Sadikshya Bhandari
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View article: Barriers to timely transitions to comfort care in cancer patients: a review
Barriers to timely transitions to comfort care in cancer patients: a review Open
Introduction: “Comfort care” is a holistic approach for patients with terminal conditions, such as cancer, who are not expected to recover. It focuses on managing pain, among other end-of-life symptoms, and providing support to both the pa…
View article: Infection-Related Glomerulonephritis in the Setting of Mssa Bacteremia
Infection-Related Glomerulonephritis in the Setting of Mssa Bacteremia Open
Infection-related glomerulonephritis (IRGN) is an immune-mediated kidney disease triggered by bacterial infections, with Staphylococcus aureus increasingly recognized as a significant causative agent. This report describes a case of methic…
View article: Mending the Valve, Burdening the Kidney: A Case of Renal Hemosiderosis With Mitral Valve Repair
Mending the Valve, Burdening the Kidney: A Case of Renal Hemosiderosis With Mitral Valve Repair Open
Renal hemosiderosis, marked by the buildup of hemosiderin in the renal cortex due to chronic intravascular hemolysis, can lead to acute kidney injury. Iron deposited may exacerbate renal damage through processes like lipid peroxidation and…
View article: Extracellular metallothionein as a therapeutic target in the early progression of type 1 diabetes
Extracellular metallothionein as a therapeutic target in the early progression of type 1 diabetes Open
Type 1 diabetes (T1D) is characterized by lymphocyte infiltration into the pancreatic islets of Langerhans, leading to the destruction of insulin-producing beta cells and uncontrolled hyperglycemia. In the nonobese diabetic (NOD) murine mo…
View article: Role of PET/CT in diagnosing and monitoring disease activity in rheumatoid arthritis: a review
Role of PET/CT in diagnosing and monitoring disease activity in rheumatoid arthritis: a review Open
Rheumatoid Arthritis (RA) is a systemic inflammatory disorder that commonly presents with polyarthritis but can have multisystemic involvement and complications, leading to increased morbidity and mortality. The diagnosis of RA continues t…
View article: PET/CT in the Evaluation of CAR-T Cell Immunotherapy in Hematological Malignancies
PET/CT in the Evaluation of CAR-T Cell Immunotherapy in Hematological Malignancies Open
Chimeric antigen receptor (CAR)-T cell-based immunotherapy has emerged as a path-breaking strategy for certain hematological malignancies. Assessment of the response to CAR-T therapy using quantitative imaging techniques such as positron e…
View article: Chimeric antigen receptor T cell therapy for the treatment of systemic rheumatic diseases: a comprehensive review of recent literature
Chimeric antigen receptor T cell therapy for the treatment of systemic rheumatic diseases: a comprehensive review of recent literature Open
Systemic rheumatoid diseases (SRDs) are autoimmune and inflammatory disorders that affect multiple organ systems, impacting patients’ quality of life, and survival rates. Standard treatment requires continuous drug therapy and immunosuppre…
View article: Is Imaging Bacteria with PET a Realistic Option or an Illusion?
Is Imaging Bacteria with PET a Realistic Option or an Illusion? Open
The application of [18F]-fluorodeoxyglucose ([18F]FDG) as a radiotracer to detect sites of inflammation (either due to bacterial infection or primary inflammation) has led to exploring the role of PET in visualizing bacteria directly at si…
View article: Anticoagulation failure in pulmonary thromboembolism in COVID-19 pneumonia despite prolonged anticoagulation: A case series
Anticoagulation failure in pulmonary thromboembolism in COVID-19 pneumonia despite prolonged anticoagulation: A case series Open
Pulmonary thromboembolism secondary to COVID-19 pneumonia is a life-threatening condition. Rivaroxaban is seen to be very effective in the management of this condition when an anticoagulation failure occurs even after the therapeutic dose …
View article: Autoimmune gastritis in a male adolescent with cerebellar involvement: A case report
Autoimmune gastritis in a male adolescent with cerebellar involvement: A case report Open
INTRODUCTION: Autoimmune gastritis is an immune mediated disorder characterized as anti-intrinsic factor and anti-parietal cell autoantibodies directed against intrinsic factor and parietal cells of the stomach respectively, leading to vit…
View article: Meningeal Signs and Cerebellar Involvement in Scrub Typhus: A Case Report
Meningeal Signs and Cerebellar Involvement in Scrub Typhus: A Case Report Open
Scrub typhus is an arthropod-borne fever that follows the bite of the larval form of Leptotrombidium mite carrying Orientia tsutsugamushi. It remains a serious health problem in the Asia-Pacific region. While it commonly presents as…
View article: Drug-Induced Gum Overgrowth With Low-Dose Amlodipine: A Case Report
Drug-Induced Gum Overgrowth With Low-Dose Amlodipine: A Case Report Open
Drug-induced gingival overgrowth is an adverse effect of certain drugs, including amlodipine, in genetically susceptible individuals. Although the exact mechanism of gingival hypertrophy remains unclear, a unifying multifactorial hypothesi…
View article: Concurrent Measurement of Mitochondrial DNA Copy Number and ATP Concentration in Single Bovine Oocytes
Concurrent Measurement of Mitochondrial DNA Copy Number and ATP Concentration in Single Bovine Oocytes Open
To sustain energy-demanding developmental processes, oocytes must accumulate adequate stores of metabolic substrates and mitochondrial numbers prior to the initiation of maturation. In the past, researchers have utilized pooled samples to …
View article: The Chemotactic Role of Metallothionein in the Extracellular Environment
The Chemotactic Role of Metallothionein in the Extracellular Environment Open
Metallothionein (MT) is a cysteine rich stress response protein that lacks a signal peptide and thus has historically been considered an intracellular protein. However, the presence of MT in a variety of extracellular fluids and spaces sug…