Sage Becker
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View article: 266 Beta-glucan induced immunomodulation: Transitioning from cell-culture to the whole pig
266 Beta-glucan induced immunomodulation: Transitioning from cell-culture to the whole pig Open
Dietary beta-glucans are readily used in swine diets to improve intestinal health and growth of nursery pigs. However, the structure of beta-glucan is different depending on source, which along with solubility, is associated with different…
View article: PSLBII-26 Butyrate receptor gene expression in myeloid cells of the lower porcine gastrointestinal tract
PSLBII-26 Butyrate receptor gene expression in myeloid cells of the lower porcine gastrointestinal tract Open
Butyrate is a microbial-produced metabolite associated with increased barrier integrity, enhanced mucosal immunity, and modulation of immune cell function. Butyrate driven immunomodulation occurs through a variety of mechanisms, including …
View article: Conserved B cell signaling, activation, and differentiation in porcine jejunal and ileal Peyer’s patches despite distinct immune landscapes
Conserved B cell signaling, activation, and differentiation in porcine jejunal and ileal Peyer’s patches despite distinct immune landscapes Open
Peyer's patches (PPs) are B cell-rich sites of intestinal immune induction, yet PP-associated B cell signaling, activation, and differentiation are poorly defined. Single-cell and spatial transcriptomics were completed to study B cells fro…
View article: Butyrate modulation of inflammatory responses to lipopolysaccharide in porcine monocytes
Butyrate modulation of inflammatory responses to lipopolysaccharide in porcine monocytes Open
Butyrate is a short-chain fatty acid produced through microbial fermentation of dietary fibers in the lower intestinal tract. Butyrate production is associated with enhanced mucosal immunity, increased barrier integrity, and modulation of …
View article: Regional epithelial cell diversity in the small intestine of pigs
Regional epithelial cell diversity in the small intestine of pigs Open
Understanding regional distribution and specialization of small intestinal epithelial cells is crucial for developing methods to control appetite, stress, and nutrient uptake in swine. To establish a better understanding of specific epithe…
View article: 270 Efficacy of Bacillus subtilis and Bacillus licheniformis (BioPlus2B®) on sow lactation performance, litter growth, nursery performance and health of pigs challenged with PRRS virus post-wean
270 Efficacy of Bacillus subtilis and Bacillus licheniformis (BioPlus2B®) on sow lactation performance, litter growth, nursery performance and health of pigs challenged with PRRS virus post-wean Open
Probiotics have been shown to support normal growth and immune function in pigs in challenging environments. A commercial probiotic (BioPlus2B®) containing two microbial species (Bacillus subtilis and Bacillus licheniformis) was tested to …
View article: Chicken Intestinal Mycobiome: Initial Characterization and Its Response to Bacitracin Methylene Disalicylate
Chicken Intestinal Mycobiome: Initial Characterization and Its Response to Bacitracin Methylene Disalicylate Open
The intestinal microbiota is critical to host physiology, metabolism, and health. However, the fungal community has been often overlooked. Recent studies in humans have highlighted the importance of the mycobiota in obesity and disease, ma…
View article: Differential Impact of Subtherapeutic Antibiotics and Ionophores on Intestinal Microbiota of Broilers
Differential Impact of Subtherapeutic Antibiotics and Ionophores on Intestinal Microbiota of Broilers Open
Antimicrobial growth promoters (AGPs) are commonly used in the livestock industry at subtherapeutic levels to improve production efficiency, which is achieved mainly through modulation of the intestinal microbiota. However, how different c…
View article: High Throughput Screening for Natural Host Defense Peptide-Inducing Compounds as Novel Alternatives to Antibiotics
High Throughput Screening for Natural Host Defense Peptide-Inducing Compounds as Novel Alternatives to Antibiotics Open
A rise in antimicrobial resistance demands novel alternatives to antimicrobials for disease control and prevention. As an important component of innate immunity, host defense peptides (HDPs) are capable of killing a broad spectrum of patho…