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View article: Global, regional, and national burden of epilepsy, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021
Global, regional, and national burden of epilepsy, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021 Open
Bill and Melinda Gates Foundation.
View article: Single-cell analysis reveals diversity of tumor-associated macrophages and their interactions with T lymphocytes in glioblastoma
Single-cell analysis reveals diversity of tumor-associated macrophages and their interactions with T lymphocytes in glioblastoma Open
Glioblastoma (GBM) is an aggressive primary CNS malignancy and clinical outcomes have remained stagnant despite introduction of new treatments. Understanding the tumor microenvironment (TME) in which tumor associated macrophages (TAMs) int…
View article: Evidence-Based Utility of Adjunct Antioxidant Supplementation for the Prevention and Treatment of Dermatologic Diseases: A Comprehensive Systematic Review
Evidence-Based Utility of Adjunct Antioxidant Supplementation for the Prevention and Treatment of Dermatologic Diseases: A Comprehensive Systematic Review Open
Skin conditions are a significant cause of fatal and nonfatal disease burdens globally, ranging from mild irritations to debilitating diseases. Oxidative stress, which is an imbalance between reactive oxygen species and the cells’ ability …
View article: Transcriptome-Derived Ligand-Receptor Interactome of Major PitNET Subgroups
Transcriptome-Derived Ligand-Receptor Interactome of Major PitNET Subgroups Open
Introduction Pituitary neuroendocrine tumors (PitNETs) are rare skull base tumors which can impart significant disability owing to their locally invasive potential. To date, the gamut of PitNET subtypes remains ill-understood at the ligand…
View article: Reimbursement for Maxillofacial Surgery: Regional Analysis of the Physician Fee Schedule Reveals Unique Payment Increases in the Western United States From 2010 to 2019
Reimbursement for Maxillofacial Surgery: Regional Analysis of the Physician Fee Schedule Reveals Unique Payment Increases in the Western United States From 2010 to 2019 Open
Introduction Medicare Part B reimbursement data has been thoroughly evaluated in several surgical subspecialties to date, with significant ramifications for continued policy research and payment reform discussions. However, trends in maxil…
View article: Utilizing the Ethereum blockchain for retrieving and archiving augmented reality surgical navigation data
Utilizing the Ethereum blockchain for retrieving and archiving augmented reality surgical navigation data Open
Aim: Conventional techniques to share and archive spinal imaging data raise issues with trust and security, with novel approaches being more greatly considered. Ethereum smart contracts present one such novel approach. Ethereum is an open-…
View article: Single Cell Metabolic Landscape of Pituitary Neuroendocrine Tumor Subgroups and Lineages
Single Cell Metabolic Landscape of Pituitary Neuroendocrine Tumor Subgroups and Lineages Open
Pituitary neuroendocrine tumors (PitNETs) are common intracranial tumors comprising numerous subtypes whose metabolic profiles have yet to be fully examined. The present in silico study analyzed single-cell expression profiles from 2311 Pi…
View article: Membranome Similarity between Glioblastoma Multiforme Cell Lines and Primary Tumors
Membranome Similarity between Glioblastoma Multiforme Cell Lines and Primary Tumors Open
Genes encoding for proteins associated with the plasma membrane, referred to as the membranome, have long been recognized to play an important role in the development and maintenance of glioblastoma multiforme (GBM). GBM cell lines are com…
View article: Primary and Metastatic Cutaneous Melanomas Discriminately Enrich Several Ligand-Receptor Interactions
Primary and Metastatic Cutaneous Melanomas Discriminately Enrich Several Ligand-Receptor Interactions Open
Introduction: Cutaneous melanoma remains a leading cancer with sobering post-metastasis mortality rates. To date, the ligand-receptor interactome of melanomas remains weakly studied despite applicability to anti-cancer drug discovery. Here…
View article: Spatial Mapping of Genes Implicated in SARS-CoV-2 Neuroinvasion to Dorsolateral Prefrontal Cortex Gray Matter
Spatial Mapping of Genes Implicated in SARS-CoV-2 Neuroinvasion to Dorsolateral Prefrontal Cortex Gray Matter Open
Introduction: SARS-CoV-2 is the newest beta coronavirus family member to demonstrate neuroinvasive capability in severe cases of infection. Despite much research activity in the SARS-CoV-2/COVID-19 space, the gene-level biology of this phe…
View article: A Decade of Global Skull Base Researchers: Authorship Trends from 3,295 Abstracts in the Journal of Neurological Surgery Part B: Skull Base
A Decade of Global Skull Base Researchers: Authorship Trends from 3,295 Abstracts in the Journal of Neurological Surgery Part B: Skull Base Open
Objective The North American Skull Base Society (NASBS) multidisciplinary annual conference hosts skull base researchers from across the globe. We hypothesized that the work presented at the NASBS annual conference would reveal diverse aut…
View article: Current Approaches to Craniopharyngioma Management
Current Approaches to Craniopharyngioma Management Open
Craniopharyngiomas (CP) are rare noncancerous brain tumors located in the skull base. To date, CP remain challenging-to-resect tumors, owing to their difficult location and invasive potential, with profound adverse effects for the patient …
View article: A Decade of Global Skull Base Researchers: Gender Data from over 2,700 Abstract Authors in the Journal of Neurological Surgery Part B: Skull Base
A Decade of Global Skull Base Researchers: Gender Data from over 2,700 Abstract Authors in the Journal of Neurological Surgery Part B: Skull Base Open
Objective The North American Skull Base Society (NASBS) annual conference brings together skull base researchers from surgical and nonsurgical fields. Our objective was to quantify the contributions of the authors by gender, who presented …
View article: Factors Associated with the Outcomes of ST-Elevation Myocardial Infarction Patients in the ED
Factors Associated with the Outcomes of ST-Elevation Myocardial Infarction Patients in the ED Open
Background ST-elevation myocardial infarction (STEMI) places a significant burden on the US healthcare system. However, there are gaps in our understanding of how patient demographics influence a STEMI’s risk to be admitted and the length …
View article: In Silico Binding Analysis of Cannabinoids with Eph Receptors for Therapeutic Use in Gliomas
In Silico Binding Analysis of Cannabinoids with Eph Receptors for Therapeutic Use in Gliomas Open
Background: Accumulating evidence suggests overexpression of Eph receptors is associated with malignant human gliomas.
View article: The differential usage of molecular machinery in brain cancer patients with iron-enriched glioma environments
The differential usage of molecular machinery in brain cancer patients with iron-enriched glioma environments Open
Gliomas are neuroepithelial tumors in the brain or spinal cord that arise from glial or precursor cells and include astrocytomas, oligodendrogliomas, and ependymomas. They are the most common malignant primary central nervous system tumors…
View article: Bioinformatic Methods for Identifying Differentially Abundant Subpopulations in scRNA-seq Data
Bioinformatic Methods for Identifying Differentially Abundant Subpopulations in scRNA-seq Data Open
Single-cell RNA sequencing data facilitates investigation of cell heterogeneity and subpopulations as well as differentially abundant states however modern single-cell RNA sequencing datasets are growing in size and complexity requiring ad…
View article: Granulocytic myeloid-derived suppressor cells to prevent and treat murine immune-mediated bone marrow failure
Granulocytic myeloid-derived suppressor cells to prevent and treat murine immune-mediated bone marrow failure Open
Myeloid-derived suppressor cells (MDSCs) are immature myeloid cells that originate in the bone marrow (BM) and have immunoregulatory functions. MDSCs have been implicated in the pathogenesis of several autoimmune diseases but have not been…
View article: The MicroRNA miR-277 Controls Physiology and Pathology of the Adult Drosophila Midgut by Regulating the Expression of Fatty Acid β-Oxidation-Related Genes in Intestinal Stem Cells
The MicroRNA miR-277 Controls Physiology and Pathology of the Adult Drosophila Midgut by Regulating the Expression of Fatty Acid β-Oxidation-Related Genes in Intestinal Stem Cells Open
Cell division, growth, and differentiation are energetically costly and dependent processes. In adult stem cell-based epithelia, cellular identity seems to be coupled with a cell’s metabolic profile and vice versa. It is thus tempting to s…
View article: Using Ethereum Smart Contracts to Store and Share COVID-19 Patient Data
Using Ethereum Smart Contracts to Store and Share COVID-19 Patient Data Open
Introduction The emergence and rapid spread of the coronavirus disease 2019 (COVID-19) pandemic have revealed the limitations in current healthcare systems to handle patient records securely and transparently, and novel protocols are requi…
View article: The Use of Electrical Nerve Stimulation to Treat Migraines: A Systematic Review
The Use of Electrical Nerve Stimulation to Treat Migraines: A Systematic Review Open
Migraines have been defined as an intense unilateral throbbing or pulsating sensation lasting anywhere between a few hours to multiple days. They are the sixth most prevalent disease in the United States, with approximately 18% of women an…
View article: A Review of Applications of Machine Learning in Mammography and Future Challenges
A Review of Applications of Machine Learning in Mammography and Future Challenges Open
Background: The aim of this study is to systematically review the literature to summarize the evidence surrounding the clinical utility of artificial intelligence (AI) in the field of mammography. Databases from PubMed, IEEE Xplore, and Sc…
View article: Immunological landscape of Neuroblastoma and its clinical significance
Immunological landscape of Neuroblastoma and its clinical significance Open
Immune infiltration in neuroblastoma (NBL) has been associated with clinical outcome. However, the diversity of distinct immune subpopulations that comprise immune infiltrates in NBL has not been examined. To this end, the present study in…
View article: In-Silico Analysis of Osmotic Stress Effects on Capsicum annuumTranscriptome
In-Silico Analysis of Osmotic Stress Effects on Capsicum annuumTranscriptome Open
Osmotic stress is a major abiotic limitation affecting yield and growth of crops worldwide, of which include one of the most cultivated bell peppers, Capsicum annuum. To understand the perturbations on gene expression in Capsicum annuum un…
View article: In silico Analysis of the Immunological Landscape of Hippocampi in Alzheimer’s Disease
In silico Analysis of the Immunological Landscape of Hippocampi in Alzheimer’s Disease Open
Introduction: Accumulating evidence suggests a relationship between neuroinflammation and neurodegenerative pathologies such as Alzheimer’s disease (AD). This study sought to investigate the immunological composition of hippocampi in patie…