Saideep Gona
YOU?
Author Swipe
View article: scPrediXcan integrates deep learning methods and single-cell data into a cell-type-specific transcriptome-wide association study framework
scPrediXcan integrates deep learning methods and single-cell data into a cell-type-specific transcriptome-wide association study framework Open
Transcriptome-wide association studies (TWASs) help identify disease-causing genes but often fail to pinpoint disease mechanisms at the cellular level because of the limited sample sizes and sparsity of cell-type-specific expression data. …
View article: scPrediXcan integrates advances in deep learning and single-cell data into a powerful cell-type–specific transcriptome-wide association study framework
scPrediXcan integrates advances in deep learning and single-cell data into a powerful cell-type–specific transcriptome-wide association study framework Open
Transcriptome-wide association studies (TWAS) help identify disease causing genes, but often fail to pinpoint disease mechanisms at the cellular level because of the limited sample sizes and sparsity of cell-type-specific expression data. …
View article: A host-directed oxadiazole compound potentiates antituberculosis treatment via zinc poisoning in human macrophages and in a mouse model of infection
A host-directed oxadiazole compound potentiates antituberculosis treatment via zinc poisoning in human macrophages and in a mouse model of infection Open
Antituberculosis drugs, mostly developed over 60 years ago, combined with a poorly effective vaccine, have failed to eradicate tuberculosis. More worryingly, multiresistant strains of Mycobacterium tuberculosis (MTB) are constantly emergin…
View article: An oxadiazole-based compound potentiates anti-tuberculosis treatment by increasing host resistance via zinc poisoning
An oxadiazole-based compound potentiates anti-tuberculosis treatment by increasing host resistance via zinc poisoning Open
Anti-tuberculosis drugs, mostly developed over 60 years ago, combined with a poorly effective vaccine, have failed to eradicate tuberculosis. More worryingly, multi-resistant strains of Mycobacterium tuberculosis are constantly emerging. I…
View article: Antigen-driven colonic inflammation is associated with development of dysplasia in primary sclerosing cholangitis
Antigen-driven colonic inflammation is associated with development of dysplasia in primary sclerosing cholangitis Open
View article: Transposable elements are associated with the variable response to influenza infection
Transposable elements are associated with the variable response to influenza infection Open
Influenza A virus (IAV) infections are frequent every year and result in a range of disease severity. Here, we wanted to explore the potential contribution of transposable elements (TEs) to the variable human immune response. Transcriptome…
View article: Neonatal imprinting of alveolar macrophages via neutrophil-derived 12-HETE
Neonatal imprinting of alveolar macrophages via neutrophil-derived 12-HETE Open
View article: GATA4 controls regionalization of tissue immunity and commensal-driven immunopathology
GATA4 controls regionalization of tissue immunity and commensal-driven immunopathology Open
View article: Aberrant T-cell exhaustion in severe combined immunodeficiency survivors with poor T-cell reconstitution after transplantation
Aberrant T-cell exhaustion in severe combined immunodeficiency survivors with poor T-cell reconstitution after transplantation Open
Recipients of unconditioned HCT for SCID may develop late post-HCT T-cell exhaustion as a result of diminished production of T-lineage cells. Elevated expression of inhibitory receptors on their T cells may be a biomarker of poor long-term…
View article: Antigen-driven colonic inflammation is associated with development of dysplasia in primary sclerosing cholangitis
Antigen-driven colonic inflammation is associated with development of dysplasia in primary sclerosing cholangitis Open
Primary sclerosing cholangitis (PSC) is an autoimmune-like disease of the bile ducts that co-occurs with inflammatory bowel disease (IBD) in almost 90% of cases. Colorectal cancer is a major complication of patients with both PSC and IBD, …
View article: Epigenetic variation impacts ancestry-associated differences in the transcriptional response to influenza infection
Epigenetic variation impacts ancestry-associated differences in the transcriptional response to influenza infection Open
Summary Humans display remarkable inter-individual variation in immune response when exposed to identical immune challenges. Yet, our understanding of the genetic and epigenetic factors contributing to such variation remains limited. Here …
View article: Transposable elements are associated with the variable response to influenza infection
Transposable elements are associated with the variable response to influenza infection Open
SUMMARY Influenza A virus (IAV) infections are frequent every year and result in a range of disease severity. Given that transposable elements (TEs) contribute to the activation of innate immunity, we wanted to explore their potential role…
View article: GATA4 regionalizes intestinal metabolism and barrier function to prevent immunopathology
GATA4 regionalizes intestinal metabolism and barrier function to prevent immunopathology Open
Summary Different regions of the gastrointestinal tract have distinct digestive and absorptive functions, which may be locally disrupted by infection or autoimmune disease. Yet, the mechanisms underlying intestinal regionalization and its …