Saeed Siri
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View article: Solid Stress Estimations via Intraoperative 3D Navigation in Patients with Brain Tumors
Solid Stress Estimations via Intraoperative 3D Navigation in Patients with Brain Tumors Open
Purpose: Physical forces exerted by expanding brain tumors—specifically the compressive stresses propagated through solid tissue structures—reduce brain perfusion and neurologic function but heretofore have not been directly measured in pa…
View article: Solid stress estimations via intraoperative 3D navigation in patients with brain tumors
Solid stress estimations via intraoperative 3D navigation in patients with brain tumors Open
Background Physical forces exerted by expanding brain tumors - specifically the compressive stresses propagated through solid tissue structures - reduces brain perfusion and neurological function, but heretofore has not been directly measu…
View article: Simulating the Impact of Tumor Mechanical Forces on Glymphatic Networks in the Brain Parenchyma
Simulating the Impact of Tumor Mechanical Forces on Glymphatic Networks in the Brain Parenchyma Open
Background The brain glymphatic system is currently being explored in the context of many neurological disorders and diseases, including traumatic brain injury, Alzheimer’s disease, and ischemic stroke. However, little is known about the i…
View article: Novel 3-D macrophage spheroid model reveals reciprocal regulation of immunomechanical stress and mechano-immunological response
Novel 3-D macrophage spheroid model reveals reciprocal regulation of immunomechanical stress and mechano-immunological response Open
Purpose: In many diseases, an overabundance of macrophages contributes to adverse outcomes. While numerous studies have compared macrophage phenotype after mechanical stimulation or with varying local stiffness, it is unclear if and how ma…
View article: Mathematical model of oxygen, nutrient, and drug transport in tuberculosis granulomas
Mathematical model of oxygen, nutrient, and drug transport in tuberculosis granulomas Open
Physiological abnormalities in pulmonary granulomas–pathological hallmarks of tuberculosis (TB)–compromise the transport of oxygen, nutrients, and drugs. In prior studies, we demonstrated mathematically and experimentally that hypoxia and …
View article: Single-cell mechanical analysis reveals viscoelastic similarities between normal and neoplastic brain cells
Single-cell mechanical analysis reveals viscoelastic similarities between normal and neoplastic brain cells Open
Understanding cancer cell mechanics allows for the identification of novel disease mechanisms, diagnostic biomarkers, and targeted therapies. In this study, we utilized our previously established fluid shear stress assay to investigate and…
View article: Do Tumor Mechanical Stresses Promote Cancer Immune Escape?
Do Tumor Mechanical Stresses Promote Cancer Immune Escape? Open
Immune evasion—a well-established cancer hallmark—is a major barrier to immunotherapy efficacy. While the molecular mechanisms and biological consequences underpinning immune evasion are largely known, the role of tissue mechanical stresse…
View article: NIMG-108. PHYSICAL STRESSES IN BRAIN TUMORS
NIMG-108. PHYSICAL STRESSES IN BRAIN TUMORS Open
Solid stress, distinct from fluid pressure, is a physical force contained in and transmitted by solid components of the brain tumor, including cells and the matrix they produce. Solid stress has been shown to promote tumor progression, and…
View article: Toward Elucidating the Physiological Impacts of Residual Stresses in the Colorectum
Toward Elucidating the Physiological Impacts of Residual Stresses in the Colorectum Open
Irritable bowel syndrome afflicts 10–20% of the global population, causing visceral pain with increased sensitivity to colorectal distension and normal bowel movements. Understanding and predicting these biomechanics will further advance o…
View article: The Macro- and Micro-Mechanics of the Colon and Rectum II: Theoretical and Computational Methods
The Macro- and Micro-Mechanics of the Colon and Rectum II: Theoretical and Computational Methods Open
Abnormal colorectal biomechanics and mechanotransduction associate with an array of gastrointestinal diseases, including inflammatory bowel disease, irritable bowel syndrome, diverticula disease, anorectal disorders, ileus, and chronic con…
View article: The Macro- and Micro-Mechanics of the Colon and Rectum I: Experimental Evidence
The Macro- and Micro-Mechanics of the Colon and Rectum I: Experimental Evidence Open
Many lower gastrointestinal diseases are associated with altered mechanical movement and deformation of the large intestine, i.e., the colon and rectum. The leading reason for patients’ visits to gastrointestinal clinics is visceral pain, …
View article: Multiscale Modeling of Endothelium Derived Wall Shear Stress Regulation in Common Carotid Artery
Multiscale Modeling of Endothelium Derived Wall Shear Stress Regulation in Common Carotid Artery Open
Shear induced autoregulation is the natural ability of organs to maintain the local hemodynamic stresses in a stable condition in spite of altering perfusion rate. Endothelium cells are shear sensitive mechanoreceptors that are responsible…
View article: Load-bearing function of the colorectal submucosa and its relevance to visceral nociception elicited by mechanical stretch
Load-bearing function of the colorectal submucosa and its relevance to visceral nociception elicited by mechanical stretch Open
Mechanical distension beyond a particular threshold evokes visceral pain from distal colon and rectum (colorectum), and thus biomechanics plays a central role in visceral nociception. In this study we focused on the layered structure of th…
View article: Differential biomechanical properties of mouse distal colon and rectum innervated by the splanchnic and pelvic afferents
Differential biomechanical properties of mouse distal colon and rectum innervated by the splanchnic and pelvic afferents Open
Visceral pain is one of the principal complaints of patients with irritable bowel syndrome, and this pain is reliably evoked by mechanical distension and stretch of distal colon and rectum (colorectum). This study focuses on the biomechani…