Explanipedia

Perinatal antibiotic exposure and risk of childhood infections: a retrospective cohort study Open

Sarah A. Coggins, William Quarshie, Robert W. Grundmeier, Di Shu, Jeffrey S. Gerber , et al. · 2025

Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, funding (K23 HD088753) supported this study.

Maternal Coronavirus Disease 2019 Test Positivity and Neonatal Intensive Care Unit Outcomes for Infants Born Extremely Preterm Open

Emily A. Messick, Somnath Saha, Jonathan L. Slaughter, Matthew J. Kielt, Kristen Benninger , et al. · 2025

Comparison of metrics of neonatal intensive care unit antibiotic use Open

Alvaro Zevallos Barboza, Sagori Mukhopadhyay, Karen M. Puopolo, Di Shu, Jeffrey S. Gerber , et al. · 2025

Objective: To compare temporal trends, variation, and correlations between antibiotic use metrics across U.S. neonatal intensive care units (NICUs) and assess associations with mortality. Methods: We conducted a retrospective cohort study …

Multicenter Evaluation of a New Strip-Based Blood Glucose System for Point-of-Care Testing in Critical and Non-Critical Care Settings Open

Michael D. Goodman, Sven Bercker, Nancy Breitenbeck, C. Cañada-Vilalta, Daisy D. Canepa , et al. · 2025

Background: Evaluation of the performance of Cobas ® Pulse (Roche Diagnostics GmbH, Mannheim, Germany), a new blood glucose (BG) monitoring system (BGMS; referred to here as BGMSA) intended for point-of-care testing using samples from pati…

Gut mycobiome maturation and its determinants during early childhood: a comparison of ITS2 amplicon and shotgun metagenomic sequencing approaches Open

Timothy Heisel, Sara Gonia, Abrielle Dillon, Suzie Hoops, Gabriel A. Al‐Ghalith , et al. · 2025

Introduction Microbial colonization of the gut in early life is important for the development of metabolism, immunity, and the brain. Fungi and bacteria both colonize the human infant gut. The relatively smaller contribution of fungi to th…

Association Between Dietary Micronutrients and Unexpected Low Cow Milk Intake in 24-Month-Old Children Open

Alyssa Tindall, J. N. Gerber, Miren Dhudasiam, Sagori Mukhopadhyay, Virginia A. Stallings · 2025

The Contributions of delivery mode and intrapartum antibiotic exposure to body mass index among children through 5 years of age Open

Corinna Koebnick, Sagori Mukhopadhyay, Darios Getahun, Sara Y. Tartof, Anny H. Xiang , et al. · 2025

Based on our findings, the widespread administration of GBS IAP and birth by cesarean delivery independently contribute to a significant upshift in body weight early in life that compares to or is higher than the annual increase in BMI in …

Improving Time to First Feeding for Preterm Infants: A Quality Improvement Approach Open

Michael L. May, Melissa A. McKinney, Danielle Cestare, Alicia Hussey, Alvaro Barboza Zevallos , et al. · 2025

Introduction: Early initiation of enteral feeding is reported to reduce sepsis and mortality in preterm infants. Less than half of stable infants born <35 weeks gestational age with birth weight <2,000 g are fed within 24 hours of birth at…

Hospital-onset bacteremia in the neonatal intensive care unit: strategies for risk adjustment Open

Erica C. Prochaska, Shaoming Xiao, Elizabeth Colantuoni, Nora Elhaissouni, Reese H. Clark , et al. · 2025

Objective: To quantify the impact of patient- and unit-level risk adjustment on infant hospital-onset bacteremia (HOB) standardized infection ratio (SIR) ranking. Design: A retrospective, multicenter cohort study. Setting and participants:…

A quantitative approach to measure and predict microbiome response to antibiotics Open

Vincent Tu, Yue Ren, Ceylan Tanes, Sagori Mukhopadhyay, Scott G. Daniel , et al. · 2024

Although antibiotics induce sizable perturbations in the human microbiome, we lack a systematic and quantitative method to measure and predict the microbiome's response to specific antibiotics. Here, we introduce such a method, which takes…

Hospital-Onset Bacteremia Among Neonatal Intensive Care Unit Patients Open

Erica C. Prochaska, Shaoming Xiao, Elizabeth Colantuoni, Reese H. Clark, Julia Johnson , et al. · 2024

Importance The Centers for Disease Control and Prevention plans to introduce hospital-onset bacteremia (HOB) as a health care–associated infection measure. The epidemiology and clinical characteristics of HOB among infants admitted to the …

Antibiotic Use Among Infants Admitted to Neonatal Intensive Care Units Open

Dustin D. Flannery, Alvaro Zevallos Barboza, Sagori Mukhopadhyay, Kelly C. Wade, Jeffrey S. Gerber , et al. · 2023

This cross-sectional study examines antibiotic exposure, days of therapy, types of antibiotics, and changes in use patterns among newborns in neonatal intensive care units (NICUs) across the US from 2009 to 2021.

Association of delivery risk phenotype with early-onset sepsis in preterm infants Open

Sarah A. Coggins, Sagori Mukhopadhyay, Jourdan E. Triebwasser, Kevin J. Downes, Jason D. Christie , et al. · 2023

Early antibiotic exposure in very-low birth weight infants and infection risk at 3–7 days after birth Open

Sarah A. Coggins, Zachary Willis, Daniel K. Benjamin, Sagori Mukhopadhyay, Matthew M. Laughon , et al. · 2023

P07-059-23 Temporal Pattern of P-Cresol Production in Infants Revealed by Fecal Metabolomic Analysis Open

Rui Su, Suzie Hoops, Islam Mabrouk, Dan Knights, Jeffrey S. Gerber , et al. · 2023

Association of postnatal age with neonatal hospital-onset bacteremia in a multicenter, retrospective cohort Open

Erica C. Prochaska, Shaoming Xiao, Elizabeth Colantuoni, Sagori Mukhopadhyay, Dustin D. Flannery , et al. · 2023

Background: Prevention of hospital-onset bacteremia (HOB) in all settings is a healthcare priority. The CDC is developing a neonatal-specific HOB quality metric, but the epidemiology of neonatal HOB is poorly understood. Our objective was …

Higher body mass index after intrapartum antibiotic exposure in children persists over 10‐years Open

Margo A. Sidell, Darios Getahun, Sara Y. Tartof, Anny H. Xiang, Andrea J. Sharma , et al. · 2023

Summary Exposure to intrapartum antibiotic prophylaxis to reduce perinatal group B streptococcal disease was associated with increased childhood body mass index (BMI) persisting to age 10 years compared to no exposure (Δ BMI at 10 years: v…

A quantitative approach to measure and predict microbiome response to antibiotics Open

Vince Tu, Yue Ren, Ceylan Tanes, Sagori Mukhopadhyay, Scott G. Daniel , et al. · 2023

Background Although antibiotics induce sizable perturbations in the human microbiome, we lack a systematic and quantitative method to measure and predict the microbiome’s response to specific antibiotics. Here, we introduce such a method, …

Maternal and Newborn Hospital Outcomes of Perinatal SARS-CoV-2 Infection: A National Registry Open

Mark L. Hudak, Dustin D. Flannery, Kimberly Barnette, Trace Getzlaff, Shiva Gautam , et al. · 2023

OBJECTIVES The American Academy of Pediatrics National Registry for the Surveillance and Epidemiology of Perinatal coronavirus disease 2019 (COVID-19) (NPC-19) was developed to provide information on the effects of perinatal severe acute r…

Diagnostic Performance and Patient Outcomes With C-Reactive Protein Use in Early-Onset Sepsis Evaluations Open

Miren B. Dhudasia, W.E. Benitz, Dustin D. Flannery, Lori Christ, David M. Rub , et al. · 2022

Preterm infants at low risk for early-onset sepsis differ in early fecal microbiome assembly Open

Sagori Mukhopadhyay, Jung‐Jin Lee, Erica Hartman, Emily C. Woodford, Miren B. Dhudasia , et al. · 2022

Antibiotics are administered near-universally to very low birth weight (VLBW) infants after birth for suspected early-onset sepsis (EOS). We previously identified a phenotypic group of VLBW infants, referred to as low-risk for EOS (LRE), w…

Comparison of Maternal and Neonatal Antibody Levels After COVID-19 Vaccination vs SARS-CoV-2 Infection Open

Dustin D. Flannery, Sigrid Gouma, Miren B. Dhudasia, Sagori Mukhopadhyay, Madeline R. Pfeifer , et al. · 2022

Importance Pregnant persons are at an increased risk of severe COVID-19 from SARS-CoV-2 infection, and COVID-19 vaccination is currently recommended during pregnancy. Objective To ascertain the association of vaccine type, time from vaccin…

Respiratory indices during sleep in healthy infants: A prospective longitudinal study and meta-analysis Open

Darko Stefanovski, Ignacio E. Tapia, Janet Lioy, Shaon Sengupta, Sagori Mukhopadhyay , et al. · 2022

Perinatal COVID-19 maternal and neonatal outcomes at two academic birth hospitals Open

Dustin D. Flannery, Alvaro Zevallos Barboza, Madeline R. Pfeifer, Mark L. Hudak, Kimberly Barnette , et al. · 2022

Assessment of SARS-CoV-2 serostatus and hypertensive disorders of pregnancy Open

Jourdan E. Triebwasser, Miren B. Dhudasia, Sagori Mukhopadhyay, Dustin D. Flannery, Sigrid Gouma , et al. · 2022

Neighborhood Characteristics and Racial Disparities in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Seropositivity in Pregnancy Open

Heather H. Burris, Anne Mullin, Miren B. Dhudasia, Dustin D. Flannery, Sagori Mukhopadhyay , et al. · 2022

OBJECTIVE: To quantify the extent to which neighborhood characteristics contribute to racial and ethnic disparities in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seropositivity in pregnancy. METHODS: This cohort study inc…

Supplementation with a probiotic mixture accelerates gut microbiome maturation and reduces intestinal inflammation in extremely preterm infants Open

Jumana Samara, Shirin Moossavi, Belal Alshaikh, Van A. Ortega, Veronika Kuchařová Pettersen , et al. · 2022

Early childhood antibiotic utilization for infants discharged from the neonatal intensive care unit Open

Dustin D. Flannery, Molly Passarella, Sagori Mukhopadhyay, Miren B. Dhudasia, Jeffrey S. Gerber , et al. · 2022

Group B <i>Streptococcus</i> Infection in Extremely Preterm Neonates and Neurodevelopmental Outcomes at 2 Years Open

Karen M. Puopolo, Sagori Mukhopadhyay, Nellie I. Hansen, Dustin D. Flannery, Rachel G. Greenberg , et al. · 2022

Background This study was performed to determine the incidence of group B Streptococcus (GBS) disease among extremely preterm infants and assess to risk of death or neurodevelopmental impairment (NDI) at a corrected age of 18–26 months. Me…

Time to positivity of blood cultures in neonatal late-onset bacteraemia Open

Sagori Mukhopadhyay, Sara M. Briker, Dustin D. Flannery, Miren B. Dhudasia, Sarah A. Coggins , et al. · 2022

Objective To determine the time to positivity (TTP) of blood cultures among infants with late-onset bacteraemia and predictors of TTP >36 hours. Design Retrospective cohort study. Setting 16 birth centres in two healthcare systems. Patient…

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