Sahar S. Abdelrahman
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View article: Chemical profile of Ficus lyrata bark extract and its therapeutic effect on non-alcoholic fatty liver disease via regulating oxidative stress, inflammation and hepatic lipogenesis
Chemical profile of Ficus lyrata bark extract and its therapeutic effect on non-alcoholic fatty liver disease via regulating oxidative stress, inflammation and hepatic lipogenesis Open
The high prevalence of non-alcoholic fatty liver disease (NAFLD) worldwide necessitates the attention and intervention of modern medical treatment options. Preliminary studies have demonstrated that Ficus Lyrata leaves can exert protective…
View article: Diagnostic Potential of Exosomal and Non-Exosomal Biomarkers in Lung Cancer: A Comparative Analysis Using a Rat Model of Lung Carcinogenesis
Diagnostic Potential of Exosomal and Non-Exosomal Biomarkers in Lung Cancer: A Comparative Analysis Using a Rat Model of Lung Carcinogenesis Open
Background: Identifying liquid biopsy biomarkers with high efficacy is crucial for cancer diagnosis. Exosomal cargo, including miRNAs and proteins, offers enhanced stability in biofluids compared with their free circulating forms, but dire…
View article: Effect of Effervescent Formulation of Silymarin against Experimental Hepatotoxicity in Rats: Involvement of NRF2/HO-1, PI3K/AKT and TLR4/NFκB Pathways
Effect of Effervescent Formulation of Silymarin against Experimental Hepatotoxicity in Rats: Involvement of NRF2/HO-1, PI3K/AKT and TLR4/NFκB Pathways Open
Despite the exploration of pharmaceutical and natural liver-protecting drugs, the number of hepatotoxicity deaths continues to rise. Milk thistle flavonoids, silymarin, have been widely investigated and demonstrated liver disease protectio…
View article: Management of cardiovascular disease by cerium oxide nanoparticles via alleviating oxidative stress and adipokine abnormalities
Management of cardiovascular disease by cerium oxide nanoparticles via alleviating oxidative stress and adipokine abnormalities Open
View article: UHPLC-QTOF-MS/MS profiling, molecular networking, and molecular docking analysis of Gliricidia sepium (Jacq.) Kunth. ex. Walp. stem ethanolic extract and its gastroprotective effect on gastritis in rats
UHPLC-QTOF-MS/MS profiling, molecular networking, and molecular docking analysis of Gliricidia sepium (Jacq.) Kunth. ex. Walp. stem ethanolic extract and its gastroprotective effect on gastritis in rats Open
View article: Inflammation alters the expression pattern of drug transporters during Caco‐2 cell stimulation and azoxymethane‐induced colon tumorigenesis
Inflammation alters the expression pattern of drug transporters during Caco‐2 cell stimulation and azoxymethane‐induced colon tumorigenesis Open
Drug transporters play a pivotal role in modulating drug disposition and are subject to alterations under inflammatory conditions. This study aimed to elucidate the intricate expression patterns of drug transporters during both acute and c…
View article: Attenuation of high-fat high-sucrose diet and CCl4-induced non-alcoholic steatohepatitis in rats by activating autophagy and SIGMAR1/GRP78/ITPR1 signaling using berberine-loaded albumin nanoparticles: in vivo prediction and in-silico molecular modeling
Attenuation of high-fat high-sucrose diet and CCl4-induced non-alcoholic steatohepatitis in rats by activating autophagy and SIGMAR1/GRP78/ITPR1 signaling using berberine-loaded albumin nanoparticles: in vivo prediction and in-silico molecular modeling Open
Purpose Non-alcoholic fatty liver disease is the most prevalent metabolic disorder that can lead to the development of non-alcoholic steatohepatitis (NASH) and, eventually, result in hepatocellular carcinoma. This study evaluated the thera…
View article: Correction to: A new approach of nano-metformin as a protector against radiation-induced cardiac fibrosis and inflammation via CXCL1/TGF-Β pathway
Correction to: A new approach of nano-metformin as a protector against radiation-induced cardiac fibrosis and inflammation via CXCL1/TGF-Β pathway Open
View article: A new approach of nano-metformin as a protector against radiation-induced cardiac fibrosis and inflammation via CXCL1/TGF-Β pathway
A new approach of nano-metformin as a protector against radiation-induced cardiac fibrosis and inflammation via CXCL1/TGF-Β pathway Open
The present work investigates the potential role of metformin nanoparticles (MTF-NPs) as a radio-protector against cardiac fibrosis and inflammation induced by gamma radiation via CXCL1/TGF-β pathway. Lethal dose fifty of nano-metformin wa…
View article: Author Correction: Zinc nanoparticles ameliorated obesity-induced cardiovascular disease: role of metabolic syndrome and iron overload
Author Correction: Zinc nanoparticles ameliorated obesity-induced cardiovascular disease: role of metabolic syndrome and iron overload Open
View article: Retraction Note: Ameliorating effect of melatonin against nicotine induced lung and heart toxicity in rats
Retraction Note: Ameliorating effect of melatonin against nicotine induced lung and heart toxicity in rats Open
View article: Renoprotective Effect of Pitavastatin against TAA-Induced Renal Injury: Involvement of the miR-93/PTEN/AKT/mTOR Pathway
Renoprotective Effect of Pitavastatin against TAA-Induced Renal Injury: Involvement of the miR-93/PTEN/AKT/mTOR Pathway Open
This research investigated if pitavastatin (Pita) might protect rats’ kidneys against thioacetamide (TAA). By altering the PTEN/AKT/mTOR pathway, pitavastatin may boost kidney antioxidant capacity and minimize oxidative damage. Statins hav…
View article: Citrus clementine Peel Essential Oil Ameliorates Potassium Dichromate-Induced Lung Injury: Insights into the PI3K/AKT Pathway
Citrus clementine Peel Essential Oil Ameliorates Potassium Dichromate-Induced Lung Injury: Insights into the PI3K/AKT Pathway Open
Acute Lung Injury (ALI) is a life-threatening syndrome that has been identified as a potential complication of COVID-19. There is a critical need to shed light on the underlying mechanistic pathways and explore novel therapeutic strategies…
View article: Neuroprotective Effects of Trimetazidine against Cisplatin‐Induced Peripheral Neuropathy: Involvement of AMPK‐Mediated PI3K/mTOR, Nrf2, and NF‐<i>κ</i>B Signaling Axes
Neuroprotective Effects of Trimetazidine against Cisplatin‐Induced Peripheral Neuropathy: Involvement of AMPK‐Mediated PI3K/mTOR, Nrf2, and NF‐<i>κ</i>B Signaling Axes Open
Cisplatin‐induced peripheral neuropathy (CIPN) is a common and debilitating side effect of cisplatin chemotherapy used in cancer treatment. This study explored the neuroprotective effects of Trimetazidine (TRI) against CIPN by preserving n…
View article: The senomorphic impact of astaxanthin on irradiated rat spleen: STING, TLR4 and mTOR contributed pathway
The senomorphic impact of astaxanthin on irradiated rat spleen: STING, TLR4 and mTOR contributed pathway Open
Objectives: Exposure of spleen tissues to ionizing radiation during radiotherapy can induce cellular stress and immune-dysfunction leading to cellular senescence. Introduction: The process of a cancerous development is facilitated by the a…
View article: Zinc nanoparticles ameliorated obesity-induced cardiovascular disease: role of metabolic syndrome and iron overload
Zinc nanoparticles ameliorated obesity-induced cardiovascular disease: role of metabolic syndrome and iron overload Open
Obesity is a complicated disease characterized by abundant fat accumulation. It is associated with cardiovascular disease. The current study aimed to appreciate the role of synthesized zinc oxide nanoparticles (ZnONPs) (18.72 nm in size) i…
View article: Erythropoietin mitigated thioacetamide-induced renal injury via JAK2/STAT5 and AMPK pathway
Erythropoietin mitigated thioacetamide-induced renal injury via JAK2/STAT5 and AMPK pathway Open
View article: The protective effect of crocin against testicular toxicity induced by ionizing radiation via <scp>AKT</scp>/<scp>FOXO</scp> pathway
The protective effect of crocin against testicular toxicity induced by ionizing radiation via <span>AKT</span>/<span>FOXO</span> pathway Open
Crocin, a pharmacologically active component of Crocus sativus L. (saffron), has been informed to be beneficial in the treatment of stress‐related oxidative impairment. In the present study, we examined the protective role of crocin agains…
View article: Erythropoietin Suppresses the Hepatic Fibrosis Caused by Thioacetamide: Role of the PI3K/Akt and TLR4 Signaling Pathways
Erythropoietin Suppresses the Hepatic Fibrosis Caused by Thioacetamide: Role of the PI3K/Akt and TLR4 Signaling Pathways Open
Erythropoietin (EPO) is recognized for its function in erythropoiesis; however, its potential antifibrotic effect against liver fibrosis remains unknown. This study examined whether EPO affects thioacetamide (TAA)-induced liver fibrosis by…
View article: Ficus Lyrata Bark Extract Alleviates Steatosis in Obesity- Induced Non-Alcoholic Fatty Liver Disease in Rats
Ficus Lyrata Bark Extract Alleviates Steatosis in Obesity- Induced Non-Alcoholic Fatty Liver Disease in Rats Open
The authors have requested that this preprint be removed from Research Square.
View article: Beneficial Effect of Rosuvastatin Therapy on Spleen Injury Induced by Gamma Irradiation in Rats: Targeting Nrf2/EPRE Pathway
Beneficial Effect of Rosuvastatin Therapy on Spleen Injury Induced by Gamma Irradiation in Rats: Targeting Nrf2/EPRE Pathway Open
Purpose The present study investigates the new approach of rosuvastatin (RUV) administration as a drug for the management of spleen injury induced by gamma irradiation. Main Methods Forty rats were used and divided equally into 4 groups: c…
View article: Apigenin role against thioacetamide-triggered liver fibrosis: Deciphering the PPARγ/TGF-β1/NF-κB and the HIF/FAK/AKT pathways
Apigenin role against thioacetamide-triggered liver fibrosis: Deciphering the PPARγ/TGF-β1/NF-κB and the HIF/FAK/AKT pathways Open
Introduction: Liver tissue malfunction is a severe worldwide health concern that arises from various chronic liver conditions. The goal of this investigation was to look into the anti-fibrotic effect of apigenin (APG), an antioxidant found…
View article: Low dose gamma irradiation attenuates cyclophosphamide-induced cardiotoxicity in rats: role of NF-κB signaling pathway
Low dose gamma irradiation attenuates cyclophosphamide-induced cardiotoxicity in rats: role of NF-κB signaling pathway Open
Cyclophosphamide (Cyp) is one of the most commonly used, wide spectrum chemotherapeutic agents. Cyp has multi-organ toxicities that are dose limiting, thus it’s mostly used in chemotherapeutic combinations. Radiation is well known as a haz…