Abida Khan
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View article: IFN-γ-Driven macrophage responses in the immunity to Mycobacterium tuberculosis and Mycobacterium leprae
IFN-γ-Driven macrophage responses in the immunity to Mycobacterium tuberculosis and Mycobacterium leprae Open
Interferon-gamma (IFN-γ) is a key stimulator of macrophage defense against Mycobacterium tuberculosis (Mtb) and Mycobacterium leprae (M. leprae) . Both pathogens adopt measures to circumvent the effects of the immune system, weakening the …
View article: HPLC method development and validation for simultaneous analysis of methotrexate and leflunomide in bulk
HPLC method development and validation for simultaneous analysis of methotrexate and leflunomide in bulk Open
High performance liquid chromatography (HPLC) is one of the commonly used techniques for the separation and quantification of various pharmaceuticals, both individually as well as in combination. The current studies were aimed to develop a…
View article: Repurposing Cofilin-Targeting Compounds for Ischemic Stroke Through Cheminformatics and Network Pharmacology
Repurposing Cofilin-Targeting Compounds for Ischemic Stroke Through Cheminformatics and Network Pharmacology Open
Background/Objectives: Cofilin, a key regulator of actin cytoskeleton dynamics, contributes to neuroinflammation, synaptic damage, and blood–brain barrier disruption in ischemic stroke. Despite its established role in stroke pathology, cof…
View article: Emerging Therapeutic Strategies for Leprosy: Trends, Challenges, and Innovations
Emerging Therapeutic Strategies for Leprosy: Trends, Challenges, and Innovations Open
Leprosy is a chronic infectious disease caused by the Gram-positive Mycobacterium leprae or M. lepromatosis. Leprosy is a significant public health concern in many parts of the world. It remains a persistent global health challenge, partic…
View article: Clinical Efficacy of Cannabinoids in PTSD Management: A Systematic Review Overcoming Limitations of Prior Evidence
Clinical Efficacy of Cannabinoids in PTSD Management: A Systematic Review Overcoming Limitations of Prior Evidence Open
Post-traumatic stress disorder (PTSD) is a debilitating mental health condition that affects the entire population, with a higher prevalence among military veterans. It is characterized by the re-experiencing of traumatic events, the avoid…
View article: Exploration of Mechanism of Withania somnifera (L.) Dunal in the Treatment of Huntington Disease: A Network Pharmacology Approaches Integrated with Molecular Docking and Dynamics
Exploration of Mechanism of Withania somnifera (L.) Dunal in the Treatment of Huntington Disease: A Network Pharmacology Approaches Integrated with Molecular Docking and Dynamics Open
Background: Withania somnifera (L.) Dunal (Ashwagandha) is a traditional medicine that has several health-promoting and therapeutic benefits, including neuroprotective, sedative, and adaptogenic effects. Aim: The objective of current study…
View article: Decoding Immune and Metabolic Dysregulation in COPD and Tuberculosis: Insights from Systems Biology and Transcriptomics
Decoding Immune and Metabolic Dysregulation in COPD and Tuberculosis: Insights from Systems Biology and Transcriptomics Open
Chronic obstructive pulmonary disease (COPD) and tuberculosis (TB) are major global health burdens that often coexist, potentially amplifying disease severity through shared inflammatory and immune dysregulation mechanisms. This study aime…
View article: Marine Bacterial Compounds Targeting <i>Mycobacterium Leprae</i> Methyltransferase: Structural Insights and Scaffold Optimization
Marine Bacterial Compounds Targeting <i>Mycobacterium Leprae</i> Methyltransferase: Structural Insights and Scaffold Optimization Open
Leprosy remains a public health problem as a result of the increased emergence of drug‐resistant Mycobacterium leprae ( M. leprae ) strains; thus, novel therapeutic strategies are needed. This is a computational drug discovery to search fo…
View article: Safety and efficacy of tocilizumab in COVID-19: A systematic evaluation of adverse effects and therapeutic outcomes
Safety and efficacy of tocilizumab in COVID-19: A systematic evaluation of adverse effects and therapeutic outcomes Open
This study confirms tocilizumab's position as a valuable therapeutic agent for COVID-19 complications while highlighting the necessity for judicious patient selection and vigilant monitoring due to its potential for significant adverse eff…
View article: Formulation and Evaluation of thermosensitive drug delivery system containing Methotrexate, Dexamethasone and Meloxicam for rheumatoid arthritis
Formulation and Evaluation of thermosensitive drug delivery system containing Methotrexate, Dexamethasone and Meloxicam for rheumatoid arthritis Open
Rheumatoid arthritis (RA) is a chronic autoimmune disease that significantly increases morbidity and mortality rates. Although Methotrexate (MTX) is the primary treatment for RA, its side effects often lead to treatment discontinuation. Th…
View article: Advances in Nanotechnology in Drug Delivery Systems for Burn Wound Healing: A Review
Advances in Nanotechnology in Drug Delivery Systems for Burn Wound Healing: A Review Open
Burn wounds (BWs) are among the most complex injuries to manage, often leading to prolonged healing times, heightened infection risks, and significant scarring. Traditional therapies frequently fall short in addressing these challenges, hi…
View article: Exploring therapeutic paradigm focusing on genes, proteins, and pathways to combat leprosy and tuberculosis: A network medicine and drug repurposing approach
Exploring therapeutic paradigm focusing on genes, proteins, and pathways to combat leprosy and tuberculosis: A network medicine and drug repurposing approach Open
This study identifies HSP90AA1 as a potential drug target in leprosy and tuberculosis. Findings support host-directed therapy approaches and highlight the importance of computational modeling in accelerating drug discovery. The study provi…
View article: Coronary artery event and CYP2C19LoF polymorphism analysis using clopidogrel: A meta-analysis
Coronary artery event and CYP2C19LoF polymorphism analysis using clopidogrel: A meta-analysis Open
Background: Clopidogrel (CLOP) has been used as an antiplatelet medication for many years to treat strokes; however, CLOP resistance may increase the risk of stroke recurrence. The poor metabolism of CLOP, which leads to resistance, is tho…
View article: Genetic Variations and Seriousness of COVID-19 Patients: A Systematic Review
Genetic Variations and Seriousness of COVID-19 Patients: A Systematic Review Open
Millions of people have died due to coronavirus infection, which has also brought an unparalleled global health crisis to the verge of collapsing several nations healthcare system. The host genetic landscape is becoming more widely acknowl…
View article: Bioinformatics-Driven Identification of Genetic Biomarkers and Therapeutic Targets in Dengue Virus Infection
Bioinformatics-Driven Identification of Genetic Biomarkers and Therapeutic Targets in Dengue Virus Infection Open
The Dengue fever virus (DENV) poses a significant and escalating worldwide health risk. Nevertheless, dengue fever's exact cause and development have yet to be understood entirely. This study used bioinformatics methods to detect probable …
View article: ANRIL's Epigenetic Regulation and Its Implications for Cardiovascular Disorders
ANRIL's Epigenetic Regulation and Its Implications for Cardiovascular Disorders Open
Cardiovascular disorders (CVDs) are a major global health concern, but their underlying molecular mechanisms are not fully understood. Recent research highlights the role of long noncoding RNAs (lncRNAs), particularly ANRIL, in cardiovascu…
View article: Innovative Therapies In The Fight Against Antimicrobial Resistance Bridging Gaps And Overcoming Barriers
Innovative Therapies In The Fight Against Antimicrobial Resistance Bridging Gaps And Overcoming Barriers Open
Purpose: The objective of this work is to assess and analyses the views of key healthcare staff on the innovative treatments as a tool in the fight against AMR. The current research will identify key determinants including geographic locat…
View article: An Extensive Computational Investigation of <i>Mycobacterium tuberculosis</i> Pantothenate Synthetase Inhibitors from Diverse‐Lib Compounds Library
An Extensive Computational Investigation of <i>Mycobacterium tuberculosis</i> Pantothenate Synthetase Inhibitors from Diverse‐Lib Compounds Library Open
Antibiotics have played a crucial role in significantly reducing the incidence of tuberculosis (TB) infection worldwide. Even before the mid‐20 th century, the mortality rate of TB onset within five years was around 50 %. So, the introduct…
View article: In-vitro and in-silico studies based discovery of 2-aryl-N-(4-morpholinophenyl)thiazol-4-amines as promising DNA gyrase inhibitors
In-vitro and in-silico studies based discovery of 2-aryl-N-(4-morpholinophenyl)thiazol-4-amines as promising DNA gyrase inhibitors Open
Background: DNA gyrase is an important enzyme for the survival of bacteria. Many DNA gyrase inhibitors are in clinical practice. However, these inhibitors also encompass certain toxic and drug/food interactions. This warrants the developme…
View article: Mavorixafor: A spotlight on the clinical aspects and prospects of the first USFDA-approved treatment for the primary immunodeficiency WHIM syndrome
Mavorixafor: A spotlight on the clinical aspects and prospects of the first USFDA-approved treatment for the primary immunodeficiency WHIM syndrome Open
WHIM syndrome (WHIMS) is an extremely rare, severe, and potentially fatal genetic condition that affects the immune system, leading to warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM). Effective therapy for WHIMS requires…
View article: Molecular characterization of curvularia leaf blight disease of olive and determination of pathogenicity by a novel disease rating scale
Molecular characterization of curvularia leaf blight disease of olive and determination of pathogenicity by a novel disease rating scale Open
During the last decade, olive (Olea europaea) production has significantly increased in Pakistan due to oil producing ability and medicine importance. Arbequina, Arbosana, BARI Zaitoon-1 and BARI Zaitoon-2 has recently introduced in Sukhan…
View article: Genetic variants associated with dengue hemorrhagic fever. A systematic review and meta-analysis
Genetic variants associated with dengue hemorrhagic fever. A systematic review and meta-analysis Open
Dengue hemorrhagic fever (DHF) is a severe condition resulting from the dengue virus, with four serotypes known as DEN-1, DEN-2, DEN-3, and DEN-4. Genetic variations play a crucial role in influencing susceptibility to DHF. Therefore, this…
View article: Innovation of 6-sulfonamide-2<i>H</i>-chromene derivatives as antidiabetic agents targeting α-amylase, α-glycosidase, and PPAR-γ inhibitors with <i>in silico</i> molecular docking simulation
Innovation of 6-sulfonamide-2<i>H</i>-chromene derivatives as antidiabetic agents targeting α-amylase, α-glycosidase, and PPAR-γ inhibitors with <i>in silico</i> molecular docking simulation Open
A new series of 2-imino or 2-oxo-2 H -chromene-6-sulfonamide derivatives 2–9 were designed and synthesized and evaluated for anti-diabetic activity.
View article: Design, In Silico Studies, and Synthesis of Some Azole Derivatives as Antimicrobial Agents
Design, In Silico Studies, and Synthesis of Some Azole Derivatives as Antimicrobial Agents Open
This work relates to the discovery of safer and more potent triazole-pyridazinone hybrid (TP) compounds as an inhibitor of sterol 14α-demethylase (SDM). The chemical structures of thirty-three TPs (TP1 to TP33) were designed. The docking s…
View article: Discovery of New Isoniazid Derivatives As Anti-tubercular Agents: In silico Studies, Synthesis, and In vitro Activity Evaluation
Discovery of New Isoniazid Derivatives As Anti-tubercular Agents: In silico Studies, Synthesis, and In vitro Activity Evaluation Open
This research aimed to discover novel isoniazid (INH) derivatives as anti-tubercular (anti-TB) agents. The chemical structures of isoniazid-based pyridazinone (IBP) derivatives were designed, and their toxicity and pharmacokinetic properti…
View article: Synthesis and Cyclooxygenase-2 Inhibitory Activity Evaluation of Some Pyridazine Derivatives
Synthesis and Cyclooxygenase-2 Inhibitory Activity Evaluation of Some Pyridazine Derivatives Open
This work aimed to discover safe and effective pyridazine-based cyclooxygenase-2 (COX-2) inhibitors. Thirty-three pyridazine-based compounds (compounds 1 to 33) were designed. The in silico studies were conducted to predict their toxicity,…
View article: Resveratrol-Laden Nano-Systems in the Cancer Environment: Views and Reviews
Resveratrol-Laden Nano-Systems in the Cancer Environment: Views and Reviews Open
The genesis of cancer is a precisely organized process in which normal cells undergo genetic alterations that cause the cells to multiply abnormally, colonize, and metastasize to other organs such as the liver, lungs, colon, and brain. Pot…