Explanipedia

Association of Bassoon (BSN) Gene Mutations with Gait and Motor Impairments in Parkinson's Disease Open

Prashanth Lingappa Kukkle, Ahamed P Kaladiyil, Thenral S. Geetha, Ramesh Menon, Rukmini Mridula Kandadai , et al. · 2025

Introduction Parkinson's Disease (PD) features debilitating motor symptoms, particularly gait and balance impairments inadequately managed by current therapies. Bassoon (BSN), a presynaptic active zone organizer, has been implicated in var…

Demographic and Clinical Profiles of Parkinson's Disease in India: Observations from a Nation‐Wide Multicenter Study Open

Asha Kishore, Rupam Borgohain, Divya Kalikavil Puthenveedu, Roopa Rajan, Pramod Kumar Pal , et al. · 2025

Background Parkinson's disease (PD) phenotype may vary with genetic, ethno‐geographic, cultural, and environmental factors. Objectives The aim was to develop a clinical database of PD in India and assess the influence of age‐at‐onset (AAO)…

Tongue Myorhythmia as a Manifestation of IgLON 5 Disease Open

Abeer Goel, Sahil Mehta, S. Datta Gupta, Dhanush Mallesh, Sidharth Chand , et al. · 2025

Exploring the role of silicon in enhancing sustainable plant growth, defense system, environmental stress mitigation and management Open

Antul Kumar, Anuj Choudhary, Harmanjot Kaur, Khushboo Singh, Satyakam Guha , et al. · 2025

Silicon (Si) is a quasi-essential but multitalented mineral predominantly found as silicon dioxide (SiO2) form that is most abundant in the earth's crust after oxygen and makes up about. Despite being 28% of mineral soil by weight, Si has …

Efficacy and Safety of Lumateperone compared to Quetiapine in Indian patients with Bipolar II depression: A subgroup analysis based on disease duration Open

A. Dharmadhikari, P. K. Chaurasia, Y. Patel, Deepanshu Choudhary, P. L. Dasud , et al. · 2025

Introduction Lumateperone, an atypical antipsychotic drug, has a dual mechanism of action by combination of activity at central serotonin (5-HT2A) and dopamine (D2) receptors. Objectives This subgroup analysis of an Indian Phase 3 study wa…

Impact of Lumateperone compared to Quetiapine on Quality of Life of Indian patients with Bipolar II depression: A post-hoc analysis of a Phase 3 study Open

A. Dharmadhikari, P. K. Chaurasia, Yash Patel, Devendra Kumar Choudhary, P. L. Dasud , et al. · 2025

Introduction Lumateperone, an atypical antipsychotic drug approved for Bipolar II depression in 2021, has a dual mechanism of action by combination of activity at central serotonin (5-HT2A) and dopamine (D2) receptors. Objectives This post…

Correlation of MADRS and YMRS in patients with Bipolar II depression: A post-hoc analysis of an Indian Phase 3 study Open

Ashwin Dharmadhikari, P. K. Chaurasia, Yogita S. Patel, Divya Choudhary, P. L. Dasud , et al. · 2025

Introduction Lumateperone, an atypical antipsychotic drug approved in 2021 for bipolar depression, has a dual mechanism of action by combination of activity at central serotonin (5-HT2A) and dopamine (D2) receptors. In India, Quetiapine is…

Correlation of Q-LES-Q-SF and YMRS in patients with Bipolar II depression: A post-hoc analysis of an Indian Phase 3 study Open

Ashwin Dharmadhikari, P. K. Chaurasia, Yash Patel, Devendra Kumar Choudhary, P. L. Dasud , et al. · 2025

Introduction Lumateperone, an atypical antipsychotic drug approved in 2021 for bipolar depression, has a dual mechanism of action by combination of activity at central serotonin (5-HT2A) and dopamine (D2) receptors. In India, Quetiapine is…

Correlation of MADRS and Q-LES-Q-SF in patients with Bipolar II depression: A post-hoc analysis of an Indian Phase 3 study Open

Ashwin Dharmadhikari, P. K. Chaurasia, Yash Patel, Devendra Kumar Choudhary, P. L. Dasud , et al. · 2025

Introduction Lumateperone, an atypical antipsychotic drug approved in 2021 for bipolar depression, has a dual mechanism of action by combination of activity at central serotonin (5-HT2A) and dopamine (D2) receptors. In India, Quetiapine is…

Early-Onset Cataracts as a Clinical Indicator of DJ-1-Related Parkinsonism Open

Sahil Mehta, Jagdeep Singh, Saurabh Mishra, Vivek Lal · 2025

Deciphering the Genetic Architecture of Parkinson’s Disease in India Open

Asha Kishore, Ashwin Ashok Kumar Sreelatha, Amabel Tenghe, Rupam Borgohain, Divya Kalikavil Puthanveedu , et al. · 2025

The genomic landscape of the Indian population, particularly for age-related disorders like Parkinson’s disease (PD) remains underrepresented in global research. Genetic variability in PD has been studied predominantly in European populati…

Progressive Supranuclear Palsy in India: Past, Present, and Future Open

Srinivas Raju, Kuldeep Shetty, Lulup Kumar Sahoo, Vijayashankar Paramanandam, Jay M. Iyer , et al. · 2024

Progressive supranuclear palsy (PSP) has emerged as a key area of interest among researchers worldwide, including those in India, who have actively studied the disorder over the past several decades. This review meticulously explores the e…

The era of genome editing: current updates and the status of food and nutrition security Open

Fathy Khaled, Sahil Mehta, P. K. Agrawal, Usama M. Abdel-Monem, Hend A. Elakkad , et al. · 2024

Food security is the situation in which all people around the globe, in all circumstances must maintain constant physical and financial access to adequate nutritious, clean, and safe food. This is why food security is regarded as a major g…

Proceedings of the Continuing Nutrition Education Conference 2023: The Impact of Nutrition on Brain Health: From Neurotrophic Factors to Gut–Brain Interactions Open

Sahil Mehta, Nancy Sahni, Aastha Takkar, Karthik Vinay Mahesh, Ritu Shree , et al. · 2024

ConferenCe ProCeedingsand different bodily regions having different communities of microbiota.The mechanisms through which bacteria exert their "psychobiotic" potential are not fully elucidated, but they primarily involve the hypothalamic-…

Recent Advancements in Parkinson\'s Disease Open

Sahil Mehta · 2024

Gender-specific treatment response to pimavanserin in Parkinson’s disease psychosis: a post-hoc analysis of phase-3 study in Indian population Open

Bhavesh B. Kathiriya, Yashwant Patıdar, Viral Patel, Ananya Singhal, Bharat Patel , et al. · 2024

Clinical and Epidemiological Profile of Parkinson's Disease in India Open

Asha Kishore, Rupam Borgohain, Divya Kalikavil Puthenveedu, Roopa Rajan, Pramod Kumar Pal , et al. · 2024

Feasibility and Efficacy of Telephone Based Follow-up in Patients with Headache - A Longitudinal Cohort Study Open

Sucharita Ray, Sulabh Tiwari, Kamalesh Chakravarty, Sahil Mehta, Jitupam Baishya , et al. · 2023

Background: Chronic headache greatly affects the quality of life and also constitutes a significant burden on the health system. Objective: The objective of this study was to evaluate the feasibility of telephone-based follow-up in a cohor…

Stereotypies in a Patient With Wilson Disease Open

Sahil Mehta, Surbhi Mahajan, Jagdeep Singh, Ravi K. Jakhar, Jitupam Baishya , et al. · 2023

A Rare Clinical and Radiological Presentation of Neurosyphilis Open

Ravi K. Jakhar, Sahil Mehta, Kamalesh Chakravarty, Chirag Ahuja, Vivek Lal · 2023

Fulminant SSPE Presenting as a Hyperkinetic Movement Disorder Open

Padma Youron, Surbhi Mahajan, Neeraj Balaini, Sahil Mehta, Vivek Lal · 2023

Boucher Neuhäuser Syndrome in Twins: A Rare and Unusual Cause of Cerebellar Ataxia Open

Surbhi Mahajan, Sahil Mehta, Jagdeep Singh, Ashish Markan, Neeraj Balaini , et al. · 2023

DHDDS Mutation: A Rare Cause of Refractory Epilepsy and Hyperkinetic Movement Disorder Open

Sahil Mehta, Vivek Lal · 2023

Etiology of new-onset seizures in adult patients of different age groups presenting to the emergency department in North India and their outcomes Open

Mandip Singh Bhatia, Saurabh C. Sharda, Gaurav Yadav, Sahil Mehta, Ritu Attri , et al. · 2022

A BSTRACT Introduction: Seizures are one of the most common neurological emergencies encountered in both urban and rural India. There is only limited research work on the etiology of new-onset seizures in adult patients of different age gr…

The Genetics of Ethambutol-Induced Optic Neuropathy: A Narrative Review Open

Prabhjit Kaur, Sofia Singh, Kirandeep Kaur, Karthik Vinay Mahesh, Ashish Markan , et al. · 2022

Tuberculosis (TB) is a global health problem with the major brunt of disease occurring in developing countries. The cornerstone of treatment of TB is anti-tubercular therapy (ATT), which includes rifampicin, isoniazid, pyrazinamide and eth…

Treatment of sialorrhea in Parkinson’s disease Open

Sahil Mehta, Vivek Lal · 2022

Sialorrhea is a common disabling nonmotor symptom of Parkinson’s disease. It can lead to several ill effects such as poor orodental hygiene, speech and feeding difficulty, depressive symptoms, poor quality of life, and aspiration pneumonia…

Dystonia and Optic Neuropathy: Expanded Phenotype of Dynactin 1 Related Neurodegeneration Open

Sahil Mehta, Abeer Goel, Deependra Vikram Singh, Sucharita Ray, Ashish Markan , et al. · 2022

Axonal transport is essential to provide nutrients to axons and nerve terminals and to clear up misfolded proteins to avoid the accumulation of toxic aggregates. There is emerging evidence about the relationship between axonal transport de…

Report of plasma exchange in a rare case of association of myasthenia gravis with thymoma and parathyroid adenoma Open

Nippun Prinja, Garima Siwach, Sarath Aleti, Rekha Hans, Aastha Takkar , et al. · 2022

Myasthenia with thymoma and parathyroid adenoma is a rare presentation. Very few cases have been reported of this association without much role of plasma exchange in these patients. Here, we present our experience of plasma exchange in thi…

Unusual Presentation of PLA2G6‐Related Neurodegeneration with Retinal Vasculitis Open

Sahil Mehta, Aastha Takkar, Deependra Vikram Singh, Aniruddha Aggarwal, Vivek Lal · 2021

Phospholipase A2 Group VI (PLA2G6)-related neurodegeneration (PLAN) is a form of neurodegeneration with brain iron accumulation (NBIA), which displays genetic and phenotypic heterogeneity. It can present in the following 4 different forms …

Dissecting the Phenotype and Genotype of PLA2G6‐Related Parkinsonism Open

Francesca Magrinelli, Sahil Mehta, Giulia Di Lazzaro, Anna Latorre, Mark J. Edwards , et al. · 2021

Background Complex parkinsonism is the commonest phenotype in late‐onset PLA2G6 ‐associated neurodegeneration. Objectives The aim of this study was to deeply characterize phenogenotypically PLA2G6 ‐related parkinsonism in the largest cohor…

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