Naruhiko Sahara
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View article: Abnormal behaviors and glial responses in an animal model of tau pathology
Abnormal behaviors and glial responses in an animal model of tau pathology Open
Tau hyperphosphorylation has been considered a major contributor to neurodegeneration in Alzheimer’s disease (AD) and frontotemporal dementia, and related tauopathies have gained prominence in the development of therapies for these conditi…
View article: PVC Termination Time: A Novel Real-Time Predictor of Ablation Success
PVC Termination Time: A Novel Real-Time Predictor of Ablation Success Open
Background: During PVC ablation, operators need real-time feedback to optimize outcomes. We hypothesized that PVC Termination Time (PTT)—the interval from radiofrequency onset to PVC disappearance—would outperform local activation time (LA…
View article: Low Power Long Duration Ablation for High Impedance Left Ventricular Summit <scp>PVCs</scp>
Low Power Long Duration Ablation for High Impedance Left Ventricular Summit <span>PVCs</span> Open
Low-power, long-duration (LPLD) ablation (≤ 25 W for ≥ 60 s with 30 mL/min irrigation) was applied to high-impedance (≥ 150 Ω) left ventricular summit PVC sites via the anterior interventricular vein. Power was escalated stepwise (10 W → 1…
View article: Pharmacological potentiation of Nav1.1 channels in interneurons mitigates tau depositions and neuronal death in a mouse model of neurodegenerative dementias
Pharmacological potentiation of Nav1.1 channels in interneurons mitigates tau depositions and neuronal death in a mouse model of neurodegenerative dementias Open
Epileptiform discharges and neuronal hyperexcitability are key pathophysiological features of Alzheimer’s disease and related tauopathies. We previously identified selective dynfuntion of parvalbumin-positive GABAergic interneurons (PV neu…
View article: Diverse tau pathologies in late‐life mood disorders revealed by PET and autopsy assays
Diverse tau pathologies in late‐life mood disorders revealed by PET and autopsy assays Open
INTRODUCTION Late‐life mood disorders (LLMDs) may represent prodromal manifestations of neurodegenerative dementia; however, the neuropathological basis of LLMDs, including depression and bipolar disorder, remains unclear. We aimed to inve…
View article: iPSC screening identifies CACNA2D2 as a potential therapeutic target for FTLD-Tau
iPSC screening identifies CACNA2D2 as a potential therapeutic target for FTLD-Tau Open
Frontotemporal Lobar Degeneration (FTLD) is a neurodegenerative disorder that affects the frontal and temporal lobes, which are crucial for regulating personality, behavior, and language. Pathologically, FTLD is characterized by Tau protei…
View article: Whole-Brain Single-Neuron Atlas Reveals Microglial Security Hole Accelerating Neuronal Vulnerability
Whole-Brain Single-Neuron Atlas Reveals Microglial Security Hole Accelerating Neuronal Vulnerability Open
Neurodegenerative diseases are characterized by progressive neuronal loss, yet subtle degeneration remains difficult to detect, hindering advancements in early diagnosis and intervention strategies. Here, we present a 3D, whole-brain, sing…
View article: GLIA RESPONSES ARE ASSOCIATED WITH ABNORMAL BEHAVIORS IN AN ANIMAL MODEL OF TAU PATHOLOGIES
GLIA RESPONSES ARE ASSOCIATED WITH ABNORMAL BEHAVIORS IN AN ANIMAL MODEL OF TAU PATHOLOGIES Open
Tau hyperphosphorylation has been considered a major contributor to neurodegeneration in Alzheimer’ s disease and related tauopathies and has gained prominence in the development of therapies for Alzheimer’ s disease. Glia responses are ke…
View article: Single<i>MAPT</i>knock-in mouse models of frontotemporal dementia for sharing with the neurodegenerative research community
Single<i>MAPT</i>knock-in mouse models of frontotemporal dementia for sharing with the neurodegenerative research community Open
We recently reported development of human MAPT knock-in mice that carry single or double pathogenic mutations of frontotemporal dementia. However, it takes more than 14 months for the line with the most aggressive phenotypes to exhibit tau…
View article: Clinical and Pathological Features of <scp>FTDP</scp>‐17 with <scp><i>MAPT</i></scp> p.K298_H299insQ Mutation
Clinical and Pathological Features of <span>FTDP</span>‐17 with <span><i>MAPT</i></span> p.K298_H299insQ Mutation Open
Background MAPT is a causative gene in frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP‐17), a hereditary degenerative disease with various clinical manifestations, including progressive supranuclear palsy, corticoba…
View article: Daratumumab‑resistant multiple myeloma with extramedullary disease successfully treated with combination elotuzumab, pomalidomide and dexamethasone: A case report
Daratumumab‑resistant multiple myeloma with extramedullary disease successfully treated with combination elotuzumab, pomalidomide and dexamethasone: A case report Open
Despite the emergence of monoclonal antibodies, the prognosis of patients with multiple myeloma (MM) with extramedullary disease remains poor. The present report describes a rare case of daratumumab-refractory MM that was successfully trea…
View article: A novel tauopathy model mimicking molecular and spatial aspects of human tau pathology
A novel tauopathy model mimicking molecular and spatial aspects of human tau pathology Open
Creating a mouse model that recapitulates human tau pathology is essential for developing strategies to intervene in tau-induced neurodegeneration. However, mimicking the pathological features seen in human pathology often involves a trade…
View article: Research on the molecular mechanism of singularity phenomenon in neurological disorders
Research on the molecular mechanism of singularity phenomenon in neurological disorders Open
In Alzheimer's disease (AD), toxic oligomers of tau proteins originate from a small number of cells deep inside the brain and propagate to other regions of the brain, ultimately causing cell death in up to 50% of neurons in the cerebral co…
View article: The aftermath of boxing: Longitudinal changes of cerebral retention patterns of <sup>18</sup>F‐florzolotau (<sup>18</sup>F‐APN‐1607) in the former professional boxers
The aftermath of boxing: Longitudinal changes of cerebral retention patterns of <sup>18</sup>F‐florzolotau (<sup>18</sup>F‐APN‐1607) in the former professional boxers Open
Background Chronic traumatic encephalopathy (CTE), formerly known as “boxer’s encephalopathy” is a neurodegenerative disease associated with mild‐repetitive TBI. CTE is characterized by the deposition of hyperphosphorylated tau as neurofib…
View article: Diagnostic and therapeutic targeting of pathological tau proteins in neurodegenerative disorders
Diagnostic and therapeutic targeting of pathological tau proteins in neurodegenerative disorders Open
Tauopathies, characterized by fibrillar tau accumulation in neurons and glial cells, constitute a major neuropathological category of neurodegenerative diseases. Neurofibrillary tau lesions are strongly associated with cognitive deficits i…
View article: Rightward lateralization of frontal cortex tau pathologies is associated with late‐onset psychosis: A PET study with <sup>18</sup>F‐PM‐PBB3
Rightward lateralization of frontal cortex tau pathologies is associated with late‐onset psychosis: A PET study with <sup>18</sup>F‐PM‐PBB3 Open
Background Several cohort studies have recently reported associations between late‐life psychosis and dementia, and postmortem studies have demonstrated that most individuals with late‐onset schizophrenia and delusional disorder had tau pa…
View article: Limitations of human tau-expressing mouse models and novel approaches of mouse modeling for tauopathy
Limitations of human tau-expressing mouse models and novel approaches of mouse modeling for tauopathy Open
Neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau protein are primarily neuropathological features of a number of neurodegenerative diseases, collectively termed tauopathy. There is no disease-modifying drug available for …
View article: Multimodal analyses of a non-human primate model harboring mutant amyloid precursor protein transgenes driven by the human EF1α promoter.
Multimodal analyses of a non-human primate model harboring mutant amyloid precursor protein transgenes driven by the human EF1α promoter. Open
Alzheimer's disease (AD) is the leading cause of dementia which afflicts tens of millions of people worldwide. Despite many scientific progresses to dissect the AD's molecular basis from studies on various mouse models, it has been suffere…
View article: Editorial: Translational imaging in neurodegenerative proteinopathies
Editorial: Translational imaging in neurodegenerative proteinopathies Open
ISSN:1662-453X
View article: Central role for p62/SQSTM1 in the elimination of toxic tau species in a mouse model of tauopathy
Central role for p62/SQSTM1 in the elimination of toxic tau species in a mouse model of tauopathy Open
Intracellular accumulation of filamentous tau aggregates with progressive neuronal loss is a common characteristic of tauopathies. Although the neurodegenerative mechanism of tau‐associated pathology remains unclear, molecular elements cap…
View article: Actin-binding protein filamin-A drives tau aggregation and contributes to progressive supranuclear palsy pathology
Actin-binding protein filamin-A drives tau aggregation and contributes to progressive supranuclear palsy pathology Open
While amyloid-β lies upstream of tau pathology in Alzheimer’s disease, key drivers for other tauopathies, including progressive supranuclear palsy (PSP), are largely unknown. Various tau mutations are known to facilitate tau aggregation, b…