Sahir Sultan Alvi
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View article: Ubiquitination of Oncogenic Mutant p53 via Attenuation of Ribosome Biogenesis Machinery Effectively Inhibits Pancreatic Tumor Growth
Ubiquitination of Oncogenic Mutant p53 via Attenuation of Ribosome Biogenesis Machinery Effectively Inhibits Pancreatic Tumor Growth Open
Dysregulated ribosome biogenesis and p53 mutations are known to play oncogenic roles in various cancers, including pancreatic cancer. In this study, we demonstrated the therapeutic potential of BMH-21, a pharmacologic inhibitor of RNA poly…
View article: Mitochondrial ribosomal protein L3 (MRPL3): An early diagnostic biomarker and potential molecular target in pancreatic cancer
Mitochondrial ribosomal protein L3 (MRPL3): An early diagnostic biomarker and potential molecular target in pancreatic cancer Open
View article: Honey Targets Ribosome Biogenesis Components to Suppress the Growth of Human Pancreatic Cancer Cells
Honey Targets Ribosome Biogenesis Components to Suppress the Growth of Human Pancreatic Cancer Cells Open
Pancreatic cancer (PanCa) is one of the deadliest cancers, with limited therapeutic response. Various molecular oncogenic events, including dysregulation of ribosome biogenesis, are linked to the induction, progression, and metastasis of P…
View article: Organosulfur Compounds, <i>S</i>‐Allyl‐L‐Cysteine and <i>S</i>‐Ethyl‐L‐Cysteine, Target <scp>PCSK</scp>‐9/<scp>LDL</scp>‐R‐Axis to Ameliorate Cardiovascular, Hepatic, and Metabolic Changes in High Carbohydrate and High Fat Diet‐Induced Metabolic Syndrome in Rats
Organosulfur Compounds, <i>S</i>‐Allyl‐L‐Cysteine and <i>S</i>‐Ethyl‐L‐Cysteine, Target <span>PCSK</span>‐9/<span>LDL</span>‐R‐Axis to Ameliorate Cardiovascular, Hepatic, and Metabolic Changes in High Carbohydrate and High Fat Diet‐Induced Metabolic Syndrome in Rats Open
Metabolic syndrome (MetS) is an ever‐evolving set of diseases that poses a serious health risk in many countries worldwide. Existing evidence illustrates that individuals with MetS have a 30%–40% higher chance of acquiring type 2 diabetes …
View article: Assessment of the mechanical and durability characteristics of bio-mineralized Bacillus subtilis self-healing concrete blended with hydrated lime and brick powder
Assessment of the mechanical and durability characteristics of bio-mineralized Bacillus subtilis self-healing concrete blended with hydrated lime and brick powder Open
View article: Targeting SARS-CoV-2 main protease (Mpro) and human ACE-2: A virtual screening of carotenoids and polyphenols from tomato (Solanum lycopersicum L.) to combat Covid-19
Targeting SARS-CoV-2 main protease (Mpro) and human ACE-2: A virtual screening of carotenoids and polyphenols from tomato (Solanum lycopersicum L.) to combat Covid-19 Open
View article: Naturally occurring organosulfur compounds effectively inhibits PCSK-9 activity and restrict PCSK-9-LDL-receptor interaction via <i>in-silico</i> and <i>in-vitro</i> approach
Naturally occurring organosulfur compounds effectively inhibits PCSK-9 activity and restrict PCSK-9-LDL-receptor interaction via <i>in-silico</i> and <i>in-vitro</i> approach Open
The present study intended to divulge the potential role of garlic-derived organosulfur compounds (OSCs) in targeting PCSK-9 and averting its interaction with the EGF-A portion of LDL-R via in-vitro and in-silico analysis. Ou…
View article: Novel Functionalized Spiro [Indoline-3,5′-pyrroline]-2,2′dione Derivatives: Synthesis, Characterization, Drug-Likeness, ADME, and Anticancer Potential
Novel Functionalized Spiro [Indoline-3,5′-pyrroline]-2,2′dione Derivatives: Synthesis, Characterization, Drug-Likeness, ADME, and Anticancer Potential Open
A highly stereo-selective, one-pot, multicomponent method was chosen to synthesize the novel functionalized 1, 3-cycloaddition spirooxindoles (SOXs) (4a–4h). Synthesized SOXs were analyzed for their drug-likeness and ADME parameters and sc…
View article: Curative Effects of Triphala Extract against Swim Stress-Induced Gastric Ulcers via Reduced Ulcer Index, Strengthened Gastric Mucosa and Improved Redox State in Rats
Curative Effects of Triphala Extract against Swim Stress-Induced Gastric Ulcers via Reduced Ulcer Index, Strengthened Gastric Mucosa and Improved Redox State in Rats Open
Recently, the percentage of Peptic ulcer disease not linked to either Helicobacter pylori or non-steroidal anti-inflammatory drugs has increased and signifies the prominent role of psychophysiological stress in the establishment and advanc…
View article: Berberis aristata and its secondary metabolites: Insights into nutraceutical and therapeutical applications
Berberis aristata and its secondary metabolites: Insights into nutraceutical and therapeutical applications Open
View article: Potential dual inhibitors of PCSK-9 and HMG-R from natural sources in cardiovascular risk management
Potential dual inhibitors of PCSK-9 and HMG-R from natural sources in cardiovascular risk management Open
Atherosclerotic cardiovascular disease (ASCVD) stands amongst the leading causes of mortality worldwide and has attracted the attention of world’s leading pharmaceutical companies in order to tackle such mortalities. The low-density lipopr…
View article: Correction to: Identification and evaluation of natural organosulfur compounds as potential dual inhibitors of α-amylase and α-glucosidase activity: an in-silico and in-vitro approach
Correction to: Identification and evaluation of natural organosulfur compounds as potential dual inhibitors of α-amylase and α-glucosidase activity: an in-silico and in-vitro approach Open
View article: Amelioration of neuropilin-1 and RAGE/matrix metalloproteinase-2 pathway-induced renal injury in diabetic rats by rosuvastatin
Amelioration of neuropilin-1 and RAGE/matrix metalloproteinase-2 pathway-induced renal injury in diabetic rats by rosuvastatin Open
Advanced glycation end-products (AGEs) induce the production of reactive oxygen species (ROS) and extra cellular matrix (ECM) degradation via suppression of neuropilin-1 (NRP-1) and interaction with AGE-receptors (RAGE). This study aimed t…
View article: Glycyrrhizic Acid Scavenges Reactive Carbonyl Species and Attenuates Glycation‐Induced Multiple Protein Modification: An <i>In Vitro</i> and <i>In Silico</i> Study
Glycyrrhizic Acid Scavenges Reactive Carbonyl Species and Attenuates Glycation‐Induced Multiple Protein Modification: An <i>In Vitro</i> and <i>In Silico</i> Study Open
The current study is aimed at studying the inhibitory effect of glycyrrhizic acid (GA) on D‐ribose‐mediated protein glycation via various physicochemical analyses and in silico approaches. Being a potent free radical scavenger and a triter…
View article: Therapeutic efficacy of Boerhaavia diffusa (Linn.) root methanolic extract in attenuating streptozotocin-induced diabetes, diabetes-linked hyperlipidemia and oxidative-stress in rats
Therapeutic efficacy of Boerhaavia diffusa (Linn.) root methanolic extract in attenuating streptozotocin-induced diabetes, diabetes-linked hyperlipidemia and oxidative-stress in rats Open
Introduction: We have previously demonstrated that sequentially extracted methanolic fractions of Boerhaavia diffusa (Linn.) showed marked antioxidant, antidiabetic and oxidative-DNA damage protective properties in vitro. The present study…
View article: Ginkgolide B Mediated Alleviation of Inflammatory Cascades and Altered Lipid Metabolism in HUVECs via Targeting PCSK-9 Expression and Functionality
Ginkgolide B Mediated Alleviation of Inflammatory Cascades and Altered Lipid Metabolism in HUVECs via Targeting PCSK-9 Expression and Functionality Open
The potential of oxidized-LDL (Ox-LDL) to elicit inflammatory responses in macrophages leading to the atherosclerosis (AS) progression is well known. Since proprotein convertase subtilisin/Kexin-9 (PCSK-9), the posttranslational regulator …
View article: Prophylactic thyroidectomy in children with multiple endocrine neoplasia type 2
Prophylactic thyroidectomy in children with multiple endocrine neoplasia type 2 Open
Background In patients with multiple endocrine neoplasia type 2 (MEN2) syndrome, genetic testing offers early diagnosis, stratifies the risk of developing medullary thyroid cancer (MTC) and informs the timing of thyroidectomy. The efficacy…
View article: Molecular rationale delineating the role of lycopene as a potent HMG-CoA reductase inhibitor: <i>in vitro</i> and <i>in silico</i> study
Molecular rationale delineating the role of lycopene as a potent HMG-CoA reductase inhibitor: <i>in vitro</i> and <i>in silico</i> study Open
This study initially aimed to depict the molecular rationale evolving the role of lycopene in inhibiting the enzymatic activity of β-hydroxy-β-methylglutaryl-CoA (HMG-CoA) reductase via in vitro and in silico analysis. Our re…