Sadaf Altaf
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View article: Exploring Pediatric Oncology Care Practices Influencing the Relationships Among Children, Caregivers, and Health Care Providers: A Multi-Institutional Study From Pakistan
Exploring Pediatric Oncology Care Practices Influencing the Relationships Among Children, Caregivers, and Health Care Providers: A Multi-Institutional Study From Pakistan Open
PURPOSE The quality of relationships between health care professionals (HCPs) and patients is an important factor influencing people's experiences with their health systems. In Pakistan, pediatric oncologists highlight the need for effecti…
View article: Using Research Capacity Enhancement to Develop and Implement National Standard-of-Care Treatment Protocols in Pakistan
Using Research Capacity Enhancement to Develop and Implement National Standard-of-Care Treatment Protocols in Pakistan Open
PURPOSE Utilization of clinical research methodology as a means for improvement in pediatric cancer outcomes is well established. Toward achievement of its WHO-Global Initiative for Childhood Cancer (GICC) goals in Pakistan, the Pakistan S…
View article: MicroRNA Expression and Neurocognitive Outcomes in Children and Young People With Primary Brain Tumor in Karachi, Pakistan: A Pilot Exploratory Study
MicroRNA Expression and Neurocognitive Outcomes in Children and Young People With Primary Brain Tumor in Karachi, Pakistan: A Pilot Exploratory Study Open
This pilot exploratory study found two statistically significant correlations: a negative correlation between pretreatment miR-210 levels and 12 months posttreatment perceptual reasoning scores and a positive correlation between miR-10b ex…
View article: A Comparative Study of RT-PCR, FISH, and Karyotyping for t(9;22) Positive Leukemias, and Their Outcomes in Pediatric Patients in a Low Middle-Income Country (LMIC)
A Comparative Study of RT-PCR, FISH, and Karyotyping for t(9;22) Positive Leukemias, and Their Outcomes in Pediatric Patients in a Low Middle-Income Country (LMIC) Open
Objectives: Various diagnostic tests are available for detecting t(9;22) transcripts in acute and chronic leukemia. This study aims to determine the most effective and cost-efficient testing strategy. Additionally, we analyzed the outcomes…
View article: Comparative Analysis of Surgical Site Infections in Pediatric Brain Tumor Patients: Hygiene Practices, Risk Factors, and Implications for Healthcare Costs and Mortality
Comparative Analysis of Surgical Site Infections in Pediatric Brain Tumor Patients: Hygiene Practices, Risk Factors, and Implications for Healthcare Costs and Mortality Open
Surgical site infections (SSIs) significantly impact pediatric central nervous system tumor outcomes. We present our data of SSIs and their influence on outcomes of pediatric brain tumor patients treated between January 2011 till December …
View article: Socio-demographic and antenatal risk factors of brain tumor in children and young people: A matched case-control study from Karachi, Pakistan
Socio-demographic and antenatal risk factors of brain tumor in children and young people: A matched case-control study from Karachi, Pakistan Open
Background: Brain tumors are a common cause of morbidity, disability, cognitive deterioration and mortality in children, even after treatment. Little is know about the specific causes. The study aimed to assess potential socio-demographic …
View article: Predictors of Control of Chemotherapy-Induced Nausea and Vomiting; experience from a tertiary oncology center in Pakistan
Predictors of Control of Chemotherapy-Induced Nausea and Vomiting; experience from a tertiary oncology center in Pakistan Open
Background: CINV is a known distressful symptom in pediatric cancer patients. In a resource-limited setting, insight regarding CINV frequency and current practice can help optimize symptom control. Methods: Prospective study in the pediatr…
View article: Impact of the COVID-19 pandemic on patients with paediatric cancer in low-income, middle-income and high-income countries: a multicentre, international, observational cohort study
Impact of the COVID-19 pandemic on patients with paediatric cancer in low-income, middle-income and high-income countries: a multicentre, international, observational cohort study Open
Objectives Paediatric cancer is a leading cause of death for children. Children in low-income and middle-income countries (LMICs) were four times more likely to die than children in high-income countries (HICs). This study aimed to test th…
View article: COMPARING THE NEEDS OF SUPPORTIVE CARE FOR FAMILIES AND PATIENTS WITH PEDIATRIC CANCER: A PERSPECTIVE OF PATIENTS, CAREGIVERS AND ONCOLOGY HEALTH PROFESSIONALS
COMPARING THE NEEDS OF SUPPORTIVE CARE FOR FAMILIES AND PATIENTS WITH PEDIATRIC CANCER: A PERSPECTIVE OF PATIENTS, CAREGIVERS AND ONCOLOGY HEALTH PROFESSIONALS Open
The pediatric cancer cases diagnosed each year is increasing at a rapid rate. With high health risks and infant mortality associated to pediatric cancer, it is crucial to recognize educational and psychosocial support among patients and ca…
View article: Risk Assessment and Outcome of Venous Thromboembolism in Pediatric Population in an Academic Care Center of a Low-Middle Income Country
Risk Assessment and Outcome of Venous Thromboembolism in Pediatric Population in an Academic Care Center of a Low-Middle Income Country Open
Venous thromboembolism (VTE) is a recognized complication of hospital stay in young patients in many developed countries, but such an information is largely unavailable from a low middle-income country (LMIC). This study aimed at identifyi…
View article: Case Study of Pediatric Cerebral Sinus Venous Thrombosis Center of a Low Middle-Income Country
Case Study of Pediatric Cerebral Sinus Venous Thrombosis Center of a Low Middle-Income Country Open
Pediatric cerebral venous sinus thrombosis (CVST) is rare but a potentially fatal disease requiring its understanding in local setting. In this study, we observed the clinical course, management, and outcome of pediatric patients with sinu…
View article: Pediatric hematology oncology during SARS‐CoV‐2: A brief communication of 28 patients and changes in clinical practice from a single institute in Pakistan
Pediatric hematology oncology during SARS‐CoV‐2: A brief communication of 28 patients and changes in clinical practice from a single institute in Pakistan Open
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View article: Pediatric Cancer Management during SARS-CoV-2: A Brief Communication of 28 Patients and Changes in Clinical Practice from a Single Leading Institute in Pakistan
Pediatric Cancer Management during SARS-CoV-2: A Brief Communication of 28 Patients and Changes in Clinical Practice from a Single Leading Institute in Pakistan Open
All tested patients were classified into two groups, Group A (patients who were tested positive) and Group B (patients who were tested negative). A total of 28 patients were evaluated. The primary diagnosis of patients in Group A was B-Cel…
View article: Prognostic factors and their influence on therapeutic outcomes in children and adolescents with parameningeal rhabdomyosarcoma: A multicenter study from Pakistan
Prognostic factors and their influence on therapeutic outcomes in children and adolescents with parameningeal rhabdomyosarcoma: A multicenter study from Pakistan Open
The study was aimed at evaluating prognostic factors and treatment outcomes of pediatric parameningeal rhabdomyosarcoma (PM-RMS) at two major pediatric oncology centers in Pakistan. PM-RMS age 1–16 years diagnosed from 2005 to 2015 at Aga …
View article: Functional outcomes of ACL reconstruction using hamstring auto graft.
Functional outcomes of ACL reconstruction using hamstring auto graft. Open
Objectives: The knee joint is made of two cruciate ligaments. One is anterior cruciate ligament (ACL) which is weaker when it comes to comparison with the other cruciate ligament known as posterior cruciate ligament (PCL). ACL tears are mo…
View article: Hepatitis C at presentation in a newly diagnosed infant with B Acute Lymphoblastic Leukemia
Hepatitis C at presentation in a newly diagnosed infant with B Acute Lymphoblastic Leukemia Open
We report the unique case of a nine-month old patient diagnosed with B- Cell Acute Lymphoblastic Leukemia also positive for Hepatitis C virus, genotype 3 and a high viral load. With no existent literature to guide treatment of Hepatitis C …
View article: Initiation and Maintenance of Cell Suspension Cultures of Two Citrus Species for Protoplast Isolation
Initiation and Maintenance of Cell Suspension Cultures of Two Citrus Species for Protoplast Isolation Open
Cell suspension cultures were initiated from six month old ovule-derived embryogenic calli of two Citrus species named Citrus aurantifolia (Christm.)Swingle cultivar Sweet lime and Citrus reticulata Blanco cultivar Kinnow.The growth rate o…