Explanipedia

Do microplastics play a role in the pathogenesis of neurodegenerative diseases? Shared pathophysiological pathways for Alzheimer’s and Parkinson’s disease Open

Alexander Chi Wang Siu, Keshav Raj Paudel, Gurjeet Singh, Gaurav Gupta, Sachin Kumar Singh , et al. · 2025

The widespread presence of microplastics (MPs) in the environment has raised significant concerns about their potential impact on human health. As of 2023, the Ocean Conservancy estimates that adults may ingest up to 121,000 MPs annually. …

Artificial Intelligence and Machine Learning Driven Multiplex Programmable Modelling for Refractive Index Based Surface Plasmon Resonance Sensor Open

Shalini Srivastava, Shambhavi Shukla, Nishant Singh, Parimal Tiwari, Ramesh Kumar Mishra , et al. · 2025

Researchers can employ various optical biosensor technologies in many biomedical diagnostic and analysis procedures because they can assess the conformational changes of biomolecules and their molecular interactions. Surface plasmon resona…

Systematic benchmarking of mass spectrometry-based antibody sequencing reveals methodological biases Open

Sachin Kumar Singh, Rowan Nelson, Melih Yilmaz, Konstantinos Kalogeropoulos, Anand Patel , et al. · 2025

The circulating antibody (Ab) repertoire is crucial for immune protection, holding significant immunological and biotechnological value. While bottom-up mass spectrometry (MS) is widely used for profiling the sequence diversity of circulat…

Nanobodies in Asthma Therapy: a Promising Frontier in Targeted Respiratory Treatment Open

Sumel Ashique, Anas Islam, Muna Barakat, Poonam Negi, Gaurav Gupta , et al. · 2025

SN 2021tsz: A luminous, short photospheric phase Type II supernova in a low-metallicity host Open

R. Dastidar, G. Pignata, Naveen Dukiya, K. Misra, D.A. Howell , et al. · 2025

We present the analysis of the luminous Type II Supernova (SN) 2021tsz, which exploded in a low-luminosity galaxy. It reached a peak magnitude of −18.88 ± 0.13 mag in the r band and exhibited an initial rapid decline of 4.05 ± 0.14 mag (10…

SN 2021tsz: A luminous, short photospheric phase Type II supernova in a low-metallicity host Open

R. Dastidar, G. Pignata, Naveen Dukiya, K. Misra, D. A. Howell , et al. · 2025

We present the analysis of the luminous Type II Supernova (SN) 2021tsz, which exploded in a low-luminosity galaxy. It reached a peak magnitude of -18.88 $\pm$ 0.13 mag in the $r$ band and exhibited an initial rapid decline of 4.05 $\pm$ 0.…

Resurgence of mumps in Gujarat: Diagnostic insights, breakthrough infections, and immunization gaps Open

Anil Chaudhary, Abhishek Padhi, Sachin Kumar Singh, Praggya Mishra, Pritesh Bhatt , et al. · 2025

Objectives: The objective of this study was to evaluate suspected mumps cases presenting to a tertiary care center in Western Gujarat between March and September 2024, using molecular diagnostics by reverse transcription polymerase chain r…

DDHD2 provides a flux of saturated fatty acids for neuronal energy and function Open

Saber H. Saber, Nyakuoy Yak, Xuan Ling Hilary Yong, Yih Tyng Bong, Hannah C. Leeson , et al. · 2025

Although fatty acids support mitochondrial ATP production in most tissues, neurons are believed to rely exclusively on glucose for energy. Here we show that genetic ablation of the triglyceride and phospholipid lipase Ddhd2 impairs mitocho…

Green-synthesized Mg-substituted PrFeO3 perovskites via waste-derived precursors for acetone gas sensing Open

Shiffali Middha, Amritpal Singh Nindrayog, Gulshan Mahajan, Nitin Tandon, Sachin Kumar Singh , et al. · 2025

The detection of volatile organic compounds (VOCs), particularly acetone, is crucial for environmental monitoring and biomedical diagnostics. In this study, Mg-substituted PrFeO 3 perovskite oxides (PrMg x Fe 1- x O 3 , x = 0.1, 0.2, 0.3) …

Computational Studies and Chromatographic Profiling of Aristolochic Acid from Roots of <i>Aristolochia indica</i> L. as a PLA2 Inhibitor against the Four Poisonous Indian Snake Venoms Open

R.S. David Paul Raj, W. Andrea Bernice, M. Beutline Malgija, S. Kavinila, J. Jannet Vennila , et al. · 2025

Background: Envenomation caused by snakebite is a rapidly developing, extremely dangerous condition that is unlike any other acute illness, contributing to an alarming global mortality of 81,000 deaths annually, according to World Health O…

Microbiome-derived bile acids as endogenous regenerative mediators in liver repair Open

Surya Nath Pandey, Kavita Goyal, Mohit Rana, Soumya V. Menon, Subhashree Ray , et al. · 2025

The liver's extraordinary capacity for self-repair is often compromised by chronic injury, fibrosis, or extensive resection, creating an urgent need for innovative regenerative therapies to restore liver function. Emerging evidence suggest…

Application of Artificial Intelligence and Machine Learning in Surface Plasmon Resonance Sensor for Blood Sample Diagnosis Open

Shalini Srivastava, Shambhavi Shukla, Parimal Tiwari, Ramesh Kumar Mishra, Sachin Kumar Singh · 2025

In recent years, various optical biosensor technologies are used by researchers to evaluate the conformational changes of biomolecules and their molecular interactions in a wide range of biomedical diagnostic and analysis operations. One o…

Cancer stem cells: mitochondria signalling pathway and strategies for therapeutic interventions Open

Ee Wern Tan, Sachin Kumar Singh, Kamal Dua, Gaurav R. Gupta, Wai-Leng Lee , et al. · 2025

Genetic evaluation of biochemical characters of local genotypes of garlic from different districts of Himachal Pradesh Open

Seema Thakur, Sachin Kumar Singh, Rajesh Thakur, Ishant Dutta, Ashima Chaudhary · 2025

Biomechanical Analysis and Design Optimization of the Human Knee Joint in Mechanical Engineering Open

Paramveer Singh, Sachin Kumar Singh · 2025

The human knee joint is a kind of hinge joint that is a pivotal component of the musculoskeletal system, providing mobility and stability in daily human activity. Mechanical engineering plays a crucial role to make us understand, analyze, …

Unravelling the role of nanomedicine in attenuating inflammation, oxidative stress and cellular ageing in chronic obstructive pulmonary disease Open

Lokesh Nagar, Annu Saini, Sukriti Vishwas, Sachin Kumar Singh, Gaurav Gupta , et al. · 2025

Correlation and Path Coefficient Analysis of Morphological and Yield Contributing Traits in Garlic Genotypes Open

Sachin Kumar Singh, Seema Thakur, R. N. Thakur, Ramesh Kumar Bhardwaj, Rajesh Kumar Dogra · 2025

Garlic (Allium sativum L.) is the second most frequently cultivated (flavour) crop after onion. Understanding the relationships between various components and their respective contributions has immense value in selection. Yield is a highly…

“The Impact of Digital Business on Financial Management” Open

Sachin Kumar Singh · 2025

Digital commerce has altogether changed money related administration by coordination progressed innovations such as fake insights (AI), blockchain, cloud computing, and huge information analytics. These advancements improve productivity, p…

Development and validation of a spectrofluorophotometric method for berberine hydrochloride quantification in diverse matrices Open

P. G. Shah, Meghana Patel, Manish Nandpal, Archita Patel, Manan Raval , et al. · 2025

Berberine hydrochloride (BHC), a key isoquinoline alkaloid from the Berberis genus, is gaining prominence for its diverse pharmacological properties. The goal was to devise rapid and sensitive spectrofluorophotometric methods (Analytical a…

Efficacy of colchicine in oral submucous fibrosis: A systematic review and meta-analysis Open

Ajay Kumar, Sonam Sah, Neha Sah, Aruna Das, Sachin Kumar Singh , et al. · 2025

One of the potentially malignant disorders of the oral mucosa in Asian nations is known as oral submucous fibrosis (OSMF). The drug, surgical and combination therapies are some of the several OSMF treatment options. The importance of colch…

Efficacy of <i>Garcinia indica</i> fractions on mast cell degranulation in experimental allergic conditions Open

L. Dayanand, Sachidananda Vijayakumar, Veeresh Prabhakar Veerapur, K S Nagashree, Sachin Kumar Singh , et al. · 2025

Objectives: Allergic reactions are classified into two categories: Early-phase response (EPR) and late-phase response (LPR). EPRs demonstrate a rapid onset of symptoms resulting from histamine release by mast cells (MCs). The introduction …

Empirically Measuring Data Localization in the EU Open

Alexander Gamero-Garrido, Kicho Yu, Sumukh Vasisht Shankar, Sachin Kumar Singh, Sridhar Balasubramanian , et al. · 2025

EU data localization regulations limit data transfers to non-EU countries with the GDPR. However, BGP, DNS and other Internet protocols were not designed to enforce jurisdictional constraints, so implementing data localization is challengi…

TGF-β SIGNALING IN HPV-POSITIVE HEAD AND NECK CANCER: FROM EARLY TUMOR SUPPRESSION TO METASTASIS AND RESISTANCE Open

Lakshmi Thangavelu, Gaurav Gupta, Muhammad Afzal, Ghala Rashid Humaid Alnuaimi, Ahsas Goyal , et al. · 2025

The TGF-β signalling pathway is an enigmatic player with a tumor suppressor effect in HPV-positive head and neck cancer during the initial stages of cancer, but has a pro-cancer effect during later stages. Specifically, HPV-positive oropha…

Luminescence-based techniques to monitor pre-, post-harvest and processing changes in fresh produce and derivatives: Principles, applications and trends Open

Sachin Kumar Singh, K. Wang, Chen Chen, Maria G. Corradini · 2025

Empirically Measuring Data Localization in the EU Open

Alexander Gamero-Garrido, Kun-Maon Yu, Sachin Kumar Singh, Sridhar Balasubramanian, Alexander Wilcox · 2025

EU data localization regulations limit data transfers to non-EU countries with the GDPR. However, BGP, DNS and other Internet protocols were not designed to enforce jurisdictional constraints, so implementing data localization is challengi…

FORMULATION OF SUSTAINED RELEASE CORE AND COAT TABLETS OF LOVASTATIN AND OLEANOLIC ACID: AN IN VITRO AND IN VIVO ANALYSIS Open

Satish Vasant Mandave, Narendra Kumar Pandey, Sachin Kumar Singh, Bimlesh Kumar, Saurabh Singh , et al. · 2025

Objectives: This research aimed to develop core and coat tablets to enhance the therapeutic efficacy of antilipidemic drugs for treating high cholesterol and triglyceride levels in the blood. Methods: The core and coat tablets were formula…

Maple Syrup Adulteration: Fluorescence Fingerprints as a Source of Information for Enhanced Detection Open

Sachin Kumar Singh, Mei Zhang, Mauricio Espinal‐Ruiz, Suramya I. Rathnayake, Jianxin Xue , et al. · 2025

Background Maple syrup is often adulterated by dilution or substitution with other syrups due to its high demand and price. Fingerprinting techniques, e.g., DNA barcoding, detect adulteration in other foods. However, extensive processing d…

Hypoxia-inducible factor and cellular senescence in pulmonary aging and disease Open

Riya Thapa, Arockia Babu Marianesan, Arcot Rekha, Subbulakshmi Ganesan, Manju Kumari , et al. · 2025

Biomembrane‐coated nanosystems as next‐generation delivery systems for the treatment of gastrointestinal cancers Open

Joana Lopes, Daniela Lopes, Mahzad Motallebi, Mengguang Ye, Yuxiang Xue , et al. · 2025

Gastrointestinal cancers, a major global cause of cancer‐related mortality and disease burden, are a heterogeneous group of malignant aliments involving different organs of the digestive system. The late clinical diagnosis, genomic tumor h…

Soil Fertility Status of Selected Panchayats in Deeh Block of Raebareli District in Uttar Pradesh, India Open

Lalit Patil, V. I. Valvi, Sachin Kumar Singh, Santosh Kumar Dixit · 2025

The present investigation aimed to assess soil fertility across twenty-five villages within group gram panchayats in the Deeh block of Raebareli district, Uttar Pradesh. The study focused on analyzing nutrients status using the nutrient in…

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