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View article: The Genetic Landscape of Familial Hypercholesterolemia in Telangana, Southern India: Novel Mutations and Clinical Implications
The Genetic Landscape of Familial Hypercholesterolemia in Telangana, Southern India: Novel Mutations and Clinical Implications Open
View article: Genetic Landscape of Familial Hypercholesterolemia in Southern India: Novel Mutations and Clinical Implications
Genetic Landscape of Familial Hypercholesterolemia in Southern India: Novel Mutations and Clinical Implications Open
Background: Familial hypercholesterolemia (FH) is a genetic disorder characterized by elevated low-density lipoprotein cholesterol (LDL-C) levels, leading to premature cardiovascular disease (CVD). This study aimed to identify genetic vari…
View article: A comparative study on clinical features and COVID-19 severity in pediatric patients and adults
A comparative study on clinical features and COVID-19 severity in pediatric patients and adults Open
Introduction Coronavirus disease (COVID-19) has emerged as a global threat affecting diverse populations. While the severity of the disease is often associated with comorbidities and inflammation, pediatric patients generally experience a …
View article: A COMPREHENSIVE REVIEW ON THE MULTIFACETED INTERACTIONS BETWEEN HOST IMMUNITY AND VIRAL PATHOGENESIS IN COVID-19
A COMPREHENSIVE REVIEW ON THE MULTIFACETED INTERACTIONS BETWEEN HOST IMMUNITY AND VIRAL PATHOGENESIS IN COVID-19 Open
The Corona Virus Disease (COVID-19) pandemic has presented unparalleled challenges, marked by a wide array of clinical presentations spanning from asymptomatic carriage to severe respiratory compromise and multi-organ dysfunction. It is cr…
View article: Systems-wide view of host-pathogen interactions across COVID-19 severities using integrated omics analysis
Systems-wide view of host-pathogen interactions across COVID-19 severities using integrated omics analysis Open
The mechanisms explaining the variability in COVID-19 clinical manifestations (mild, moderate, and severe) are not fully understood. To identify key gene expression markers linked to disease severity, we employed an integrated approach, co…
View article: Determinants of Severity due to Covid-19 Among Young Adults
Determinants of Severity due to Covid-19 Among Young Adults Open
Background Coronavirus disease (COVID-19) is an emerging infectious disease affecting people of all ages, races, and countries, caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2). The disease has been shown to be more…
View article: Systems-Wide View of Host-Pathogen Interactions Across COVID-19 Severities Using Integrated Omics Analysis
Systems-Wide View of Host-Pathogen Interactions Across COVID-19 Severities Using Integrated Omics Analysis Open
View article: Drug Re-purposing from SARS-CoV Led the Identification of Potential Candidate Drug Target and Alternate Drug Molecules Against SARSCoV- 2
Drug Re-purposing from SARS-CoV Led the Identification of Potential Candidate Drug Target and Alternate Drug Molecules Against SARSCoV- 2 Open
Background: SARS-CoV-2 causes COVID19 disease where there are no suitable drugs available. Objective: The objective of the work is to repurpose the drugs prescribed for SARS-CoV as the drugs for the control of SARS-CoV-2. Methods:: In this…
View article: Comparative transcriptome profiling of pomegranate genotypes having resistance and susceptible reaction to Xanthomonas axonopodis pv. punicae
Comparative transcriptome profiling of pomegranate genotypes having resistance and susceptible reaction to Xanthomonas axonopodis pv. punicae Open
View article: Metabolic remodeling in <i>Escherichia coli</i> <scp>MG</scp>1655. A prophage e14‐encoded small <scp>RNA</scp>, <i>co293</i>, post‐transcriptionally regulates transcription factors HcaR and FadR
Metabolic remodeling in <i>Escherichia coli</i> <span>MG</span>1655. A prophage e14‐encoded small <span>RNA</span>, <i>co293</i>, post‐transcriptionally regulates transcription factors HcaR and FadR Open
In previous studies, we have shown the existence of metabolic remodeling in glucose‐grown Escherichia coli MG 1655 cells expressing the esterase Orf306 from the opd island of Sphingobium fuliginis . We now show that Orf306‐dependent metabo…
View article: The Cuon Enigma: Genome survey and comparative genomics of the endangered Dhole (<i>Cuon alpinus</i>)
The Cuon Enigma: Genome survey and comparative genomics of the endangered Dhole (<i>Cuon alpinus</i>) Open
The Asiatic wild dog is an endangered monophyletic canid restricted to Asia; facing threats from habitat fragmentation and other anthropogenic factors. Dholes have unique adaptations as compared to other wolf-like canids for large litter s…
View article: Comprehensive profiling of transcriptional networks specific for lactogenic differentiation of HC11 mammary epithelial stem-like cells
Comprehensive profiling of transcriptional networks specific for lactogenic differentiation of HC11 mammary epithelial stem-like cells Open
The development of mammary gland as a lactogenic tissue is a highly coordinated multistep process. The epithelial cells of lactiferous tubules undergo profound changes during the developmental window of puberty, pregnancy, and lactation. S…
View article: RNA sequencing of murine mammary epithelial stem-like cells (HC11) undergoing lactogenic differentiation and its comparison with embryonic stem cells
RNA sequencing of murine mammary epithelial stem-like cells (HC11) undergoing lactogenic differentiation and its comparison with embryonic stem cells Open
View article: System-wide coordinates of higher order functions in host-pathogen environment upon Mycobacterium tuberculosis infection
System-wide coordinates of higher order functions in host-pathogen environment upon Mycobacterium tuberculosis infection Open
View article: Inhibitors of Apoptosis Protein Antagonists (Smac Mimetic Compounds) Control Polarization of Macrophages during Microbial Challenge and Sterile Inflammatory Responses
Inhibitors of Apoptosis Protein Antagonists (Smac Mimetic Compounds) Control Polarization of Macrophages during Microbial Challenge and Sterile Inflammatory Responses Open
Apoptosis is a physiological cell death process essential for development, tissue homeostasis, and for immune defense of multicellular animals. Inhibitors of apoptosis proteins (IAPs) regulate apoptosis in response to various cellular assa…
View article: Spatiotemporal Dynamics of 3D Genome Architecture and Gene Expression during Lactogenic Differentiation of Murine Mammary Epithelial Cells
Spatiotemporal Dynamics of 3D Genome Architecture and Gene Expression during Lactogenic Differentiation of Murine Mammary Epithelial Cells Open
Orchestration of differential gene expression program during cellular development and differentiation is tightly coordinated in each and every cell type. Cell-type specific gene expression is primarily regulated by the spatial arrangement …
View article: Identification and functional analysis of essential, conserved, housekeeping and duplicated genes
Identification and functional analysis of essential, conserved, housekeeping and duplicated genes Open
Gene conservation, duplication and constitutive expression are intricately linked and strong predictors of essentiality. Here, we introduce metrics based on diversity indices to measure gene conservation, duplication and constitutive expre…