Sahib Gul Afridi
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View article: Age-Related Histomorphological Changes in Human Kidneys: A Cadaveric Study
Age-Related Histomorphological Changes in Human Kidneys: A Cadaveric Study Open
Background: As people become older, their kidneys change in both structure and function, which makes them less able to do their job and raises the risk of chronic kidney disease (CKD), especially in older people. Even though a lot of resea…
View article: Genetic diversity of Plasmodium falciparum and Plasmodium vivax field isolates from the Nowshera district of Pakistan
Genetic diversity of Plasmodium falciparum and Plasmodium vivax field isolates from the Nowshera district of Pakistan Open
This first ever report of molecular characterization of P. falciparum and P. vivax genotypes from District Nowshera, Pakistan reveals moderate to high allelic diversity in parasite population from District Nowshera, Pakistan.
View article: Genetic Diversity of Plasmodium falciparum and Plasmodium vivax Field Isolates from the Nowshera District of Pakistan
Genetic Diversity of Plasmodium falciparum and Plasmodium vivax Field Isolates from the Nowshera District of Pakistan Open
Background The genetic diversity of malaria parasites contributes to their ability to adapt to environmental changes, develop drug resistance and escape from the host immune system; hence, it is very important for control measures of malar…
View article: Genetic structure of apical membrane antigen-1 in Plasmodium falciparum isolates from Pakistan
Genetic structure of apical membrane antigen-1 in Plasmodium falciparum isolates from Pakistan Open
Plasmodium falciparum apical membrane antigen-1 (PfAMA-1) is a major candidate for the blood-stage malaria vaccine. Genetic polymorphisms of global pfama-1suggest that the genetic diversity of the gene can disturb effective vaccine develop…
View article: Population genetic analysis of Plasmodium vivax vir genes in Pakistan
Population genetic analysis of Plasmodium vivax vir genes in Pakistan Open
Plasmodium vivax variant interspersed repeats (vir) refer to the key protein used for escaping the host immune system. Knowledge in the genetic variation of vir genes can be used for the development of vaccines or diagnostic methods. There…
View article: Identification of new potent NLRP3 inhibitors by multi-level in-silico approaches
Identification of new potent NLRP3 inhibitors by multi-level in-silico approaches Open
Nod-like receptor protein 3 (NLRP-3), is an intracellular sensor that is involved in inflammasome activation, and the aberrant expression of NLRP3 is responsible for diabetes mellitus, its complications, and many other inflammatory disease…
View article: Salivary Oxidative Stress and Antioxidant Capacity in Smokeless Tobacco (Naswar) Users
Salivary Oxidative Stress and Antioxidant Capacity in Smokeless Tobacco (Naswar) Users Open
Habitual Naswar use is associated with increased salivary flow rate, pH, and TOS, and reduced TAC levels in Pakistani adults compared to non-users. The pro-oxidant changes may contribute toward deleterious effects of Naswar use including o…
View article: Combinatorial Therapeutic Potential of Stem Cells and Benzimidazol Derivatives for the Reduction of Liver Fibrosis
Combinatorial Therapeutic Potential of Stem Cells and Benzimidazol Derivatives for the Reduction of Liver Fibrosis Open
(1) Background: Liver fibrosis is currently one of the top ten causes of death worldwide. Stem cells transplantation using mesenchymal stem cells (MSCs) is an alternative therapy which is used in the place of organ transplant, due to the i…
View article: CORRELATION OF COVID-19 SEVERITY with HEMATOLOGICAL, BIOCHEMICAL, COAGULA-TION AND INFLAMMATORY MARKERS- A CROSS-SECTIONAL STUDY
CORRELATION OF COVID-19 SEVERITY with HEMATOLOGICAL, BIOCHEMICAL, COAGULA-TION AND INFLAMMATORY MARKERS- A CROSS-SECTIONAL STUDY Open
Coronaviruses cause exceptionally contagious infections and at present they pose a major concern of public health worldwide. This study was conducted to evaluate the severity of Corona Virus (COVID)-19 through hematological, biochemical, c…
View article: Molecular Mimicry Analyses Unveiled the Human Herpes Simplex and Poxvirus Epitopes as Possible Candidates to Incite Autoimmunity
Molecular Mimicry Analyses Unveiled the Human Herpes Simplex and Poxvirus Epitopes as Possible Candidates to Incite Autoimmunity Open
Clinical epidemiological studies have reported that viral infections cause autoimmune pathology in humans. Host-pathogen protein sequences and structure-based molecular mimicry cause autoreactive T cells to cross-activate. The aim of the c…
View article: Population genetic analyses inferred a limited genetic diversity across the pvama-1 DI domain among Plasmodium vivax isolates from Khyber Pakhtunkhwa regions of Pakistan
Population genetic analyses inferred a limited genetic diversity across the pvama-1 DI domain among Plasmodium vivax isolates from Khyber Pakhtunkhwa regions of Pakistan Open
Background Plasmodium vivax apical membrane antigen-1 ( pvama-1 ) is an important vaccine candidate against Malaria. The genetic composition assessment of pvama-1 from wide-range geography is vital to plan the antigen based vaccine designi…
View article: "Prevalence of Typhoid Fever in Pregnant Women of District Mardan Pakistan"
"Prevalence of Typhoid Fever in Pregnant Women of District Mardan Pakistan" Open
Objectives: Typhoid fever is caused by the bacterium named Salmonella typhi, it affects considerable number of populations of the world.The objective of this study was to find the prevalence of typhoid fever at district level with respect …
View article: Therapeutic potential of stem cell and melatonin on the reduction of CCl4-induced liver fibrosis in experimental mice model
Therapeutic potential of stem cell and melatonin on the reduction of CCl4-induced liver fibrosis in experimental mice model Open
Liver fibrosis is initial stage of any chronic liver disease and its end stage is develops into cirrhosis. Chronic liver diseases are a crucial global health issue and the cause of approximately 2 million deaths per year worldwide. Cirrhos…
View article: Genomic miscellany and allelic frequencies of Plasmodium falciparum msp-1, msp-2 and glurp in parasite isolates
Genomic miscellany and allelic frequencies of Plasmodium falciparum msp-1, msp-2 and glurp in parasite isolates Open
Introduction The genomic miscellany of malaria parasites can help inform the intensity of malaria transmission and identify potential deficiencies in malaria control programs. This study was aimed at investigating the genomic miscellany, a…
View article: Dispersal into the Qinghai–Tibet plateau: evidence from the genetic structure and demography of the alpine plant<i>Triosteum pinnatifidum</i>
Dispersal into the Qinghai–Tibet plateau: evidence from the genetic structure and demography of the alpine plant<i>Triosteum pinnatifidum</i> Open
Triosteum pinnatifidum Maxim., an alpine plant, is traditionally used for several medicinal purposes. Here, both chloroplast DNA sequences and nuclear low copy sequence markers were used to investigate the genetic diversity and population …
View article: Population Genetic Analyses Inferred a Limited Genetic Diversity in the Pvama-1 of Plasmodium Vivax Isolates from Khyber Pakhtunkhwa Regions of Pakistan
Population Genetic Analyses Inferred a Limited Genetic Diversity in the Pvama-1 of Plasmodium Vivax Isolates from Khyber Pakhtunkhwa Regions of Pakistan Open
Background: Plasmodium vivax apical membrane antigen-1 ( pvama-1 ) is an important vaccine candidate. Assessment of the genetic composition of pvama-1 is preliminary important to better plan the vaccine designing strategies based on the an…
View article: In Silico Drug Designing for ala438 Deleted Ribosomal Protein S1 (RpsA) on the Basis of the Active Compound <i>Zrl</i>15
In Silico Drug Designing for ala438 Deleted Ribosomal Protein S1 (RpsA) on the Basis of the Active Compound <i>Zrl</i>15 Open
Pyrazinoic acid-resistant tuberculosis is a severe chronic disorder. First-line drugs specifically target the ribosomal protein subunit-1 (RpsA) and stop trans-translation in the wild-type bacterium, causing bacterial cell death. In mutant…
View article: Computational Analysis of Plant-Derived Terpenes as α -glucosidase Inhibitors for the Discovery of Therapeutic Agents against Type 2 Diabetes Mellitus
Computational Analysis of Plant-Derived Terpenes as α -glucosidase Inhibitors for the Discovery of Therapeutic Agents against Type 2 Diabetes Mellitus Open
The hyperglycemic condition due to diabetes could be managed through retardation of the carbohydrate metabolism by inhibiting the enzymes involved in its degradation. Currently available therapeutic drugs for diabetes as inhibitors of α-gl…
View article: Phyto-ecological studies and distribution pattern of plant species and communities of Dhirkot, Azad Jammu and Kashmir, Pakistan
Phyto-ecological studies and distribution pattern of plant species and communities of Dhirkot, Azad Jammu and Kashmir, Pakistan Open
Plant species represent the hierarchical expression of vegetation as it is affected by various environmental gradients. We explored the plant species composition, distribution pattern, communities formation and their respective indicators …
View article: Genomic miscellany and allelic frequencies of <i>Plasmodium falciparum msp-1, msp-2</i> and <i>glurp</i> in parasite isolates
Genomic miscellany and allelic frequencies of <i>Plasmodium falciparum msp-1, msp-2</i> and <i>glurp</i> in parasite isolates Open
The genomic miscellany of malaria parasites can inform the intensity of transmission and identify potential deficiencies in malaria control programs. The aim of this study was to investigate the genomic miscellany, allele frequencies and m…
View article: PCR-RFLP Based genetic diversity of Plasmodium vivax genotypes in district Mardan, Pakistan
PCR-RFLP Based genetic diversity of Plasmodium vivax genotypes in district Mardan, Pakistan Open
Plasmodium vivax is the most common human malaria parasite in Asian countries including Pakistan. Present study was designed to explore the genetic diversity of plasmodium vivax genotypes based on Pvmsp-3α and Pvmsp-3βgenes using allelic s…
View article: Analyzing the Essential Proteins Set of Plasmodium Falciparum PF3D7&nbsp;for Novel Drug Targets Identification Against Malaria
Analyzing the Essential Proteins Set of Plasmodium Falciparum PF3D7 for Novel Drug Targets Identification Against Malaria Open
Background: Plasmodium falciparum is an obligate intracellular parasite of humans that causes malaria. P. falciparum is a major public health threat to human life responsible for high mortality. Currently, the risk of multi-drug resistance…
View article: Additional file 2 of Analysing the essential proteins set of Plasmodium falciparum PF3D7 for novel drug targets identification against malaria
Additional file 2 of Analysing the essential proteins set of Plasmodium falciparum PF3D7 for novel drug targets identification against malaria Open
Additional file 2 : Plasmodium falciparum strain 3D7 proteins, non-homologous to human as well as human’s gut flora proteins.
View article: Additional file 1 of Analysing the essential proteins set of Plasmodium falciparum PF3D7 for novel drug targets identification against malaria
Additional file 1 of Analysing the essential proteins set of Plasmodium falciparum PF3D7 for novel drug targets identification against malaria Open
Additional file 1: Plasmodium falciparum strain 3D7 non paralogous essential proteins.
View article: Additional file 3 of Analysing the essential proteins set of Plasmodium falciparum PF3D7 for novel drug targets identification against malaria
Additional file 3 of Analysing the essential proteins set of Plasmodium falciparum PF3D7 for novel drug targets identification against malaria Open
Additional file 3 : Plasmodium falciparum 3D7 essential proteins homologs to human gut microbiome proteome.
View article: Inhibitory effects of plant extracts and in Silico screening of the bioactive compounds against α-glucosidase
Inhibitory effects of plant extracts and in Silico screening of the bioactive compounds against α-glucosidase Open
α-glucosidase is a primary carbohydrate digestive enzyme, present in the brush border of the small intestine that acts on the 1–4 associated α-glucose residues and could play an effective role in overall glycemic control. Barberis lyceum a…
View article: Frequency of Hyperemesis Gravidarum and associated risk factors among pregnant women
Frequency of Hyperemesis Gravidarum and associated risk factors among pregnant women Open
The prevalence of hyperemesis gravidarum was high in Nowshera, Mardan and Peshawar, predominantly during the first trimester of pregnancy.
View article: The In Silico Characterization of a Salicylic Acid Analogue Coding Gene Clusters in Selected <i>Pseudomonas fluorescens</i> Strains.
The In Silico Characterization of a Salicylic Acid Analogue Coding Gene Clusters in Selected <i>Pseudomonas fluorescens</i> Strains. Open
The computational biology and drug discovery analyses identified different gene clusters in P. fluorescens genomes coding for salicylic acid-like chemotypes biosynthesis. These gene clusters may worthy to target through metabolic engineeri…