Sachin Aryal
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View article: Akkermansia muciniphila induces sex specific blood pressure changes and RAS activation
Akkermansia muciniphila induces sex specific blood pressure changes and RAS activation Open
View article: Ketone body β-hydroxybutyrate-mediated histone β-hydroxybutyrylation upregulates lipolysis and attenuates metabolic syndrome
Ketone body β-hydroxybutyrate-mediated histone β-hydroxybutyrylation upregulates lipolysis and attenuates metabolic syndrome Open
This is the first study to demonstrate that exogenous β-hydroxybutyrate supplementation attenuates metabolic syndrome (MetS) and identifies histone β-hydroxybutyrylation-mediated chromatin remodeling as one of the mechanisms to upregulate …
View article: Genetically engineered Lactobacillus paracasei rescues colonic angiotensin converting enzyme 2 (ACE2) and attenuates hypertension in female Ace2 knock out rats
Genetically engineered Lactobacillus paracasei rescues colonic angiotensin converting enzyme 2 (ACE2) and attenuates hypertension in female Ace2 knock out rats Open
Engineered gut microbiota represents a new frontier in medicine, in part serving as a vehicle for the delivery of therapeutic biologics to treat a range of host conditions. The gut microbiota plays a significant role in blood pressure regu…
View article: Combating Hypertension Beyond GWAS: Microbiome and Artificial Intelligence as Opportunities for Precision Medicine
Combating Hypertension Beyond GWAS: Microbiome and Artificial Intelligence as Opportunities for Precision Medicine Open
The single largest contributor to human mortality is cardiovascular disease, the top risk factor for which is hypertension (HTN). The last two decades have placed much emphasis on the identification of genetic factors contributing to HTN. …
View article: Survey and Evaluation of Hypertension Machine Learning Research
Survey and Evaluation of Hypertension Machine Learning Research Open
Background Machine learning (ML) is pervasive in all fields of research, from automating tasks to complex decision‐making. However, applications in different specialities are variable and generally limited. Like other conditions, the numbe…
View article: Genetically Engineered Lactobacillus Paracasei Rescues Colonic Angiotensin Converting Enzyme 2 (Ace2) and Attenuates Hypertension in Female Ace2 Knock Out Rats
Genetically Engineered Lactobacillus Paracasei Rescues Colonic Angiotensin Converting Enzyme 2 (Ace2) and Attenuates Hypertension in Female Ace2 Knock Out Rats Open
View article: Repurposing a Drug Targeting Inflammatory Bowel Disease for Lowering Hypertension
Repurposing a Drug Targeting Inflammatory Bowel Disease for Lowering Hypertension Open
Background The gut and gut microbiota, which were previously neglected in blood pressure regulation, are becoming increasingly recognized as factors contributing to hypertension. Diseases affecting the gut such as inflammatory bowel diseas…
View article: <i>Faecalibacterium prausnitzii</i> Attenuates CKD via Butyrate-Renal GPR43 Axis
<i>Faecalibacterium prausnitzii</i> Attenuates CKD via Butyrate-Renal GPR43 Axis Open
Background: Despite available clinical management strategies, chronic kidney disease (CKD) is associated with severe morbidity and mortality worldwide, which beckons new solutions. Host-microbial interactions with a depletion of Faecalibac…
View article: Prospects for Probiotic Approach inthe Management of the Oral Ailments: A Review
Prospects for Probiotic Approach inthe Management of the Oral Ailments: A Review Open
The term ''Probiotic'' is composed of words pro, representing ''for'' and biotic, implying ''life''.Probiotics are live microorganisms when consumed in suitable quantity, avails the host with desired health benefits.Previously, Probiotics …
View article: Gut microbiome-based supervised machine learning for clinical diagnosis of inflammatory bowel diseases
Gut microbiome-based supervised machine learning for clinical diagnosis of inflammatory bowel diseases Open
Our study demonstrates the promising potential of artificial intelligence via supervised machine learning modeling for predictive diagnostics of different types of inflammatory bowel diseases using fecal gut microbiome data.
View article: Machine Learning Strategy for Gut Microbiome-Based Diagnostic Screening of Cardiovascular Disease
Machine Learning Strategy for Gut Microbiome-Based Diagnostic Screening of Cardiovascular Disease Open
Cardiovascular disease (CVD) is the number one leading cause for human mortality. Besides genetics and environmental factors, in recent years, gut microbiota has emerged as a new factor influencing CVD. Although cause-effect relationships …
View article: Machine learning-based classification and diagnosis of clinical cardiomyopathies
Machine learning-based classification and diagnosis of clinical cardiomyopathies Open
Dilated cardiomyopathy (DCM) and ischemic cardiomyopathy (ICM) are two common types of cardiomyopathies leading to heart failure. Accurate diagnostic classification of different types of cardiomyopathies is critical for precision medicine …
View article: Identification of Upstream Transcriptional Regulators of Ischemic Cardiomyopathy Using Cardiac RNA-Seq Meta-Analysis
Identification of Upstream Transcriptional Regulators of Ischemic Cardiomyopathy Using Cardiac RNA-Seq Meta-Analysis Open
Ischemic cardiomyopathy (ICM), characterized by pre-existing myocardial infarction or severe coronary artery disease, is the major cause of heart failure (HF). Identification of novel transcriptional regulators in ischemic HF can provide i…
View article: Artificial intelligence and machine learning to fight COVID-19
Artificial intelligence and machine learning to fight COVID-19 Open