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View article: Ultrasound-Assisted Extraction: Unlocking the Antibacterial Potential of Coptis chinensis Franch. Against ESBL-Producing Enterobacterales
Ultrasound-Assisted Extraction: Unlocking the Antibacterial Potential of Coptis chinensis Franch. Against ESBL-Producing Enterobacterales Open
The global rise of multidrug-resistant Extended Spectrum β-Lactamase Producing-Enterobacterales (ESBL-PE) poses a critical threat to public health, driving the urgent need for alternative therapeutic approaches. This study evaluates the an…
View article: <i>Medulla Tetrapanacis</i> Water Extract Ameliorates Dextran Sulfate Sodium‐Induced Ulcerative Colitis by Reprogramming Macrophage Polarization and Maintaining Intestinal Barrier Integrity
<i>Medulla Tetrapanacis</i> Water Extract Ameliorates Dextran Sulfate Sodium‐Induced Ulcerative Colitis by Reprogramming Macrophage Polarization and Maintaining Intestinal Barrier Integrity Open
Medulla Tetrapanacis (MT) is traditionally consumed as herbal soup to manage mastitis. Although scientific evidence supports its anti‐inflammatory effect, no study has investigated its effect on ulcerative colitis (UC). This study aimed to…
View article: <i>Medulla Tetrapanacis</i> water extract ameliorates mastitis by suppressing bacterial internalization and inflammation via MAPKs signaling in vitro and in vivo
<i>Medulla Tetrapanacis</i> water extract ameliorates mastitis by suppressing bacterial internalization and inflammation via MAPKs signaling in vitro and in vivo Open
Medulla Tetrapanacis (MT) is a commonly used herbal ingredient in soup to promote lactation and management of mastitis among lactating mothers worldwide, particularly in Asian countries. However, scientific evidence to support its usage in…
View article: Acceleration of Ethanol Metabolism by a Patented Bos taurus Isolated Alcohol Degradation Protein (ADP) on Acute Alcohol Consumption
Acceleration of Ethanol Metabolism by a Patented Bos taurus Isolated Alcohol Degradation Protein (ADP) on Acute Alcohol Consumption Open
Alcoholic beverages are among the most widely enjoyed leisure drinks around the world. However, irresponsible drinking habits can have detrimental effects on human health. Therefore, exploring strategies to alleviate discomfort following a…
View article: Characteristics and pathogenicity of Vibrio alginolyticus SWS causing high mortality in mud crab (Scylla serrata) aquaculture in Hong Kong
Characteristics and pathogenicity of Vibrio alginolyticus SWS causing high mortality in mud crab (Scylla serrata) aquaculture in Hong Kong Open
Introduction Vibrio alginolyticus is a Gram-negative, rod-shaped bacterium belonging to the family of Vibrionaceae , a common pathogen in aquaculture animals, However, studies on its impact on Scylla serrata (mud crabs) are limited. In thi…
View article: Garcinone E suppresses breast cancer growth and metastasis by modulating tumor‐associated macrophages polarization via STAT6 signaling
Garcinone E suppresses breast cancer growth and metastasis by modulating tumor‐associated macrophages polarization via STAT6 signaling Open
Cancer metastasis remains the most common cause of death in breast cancer patients. Tumor‐associated macrophages (TAMs) are a novel therapeutic target for the treatment of metastatic breast cancer. Despite the good anti‐cancer activity of …
View article: Editorial: Drugging p53 for non-cancer diseases
Editorial: Drugging p53 for non-cancer diseases Open
EDITORIAL article Front. Pharmacol., 30 November 2022Sec. Experimental Pharmacology and Drug Discovery https://doi.org/10.3389/fphar.2022.1101742
View article: The role of p53 in the alternation of vascular functions
The role of p53 in the alternation of vascular functions Open
Ageing is a risk factor for many degenerative diseases. Cardiovascular diseases (CVDs) are usually big burdens for elderly, caregivers and the health system. During the aging process, normal functions of vascular cells and tissue progressi…
View article: Crocins for Ischemic Stroke: A Review of Current Evidence
Crocins for Ischemic Stroke: A Review of Current Evidence Open
Crocins (CRs) and the related active constituents derived from Crocus sativus L. (Saffron) have demonstrated protective effects against cerebral ischemia and ischemic stroke, with various bioactivities including neuroprotection, anti-neuro…
View article: Structure-Activity Relationship Studies of 4-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-6-imino-N-(naphthalen-2-yl)-1,3,5-triazin-2-amine (FPMINT) Analogues as Inhibitors of Human Equilibrative Nucleoside Transporters
Structure-Activity Relationship Studies of 4-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-6-imino-N-(naphthalen-2-yl)-1,3,5-triazin-2-amine (FPMINT) Analogues as Inhibitors of Human Equilibrative Nucleoside Transporters Open
Equilibrative nucleoside transporters (ENTs) play a vital role in nucleotide synthesis, regulation of adenosine function and chemotherapy. Current inhibitors of ENTs are mostly ENT1-selective. Our previous study has demonstrated that 4-((4…
View article: A novel tri‐culture model for neuroinflammation
A novel tri‐culture model for neuroinflammation Open
Neuroinflammation is believed to play a primary role in the pathogenesis of most neurodegenerative diseases including Alzheimer's disease, Parkinson's disease and schizophrenia. Currently, suitable in vitro neuroinflammation models for stu…
View article: Vitamin D deficiency promotes large rupture-prone abdominal aortic aneurysms and cholecalciferol supplementation limits progression of aneurysms in a mouse model
Vitamin D deficiency promotes large rupture-prone abdominal aortic aneurysms and cholecalciferol supplementation limits progression of aneurysms in a mouse model Open
Vitamin D deficiency has been associated with human abdominal aortic aneurysm (AAA); however, its role in AAA pathogenesis is unclear. The aim of the present study was to investigate the effect of vitamin D deficiency on AAA development an…
View article: Factor XII blockade inhibits aortic dilatation in angiotensin II-infused apolipoprotein E-deficient mice
Factor XII blockade inhibits aortic dilatation in angiotensin II-infused apolipoprotein E-deficient mice Open
Abdominal aortic aneurysm (AAA) is an important cause of mortality in older adults. Chronic inflammation and excessive matrix remodelling are considered important in AAA pathogenesis. Kinins are bioactive peptides important in regulating i…
View article: Endothelium‐Independent Vasodilatory Effect of Sailuotong (SLT) on Rat Isolated Tail Artery
Endothelium‐Independent Vasodilatory Effect of Sailuotong (SLT) on Rat Isolated Tail Artery Open
Background . Sailuotong (SLT) is a standardized three‐herb formulation consisting of extracts of Panax ginseng , Ginkgo biloba , and Crocus sativus for the treatment of vascular dementia (VaD). Although SLT has been shown to increase cereb…
View article: Chromatographic Analysis and Anti-Oxidative Property of Naoxinqing Tablet, a Proprietary Preparation of Diospyros Kaki Leaves
Chromatographic Analysis and Anti-Oxidative Property of Naoxinqing Tablet, a Proprietary Preparation of Diospyros Kaki Leaves Open
The Naoxinqing (NXQ) tablet is a standardised proprietary herbal product containing an extract of persimmon leaves (Diospyros kaki) for the management of cardio- and cerebrovascular diseases. Although previous reports suggested that the ef…
View article: The Establishment of the Method of Cell Biochromatograpy and Analysis of the Active Ingredients from TongQiaoHuoXue Decoction Acting on the Neurocytes
The Establishment of the Method of Cell Biochromatograpy and Analysis of the Active Ingredients from TongQiaoHuoXue Decoction Acting on the Neurocytes Open
A novel strategy for screening active components in traditional Chinese medicines (TCM) using living cells and HPLC and GC analysis are proposed. The hypothesis is that when cells are incubated with the extract of Tongqiao Huoxue Decoction…
View article: Chinese Herbal Medicine as a Potential Treatment of Abdominal Aortic Aneurysm
Chinese Herbal Medicine as a Potential Treatment of Abdominal Aortic Aneurysm Open
Abdominal aortic aneurysm (AAA) is an irreversible condition where the abdominal aorta is dilated leading to potentially fatal consequence of aortic rupture. Multiple mechanisms are involved in the development and progression of AAA, inclu…
View article: High serum thrombospondin-1 concentration is associated with slower abdominal aortic aneurysm growth and deficiency of thrombospondin-1 promotes angiotensin II induced aortic aneurysm in mice
High serum thrombospondin-1 concentration is associated with slower abdominal aortic aneurysm growth and deficiency of thrombospondin-1 promotes angiotensin II induced aortic aneurysm in mice Open
Abdominal aortic aneurysm (AAA) is a common age-related vascular disease characterized by progressive weakening and dilatation of the aortic wall. Thrombospondin-1 (TSP-1; gene Thbs1) is a member of the matricellular protein family importa…
View article: Sailuotong Prevents Hydrogen Peroxide (H2O2)-Induced Injury in EA.hy926 Cells
Sailuotong Prevents Hydrogen Peroxide (H2O2)-Induced Injury in EA.hy926 Cells Open
Sailuotong (SLT) is a standardised three-herb formulation consisting of Panax ginseng, Ginkgo biloba, and Crocus sativus designed for the management of vascular dementia. While the latest clinical trials have demonstrated beneficial effect…
View article: A Systematic Review of Intervention Studies Examining Nutritional and Herbal Therapies for Mild Cognitive Impairment and Dementia Using Neuroimaging Methods: Study Characteristics and Intervention Efficacy
A Systematic Review of Intervention Studies Examining Nutritional and Herbal Therapies for Mild Cognitive Impairment and Dementia Using Neuroimaging Methods: Study Characteristics and Intervention Efficacy Open
Neuroimaging facilitates the assessment of complementary medicines (CMs) by providing a noninvasive insight into their mechanisms of action in the human brain. This is important for identifying the potential treatment options for target di…
View article: Wnt Signaling Pathway Inhibitor Sclerostin Inhibits Angiotensin II–Induced Aortic Aneurysm and Atherosclerosis
Wnt Signaling Pathway Inhibitor Sclerostin Inhibits Angiotensin II–Induced Aortic Aneurysm and Atherosclerosis Open
Objective— Sclerostin (SOST) has been identified as an important regulator of bone formation; however, it has not been previously implicated in arterial disease. The aim of this study was to assess the role of SOST in aortic aneurysm (AA) …
View article: Synergistic Effects of Chinese Herbal Medicine: A Comprehensive Review of Methodology and Current Research
Synergistic Effects of Chinese Herbal Medicine: A Comprehensive Review of Methodology and Current Research Open
Traditional Chinese medicine (TCM) is an important part of primary health care in Asian countries that has utilized complex herbal formulations (consisting 2 or more medicinal herbs) for treating diseases over thousands of years. There see…
View article: Angiogenesis in Ischemic Stroke and Angiogenic Effects of Chinese Herbal Medicine
Angiogenesis in Ischemic Stroke and Angiogenic Effects of Chinese Herbal Medicine Open
Stroke is one of the major causes of death and adult disability worldwide. The underlying pathophysiology of stroke is highly complicated, consisting of impairments of multiple signalling pathways, and numerous pathological processes such …