Saef Izzy
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View article: Traumatic Spinal Cord Injury and Subsequent Risk of Developing Chronic Cardiovascular, Neurologic, Psychiatric, and Endocrine Disorders
Traumatic Spinal Cord Injury and Subsequent Risk of Developing Chronic Cardiovascular, Neurologic, Psychiatric, and Endocrine Disorders Open
Importance While acute complications of traumatic spinal cord injury (TSCI) are well characterized, long-term systemic sequelae remain poorly understood, particularly in previously healthy individuals. Objective To evaluate the long-term r…
View article: Traumatic Brain Injury and Risk of Malignant Brain Tumors in Civilian Populations
Traumatic Brain Injury and Risk of Malignant Brain Tumors in Civilian Populations Open
Importance A 2024 US study reported that veterans of the Iraq and Afghanistan wars affected by traumatic brain injury (TBI) had an increased risk of developing brain tumors. However, studies among civilians have shown conflicting results a…
View article: Gabapentinoids confer survival benefit in human glioblastoma
Gabapentinoids confer survival benefit in human glioblastoma Open
View article: Traumatic spinal cord injury: a review of the current state of art and future directions – what do we know and where are we going?
Traumatic spinal cord injury: a review of the current state of art and future directions – what do we know and where are we going? Open
View article: Nasal anti-CD3 monoclonal antibody ameliorates traumatic brain injury, enhances microglial phagocytosis and reduces neuroinflammation via IL-10-dependent Treg–microglia crosstalk
Nasal anti-CD3 monoclonal antibody ameliorates traumatic brain injury, enhances microglial phagocytosis and reduces neuroinflammation via IL-10-dependent Treg–microglia crosstalk Open
View article: Detection of GFAP and D‐Dimer in a Point‐of‐Care Test for Large Vessel Occlusion Ischemic Stroke
Detection of GFAP and D‐Dimer in a Point‐of‐Care Test for Large Vessel Occlusion Ischemic Stroke Open
Background The blood biomarkers GFAP (glial fibrillary acidic protein) and D‐dimer have been shown to accurately diagnose large vessel occlusion ischemic stroke. The Upfront DX LVOne is a novel lateral flow‐based point‐of‐care test used fo…
View article: Traumatic Brain Injury and Risk of Incident Comorbidities
Traumatic Brain Injury and Risk of Incident Comorbidities Open
Importance Traumatic brain injury (TBI) is associated with chronic medical conditions. Evidence from diverse clinical administrative datasets may improve care delivery. Objective To characterize post-TBI risk of incident neuropsychiatric a…
View article: Abstract 131: Perspectives on Immune modulation and Recovery of Stem Cells in Stroke
Abstract 131: Perspectives on Immune modulation and Recovery of Stem Cells in Stroke Open
View article: Prognostication Following Aneurysmal Subarachnoid Hemorrhage: The Modified Hunt and Hess Grading Scale
Prognostication Following Aneurysmal Subarachnoid Hemorrhage: The Modified Hunt and Hess Grading Scale Open
Background This study proposes a modification to the traditional Hunt and Hess (tHH) grading scale for prognostication in aneurysmal subarachnoid hemorrhage (aSAH), which differentiates the most severe‐grade patients based on the presence …
View article: Concussion burden and later‐life cardiovascular risk factors in former professional American‐style football players
Concussion burden and later‐life cardiovascular risk factors in former professional American‐style football players Open
Objective Mid‐life cardiovascular risk factors are associated with later cognitive decline. Whether repetitive head injury among professional athletes impacts cardiovascular risk is unknown. We investigated associations between concussion …
View article: Optimal Timing for Resumption of Anticoagulation After Intracranial Hemorrhage in Patients With Mechanical Heart Valves
Optimal Timing for Resumption of Anticoagulation After Intracranial Hemorrhage in Patients With Mechanical Heart Valves Open
Background Anticoagulation in patients with intracranial hemorrhage (ICH) and mechanical heart valves is often held for risk of ICH expansion; however, there exists a competing risk of acute ischemic stroke (AIS). Optimal timing to resume …
View article: Prospective Validation of Glial Fibrillary Acidic Protein, <scp>d</scp> ‐Dimer, and Clinical Scales for Acute Large‐Vessel Occlusion Ischemic Stroke Detection
Prospective Validation of Glial Fibrillary Acidic Protein, <span>d</span> ‐Dimer, and Clinical Scales for Acute Large‐Vessel Occlusion Ischemic Stroke Detection Open
Background Large‐vessel occlusion (LVO) ischemic stroke is responsible for significant morbidity and mortality. We have previously described a novel tool for acute LVO detection that combines blood‐based biomarkers (glial fibrillary acidic…
View article: Risk of Long-Term Ischemic Stroke in Patients With Traumatic Brain Injury and Incident Hypertension
Risk of Long-Term Ischemic Stroke in Patients With Traumatic Brain Injury and Incident Hypertension Open
Traumatic brain injury (TBI) is independently associated with hypertension and ischemic stroke. The goal of this study was to determine the interplay between TBI and incident hypertension in the occurrence of post-TBI stroke. This prospect…
View article: Traumatic Spinal Cord Injury
Traumatic Spinal Cord Injury Open
Traumatic spinal cord injury is a complex and devastating condition that leads to long-term neurologic deficits with profound physical, social, and vocational implications, resulting in a diminished quality of life, particularly for severe…
View article: High-salt diet induces microbiome dysregulation, neuroinflammation and anxiety in the chronic period after mild repetitive closed head injury in adolescent mice
High-salt diet induces microbiome dysregulation, neuroinflammation and anxiety in the chronic period after mild repetitive closed head injury in adolescent mice Open
The associations between human concussions and subsequent sequelae of chronic neuropsychiatric and cardiovascular diseases such as hypertension have been reported; however, little is known about the underlying biological processes. We hypo…
View article: Elucidating the neuroimmunology of traumatic brain injury: methodological approaches to unravel intercellular communication and function
Elucidating the neuroimmunology of traumatic brain injury: methodological approaches to unravel intercellular communication and function Open
The neuroimmunology of traumatic brain injury (TBI) has recently gained recognition as a crucial element in the secondary pathophysiological consequences that occur following neurotrauma. Both immune cells residing within the central nervo…
View article: Long-term risk of cardiovascular disease after traumatic brain injury: screening and prevention
Long-term risk of cardiovascular disease after traumatic brain injury: screening and prevention Open
View article: Neuroendovascular Surgery Applications in Craniocervical Trauma
Neuroendovascular Surgery Applications in Craniocervical Trauma Open
Cerebrovascular injuries resulting from blunt or penetrating trauma to the head and neck often lead to local hemorrhage and stroke. These injuries present with a wide range of manifestations, including carotid or vertebral artery dissectio…
View article: Predicting Functional Dependency in Patients with Disorders of Consciousness: A <scp>TBI‐Model</scp> Systems and <scp>TRACK‐TBI</scp> Study
Predicting Functional Dependency in Patients with Disorders of Consciousness: A <span>TBI‐Model</span> Systems and <span>TRACK‐TBI</span> Study Open
Objective It is not currently possible to predict long‐term functional dependency in patients with disorders of consciousness (DoC) after traumatic brain injury (TBI). Our objective was to fit and externally validate a prediction model for…
View article: Vγ1 and Vγ4 gamma-delta T cells play opposing roles in the immunopathology of traumatic brain injury in males
Vγ1 and Vγ4 gamma-delta T cells play opposing roles in the immunopathology of traumatic brain injury in males Open
View article: External Ventricular Drains versus Intraparenchymal Pressure Monitors in the Management of Moderate to Severe Traumatic Brain Injury: Experience at Two Academic Centers over a Decade
External Ventricular Drains versus Intraparenchymal Pressure Monitors in the Management of Moderate to Severe Traumatic Brain Injury: Experience at Two Academic Centers over a Decade Open
While EDH, greater midline shift, and hospital with larger patient volume were associated with receiving an IPM, the need for a craniectomy was associated with receiving an EVD. EVD patients received different clinical management than IPM …
View article: Integrative transcriptomic and metabolic analyses of the mammalian hibernating brain identifies a key role for succinate dehydrogenase in ischemic tolerance
Integrative transcriptomic and metabolic analyses of the mammalian hibernating brain identifies a key role for succinate dehydrogenase in ischemic tolerance Open
Ischemic stroke results in a loss of tissue homeostasis and integrity, the underlying pathobiology of which stems primarily from the depletion of cellular energy stores and perturbation of available metabolites 1 . Hibernation in thirteen-…
View article: Rash, Facial Droop, and Multifocal Intracranial Stenosis Due to Varicella Zoster Virus Vasculitis
Rash, Facial Droop, and Multifocal Intracranial Stenosis Due to Varicella Zoster Virus Vasculitis Open
Background: This is a case of multifocal intracranial stenosis in a 74 year old male ultimately discovered to be due to Varicella Zoster Virus infection. Purpose: We highlight the importance of a broad differential diagnosis, even when the…
View article: Predicting Functional Dependency in Patients with Disorders of Consciousness: A TBI-Model Systems and TRACK-TBI Study
Predicting Functional Dependency in Patients with Disorders of Consciousness: A TBI-Model Systems and TRACK-TBI Study Open
Importance There are currently no models that predict long-term functional dependency in patients with disorders of consciousness (DoC) after traumatic brain injury (TBI). Objective Fit, test, and externally validate a prediction model for…
View article: Nasal administration of anti-CD3 mAb (Foralumab) downregulates <i>NKG7</i> and increases <i>TGFB1</i> and <i>GIMAP7</i> expression in T cells in subjects with COVID-19
Nasal administration of anti-CD3 mAb (Foralumab) downregulates <i>NKG7</i> and increases <i>TGFB1</i> and <i>GIMAP7</i> expression in T cells in subjects with COVID-19 Open
T cells are present in early stages of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and play a major role in disease outcome and long-lasting immunity. Nasal administration of a fully human anti-CD3 monoclonal…
View article: Nasal anti-CD3 mAb (Foralumab) dampens CD3+ T effector function and decreases NKG7 in COVID-19 through a mechanism involving GIMAP-7 and TGFb1
Nasal anti-CD3 mAb (Foralumab) dampens CD3+ T effector function and decreases NKG7 in COVID-19 through a mechanism involving GIMAP-7 and TGFb1 Open
T cells are present in early stages of the SARS-CoV-2 infection and play a major role in disease outcome and long-lasting immunity. Nasal administration of a fully humanized anti-CD3 monoclonal antibody (Foralumab) reduced lung inflammatio…
View article: Vγ1 and Vγ4 γδ T cell subsets play opposing roles in traumatic brain injury
Vγ1 and Vγ4 γδ T cell subsets play opposing roles in traumatic brain injury Open
Traumatic brain injury (TBI) results in both morbidity and mortality in which both innate and adaptive immune responses play an important role in the pathogenesis of TBI. Nonetheless, the role of gamma-delta (γδ) T cells in acute and chron…
View article: Comparison of Common Outcome Measures for Assessing Independence in Patients Diagnosed with Disorders of Consciousness: A Traumatic Brain Injury Model Systems Study
Comparison of Common Outcome Measures for Assessing Independence in Patients Diagnosed with Disorders of Consciousness: A Traumatic Brain Injury Model Systems Study Open
Patients with disorders of consciousness (DoC) after traumatic brain injury (TBI) recover to varying degrees of functional dependency. Dependency is difficult to measure but critical for interpreting clinical trial outcomes and prognostic …
View article: Association of Traumatic Brain Injury With the Risk of Developing Chronic Cardiovascular, Endocrine, Neurological, and Psychiatric Disorders
Association of Traumatic Brain Injury With the Risk of Developing Chronic Cardiovascular, Endocrine, Neurological, and Psychiatric Disorders Open
These findings suggest that TBI of any severity was associated with a higher risk of chronic cardiovascular, endocrine, and neurological comorbidities in patients without baseline diagnoses. Medical comorbidities were observed in relativel…
View article: A genome-wide association study of outcome from traumatic brain injury
A genome-wide association study of outcome from traumatic brain injury Open