Sagarika Biswas
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View article: A Study And Analysis of the Relation Between Politics And Education Policies
A Study And Analysis of the Relation Between Politics And Education Policies Open
View article: Evaluating the role of 2-hydroxyestradiol in modulating TNF-α signaling and its implications in rheumatoid arthritis
Evaluating the role of 2-hydroxyestradiol in modulating TNF-α signaling and its implications in rheumatoid arthritis Open
Estrogen metabolites, a subset of female sex hormones, are known to play a role in autoimmunity and the inflammatory response associated with rheumatoid arthritis (RA). Current therapeutic approaches have focused on the development of smal…
View article: Deduction of Crime in the Urban Matrix: A Comparative Analysis between Kiriti Roy and Sherlock HolmesIntroduction
Deduction of Crime in the Urban Matrix: A Comparative Analysis between Kiriti Roy and Sherlock HolmesIntroduction Open
Detective fiction, as a literary genre, provides a compelling lens to examine the interplay of crime, society, and urban spaces. This study offers a comparative analysis of two iconic literary detectives—Sherlock Holmes, the emblematic fig…
View article: Measurement-Induced Dynamical Quantum Thermalization
Measurement-Induced Dynamical Quantum Thermalization Open
One of the fundamental problems of quantum statistical physics is, how an ideally isolated quantum system can ever reach thermal equilibrium behavior despite the unitary time evolution of quantum-mechanical systems. Here we study by explic…
View article: Unilateral Tensor Fascia Suralis: A Rare Type Ia Variant and Its Clinical Implications
Unilateral Tensor Fascia Suralis: A Rare Type Ia Variant and Its Clinical Implications Open
Tensor fascia suralis is a rare supernumerary muscle in the posterior thigh and leg, with a male preponderance as reported in the literature. We present a unique Type Ia variant discovered during cadaver dissection of the left lower limb, …
View article: Craniorachischisis Totalis: A Detailed Case Report.
Craniorachischisis Totalis: A Detailed Case Report. Open
Neural tube defects (NTDs) are severe congenital anomalies resulting from improper neural tube closure. Craniorachischisis totalis, the most extreme form, involves failure of neural tube formation along the entire cranio-spinal axis. This …
View article: Exploring the Therapeutic Impact of Phytoestrogen Bavachin in Rheumatoid Arthritis: Insights from Synovial Fibroblasts and Collagen Induced Arthritis Rat Model
Exploring the Therapeutic Impact of Phytoestrogen Bavachin in Rheumatoid Arthritis: Insights from Synovial Fibroblasts and Collagen Induced Arthritis Rat Model Open
View article: Exploring the Relationship Between Obesity and Metabolic Diseases: A Review of Current Treatments.
Exploring the Relationship Between Obesity and Metabolic Diseases: A Review of Current Treatments. Open
View article: Integrative metabolomic-proteomic analysis uncovers a new therapeutic approach in targeting rheumatoid arthritis
Integrative metabolomic-proteomic analysis uncovers a new therapeutic approach in targeting rheumatoid arthritis Open
View article: Mustard price dynamics due to ban on blending: time series intervention model with nonlinear function
Mustard price dynamics due to ban on blending: time series intervention model with nonlinear function Open
View article: Pathogenic Mechanisms of Collagen TypeⅦA1 (COL7A1) and Transporter Protein Transport and Golgi Organization 1 (TANGO1) in Rheumatoid Arthritis: A New Therapeutic Target
Pathogenic Mechanisms of Collagen TypeⅦA1 (COL7A1) and Transporter Protein Transport and Golgi Organization 1 (TANGO1) in Rheumatoid Arthritis: A New Therapeutic Target Open
Rheumatoid arthritis (RA) is an autoimmune disorder causing chronic inflammation primarily due to collagen regulation and transport imbalances. Collagen VII A1(COL7A1), a major component of anchoring fibrils, regulates inflammation via int…
View article: Alpha-Taxilin: A Potential Diagnosis and Therapeutics Target in Rheumatoid Arthritis Which Interacts with Key Glycolytic Enzymes Associated with Metabolic Shifts in Fibroblast-Like Synoviocytes
Alpha-Taxilin: A Potential Diagnosis and Therapeutics Target in Rheumatoid Arthritis Which Interacts with Key Glycolytic Enzymes Associated with Metabolic Shifts in Fibroblast-Like Synoviocytes Open
α-Taxilin has been found to be associated with glycolysis and gluconeogenesis. This may lead to a metabolic shift in synovial cells, ROS generation, and TLR activation. Therefore, α-Taxilin can be targeted for its diagnostic and therapeuti…
View article: Integrative Metabolomic-Proteomic Analysis Uncovers a New Therapeutic Approach in Targeting Rheumatoid Arthritis
Integrative Metabolomic-Proteomic Analysis Uncovers a New Therapeutic Approach in Targeting Rheumatoid Arthritis Open
Objective: Rheumatoid arthritis (RA) is a chronic inflammatory condition that, despite available approaches to manage the disease, lacks an efficient treatment and timely diagnosis. Using the most advanced omics technique, metabolomics and…
View article: ITIH4 in Rheumatoid Arthritis Pathogenesis: Network Pharmacology and Molecular Docking Analysis Identify CXCR4 as a Potential Receptor
ITIH4 in Rheumatoid Arthritis Pathogenesis: Network Pharmacology and Molecular Docking Analysis Identify CXCR4 as a Potential Receptor Open
Elevated levels of Inter-alpha-trypsin-inhibitor heavy chain 4 (ITIH4) have grabbed attention in rheumatoid arthritis (RA) pathogenesis, though its precise mechanisms remain unexplored. To elucidate these mechanisms, a comprehensive strate…
View article: Clo-miR-14: a medicinally valued spice-derived miRNA with therapeutic implications in rheumatoid arthritis
Clo-miR-14: a medicinally valued spice-derived miRNA with therapeutic implications in rheumatoid arthritis Open
Plant microRNAs (miRNA) are regularly consumed orally along with diet, gaining attention for their RNA-based drug potential because of their ability to regulate mammalian gene expression specifically at the post-transcriptional level. Medi…
View article: Chronic disease management via modulation of cellular signaling by phytoestrogen Bavachin
Chronic disease management via modulation of cellular signaling by phytoestrogen Bavachin Open
The emergence of chronic diseases, particularly cancers, cardiovascular, and bone disorders, presents a formidable challenge, as currently available synthetic drugs often result in significant side effects and incur higher costs. Phytoestr…
View article: Unveiling the Nexus: Cellular Metabolomics Unravels the Impact of Estrogen on Nicotinamide Metabolism in Mitigating Rheumatoid Arthritis Pathogenesis
Unveiling the Nexus: Cellular Metabolomics Unravels the Impact of Estrogen on Nicotinamide Metabolism in Mitigating Rheumatoid Arthritis Pathogenesis Open
Rheumatoid arthritis (RA) is a metabolic joint disorder influenced by hormonal regulation, notably estrogen, which plays a cytoprotective role against inflammation. While estrogen’s impact on RA pathogenesis has been studied, the altered m…
View article: Functional Significance of miR-4693-5p in Targeting HIF1α and Its Link to Rheumatoid Arthritis Pathogenesis
Functional Significance of miR-4693-5p in Targeting HIF1α and Its Link to Rheumatoid Arthritis Pathogenesis Open
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that causes joint inflammation and destruction with an unknown origin. Our study aims to elucidate the molecular mechanism behind HIF1α overexpression in RA. Dysregulat…
View article: Anti-inflammatory potential of selective small compounds by targeting TNF-α & NF-kB signaling: a comprehensive molecular docking and simulation study
Anti-inflammatory potential of selective small compounds by targeting TNF-α & NF-kB signaling: a comprehensive molecular docking and simulation study Open
Tumor necrosis factor alpha (TNF-α) is the major cause of inflammation in autoimmune diseases like rheumatoid arthritis (RA). It’s mechanisms of signal transduction through nuclear factor kappa B (NF-kB) pathway via small molecules such as…
View article: Upregulation of leucine-rich alpha-2 glycoprotein: A key regulator of inflammation and joint fibrosis in patients with severe knee osteoarthritis
Upregulation of leucine-rich alpha-2 glycoprotein: A key regulator of inflammation and joint fibrosis in patients with severe knee osteoarthritis Open
Introduction Osteoarthritis (OA) is a degenerative disease of the joints mainly affecting older individuals. Since the etiology behind the progression of OA is not well understood, several associated consequences, such as synovial joint st…
View article: Regulation of PTU-induced hypothyroidism in rats by caffeic acid primarily by activating thyrotropin receptors and by inhibiting oxidative stress
Regulation of PTU-induced hypothyroidism in rats by caffeic acid primarily by activating thyrotropin receptors and by inhibiting oxidative stress Open
Background: Earlier, nothing was known on the thyroid-regulatory potential of caffeic acid (CA). We investigated its role in 6-propyl-thiouracil (PTU)-induced hypothyroid rats and also worked out the possible involvement of 5’-deiodinase I…
View article: Antitumor Activity of Choerospondias axillaris Fruit Extract by Regulating the Expression of SNCAIP and SNCA on MDA-MB-231 Cells
Antitumor Activity of Choerospondias axillaris Fruit Extract by Regulating the Expression of SNCAIP and SNCA on MDA-MB-231 Cells Open
Our data implicate that the presence of bioactive compound(s) in C. axillaris fruits might play an important role in inhibiting the proliferation of breast carcinoma cells and Synphilin-1 protein may play a role of apoptotic function.
View article: Review of: "New Druggable Targets for Rheumatoid Arthritis Based on Insights From Synovial Biology"
Review of: "New Druggable Targets for Rheumatoid Arthritis Based on Insights From Synovial Biology" Open
View article: Transthyretin and Receptor for Advanced Glycation End Product’s Differential Levels Associated with the Pathogenesis of Rheumatoid Arthritis
Transthyretin and Receptor for Advanced Glycation End Product’s Differential Levels Associated with the Pathogenesis of Rheumatoid Arthritis Open
Monu,1,2 Prachi Agnihotri,1 Mohd Saquib,1,2 Ashish Sarkar,1,2 Debolina Chakraborty,1,2 Uma Kumar,3 Sagarika Biswas1 1Council of Scientific and Industrial Research -Institute of Genomics & Integrative Biology (CSIR–IGIB), Delhi, 110007, Ind…
View article: Transthyretin and Receptor for Advanced Glycation End Product’s Differential Levels Associated with the Pathogenesis of Rheumatoid Arthritis
Transthyretin and Receptor for Advanced Glycation End Product’s Differential Levels Associated with the Pathogenesis of Rheumatoid Arthritis Open
Our findings showed that the level of TTR was increased in RA plasma, along with an altered glycation rate. TTR and RAGE aberrant gene expression in PBMCs are the key events associated with RA, and TNF-α activates the NF-KB pathways and pr…
View article: PrkC, a Transmembrane Serine/Threonine Protein Kinase, Regulates Bacterial Chain Length in Bacillus anthracis
PrkC, a Transmembrane Serine/Threonine Protein Kinase, Regulates Bacterial Chain Length in Bacillus anthracis Open
Chaining phenotype acts as a virulence factor in Bacillus anthracis . This is the first study that identifies a signal transduction protein with an ability to regulate the chaining phenotype in Bacillus anthracis .
View article: Poor Clearance of Free Hemoglobin Due to Lower Active Haptoglobin Availability is Associated with Osteoarthritis Inflammation
Poor Clearance of Free Hemoglobin Due to Lower Active Haptoglobin Availability is Associated with Osteoarthritis Inflammation Open
Our data suggest that poor clearance of free hemoglobin and low levels of Hp tetramers may be associated with OA pathogenesis and inflammation.
View article: Biomarkers of Joint Damage in Osteoarthritis: Current Status and Future Directions
Biomarkers of Joint Damage in Osteoarthritis: Current Status and Future Directions Open
Osteoarthritis (OA) is a disease of the whole joint organ, characterized by the loss of cartilage, and structural changes in bone including the formation of osteophytes, causing disability and loss of function. It is also associated with s…
View article: Referee report. For: In silico docking analysis of CCL28 (C-C motif chemokine ligand 28) and astragalin as the potential inhibitor of rheumatoid arthritis [version 1; peer review: 1 approved, 1 approved with reservations]
Referee report. For: In silico docking analysis of CCL28 (C-C motif chemokine ligand 28) and astragalin as the potential inhibitor of rheumatoid arthritis [version 1; peer review: 1 approved, 1 approved with reservations] Open
View article: A mechanistic insight of phytoestrogens used for Rheumatoid arthritis: An evidence-based review
A mechanistic insight of phytoestrogens used for Rheumatoid arthritis: An evidence-based review Open
Assessment of the potential therapeutic benefits offered by naturally occurring phytoestrogens necessitate inspection of their potency and sites of action in impeding the chronic, systemic, autoimmune, joint destructing disorder Rheumatoid…