Sadaf Ashraf
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View article: FREQUENCY OF PATIENTS MEETING KIDNEY DISEASE OUTCOMES QUALITY INITIATIVE CRITERIA FOR SERUM CALCIUM, PHOSPHORUS, AND PARATHYROID HORMONE LEVELS ON MAINTENANCE HEMODIALYSIS PRESENTING AT CAPITAL DEVELOPMENT AUTHORITY HOSPITAL, ISLAMABAD
FREQUENCY OF PATIENTS MEETING KIDNEY DISEASE OUTCOMES QUALITY INITIATIVE CRITERIA FOR SERUM CALCIUM, PHOSPHORUS, AND PARATHYROID HORMONE LEVELS ON MAINTENANCE HEMODIALYSIS PRESENTING AT CAPITAL DEVELOPMENT AUTHORITY HOSPITAL, ISLAMABAD Open
Background: Chronic kidney disease patients on maintenance hemodialysis are vulnerable to mineral and bone disorders, which significantly contribute to morbidity and mortality. Monitoring and achieving recommended biochemical targets for c…
View article: Neurobiological Correlates of Rheumatoid Arthritis and Osteoarthritis: Remodelling and Plasticity of Nociceptive and Autonomic Innervations in Synovial Joints
Neurobiological Correlates of Rheumatoid Arthritis and Osteoarthritis: Remodelling and Plasticity of Nociceptive and Autonomic Innervations in Synovial Joints Open
Swelling, stiffness, and pain in synovial joints are primary hallmarks of osteoarthritis and rheumatoid arthritis. Hyperactivity of nociceptors and excessive release of inflammatory factors and pain mediators play a crucial role, with emer…
View article: Cordycepin generally inhibits growth factor signal transduction in a systems pharmacology study
Cordycepin generally inhibits growth factor signal transduction in a systems pharmacology study Open
Cordycepin (3′ deoxyadenosine) has been widely researched as a potential cancer therapy, but many diverse mechanisms of action have been proposed. Here, we confirm that cordycepin triphosphate is likely to be the active metabolite of cordy…
View article: A Systematic Review of the Biological Effects of Cordycepin
A Systematic Review of the Biological Effects of Cordycepin Open
We conducted a systematic review of the literature on the effects of cordycepin on cell survival and proliferation, inflammation, signal transduction and animal models. A total of 1204 publications on cordycepin were found by the cut-off d…
View article: BMP signaling: A significant player and therapeutic target for osteoarthritis
BMP signaling: A significant player and therapeutic target for osteoarthritis Open
Objective To investigate the role of BMP signaling in osteoarthritis' pathogenesis and propose a disease-modifying therapy for OA. Methods C57BL6/J mouse line was used to perform ACLT surgery at P120 to study the expression pattern of the …
View article: Gene Cloning and Characterization of Pcal_0222, α-Amylase from Pyrobaculum calidifontis
Gene Cloning and Characterization of Pcal_0222, α-Amylase from Pyrobaculum calidifontis Open
The current research trial was conducted to evaluate the effects of a non-antibiotic growth promoter on growth performance and histomorphology in broiler chickens.One hundred and twenty day-old broiler chicks were randomly distributed into…
View article: Involvement of TRPV1 and TRPV4 Channels in Retinal Angiogenesis
Involvement of TRPV1 and TRPV4 Channels in Retinal Angiogenesis Open
TRPV1 and TRPV4 channels represent promising targets for therapeutic intervention in vasoproliferative diseases of the retina.
View article: The polyadenylation inhibitor cordycepin reduces pain, inflammation and joint pathology in rodent models of osteoarthritis
The polyadenylation inhibitor cordycepin reduces pain, inflammation and joint pathology in rodent models of osteoarthritis Open
Clinically, osteoarthritis (OA) pain is significantly associated with synovial inflammation. Identification of the mechanisms driving inflammation could reveal new targets to relieve this prevalent pain state. Herein, a role of polyadenyla…
View article: CAMKII as a therapeutic target for growth factor-induced retinal and choroidal neovascularisation
CAMKII as a therapeutic target for growth factor-induced retinal and choroidal neovascularisation Open
While anti-VEGF drugs are commonly used to inhibit pathological retinal and choroidal neovascularization, not all patients respond in an optimal manner. Mechanisms underpinning resistance to anti‑VEGF therapy include the upregulation of ot…
View article: Targeting the D Series Resolvin Receptor System for the Treatment of Osteoarthritis Pain
Targeting the D Series Resolvin Receptor System for the Treatment of Osteoarthritis Pain Open
Objective Pain is a major symptom of osteoarthritis (OA); currently available analgesics either do not provide adequate pain relief or are associated with serious side effects. The aim of this study was to investigate the therapeutic poten…