Sailing Chen
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View article: A One‐Two Punch Strategy Against Cancer: Simultaneously Inducing and Eliminating Senescent Tumor Cells
A One‐Two Punch Strategy Against Cancer: Simultaneously Inducing and Eliminating Senescent Tumor Cells Open
Senolytics, an emerging class of agents that selectively deplete pro‐tumorigenic senescent cells, offer a novel adjuvant strategy to re‐engineer the tumor microenvironment and potentiate anticancer therapy. However, direct senolytic treatm…
View article: Structure-activity relationship and in silico docking analysis of dicarboximide fungicides on 17β-hydroxysteroid dehydrogenase 1 of human, rat, and pig
Structure-activity relationship and in silico docking analysis of dicarboximide fungicides on 17β-hydroxysteroid dehydrogenase 1 of human, rat, and pig Open
Dicarboximide fungicides, including captafol, captan, cyclohexylthiophthalimide, folpet, and procymidone, represent a distinct category of fungicides. 17β-Hydroxysteroid dehydrogenase 1 (17β-HSD1) catalyzes the conversion of estrone to est…
View article: Aromatase as a novel target of parabens in human and rat placentas: 3D-quantitative structure-activity relationship and docking analysis
Aromatase as a novel target of parabens in human and rat placentas: 3D-quantitative structure-activity relationship and docking analysis Open
Aromatase (CYP19A1), a pivotal enzyme in the biosynthesis of estradiol from testosterone, is predominantly expressed in reproductive tissues including placentas. This study investigated the effects of paraben acid and nine parabens on the …
View article: Type I collagen extracellular matrix facilitates nerve regeneration via the construction of a favourable microenvironment
Type I collagen extracellular matrix facilitates nerve regeneration via the construction of a favourable microenvironment Open
Background The extracellular matrix (ECM) provides essential physical support and biochemical cues for diverse biological activities, including tissue remodelling and regeneration, and thus is commonly applied in the construction of artifi…
View article: Enhanced inhibition of human and rat aromatase activity by benzene ring substitutions in bisphenol A: QSAR structure-activity relationship and in silico docking analysis
Enhanced inhibition of human and rat aromatase activity by benzene ring substitutions in bisphenol A: QSAR structure-activity relationship and in silico docking analysis Open
Bisphenol A (BPA) is a widely used plastic material, but its potential endocrine disrupting effect has restricted its use. The BPA alternatives have raised concerns. This study aimed to compare inhibitory potencies of 11 BPA analogues on h…
View article: Biocompatible Assessment of Erythrocyte Membrane-Camouflaged Polymeric PLGA Nanoparticles in Pregnant Mice: Both on Maternal and Fetal/Juvenile Mice
Biocompatible Assessment of Erythrocyte Membrane-Camouflaged Polymeric PLGA Nanoparticles in Pregnant Mice: Both on Maternal and Fetal/Juvenile Mice Open
These results indicate that RBC-NP is considered to be generally safe and biocompatible both for maternal mice and fetus during pregnancy, and for the subsequent juvenile mice post-birth, although future studies will need to examine higher…
View article: miR‑328a‑3p stimulates endothelial cell migration and tubulogenesis
miR‑328a‑3p stimulates endothelial cell migration and tubulogenesis Open
Endothelial cells have important biological roles after peripheral nerve injury by forming blood vessels within the nerve gap and guiding Schwann cell migration. MicroRNAs (miRNAs/miRs) affect cellular behavior and regulate a wide variety …
View article: miR-328a-3p stimulates endothelial cell migration and angiogenesis
miR-328a-3p stimulates endothelial cell migration and angiogenesis Open
Background Endothelial cells play important biological roles after peripheral nerve injury by forming blood vessels within the nerve gap after peripheral nerve injury and guiding Schwann cell migration. microRNAs (miRNAs) affect cellular b…
View article: The Association of Polymorphisms in Base Excision Repair Genes with Ovarian Cancer Susceptibility in Chinese Women: A Two-Center Case-Control Study
The Association of Polymorphisms in Base Excision Repair Genes with Ovarian Cancer Susceptibility in Chinese Women: A Two-Center Case-Control Study Open
Base excision repair (BER) acts upon the most important mechanism of the DNA repair system, protecting DNA stability and integrity from the mutagenic and cytotoxic effects. Multiple researches have indicated that single-nucleotide polymorp…
View article: Characteristics of cytokines in the sciatic nerve stumps and DRGs after rat sciatic nerve crush injury
Characteristics of cytokines in the sciatic nerve stumps and DRGs after rat sciatic nerve crush injury Open
Background: Cytokines are essential cellular modulators of a variety of physiological and pathological activities, including peripheral nerve repair and regeneration. However, the molecular changes of these cellular mediators after periphe…
View article: Characteristics of cytokines in regeneration of injured peripheral nerves
Characteristics of cytokines in regeneration of injured peripheral nerves Open
Background Cytokines are essential cellular modulators of a variety of physiological and pathological activities, including peripheral nerve repair and regeneration. However, the molecular changes of these cellular mediators during periphe…
View article: Association of polymorphisms in <i>MALAT1</i> with the risk of endometrial cancer in Southern Chinese women
Association of polymorphisms in <i>MALAT1</i> with the risk of endometrial cancer in Southern Chinese women Open
Background Endometrial cancer is the most common gynecologic malignancy worldwide. Polymorphisms in MALAT1 have been demonstrated to play critical roles in cancer. However, the roles of MALAT1 polymorphisms in the etiology of endometrial c…
View article: Correlation Analysis of Phenolic Contents and Antioxidation in Yellow- and Black-Seeded Brassica napus
Correlation Analysis of Phenolic Contents and Antioxidation in Yellow- and Black-Seeded Brassica napus Open
Brassica napus L. is rich in phenolic components and it has natural antioxidant characteristics which are important to human health. In the present study, the total phenolic and flavonoid contents of developing seeds of yellow- and black-s…