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Rising illicit drug Adulterants: Xylazine and levamisole Open
The increasing prevalence of xylazine and levamisole as adulterants in illicit drugs presents significant challenges for medical professionals. This review aims to provide an overview of the mechanisms of action, prevalence of adulteration…
Despite the improved clinical sensitivity of the Roche benzodiazepines II assay it cannot replace mass spectrometry in all patient populations Open
Due to its improved performance and rapid turnaround time, the BNZ2 assay should be implemented for UDS in the ED. However, the assay should not replace LC-MS/MS testing for compliance monitoring, as unsuspected benzodiazepine use may go u…
Clinical Consequences of Occult Free Valproate Toxicity in Critically Ill Adult Patients: A Multicenter Retrospective Cohort Study Open
Background and Objectives Valproate has wide pharmacokinetic variability and a narrow therapeutic index. Its protein binding is unpredictable, particularly among critically ill patients who may experience unexpectedly elevated free concent…
View article: Performance of a Norfentanyl Immunoassay in Specimens with Low Concentrations of Fentanyl and/or Norfentanyl
Performance of a Norfentanyl Immunoassay in Specimens with Low Concentrations of Fentanyl and/or Norfentanyl Open
Background Many fentanyl immunoassays are limited in their ability to detect norfentanyl. Urine specimens collected from individuals who have been exposed to fentanyl frequently have detectable concentrations of norfentanyl (≥2 ng/mL) but …
False positive lupus anticoagulant tests in patients with high C‐reactive protein: A comparison of two hexagonal phase reagents Open
Lupus anticoagulants (LA) are a heterogeneous group of autoantibodies that bind to negatively charged phospholipids or protein/phospholipid complexes. The design of a laboratory testing algorithm is complicated by the biological heterogene…
PB0467 Antithrombin Levels after Acute Pulmonary Embolism: The Thromboembolism Heparinization and Antithrombin Observational Study (THANOS-1) Open
Conclusion(s): Tinzaparin used at prophylactic and therapeutic standard doses seems to be safe in patients with eGFR< 30 mL/min, who are at increased risk for bleeding and thrombosis.A tinzaparin population pharmacokinetics approach, using…
View article: Cannabis positivity rates in 17 emergency departments across the United States with varying degrees of marijuana legalization
Cannabis positivity rates in 17 emergency departments across the United States with varying degrees of marijuana legalization Open
States may experience an increase in cannabis-related emergency department visits with progression toward marijuana legalization. The differences between states, including those in which no impact was seen, are likely multifactorial and in…
Impact of marijuana legalization on cannabis-related visits to the emergency department Open
Legalization of marijuana in MA has led to an increase in cannabis use as indicated by both increasing rates of positive THC IA results, in older adults, as well as increasing cannabis-related ICD-10 codes. Data suggest a steady increase i…
Trib1 regulates T cell differentiation during chronic infection by restraining the effector program Open
In chronic infections, the immune response fails to control virus, leading to persistent antigen stimulation and the progressive development of T cell exhaustion. T cell effector differentiation is poorly understood in the context of exhau…
Validation and Implementation of an Ordering Alert to Improve the Efficiency of Monoclonal Gammopathy Evaluation Open
Objectives To evaluate the use of a provider ordering alert to improve laboratory efficiency and reduce costs. Methods We conducted a retrospective study to assess the use of an institutional reflex panel for monoclonal gammopathy evaluati…
X-Ray Diffraction data from WD40 domain of Human E3 Ubiquitin Ligase COP1 (RFWD2) , source of 5HQG structure Open
single wavelength dataset of single crystal
X-Ray Diffraction data from WD40 domain of Human E3 Ubiquitin Ligase COP1 (RFWD2) bound to peptide from Trib1, source of 5IGQ structure Open
single wavelength dataset of single crystal
X-Ray Diffraction data from WD40 domain of Arabidopsis thaliana E3 Ubiquitin Ligase COP1 in complex with peptide from Trib1, source of 5IGO structure Open
single wavelength x ray data set of single crystal