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Table S7 from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity Open

Tong Han, Xujun Wang, Sailing Shi, Qiu Wu, Ziyi Li , et al. · 2025

Cox regression model of IFNG expression on patients’ survival in TCGA and Available expression data of ICB treatment.

Table S6 from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity Open

Tong Han, Xujun Wang, Sailing Shi, Wubing Zhang, Jue Wang , et al. · 2023

Expression of DSB repair genes especially resistant or non-resistant DSB repair genes in TCGA datasets with SSB repair genes mutation and deletion.

Table S3 from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity Open

Tong Han, Xujun Wang, Sailing Shi, Wubing Zhang, Jue Wang , et al. · 2023

Genes’ average Δβ-scores across all cancer cell lines (sheet1); Gene sets enrichment for positively (sheet2) / negatively (sheet3) selected genes in CRISPR screen. GSEA was used to perform the enrichment analysis; sgRNA sequences of AAVS1,…

Table S1 from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity Open

Tong Han, Xujun Wang, Sailing Shi, Wubing Zhang, Jue Wang , et al. · 2023

IFN-γ sensitivity of cancer cells (n = 43) from CCLE (sheet1); Gene sets enrichment for highly expressed gene sets in IFN-γ resistant/sensitive cell lines using CCLE transcriptomic dataset (sheet2-3).

Table S7 from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity Open

Tong Han, Xujun Wang, Sailing Shi, Wubing Zhang, Jue Wang , et al. · 2023

Cox regression model of IFNG expression on patients’ survival in TCGA and Available expression data of ICB treatment.

Table S4 from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity Open

Tong Han, Xujun Wang, Sailing Shi, Wubing Zhang, Jue Wang , et al. · 2023

Raw count table for RNA-seq.

Table S2 from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity Open

Tong Han, Xujun Wang, Sailing Shi, Wubing Zhang, Jue Wang , et al. · 2023

Beta score (sheet1), mapping ratio (sheet2), and essential genes list (sheet3) of CRISPR screens.

Table S5 from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity Open

Tong Han, Xujun Wang, Sailing Shi, Wubing Zhang, Jue Wang , et al. · 2023

Single-strand break repair genes (sheet1), double-strand break repair genes (sheet2), and DNA methylation related genes (sheet3).

Table S5 from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity Open

Tong Han, Xujun Wang, Sailing Shi, Wubing Zhang, Jue Wang , et al. · 2023

Single-strand break repair genes (sheet1), double-strand break repair genes (sheet2), and DNA methylation related genes (sheet3).

Data from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity Open

Tong Han, Xujun Wang, Sailing Shi, Wubing Zhang, Jue Wang , et al. · 2023

The pleiotropic cytokine interferon-gamma (IFNγ) is associated with cytostatic, antiproliferation, and proapoptotic functions in cancer cells. However, resistance to IFNγ occurs in many cancer cells, and the underlying mechanism is not ful…

Supplementary Figures from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity Open

Tong Han, Xujun Wang, Sailing Shi, Wubing Zhang, Jue Wang , et al. · 2023

Supplementary Figures S1-S8

Table S4 from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity Open

Tong Han, Xujun Wang, Sailing Shi, Wubing Zhang, Jue Wang , et al. · 2023

Raw count table for RNA-seq.

Table S1 from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity Open

Tong Han, Xujun Wang, Sailing Shi, Wubing Zhang, Jue Wang , et al. · 2023

IFN-γ sensitivity of cancer cells (n = 43) from CCLE (sheet1); Gene sets enrichment for highly expressed gene sets in IFN-γ resistant/sensitive cell lines using CCLE transcriptomic dataset (sheet2-3).

Table S3 from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity Open

Tong Han, Xujun Wang, Sailing Shi, Wubing Zhang, Jue Wang , et al. · 2023

Genes’ average Δβ-scores across all cancer cell lines (sheet1); Gene sets enrichment for positively (sheet2) / negatively (sheet3) selected genes in CRISPR screen. GSEA was used to perform the enrichment analysis; sgRNA sequences of AAVS1,…

Data from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity Open

Tong Han, Xujun Wang, Sailing Shi, Wubing Zhang, Jue Wang , et al. · 2023

The pleiotropic cytokine interferon-gamma (IFNγ) is associated with cytostatic, antiproliferation, and proapoptotic functions in cancer cells. However, resistance to IFNγ occurs in many cancer cells, and the underlying mechanism is not ful…

Supplementary Figures from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity Open

Tong Han, Xujun Wang, Sailing Shi, Wubing Zhang, Jue Wang , et al. · 2023

Supplementary Figures S1-S8

Table S2 from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity Open

Tong Han, Xujun Wang, Sailing Shi, Wubing Zhang, Jue Wang , et al. · 2023

Beta score (sheet1), mapping ratio (sheet2), and essential genes list (sheet3) of CRISPR screens.

Table S6 from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity Open

Tong Han, Xujun Wang, Sailing Shi, Wubing Zhang, Jue Wang , et al. · 2023

Expression of DSB repair genes especially resistant or non-resistant DSB repair genes in TCGA datasets with SSB repair genes mutation and deletion.

Table S7 from Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity Open

Tong Han, Xujun Wang, Sailing Shi, Wubing Zhang, Jue Wang , et al. · 2023

Cox regression model of IFNG expression on patients’ survival in TCGA and Available expression data of ICB treatment.

Figure S4 from Inhibition of MAN2A1 Enhances the Immune Response to Anti–PD-L1 in Human Tumors Open

Sailing Shi, Shengqing Gu, Tong Han, Wubing Zhang, Lei Huang , et al. · 2023

Sup.Fig.4: The effect of Man2a1 knockout on the IFN-γ downstream activation and cytokine sensitivity.

Figure S10 from Inhibition of MAN2A1 Enhances the Immune Response to Anti–PD-L1 in Human Tumors Open

Sailing Shi, Shengqing Gu, Tong Han, Wubing Zhang, Lei Huang , et al. · 2023

Sup.Fig.10: H&E staining to evaluate immune-related adverse events of anti-PD-L1 and swainsonine.

Table S2 from Inhibition of MAN2A1 Enhances the Immune Response to Anti–PD-L1 in Human Tumors Open

Sailing Shi, Shengqing Gu, Tong Han, Wubing Zhang, Lei Huang , et al. · 2023

Sup.Table.S2: Gene sets enrichment for down regulated (Log2 fold change < 0 & adj.p.value < 0.1) genes in Man2a1-knockout B16F10 cells. "MAGeCKFlute" R package was used to perform the analysis.

Figure S3 from Inhibition of MAN2A1 Enhances the Immune Response to Anti–PD-L1 in Human Tumors Open

Sailing Shi, Shengqing Gu, Tong Han, Wubing Zhang, Lei Huang , et al. · 2023

Sup.Fig.3: Gating strategy of T cell co-culture validation experiment.

Figure S9 from Inhibition of MAN2A1 Enhances the Immune Response to Anti–PD-L1 in Human Tumors Open

Sailing Shi, Shengqing Gu, Tong Han, Wubing Zhang, Lei Huang , et al. · 2023

Sup.Fig.9: The effect of Man2a1 inhibition on the immune cell infiltration.

Table S7 from Inhibition of MAN2A1 Enhances the Immune Response to Anti–PD-L1 in Human Tumors Open

Sailing Shi, Shengqing Gu, Tong Han, Wubing Zhang, Lei Huang , et al. · 2023

Sup.Table.S7: Gene sets enriched in B16F10 tumors treated with anti-PD-L1 + swainsonine vs IgG +PBS. Pre-ranked gene set enrichment analysis (GSEA) was used to perform the analysis.

Figure S1 from Inhibition of MAN2A1 Enhances the Immune Response to Anti–PD-L1 in Human Tumors Open

Sailing Shi, Shengqing Gu, Tong Han, Wubing Zhang, Lei Huang , et al. · 2023

Sup.Fig.1: The association between the CTL level and overall patient survival.

Table S1 from Inhibition of MAN2A1 Enhances the Immune Response to Anti–PD-L1 in Human Tumors Open

Sailing Shi, Shengqing Gu, Tong Han, Wubing Zhang, Lei Huang , et al. · 2023

Sup.Table.S1: N-glycan bio-synthesis gene list downloaded from KEGG (hsa00510).

Figure S1 from Inhibition of MAN2A1 Enhances the Immune Response to Anti–PD-L1 in Human Tumors Open

Sailing Shi, Shengqing Gu, Tong Han, Wubing Zhang, Lei Huang , et al. · 2023

Sup.Fig.1: The association between the CTL level and overall patient survival.

Supplementary Figure Legend from Inhibition of MAN2A1 Enhances the Immune Response to Anti–PD-L1 in Human Tumors Open

Sailing Shi, Shengqing Gu, Tong Han, Wubing Zhang, Lei Huang , et al. · 2023

Supplementary Figure Legend

Figure S9 from Inhibition of MAN2A1 Enhances the Immune Response to Anti–PD-L1 in Human Tumors Open

Sailing Shi, Shengqing Gu, Tong Han, Wubing Zhang, Lei Huang , et al. · 2023

Sup.Fig.9: The effect of Man2a1 inhibition on the immune cell infiltration.

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