virus disease (EVD) and are characterized by one or several abnormalities in blood cells, including hemostasis, which is poorly documented. This study described the …
View article: Dysglycaemia in Ebola virus disease: a retrospective analysis from the 2018 to 2020 outbreak
Dysglycaemia in Ebola virus disease: a retrospective analysis from the 2018 to 2020 outbreak Open
View article: The Human Mpox Global Outbreak: Available Control Tools and the Opportunity to Break a Cycle of Neglect in Endemic Countries
The Human Mpox Global Outbreak: Available Control Tools and the Opportunity to Break a Cycle of Neglect in Endemic Countries Open
The 2022 global outbreak of human Mpox (formerly monkeypox) virus (MPXV) infection outside of the usual endemic zones in Africa challenged our understanding of the virus’s natural history, transmission dynamics, and risk factors. This outb…
View article: Comparison of the performance of linear discriminant analysis and binary logistic regression applied to risk factors for mortality in Ebola virus disease patients
Comparison of the performance of linear discriminant analysis and binary logistic regression applied to risk factors for mortality in Ebola virus disease patients Open
Our study aimed to identify risk factors associated with mortality in Ebola patients using binary logistic regression analysis and linear discriminant analysis, and to assess the predictive power of these two methods. Our study was a rando…
View article: The prophylactic and therapeutic efficacy of the broadly active antiviral ribonucleoside N-Hydroxycytidine (EIDD-1931) in a mouse model of lethal Ebola virus infection
The prophylactic and therapeutic efficacy of the broadly active antiviral ribonucleoside N-Hydroxycytidine (EIDD-1931) in a mouse model of lethal Ebola virus infection Open
The unprecedented magnitude of the 2013-2016 Ebola virus (EBOV) epidemic in West Africa resulted in over 11 000 deaths and spurred an international public health emergency. A second outbreak in 2018-2020 in DRC resulted in an additional >3…
View article: The Prophylactic and Therapeutic Efficacy of the Broadly Active Antiviral Ribonucleoside<i>N</i><sup><i>4</i></sup>-Hydroxycytidine (EIDD-1931) in a Mouse Model of Lethal Ebola Virus Infection
The Prophylactic and Therapeutic Efficacy of the Broadly Active Antiviral Ribonucleoside<i>N</i><sup><i>4</i></sup>-Hydroxycytidine (EIDD-1931) in a Mouse Model of Lethal Ebola Virus Infection Open
The unprecedented magnitude of the 2013-2016 Ebola virus (EBOV) epidemic in West Africa resulted in over 11,000 deaths and spurred an international public health emergency. A second outbreak in 2018-2020 in DRC resulted in an additional >3…
View article: Development of the PREDS score to predict in-hospital mortality of patients with Ebola virus disease under advanced supportive care: Results from the EVISTA cohort in the Democratic Republic of the Congo
Development of the PREDS score to predict in-hospital mortality of patients with Ebola virus disease under advanced supportive care: Results from the EVISTA cohort in the Democratic Republic of the Congo Open
View article: Virus kinetics and biochemical derangements among children with Ebolavirus disease
Virus kinetics and biochemical derangements among children with Ebolavirus disease Open
This study was not funded.
View article: Antibody Use during an Outbreak of Ebola Virus Disease in the Democratic Republic of Congo, 2020
Antibody Use during an Outbreak of Ebola Virus Disease in the Democratic Republic of Congo, 2020 Open
These findings indicate that from August 2020 through September 2021, approximately 7% of lung transplantations nationally were performed in patients with respiratory failure due to Covid-19 (Table S3).Because the 3-month survival among th…
View article: Review: Insights on Current FDA-Approved Monoclonal Antibodies Against Ebola Virus Infection
Review: Insights on Current FDA-Approved Monoclonal Antibodies Against Ebola Virus Infection Open
The unprecedented 2013-2016 West Africa Ebola outbreak accelerated several medical countermeasures (MCMs) against Ebola virus disease (EVD). Several investigational products (IPs) were used throughout the outbreak but were not conclusive f…
View article: Ebola Virus Transmission Initiated by Relapse of Systemic Ebola Virus Disease
Ebola Virus Transmission Initiated by Relapse of Systemic Ebola Virus Disease Open
During the 2018-2020 Ebola virus disease (EVD) outbreak in North Kivu province in the Democratic Republic of Congo, EVD was diagnosed in a patient who had received the recombinant vesicular stomatitis virus-based vaccine expressing a ZEBOV…
View article: Development of the PREDS Score to Predict In-Hospital Mortality of Patients With Ebola Virus Disease Under Advanced Supportive Care: Results From the EVISTA Cohort in the Democratic Republic of the Congo
Development of the PREDS Score to Predict In-Hospital Mortality of Patients With Ebola Virus Disease Under Advanced Supportive Care: Results From the EVISTA Cohort in the Democratic Republic of the Congo Open
View article: Creating a Framework for Conducting Randomized Clinical Trials during Disease Outbreaks
Creating a Framework for Conducting Randomized Clinical Trials during Disease Outbreaks Open
Conducting trials of novel interventions during infectious disease emergencies, such as the ongoing Covid-19 pandemic, is increasingly recognized as important for determining the efficacy of potential vaccines and therapies. Clinical trial…
View article: Shifting the Paradigm — Applying Universal Standards of Care to Ebola Virus Disease
Shifting the Paradigm — Applying Universal Standards of Care to Ebola Virus Disease Open
Shifting the Paradigm As the treatment paradigm for patients with Ebola virus disease shifts from isolation to aggressive supportive care and antiviral therapy, the global health community can work...
View article: Serologic Evidence of Ebolavirus Infection in a Population With No History of Outbreaks in the Democratic Republic of the Congo
Serologic Evidence of Ebolavirus Infection in a Population With No History of Outbreaks in the Democratic Republic of the Congo Open
These results provide serologic evidence of Ebolavirus exposure in a population residing in non-EBOV outbreak locations in the DRC and define statistically significant activities and animal exposures that associate with EBOV seropositivity.
View article: High prevalence of IgG antibodies to Ebola virus in the Efé pygmy population in the Watsa region, Democratic Republic of the Congo
High prevalence of IgG antibodies to Ebola virus in the Efé pygmy population in the Watsa region, Democratic Republic of the Congo Open
View article: Structural and molecular basis for Ebola virus neutralization by protective human antibodies
Structural and molecular basis for Ebola virus neutralization by protective human antibodies Open
Antibodies block Ebola virus entry The recent Ebola virus outbreak in West Africa illustrates the need for both an effective vaccine and therapies to treat infected individuals. Corti et al. isolated two monoclonal antibodies from a surviv…
View article: Additional file 1: of High prevalence of IgG antibodies to Ebola virus in the EfĂŠ pygmy population in the Watsa region, Democratic Republic of the Congo
Additional file 1: of High prevalence of IgG antibodies to Ebola virus in the EfĂŠ pygmy population in the Watsa region, Democratic Republic of the Congo Open
Efe pygmy, Watsa, DRC: EBOV exposures data. (XLSX 49 kb)