Saidan Ding
YOU?
Author Swipe
View article: Dihydro‐resveratrol ameliorates NLRP3 inflammasome‐mediated neuroinflammation via Bnip3‐dependent mitophagy in Alzheimer's disease
Dihydro‐resveratrol ameliorates NLRP3 inflammasome‐mediated neuroinflammation via Bnip3‐dependent mitophagy in Alzheimer's disease Open
Background and Purpose Dihydro‐resveratrol (DHR), a polyphenol derivative, that has been demonstrated to suppress inflammation‐mediated injury. However, it is still unknown whether it has anti‐neuroinflammatory and neuroprotective effects,…
View article: Autocrine S100B in astrocytes promotes VEGF-dependent inflammation and oxidative stress, and causes impairment of neuroprotection
Autocrine S100B in astrocytes promotes VEGF-dependent inflammation and oxidative stress, and causes impairment of neuroprotection Open
Minimal hepatic encephalopathy (MHE) is strongly associated with neuroinflammation. Nevertheless, the underlying mechanism of the induction of inflammatory response in MHE astrocytes remains unclear. In this study, we further investigated …
View article: Thrombospondin1 Enhanced Neuronal Wnt7a and CNTF Expressions by TNFα Signaling Pathway
Thrombospondin1 Enhanced Neuronal Wnt7a and CNTF Expressions by TNFα Signaling Pathway Open
Background: Thrombospondin (TSP) is an astrocyte-secreted protein, well-known for its function as a modulator of synaptogenesis and neurogenesis. The mechanism underlying the effects of TSP1 on synaptic activity and formation involved in M…
View article: Thrombopoietin Receptor Agonist Eltrombopag Prevents Insulin Resistance and Synaptic Pathology via HIF1α/COX2/Sirt1 Signaling Pathway 
Thrombopoietin Receptor Agonist Eltrombopag Prevents Insulin Resistance and Synaptic Pathology via HIF1α/COX2/Sirt1 Signaling Pathway Open
Background: Insulin resistance has been reported to be closely correlated with the pathogenesis of MHE. The mechanism underlying the effects of thrombopoietin receptor agonist eltrombopag (ELT) on synaptic activity and formation involved i…
View article: Autocrine S100B in Astrocytes Promotes VEGF-dependent Inflammation and Oxidative Stress, and Causes Impairment of Neuroprotection
Autocrine S100B in Astrocytes Promotes VEGF-dependent Inflammation and Oxidative Stress, and Causes Impairment of Neuroprotection Open
Background: Our previous study revealed that minimal hepatic encephalopathy (MHE) is strongly associated with neuroinflammation. Nevertheless, the underlying mechanism of the induction of inflammatory response in MHE astrocytes remains unc…
View article: Thrombopoietin receptor agonist eltrombopag alleviates cognitive impairment via NRG1/ErbB4 signaling
Thrombopoietin receptor agonist eltrombopag alleviates cognitive impairment via NRG1/ErbB4 signaling Open
Background Patients with minimal hepatic encephalopathy (MHE) show mild cognitive impairments. Thrombopoietin (TPO) has been shown to be neuroprotective. This study aimed to explore the therapeutic effect of Thrombopoietin receptor agonist…
View article: Thrombopoietin receptor agonist eltrombopag prevents insulin resistance-mediated synaptic pathology via HIF1α/GSK3β/Sirt1 pathway
Thrombopoietin receptor agonist eltrombopag prevents insulin resistance-mediated synaptic pathology via HIF1α/GSK3β/Sirt1 pathway Open
Background Minimal hepatic encephalopathy (MHE) is characterized by impaired cognitive function and memory loss, which are often the result of synaptic pathology. Insulin resistance has been reported to be closely correlated with the patho…
View article: Hydrogen sulphide ameliorates dopamine‐induced astrocytic inflammation and neurodegeneration in minimal hepatic encephalopathy
Hydrogen sulphide ameliorates dopamine‐induced astrocytic inflammation and neurodegeneration in minimal hepatic encephalopathy Open
It has been demonstrated that the action of dopamine (DA) could enhance the production of tumour necrosis factor‐α (TNF‐α) by astrocytes and potentiate neuronal apoptosis in minimal hepatic encephalopathy (MHE). Recently, sodium hydrosulfi…
View article: The Neurotrophic and Anti-Inflammatory Effect of β-asarone on the DA-Induced the Pathology of Minimal Hepatic Encephalopathy
The Neurotrophic and Anti-Inflammatory Effect of β-asarone on the DA-Induced the Pathology of Minimal Hepatic Encephalopathy Open
Background: The mechanism underlying the impaired cognitive function and memory loss in Minimal hepatic encephalopathy (MHE) remains unclear. Dopamine (DA) is reported to be associated with dementia. Methods: In this study, we investigated…
View article: The Neurotrophic and Anti-Inflammatory Effect of β-asarone on the DA-Induced the Pathology of Minimal Hepatic Encephalopathy
The Neurotrophic and Anti-Inflammatory Effect of β-asarone on the DA-Induced the Pathology of Minimal Hepatic Encephalopathy Open
Background: The mechanism underlying the impaired cognitive function and memory loss in Minimal hepatic encephalopathy (MHE) remains unclear. Dopamine (DA) is reported to be associated with dementia. Methods: In this study, we investigated…
View article: Fibroblast Growth Factor-2 Prevents Synaptic Pathology in Minimal Hepatic Encephalopathy via NRG1/ErbB4 Signaling
Fibroblast Growth Factor-2 Prevents Synaptic Pathology in Minimal Hepatic Encephalopathy via NRG1/ErbB4 Signaling Open
Minimal hepatic encephalopathy (MHE) is implicated in the impairment of memory function. Fibroblast growth factor-2 (FGF2) is involved in modulating synaptic and neuronal formation. The aim of this study is to examined the impacts of FGF2 …
View article: Swimming Differentially Affects T2DM-Induced Skeletal Muscle ER Stress and Mitochondrial Dysfunction Related to MAM
Swimming Differentially Affects T2DM-Induced Skeletal Muscle ER Stress and Mitochondrial Dysfunction Related to MAM Open
Zhe Zhang,1,2 Di Cui,1,2 Tan Zhang,1,2 Yi Sun,1,2 Shuzhe Ding1,2 1Key Laboratory of Adolescent Health Assessment and Exercise Intervention of Ministry of Education, East China Normal University, Shanghai 200241, People’s Republic…
View article: New Measures for the Coronavirus Disease 2019 Response: A Lesson From the Wenzhou Experience
New Measures for the Coronavirus Disease 2019 Response: A Lesson From the Wenzhou Experience Open
As the outbreak of coronavirus disease 2019 (COVID-19) has spread globally, determining how to prevent the spread is of paramount importance. We reported the effectiveness of different responses of 4 affected cities in preventing the COVID…
View article: Fibroblast growth factor-2 prevents synaptic pathology in minimal hepatic encephalopathy via NRG1/ErbB4 signaling
Fibroblast growth factor-2 prevents synaptic pathology in minimal hepatic encephalopathy via NRG1/ErbB4 signaling Open
Background and Purpose: Minimal hepatic encephalopathy (MHE) is implicated in the impairment of memory function. Fibroblast growth factor-2 (FGF2) is involved in modulating synaptic and neuronal formation. Experimental Approach: The aim of…
View article: Fibroblast growth factor-2 prevents synaptic pathology in minimal hepatic encephalopathy via NRG1/ErbB4 signaling
Fibroblast growth factor-2 prevents synaptic pathology in minimal hepatic encephalopathy via NRG1/ErbB4 signaling Open
Background Minimal hepatic encephalopathy (MHE) is implicated in the impairment of memory function. Fibroblast growth factor-2 (FGF2) is involved in modulating synaptic and neuronal formation. Methods The aim of this study is to examined t…
View article: Oridonin prevents insulin resistance–mediated cognitive disorder through PTEN/Akt pathway and autophagy in minimal hepatic encephalopathy
Oridonin prevents insulin resistance–mediated cognitive disorder through PTEN/Akt pathway and autophagy in minimal hepatic encephalopathy Open
Minimal hepatic encephalopathy (MHE) was characterized for cognitive dysfunction. Insulin resistance (IR) has been identified to be correlated with the pathogenesis of MHE. Oridonin (Ori) is an active terpenoid, which has been reported to …
View article: Pharmacokinetics and tissue distribution of N-3- methoxybenzyl-palmitamide in rat: A macamide derived from <i>Lepidium meyenii</i>
Pharmacokinetics and tissue distribution of N-3- methoxybenzyl-palmitamide in rat: A macamide derived from <i>Lepidium meyenii</i> Open
Purpose: To study the pharmacokinetics and tissue distribution of N-3-methoxybenzyl-palmitamide (MPM) derived from Lepidium meyenii (Maca)Methods: MPM and N-benzylpalmitamide (BPM, as the internal standard, IS) were prepared by one-pot syn…
View article: RETRACTED: DA Negatively Regulates IGF-I Actions Implicated in Cognitive Function via Interaction of PSD95 and nNOS in Minimal Hepatic Encephalopathy
RETRACTED: DA Negatively Regulates IGF-I Actions Implicated in Cognitive Function via Interaction of PSD95 and nNOS in Minimal Hepatic Encephalopathy Open
Insulin-like growth factor I (IGF-I) has been positively correlated with cognitive ability. Cognitive decline in minimal hepatic encephalopathy (MHE) was shown to be induced by elevated intracranial dopamine (DA). The beneficial effect of …
View article: Insulin Resistance Disrupts the Interaction Between AKT and the NMDA Receptor and the Inactivation of the CaMKIV/CREB Pathway in Minimal Hepatic Encephalopathy
Insulin Resistance Disrupts the Interaction Between AKT and the NMDA Receptor and the Inactivation of the CaMKIV/CREB Pathway in Minimal Hepatic Encephalopathy Open
Hepatic cirrhosis-induced Minimal hepatic encephalopathy (MHE) has been characterized for cognitive dysfunction and central nervous system (CNS) insulin resistance (IR) has been acknowledged to be closely correlated with cognitive impairme…
View article: Dopamine Burden Induced the Inactivation of Sonic Hedgehog Signaling to Cognitive Decline in Minimal Hepatic Encephalopathy
Dopamine Burden Induced the Inactivation of Sonic Hedgehog Signaling to Cognitive Decline in Minimal Hepatic Encephalopathy Open
Minimal hepatic encephalopathy (MHE) is induced by elevated intracranial dopamine (DA). The relationship of the Shh pathway with memory loss in MHE, however, is elusive. In the current study, rats with MHE induced with DA displayed downreg…
View article: Carnosine Inhibits the Proliferation of Human Cervical Gland Carcinoma Cells Through Inhibiting Both Mitochondrial Bioenergetics and Glycolysis Pathways and Retarding Cell Cycle Progression
Carnosine Inhibits the Proliferation of Human Cervical Gland Carcinoma Cells Through Inhibiting Both Mitochondrial Bioenergetics and Glycolysis Pathways and Retarding Cell Cycle Progression Open
Carnosine has been demonstrated to play an antitumorigenic role in certain types of cancer. However, its underlying mechanism is unclear. In this study, the roles of carnosine in cell proliferation and its underlying mechanism were investi…
View article: Interleukin-4 Ameliorates the Functional Recovery of Intracerebral Hemorrhage Through the Alternative Activation of Microglia/Macrophage
Interleukin-4 Ameliorates the Functional Recovery of Intracerebral Hemorrhage Through the Alternative Activation of Microglia/Macrophage Open
Neuro-inflammation plays an important role in the recovery of brain injury after stroke. Microglia/macrophage is the major executor in the neuro-inflammation, which can be polarized into two distinct phenotypes: injurious/toxic classical a…