Explanipedia

Pathology of Self-Expanding Transcatheter Aortic Bioprostheses and Hypoattenuated Leaflet Thickening Open

Yu Sato, Sho Torii, Kenji Kawai, Kazuyuki Yahagi, Matthew Kutyna , et al. · 2025

BACKGROUND: Hypoattenuated leaflet thickening (HALT) is believed to reflect leaflet thrombosis; however, no systematic histological examination of HALT has ever been performed. The aim of this study was to evaluate histological findings of…

Amplification and Attenuation of Asymmetry via Kinetically Controlled Seed‐Induced Supramolecular Polymerization Open

Angshuman Das, Saikat Ghosh, Subi J. George · 2024

The amplification of asymmetry in supramolecular polymers has recently garnered significant attention. While asymmetry amplification has predominantly been explored under thermodynamic conditions, the kinetic aspect of this process unveils…

Amplification and Attenuation of Asymmetry via Kinetically Controlled Seed‐Induced Supramolecular Polymerization Open

Angshuman Das, Saikat Ghosh, Subi J. George · 2024

The amplification of asymmetry in supramolecular polymers has recently garnered significant attention. While asymmetry amplification has predominantly been explored under thermodynamic conditions, the kinetic aspect of this process unveils…

The Influence of Brood Survival Rates on the Behavioral Patterns, Economic Aspects and Resistant Traits of Italian Honeybee Apis mellifera L. Reared on Indian Mustard in Bihar Open

Nagendra Kumar, Saikat Ghosh, Katta Subramanya Sai Teja, G Balraj · 2024

To better understand Apis mellifera foraging behaviour for mustard, this study examined how brood survival rates affected the species behavioural, economic and resistant traits. Out of 10 colonies used for the study, the results showed tha…

145P Real-world evidence on thymic epithelial tumours (TETs): A decade of surgical experience and recurrence outcomes Open

E. Josephides, Akash Patel, Gianluca Lucchese, Cienne Morton, S. Gennatas , et al. · 2024

TETs are rare, diverse cancers. Treatment variations and lack of consensus on follow-up strategies require real-world data for evidence-based guidelines. We retrospectively analysed consecutive TET patients treated surgically from 2012 to …

Wool Fiber as an in Situ Reducing Agent Towards Zno-Based Surface Modified Fabric Development: Durability Assessment in the Realm of Textile Applications Open

Saikat Ghosh, Parikshit Goswami, Sohel Rana · 2024

Secreted protein profiling of human aortic smooth muscle cells identifies vascular disease associations Open

Rédouane Aherrahrou, Ferheen Baig, Konstantinos Theofilatos, Dillon Lue, Alicia Beele , et al. · 2023

Background Smooth muscle cells (SMCs), which make up the medial layer of arteries, are key cell types involved in cardiovascular diseases (CVD), the leading cause of mortality and morbidity worldwide. In response to microenvironment altera…

Leukocytes carrying<i>Clonal Hematopoiesis of Indeterminate Potential</i>(CHIP) Mutations invade Human Atherosclerotic Plaques Open

Moritz von Scheidt, Sabine Bauer, Angela Ma, Ke Hao, Thorsten Kessler , et al. · 2023

Background Leukocyte progenitors derived from clonal hematopoiesis of undetermined potential (CHIP) are associated with increased cardiovascular events. However, the prevalence and functional relevance of CHIP in coronary artery disease (C…

Polygenic Risk Score Associates with Atherosclerotic Plaque Characteristics at Autopsy Open

Anne Cornelissen, Neel Gadhoke, Kathleen A. Ryan, Chani J. Hodonsky, Rebecca Mitchell , et al. · 2023

Background Polygenic risk scores (PRS) for coronary artery disease (CAD) potentially improve cardiovascular risk prediction. However, their relationship with histopathologic features of CAD has never been examined systematically. Methods F…

Enhanced Thromboresistance and Endothelialization of a Novel Fluoropolymer-Coated Left Atrial Appendage Closure Device Open

Walid I. Saliba, Kenji Kawai, Yu Sato, Edward Kopesky, Qi Cheng , et al. · 2023

The FP-WM device showed significantly less thrombus and reduced inflammation in a challenging canine model. Mechanistic studies indicated that the fluoropolymer-coated device binds more albumin, leading to reduced platelet binding, less in…

Researching COVID to enhance recovery (RECOVER) autopsy tissue pathology study protocol: Rationale, objectives, and design Open

Andrea B. Troxel, Marie‐Abèle Bind, Thomas J. Flotte, Carlos Cordon‐Cardo, Lauren A. Decker , et al. · 2023

Importance SARS-CoV-2 infection can result in ongoing, relapsing, or new symptoms or organ dysfunction after the acute phase of infection, termed Post-Acute Sequelae of SARS-CoV-2 (PASC), or long COVID. The characteristics, prevalence, tra…

Observation of tunable discrete time crystalline phases Open

Arnab Sarkar, Anurag, Rajiv K. Singh, Aamir A. Makki, Javed A. Mondal , et al. · 2023

Discrete time crystals (DTCs) are emergent non-equilibrium phases of periodically driven many-body systems, with potential applications ranging from quantum computing to sensing and metrology. There has been significant recent interest in …

CD163+ macrophages restrain vascular calcification, promoting the development of high-risk plaque Open

Atsushi Sakamoto, Rika Kawakami, Masayuki Mori, Liang Guo, Ka Hyun Paek , et al. · 2023

Vascular calcification (VC) is concomitant with atherosclerosis, yet it remains uncertain why rupture-prone high-risk plaques do not typically show extensive calcification. Intraplaque hemorrhage (IPH) deposits erythrocyte-derived choleste…

Opportunities and Challenges in Understanding Atherosclerosis by Human Biospecimen Studies Open

Maria Elishaev, Chani J. Hodonsky, Saikat Ghosh, Aloke V. Finn, Moritz von Scheidt , et al. · 2022

Over the last few years, new high-throughput biotechnologies and bioinformatic methods are revolutionizing our way of deep profiling tissue specimens at the molecular levels. These recent innovations provide opportunities to advance our un…

Author Correction: Single-nucleus chromatin accessibility profiling highlights regulatory mechanisms of coronary artery disease risk Open

Adam W. Turner, Shengen Shawn Hu, José Verdezoto Mosquera, Wei Feng, Chani J. Hodonsky , et al. · 2022

Generalized Arterial Calcification of Infancy (GACI): Optimizing Care with a Multidisciplinary Approach Open

Kenji Kawai, Yu Sato, Rika Kawakami, Atsushi Sakamoto, Anne Cornelissen , et al. · 2022

Kenji Kawai,1,&ast; Yu Sato,1,&ast; Rika Kawakami,1 Atsushi Sakamoto,1 Anne Cornelissen,1 Masayuki Mori,1 Saikat Ghosh,1 Robert Kutys,1 Renu Virmani,1 Aloke V Finn1,2 1CVPath Institute, Gaithersburg, MD, USA; 2University of Marylan…

Single-nucleus chromatin accessibility profiling highlights regulatory mechanisms of coronary artery disease risk Open

Adam W. Turner, Shengen Shawn Hu, José Verdezoto Mosquera, Wei Feng, Chani J. Hodonsky , et al. · 2022

Characterization of Cerebral Embolic Capture Using the SENTINEL Device During Transcatheter Aortic Valve Implantation in Low to Intermediate-Risk Patients: The SENTINEL-LIR Study Open

Rika Kawakami, Hemal Gada, Michael Rinaldi, Tamim Nazif, Martin B. Leon , et al. · 2022

Cell-specific chromatin landscape of human coronary artery resolves regulatory mechanisms of disease risk Open

Adam W. Turner, Shengen Shawn Hu, José Verdezoto Mosquera, Wei Feng, Chani J. Hodonsky , et al. · 2021

Coronary artery disease (CAD) is a complex inflammatory disease involving genetic influences across several cell types. Genome-wide association studies (GWAS) have identified over 170 loci associated with CAD, where the majority of risk va…

Native Tertiary Structure and Nucleoside Modifications Suppress tRNA’s Intrinsic Ability to Activate the Innate Immune Sensor PKR Open

Subba Rao Nallagatla, Christie N. Jones, Saikat Ghosh, Suresh D. Sharma, Craig E. Cameron , et al. · 2020

Interferon inducible protein kinase PKR is an essential component of innate immunity. It is activated by long stretches of dsRNA and provides the first line of host defense against pathogens by inhibiting translation initiation in the infe…

Van der Knaap disease Open

Manoj Kumar Mahata, Saikat Ghosh, K. Ghosh, Rajarshi Bhattacharya, G Mondal · 2019

Van der Knaap disease is a rare form of leukodystrophy, phenotypically characterized by megalencephaly, early-onset ataxia, pyramidal features, cognitive impairment, with an autosomal recessive inheritence. MRI Brain shows T1 and FLAIR hyp…

Ross syndrome: a case report Open

Manoj Mahata, Saikat Ghosh, Kalyan Ghosh, Rasamay Bhattacharyya, G Mondal · 2019

Ross syndrome is a rare partial dysautonomic syndrome of unknown aetiology, characterized by segmental hypo/ anhidrosis associated with Holmes-Adie syndrome (tonic pupil and hypo/areflexia). The hypohydrosis or anhydrosis is patchy initial…

Clinical Features and Outcome of Refractory Status Epilepticus Patients in an Eastern Indian Tertiary Care Hospital Open

K. Ghosh, Ramesh Bhattacharya, Saikat Ghosh, Sarbajit Das, Suman Das , et al. · 2019

Is HCC associated with worse surgical outcomes compared to CRLM? Open

Joseph F. Amaral, MJ Guitierrez, Laura H. Goldstein, Saikat Ghosh · 2018

De novo formation of an aggregation pheromone precursor by an isoprenyl diphosphate synthase-related terpene synthase in the harlequin bug Open

Jason Lancaster, Ashot Khrimian, Sharon M. Young, Bryan Lehner, Katrin Luck , et al. · 2018

Significance Many insects release volatile terpenes for chemical communication. However, the biosynthetic origin and evolution of these infochemicals are mostly unknown. We show that the harlequin bug, Murgantia histrionica , a stink bug p…

Double-stranded RNA Oral Delivery Methods to Induce RNA Interference in Phloem and Plant-sap-feeding Hemipteran Insects Open

Saikat Ghosh, Wayne B. Hunter, Alexis L. Park, Dawn E. Gundersen‐Rindal · 2018

Phloem and plant sap feeding insects invade the integrity of crops and fruits to retrieve nutrients, in the process damaging food crops. Hemipteran insects account for a number of economically substantial pests of plants that cause damage …

Double strand RNA-mediated RNA interference through feeding in larval gypsy moth, Lymantria dispar (Lepidoptera: Erebidae) Open

Saikat Ghosh, Dawn E. Gundersen‐Rindal · 2017

RNA interference (RNAi) technology uses dsRNAs to silence specific targeted genes by downregulating their expression. It has become a potent tool for functional and regulatory studies of insect genes and has potential to be applied for ins…

Double strand RNA delivery system for plant-sap-feeding insects Open

Saikat Ghosh, Wayne B. Hunter, Alexis L. Park, Dawn E. Gundersen‐Rindal · 2017

Double-stranded RNA (dsRNA)-mediated gene silencing, also known as RNA interference (RNAi), has been a breakthrough technology for functional genomic studies and represents a potential tool for the management of insect pests. Since the inc…

Effects of co-treatment with pioglitazone and methotrexate on experimentally induced rheumatoid arthritis in Wistar albino rats Open

Tanushree Roy, Indranil Banerjee, Saikat Ghosh, Ranjita Santra Dhali, Anuradha De Pati , et al. · 2017

The present study demonstrates that the combination therapy of MTX with pioglitazone offers better control of disease activities in RA as compared to MTX or pioglitazone monotherapy.

Erratum to: Neuroprotective effect of Spirulina fusiform and amantadine in the 6-OHDA induced Parkinsonism in rats Open

Ipshita Chattopadhyaya, Sumeet Gupta, Mohammed Asad, N Mushtaq, Samrat Chauhan , et al. · 2015

Multi-factorial etiology exists in pathophysiology of neurodegenerative diseases. The imbalance of anti-oxidant enzymes and dopamine level leads to Parkinsonism. The objective of this study was to assess the protective effect of Spirulina …

Saikat Ghosh YOU? Author Swipe