Explanipedia

Assessment of differences in clinical consequences between rituximab and interferon recipients in multiple sclerosis patients after recovery from COVID-19 Open

Arash Musa AL-Rezai Aghdam, Seyyed Mahdi Hosseini Sarkhosh, Zahra Farrokhi, Saleh Behzadi, Nazanin Moeini , et al. · 2025

Background: Multiple sclerosis (MS) patients using disease-modifying treatments (DMTs) are at serious danger from the Coronavirus Disease 2019 (COVID-19) pandemic, which is brought on by the severe acute respiratory syndrome coronavirus-2 …

The common bisulfite-conversion-based techniques to analyze DNA methylation in human cancers Open

Farhad Jeddi, Elnaz Faghfuri, Sahar Mehranfar, Narges Soozangar · 2024

DNA methylation is an important molecular modification that plays a key role in the expression of cancer genes. Evaluation of epigenetic changes, hypomethylation and hypermethylation, in specific genes are applied for cancer diagnosis. Num…

Janus kinase inhibitors: A new therapeutic option for autoimmune diseases Open

Vida Hashemi, Mohammad Ahmadpour, Sahar Mehranfar, Reza Shiri Haris, Arezou Hoseini · 2024

Background & Aim: Cytokines play a pivotal role in the pathogenesis of inflammatory and autoimmune diseases.Following the binding of cytokines to their respective receptors, Janus kinase (JAK) and Signal Transducer and Activator of Transcr…

ARTIFICIAL INTELLIGENCE AND GENE THERAPY OF BREAST CANCER Open

Shabnam Kabaranzadghadim, Shiva Gholizadeh‐Ghaleh Aziz, Ghader Babaei, Sahar Mehranfar, Rahim Mahmodlou · 2024

Background & Aims: Gene therapy is used in various diseases such as cancer.Breast cancer is the most common malignancy in women worldwide, which shows the necessity of using innovative approaches in treatment methods.The ability of artific…

Evaluation of Diagnostic Modalities for SARS-Cov-2: A Review Study Open

Roghayeh Sheervalilou, Jamal Ahmadzadeh, Sahel Alavi, Kazhal Mobaraki, Saman Sargazi , et al. · 2021

Background and aims: In late December 2019, a cluster of progressive pneumonia-like respiratory syndromes broke out in Wuhan, China. As the number of cases continued to rise, the 2019 coronavirus disease (COVID-19) has been declared a glob…

Systematic review and meta-analytic findings on the association between killer-cell immunoglobulin-like receptor genes and susceptibility to pulmonary tuberculosis Open

Melody Omraninava, Sahar Mehranfar, Arezou Khosrojerdi, Sirous Jamalzehi, Jafar Karami , et al. · 2020

Several studies have evaluated the association between killer-cell immunoglobulin-like receptors (KIR) genes and susceptibility risk to tuberculosis (TB) infection. Nonetheless, their outcomes have not been conclusive and consistent. Here …

Frequency and Correlation of Common Genes Copy Number Alterations in Childhood Acute Lymphoblastic Leukemia with Prognosis Open

Abbasali Hosein Pour feizi, Sirous Zeinali, Jacek Toporski, Roghayeh Sheervalilou, Sahar Mehranfar · 2020

The multiplex ligation-dependent probe amplification could be considered as an independent diagnostic tool allowing prompt identification of patients at high risk of treatment failure and, subsequently, a more adequate treatment approach.

DELAYS IN INITIAL REFERRAL, DIAGNOSIS AND TREATMENT IN CHILDREN WITH CANCER Open

Abbasali Hosein Pourfeizi, Rana Hosseini, Roghayeh Sheervalilou, Sahar Mehranfar · 2020

Objective: Cancer has been one of the most critical health problems during the past decades which requires serious consideration, especially in developing countries. Methods: 80 parents of children with different types of cancers were stud…

Delays in Initial Referral, Diagnosis and Treatment in Children with Cancer Open

Abbasali Hosein Pourfeizi, Rana Hosseini, Roghayeh Sheervalilou, Sahar Mehranfar · 2020

Background: Cancer has been one of the most critical health problems during the past decades which require serious consideration, especially in developing countries. Methods: 80 parents of the children with different types of cancers were …

The Effects of Evening Primrose/Hemp Seed Oil Compared to Rapamycin on the Gene Expression of Immunological Parameters in Experimental Autoimmune Encephalomyelitis Splenocytes Open

Soheila Rezapour-Firouzi, Mahshid Mohammadian, Maryam Sadeghzadeh, Sahar Mehranfar, Ebrahim Mazloomi · 2020

Mouse model of multiple sclerosis (MS) is used for the inflammatory demyelinating disease. Rapamycin (RAPA) may contribute to the reduction of inflammatory responses to experimental autoimmune encephalomyelitis (EAE). Due to its adverse si…

The use of stromal vascular fraction (SVF), platelet-rich plasma (PRP) and stem cells in the treatment of osteoarthritis: an overview of clinical trials Open

Sahar Mehranfar, Isa Abdi Rad, Ebrahim Mostafavi, Abolfazl Akbarzadeh · 2019

Osteoarthritis (OA) is a major cause of disability across the world, which its prevalence is relatively high in elder population. Current accepted therapies such as exercise, anti-inflammatory drugs and intra-articular inoculation of corti…

Delays in Initial Referral, Diagnosis and Treatment in Children with Cancer<strong> </strong> Open

Abbasali Hosein Pourfeizi, Rana Hosseini, Roghayeh Sheervaliloo, Sahar Mehranfar · 2018

Background: Cancer has been one of the most critical health problems during the past decades which require serious consideration, especially in developing countries. Methods: 80 parents of the children with different types of cancers were …

Comparison of multiplex ligation-dependent probe amplifi cation and qPCR for screening PAX5 gene detection in acute lymphoblastic leukemia Open

Sahar Mehranfar, Zeniali Sirous, Naser Samadi, Nazanin Maleki, Abbasali Hosein Pour feizi · 2017

Despite the advances in diagnosis of leukemia, still we need a rapid and cost-benefi t screening method in patients with acute lymphoblastic leukemia (ALL).The aim of the present study is to evaluate the ability of Multiplex Ligationdepend…

History of Leukemia: Diagnosis and Treatment from Beginning to Now Open

Sahar Mehranfar, Sirous Zeinali, Rana Hosseini, Abolfazl Akbarzadeh, Mozhdeh Mohammadian , et al. · 2017

In 1845, leukemia was known as a systemic illness; and it was more than 100 years later that the first report of a significant therapy for leukemia was published in 1948. Leukemia was known as a multifactorial disease rather than a single …

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