Saebom Lee
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View article: Soft multistable magnetic-responsive metamaterials
Soft multistable magnetic-responsive metamaterials Open
The wireless actuation of magnetic soft architectures can enable complex functionalities important in biomedicine and soft robotics. However, transforming and maintaining a device’s desired geometry without a sustained energy input remains…
View article: Efficient Data Augmentation Methods for Crop Disease Recognition in Sustainable Environmental Systems
Efficient Data Augmentation Methods for Crop Disease Recognition in Sustainable Environmental Systems Open
Crop diseases significantly threaten agricultural productivity, leading to unstable food supply and economic losses. The current approaches to automated crop disease recognition face challenges such as limited datasets, restricted coverage…
View article: Curvature-dependent propulsion of elastic flagella
Curvature-dependent propulsion of elastic flagella Open
We use experiments and simulations to investigate the propulsion of flagella with uniform intrinsic curvature in the stress-free state. Results suggest the propulsion can transition between positive and negative by changing curvature or Sp.
View article: <i>Gba1</i> E326K renders motor and non-motor symptoms with pathological α-synuclein, tau and glial activation
<i>Gba1</i> E326K renders motor and non-motor symptoms with pathological α-synuclein, tau and glial activation Open
Mutations in the GBA1 gene are common genetic risk factors for Parkinson’s disease, disrupting enzymatic activity and causing lysosomal dysfunction, leading to elevated α-synuclein levels. Although the role of GBA1 in synucleinopathy is we…
View article: Linking<i>Gba1</i>E326K mutation to microglia activation and mild age-dependent dopaminergic Neurodegeneration
Linking<i>Gba1</i>E326K mutation to microglia activation and mild age-dependent dopaminergic Neurodegeneration Open
Mutations in the GBA1 gene have been identified as a prevalent genetic risk factor for Parkinson’s disease (PD). GBA1 mutations impair enzymatic activity, leading to lysosomal dysfunction and elevated levels of α-synuclein (α-syn). While m…
View article: c-Abl Regulates the Pathological Deposition of TDP-43 via Tyrosine 43 Phosphorylation
c-Abl Regulates the Pathological Deposition of TDP-43 via Tyrosine 43 Phosphorylation Open
Non-receptor tyrosine kinase, c-Abl plays a role in the pathogenesis of several neurodegenerative disorders such as Alzheimer’s disease and Parkinson’s disease. Here, we found that TDP-43, which was one of the main proteins comprising path…
View article: Automatic Classification Service System for Citrus Pest Recognition Based on Deep Learning
Automatic Classification Service System for Citrus Pest Recognition Based on Deep Learning Open
Plant diseases are a major cause of reduction in agricultural output, which leads to severe economic losses and unstable food supply. The citrus plant is an economically important fruit crop grown and produced worldwide. However, citrus pl…
View article: Enhancing Mixing Performance in a Rotating Disk Mixing Chamber: A Quantitative Investigation of the Effect of Euler and Coriolis Forces
Enhancing Mixing Performance in a Rotating Disk Mixing Chamber: A Quantitative Investigation of the Effect of Euler and Coriolis Forces Open
Lab-on-a-CD (LOCD) is gaining importance as a diagnostic platform due to being low-cost, easy-to-use, and portable. During LOCD usage, mixing and reaction are two processes that play an essential role in biochemical applications such as po…
View article: Control of the Drying Patterns for Complex Colloidal Solutions and Their Applications
Control of the Drying Patterns for Complex Colloidal Solutions and Their Applications Open
The uneven deposition at the edges of an evaporating droplet, termed the coffee-ring effect, has been extensively studied during the past few decades to better understand the underlying cause, namely the flow dynamics, and the subsequent p…
View article: On-chip selection of adenosine aptamer using graphene oxide-coated magnetic nanoparticles
On-chip selection of adenosine aptamer using graphene oxide-coated magnetic nanoparticles Open
Systematic evolution of ligands by exponential enrichment (SELEX) is a method that is generally used for developing aptamers, which have arisen the promising alternatives for antibodies. However, conventional SELEX methods have limitations…
View article: A Novel, Selective c-Abl Inhibitor, Compound 5, Prevents Neurodegeneration in Parkinson’s Disease
A Novel, Selective c-Abl Inhibitor, Compound 5, Prevents Neurodegeneration in Parkinson’s Disease Open
Parkinson's disease (PD) is a progressive neurodegenerative disorder that affects movement. The nonreceptor tyrosine kinase c-Abl has shown a potential role in the progression of PD. As such, c-Abl inhibition is a promising candidate for n…
View article: Cyclin Y, a novel actin-binding protein, regulates spine plasticity through the cofilin-actin pathway
Cyclin Y, a novel actin-binding protein, regulates spine plasticity through the cofilin-actin pathway Open
While positive regulators of hippocampal long-term potentiation (LTP) have extensively been investigated, relatively little is known about the inhibitory regulators of LTP. We previously reported that Cyclin Y (CCNY), a member of cyclin fa…
View article: Dopamine D1 receptor (D1R) expression is controlled by a transcriptional repressor complex containing DISC1
Dopamine D1 receptor (D1R) expression is controlled by a transcriptional repressor complex containing DISC1 Open
Disrupted-in-Schizophrenia 1 (DISC1) is a scaffold protein implicated in various psychiatric diseases. Dysregulation of the dopamine system has been associated with DISC1 deficiency, while the molecular mechanism is unclear. In this study,…
View article: Parkin interacting substrate zinc finger protein 746 is a pathological mediator in Parkinson’s disease
Parkin interacting substrate zinc finger protein 746 is a pathological mediator in Parkinson’s disease Open
α-Synuclein misfolding and aggregation plays a major role in the pathogenesis of Parkinson’s disease. Although loss of function mutations in the ubiquitin ligase, parkin, cause autosomal recessive Parkinson’s disease, there is evidence tha…
View article: The c-Abl inhibitor, Radotinib HCl, is neuroprotective in a preclinical Parkinson’s disease mouse model
The c-Abl inhibitor, Radotinib HCl, is neuroprotective in a preclinical Parkinson’s disease mouse model Open
Accumulating evidence suggests that the non-receptor tyrosine kinase c-Abl plays an important role in the progression of Parkinson's disease (PD) and c-Abl inhibition could be neuroprotective in PD and related α-synucleinopathies. Nilotini…
View article: α-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced parkinsonism
α-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced parkinsonism Open
Our results suggest that GBA deficiency due to L444P GBA heterozygous mutation and the accompanying accumulation of α-synuclein render DA neurons more susceptible to MPTP intoxication. Thus, GBA and α-synuclein play dual physiological role…
View article: GBA1 deficiency negatively affects physiological α-synuclein tetramers and related multimers
GBA1 deficiency negatively affects physiological α-synuclein tetramers and related multimers Open
Significance Recent studies have identified a helically folded tetramer as the major normal structure of α-synuclein (α-syn) and that the tetramer resists aggregation. However, the underlying mechanisms that regulate the formation of α-syn…
View article: Additional file 2: Figure S2. of α-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced parkinsonism
Additional file 2: Figure S2. of α-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced parkinsonism Open
The schematic diagram depicts the time schedule of intervention and analyses performed. Numerals represent the days experiments were conducted. On 1th day we injected saline or MPTP (2 h interval, 4 times, 20 mg/kg free base) in 8 months W…
View article: c-Abl and Parkinson’s Disease: Mechanisms and Therapeutic Potential
c-Abl and Parkinson’s Disease: Mechanisms and Therapeutic Potential Open
Although the etiology of Parkinson’s disease (PD) is poorly understood, oxidative stress has long been implicated in the pathogenesis of the disease. However, multifaceted and divergent signaling cascades downstream of oxidative stress hav…