Safee Ullah Chaudhary
YOU?
Author Swipe
View article: In-hospital mortality prognostication for cancer patients with febrile neutropenia
In-hospital mortality prognostication for cancer patients with febrile neutropenia Open
View article: StACS3-mediated drought stress adaptation in potato involves interactions with StPP2C2 and St14-3-3 proteins
StACS3-mediated drought stress adaptation in potato involves interactions with StPP2C2 and St14-3-3 proteins Open
Ethylene plays a critical role in plant development and stress adaptation, with its biosynthesis tightly regulated by the stability of 1-aminocyclopropane-1-carboxylic acid synthase (ACS) proteins. Here, we investigate the potato isozyme S…
View article: Conservation of the hydrogen-bond network in bacterial response regulators
Conservation of the hydrogen-bond network in bacterial response regulators Open
The bacterial response regulator (RR) superfamily is activated by single aspartyl phosphorylation to modulate a distant target binding surface for diverse functions. The enteric CheY RRs, which represent the chemotaxis subfamily, have been…
View article: Correction: CanSeer: a translational methodology for developing personalized cancer models and therapeutics
Correction: CanSeer: a translational methodology for developing personalized cancer models and therapeutics Open
View article: CanSeer: a translational methodology for developing personalized cancer models and therapeutics
CanSeer: a translational methodology for developing personalized cancer models and therapeutics Open
View article: In-hospital Mortality Prognostication for Cancer Patients with Febrile Neutropenia: A Single Center Observational Study
In-hospital Mortality Prognostication for Cancer Patients with Febrile Neutropenia: A Single Center Observational Study Open
Febrile neutropenia (FN) in cancer patients undergoing chemotherapy can result in life-threatening outcomes. Hence, an evaluation of associated risk factors can enable clinical surveillance as well as inform prophylactic measures. In this …
View article: Causality Mapping Using Resting-state fMRI Reveals Hyperactivity and Hypoconnectivity in Schizophrenia Patients
Causality Mapping Using Resting-state fMRI Reveals Hyperactivity and Hypoconnectivity in Schizophrenia Patients Open
Schizophrenia (SZ) is a debilitating disorder in which patients exhibit psychotic behavior due to aberrant connectivity between different regions of the brain. Advances in neuroimaging have now enabled the diagnosis and analysis of SZ in o…
View article: Pharmacophore-Assisted Covalent Docking Identifies a Potential Covalent Inhibitor for Drug-Resistant Genotype 3 Variants of Hepatitis C Viral NS3/4A Serine Protease
Pharmacophore-Assisted Covalent Docking Identifies a Potential Covalent Inhibitor for Drug-Resistant Genotype 3 Variants of Hepatitis C Viral NS3/4A Serine Protease Open
The emergence of drug-resistance-inducing mutations in Hepatitis C virus (HCV) coupled with genotypic heterogeneity has made targeting NS3/4A serine protease difficult. In this work, we investigated the mutagenic variations in the binding …
View article: Pharmacophore-Assisted Covalent Docking Identifies a Potential Covalent Inhibitor for Drug-Resistant Genotype 3 Variants of Hepatitis C Viral NS3/4A Serine Protease
Pharmacophore-Assisted Covalent Docking Identifies a Potential Covalent Inhibitor for Drug-Resistant Genotype 3 Variants of Hepatitis C Viral NS3/4A Serine Protease Open
The emergence of drug resistance inducing mutations in Hepatitis C virus (HCV) coupled with genotypic heterogeneity has made targeting NS3/4A serine protease difficult. In this work, we investigated the mutagenic variations in the binding …
View article: Editorial: From assessment to intervention: role of consumer technology and neurotech in preventive mental health
Editorial: From assessment to intervention: role of consumer technology and neurotech in preventive mental health Open
Editorial: From assessment to intervention: role of consumer technology and neurotech in preventive mental health
View article: Fingerprinting hyperglycemia using predictive modelling approach based on low-cost routine CBC and CRP diagnostics
Fingerprinting hyperglycemia using predictive modelling approach based on low-cost routine CBC and CRP diagnostics Open
View article: Perceptron-Xfms: An Open-Source Web Server for Analysis of X-Ray Footprinting with Mass Spectrometry Data
Perceptron-Xfms: An Open-Source Web Server for Analysis of X-Ray Footprinting with Mass Spectrometry Data Open
View article: Aquatic Microplastic Pollution Quantification in Urban Environment of Pakistan
Aquatic Microplastic Pollution Quantification in Urban Environment of Pakistan Open
View article: Fingerprinting Hyperglycemia using Predictive Modelling Approach based on Low-Cost Routine CBC and CRP Diagnostics
Fingerprinting Hyperglycemia using Predictive Modelling Approach based on Low-Cost Routine CBC and CRP Diagnostics Open
Hyperglycemia is an outcome of dysregulated glucose homeostasis in the human body and may induce chronic elevation of blood glucose levels. Lifestyle factors such as overnutrition, physical inactivity, and psychosocials coupled with system…
View article: NMR-Based Metabolomics: A New Paradigm to Unravel Defense-Related Metabolites in Insect-Resistant Cotton Variety through Different Multivariate Data Analysis Approaches
NMR-Based Metabolomics: A New Paradigm to Unravel Defense-Related Metabolites in Insect-Resistant Cotton Variety through Different Multivariate Data Analysis Approaches Open
Cotton (Gossypium hirsutum) is an economically important crop and is widely cultivated around the globe. However, the major problem of cotton is its high vulnerability to biotic and abiotic stresses. It has been around three decades since …
View article: Fingerprinting of heavy metal and microbial contamination uncovers the unprecedented scale of water pollution and its implication on human health around transboundary Hudiara drain in South Asia
Fingerprinting of heavy metal and microbial contamination uncovers the unprecedented scale of water pollution and its implication on human health around transboundary Hudiara drain in South Asia Open
Environment and health hazards posed by the contamination of existing underground water resources are amongst the leading anthropogenic challenges in South Asia. One such major environmental hazard is posed by the transnational wastewater …
View article: The Solvation of the E. coli CheY Phosphorylation Site Mapped by XFMS
The Solvation of the E. coli CheY Phosphorylation Site Mapped by XFMS Open
The Escherichia coli CheY protein belongs to a large bacterial response regulator superfamily. X-ray hydroxy radical foot-printing with mass spectroscopy (XFMS) has shown that allosteric activation of CheY by its motor target triggers a co…
View article: The Solvation of the <i>E. coli</i> CheY Phosphorylation Site Mapped by XFMS
The Solvation of the <i>E. coli</i> CheY Phosphorylation Site Mapped by XFMS Open
The Escherichia coli CheY protein belongs to a large bacterial response regulator superfamily. X-ray hydroxy radical foot-printing with mass spectroscopy (XFMS) has shown that allosteric activation of CheY by its motor target triggers a co…
View article: CanSeer: A Method for Development and Clinical Translation of Personalized Cancer Therapeutics
CanSeer: A Method for Development and Clinical Translation of Personalized Cancer Therapeutics Open
Computational modeling and analysis of biomolecular network models annotated with cancer patient-specific multi-omics data can enable the development of personalized therapies. Current endeavors aimed at employing in silico models towards …
View article: O01 Trends in antimicrobial resistance amongst pathogens isolated from blood and cerebrospinal fluid cultures in Pakistan (2011–15): a retrospective cross-sectional study
O01 Trends in antimicrobial resistance amongst pathogens isolated from blood and cerebrospinal fluid cultures in Pakistan (2011–15): a retrospective cross-sectional study Open
Background While antimicrobial resistance (AMR) continues to be a major public health problem in Pakistan, data regarding trends of resistance among pathogenic bacteria remain scarce, with few studies presenting long-term trends in AMR. Th…
View article: Navigating Multi-Scale Cancer Systems Biology Towards Model-Driven Clinical Oncology and Its Applications in Personalized Therapeutics
Navigating Multi-Scale Cancer Systems Biology Towards Model-Driven Clinical Oncology and Its Applications in Personalized Therapeutics Open
Rapid advancements in high-throughput omics technologies and experimental protocols have led to the generation of vast amounts of scale-specific biomolecular data on cancer that now populates several online databases and resources. Cancer …
View article: Expression of cyanobacterial genes enhanced CO<sub>2</sub> assimilation and biomass production in transgenic <i>Arabidopsis thaliana</i>
Expression of cyanobacterial genes enhanced CO<sub>2</sub> assimilation and biomass production in transgenic <i>Arabidopsis thaliana</i> Open
Background Photosynthesis is a key process in plants that is compromised by the oxygenase activity of Rubisco, which leads to the production of toxic compound phosphoglycolate that is catabolized by photorespiratory pathway. Transformation…
View article: 1H-NMR-Based Metabolomics: An Integrated Approach for the Detection of the Adulteration in Chicken, Chevon, Beef and Donkey Meat
1H-NMR-Based Metabolomics: An Integrated Approach for the Detection of the Adulteration in Chicken, Chevon, Beef and Donkey Meat Open
Meat is a rich source of energy that provides high-value animal protein, fats, vitamins, minerals and trace amounts of carbohydrates. Globally, different types of meats are consumed to fulfill nutritional requirements. However, the increas…
View article: A Personalized Therapeutics Approach Using an In Silico Drosophila Patient Model Reveals Optimal Chemo- and Targeted Therapy Combinations for Colorectal Cancer
A Personalized Therapeutics Approach Using an In Silico Drosophila Patient Model Reveals Optimal Chemo- and Targeted Therapy Combinations for Colorectal Cancer Open
In silico models of biomolecular regulation in cancer, annotated with patient-specific gene expression data, can aid in the development of novel personalized cancer therapeutic strategies. Drosophila melanogaster is a well-established anim…
View article: Author Correction: An evaluation of lipid profile and pro-inflammatory cytokines as determinants of cardiovascular disease in those with diabetes: a study on a Mexican American cohort
Author Correction: An evaluation of lipid profile and pro-inflammatory cytokines as determinants of cardiovascular disease in those with diabetes: a study on a Mexican American cohort Open
Sedentary life styles coupled with high-calorie diets and unhealthy social habits such as smoking, have put an ever-increasing number of people at risk of cardiovascular disorders (CVD), worldwide. A concomitant increase in the prevalence …
View article: Navigating Multi-scale Cancer Systems Biology towards Model-driven Personalized Therapeutics
Navigating Multi-scale Cancer Systems Biology towards Model-driven Personalized Therapeutics Open
Rapid advancements in high-throughput omics technologies and experimental protocols have led to the generation of vast amounts of biomolecular data on cancer that now populates several online databases and resources. Cancer systems biology…
View article: TISON: a next-generation multi-scale modeling theatre for<i>in silico</i>systems oncology
TISON: a next-generation multi-scale modeling theatre for<i>in silico</i>systems oncology Open
Multi-scale models integrating biomolecular data from genetic, transcriptional, and translational levels, coupled with extracellular microenvironments can assist in decoding the complex mechanisms underlying system-level diseases such as c…
View article: Trends in antimicrobial resistance amongst pathogens isolated from blood and cerebrospinal fluid cultures in Pakistan (2011-2015): A retrospective cross-sectional study
Trends in antimicrobial resistance amongst pathogens isolated from blood and cerebrospinal fluid cultures in Pakistan (2011-2015): A retrospective cross-sectional study Open
While antimicrobial resistance (AMR) continues to be a major public health problem in Pakistan, data regarding trends of resistance among pathogenic bacteria remains scarce, with few studies presenting long-term trends in AMR. This study w…
View article: PERCEPTRON: an open-source GPU-accelerated proteoform identification pipeline for top-down proteomics
PERCEPTRON: an open-source GPU-accelerated proteoform identification pipeline for top-down proteomics Open
PERCEPTRON is a next-generation freely available web-based proteoform identification and characterization platform for top-down proteomics (TDP). PERCEPTRON search pipeline brings together algorithms for (i) intact protein mass tuning, (ii…
View article: Host biomarkers for monitoring therapeutic response in extrapulmonary tuberculosis
Host biomarkers for monitoring therapeutic response in extrapulmonary tuberculosis Open
Change in inflammatory biomarkers correlates with treatment success. A five biomarker biosignature (MIG, IP-10, MIF, CCL22 and CCL23) could be used as an indicator of treatment success.