Explanipedia

Evaluating the real-world scale-up of the CRADLE Vital Signs Alert intervention into routine maternity care in Sierra Leone (CRADLE-5): a stepped-wedge, type 2 hybrid implementation–effectiveness, cluster-randomised controlled trial Open

Alexandra Ridout, Francis Moses, Simren Herm-Singh, Candace Beoku-Betts, Edward Businge , et al. · 2025

The Origins and Future of Sentinel: An Early-Warning System for Pandemic Preemption and Response Open

Yolanda Botti-Lodovico, Parvathy Nair, Dolo Nosamiefan, Matthew Stremlau, S. F. Schaffner , et al. · 2021

While investigating a signal of adaptive evolution in humans at the gene LARGE, we encountered an intriguing finding by Dr. Stefan Kunz that the gene plays a critical role in Lassa virus binding and entry. This led us to pursue field work …

Ebola virus antibody decay–stimulation in a high proportion of survivors Open

Charlene Adaken, J. T. Scott, Raman Sharma, Robin Gopal, Steven Dicks , et al. · 2021

Seroprevalence of hepatitis B and hepatitis C among blood donors in Sierra Leone: A multi-year retrospective study Open

Francesca Tognon, Stephen Sevalie, Joseph Gassimu, John Sesay, Katrina Hann , et al. · 2020

Our findings stress the presence of viral hepatitis infection throughout the country and the need to invest in safe blood services, vaccination and treatment of viral hepatitis at the national level.

dictionary.txt Open

John S. Schieffelin, Jeffrey Shaffer, Augustine Goba, Michael Gbakie, Stephen Gire , et al. · 2019

data.tab Open

John S. Schieffelin, Jeffrey G. Shaffer, Augustine Goba, Michael Gbakie, Stephen Gire , et al. · 2019

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Virus genomes reveal factors that spread and sustained the Ebola epidemic Open

Gytis Dudas, Luiz Max Carvalho, Trevor Bedford, Andrew J. Tatem, Guy Baele , et al. · 2017

Evaluation of convalescent whole blood for treating Ebola Virus Disease in Freetown, Sierra Leone Open

Foday Sahr, Rashid Ansumana, Thomas Massaquoi, Baimba Idriss, Foday Sesay , et al. · 2016

Virus genomes reveal the factors that spread and sustained the West African Ebola epidemic Open

Gytis Dudas, Luiz Max Carvalho, Trevor Bedford, Andrew J. Tatem, Guy Baele , et al. · 2016

Summary The 2013-2016 epidemic of Ebola virus disease in West Africa was of unprecedented magnitude, duration and impact. Extensive collaborative sequencing projects have produced a large collection of over 1600 Ebola virus genomes, repres…

Analytical Validation of the ReEBOV Antigen Rapid Test for Point-of-Care Diagnosis of Ebola Virus Infection Open

Robert W. Cross, Matthew L. Boisen, Molly M. Millett, Diana S. Nelson, Darin Oottamasathien , et al. · 2016

The analytical validation presented here contributed to the ReEBOV RDT being the first antigen-based assay to receive FDA and World Health Organization emergency use authorization for this EVD outbreak, in February 2015.

Field Validation of the ReEBOV Antigen Rapid Test for Point-of-Care Diagnosis of Ebola Virus Infection Open

Matthew L. Boisen, Robert W. Cross, Jessica N. Hartnett, Augustine Goba, Mambu Momoh , et al. · 2016

The ReEBOV RDT demonstrated the potential to provide clinically effective rapid and accurate point-of-care test results and, thus, to be a powerful tool for increasing triage efficiency.

An Outbreak of Ebola Virus Disease in the Lassa Fever Zone Open

Augustine Goba, Sheik Humarr Khan, Mbalu Fonnie, Mohamed Fullah, Alex Moigboi , et al. · 2016

Responding to the challenges of confronting 2 hemorrhagic fever viruses will require continued investments in the development of countermeasures (vaccines, therapeutic agents, and diagnostic assays), infrastructure, and human resources.

Most neutralizing human monoclonal antibodies target novel epitopes requiring both Lassa virus glycoprotein subunits Open

James E. Robinson, Kathryn M. Hastie, Robert W. Cross, Rachael E. Yenni, Deborah H. Elliott , et al. · 2016

Lassa fever is a severe multisystem disease that often has haemorrhagic manifestations. The epitopes of the Lassa virus (LASV) surface glycoproteins recognized by naturally infected human hosts have not been identified or characterized. He…

Managing dangerous pathogens: challenges in the wake of the recent West African Ebola outbreak Open

Abraham Ayodeji Abayomi, Rebecca Katz, S. E. Spence, Brian Conton, Sahr M. Gevao · 2016

In the aftermath of the 2014–2016 West Africa Ebola outbreak, there are a multitude of Ebola samples that are unaccounted for as well as virus samples stored in facilities that do not have an appropriate level of biosecurity and biosafety,…

African civil society initiatives to drive a biobanking, biosecurity and infrastructure development agenda in the wake of the West African Ebola outbreak Open

Abraham Ayodeji Abayomi, Sahr M. Gevao, Brian Conton, Pasquale DeBlasio, Rebecca Katz · 2016

This paper describes the formation of a civil society consortium, spurred to action by frustration over the Ebola crises, to facilitate the development of infrastructure and frameworks including policy development to support a harmonized, …

Rapid outbreak sequencing of Ebola virus in Sierra Leone identifies transmission chains linked to sporadic cases Open

Armando Arias, Simon J. Watson, Danny Asogun, Ekaete Tobin, Jia Lu , et al. · 2016

To end the largest known outbreak of Ebola virus disease (EVD) in West Africa and to prevent new transmissions, rapid epidemiological tracing of cases and contacts was required. The ability to quickly identify unknown sources and chains of…

Ebola Virus Epidemiology, Transmission, and Evolution during Seven Months in Sierra Leone Open

Daniel J. Park, Gytis Dudas, Shirlee Wohl, Augustine Goba, Shannon Whitmer , et al. · 2015

Clinical Illness and Outcomes in Patients with Ebola in Sierra Leone Open

John S. Schieffelin, Jeffrey G. Shaffer, Augustine Goba, Michael Gbakie, Stephen Gire , et al. · 2015

This data comprises a total of 213 cases evaluated for Ebola virus infection at the Kenema Government Hospital in Sierra Leone between May 25 and June 18, 2014. Outcome data was available for 87 of 106 EBOV positive cases. Metabolic panels…

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