Saima Aslam
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View article: Intermediate-term risk of cardiac allograft vasculopathy following heart transplantation from hepatitis C viremic donors in the era of direct-acting antiviral therapy
Intermediate-term risk of cardiac allograft vasculopathy following heart transplantation from hepatitis C viremic donors in the era of direct-acting antiviral therapy Open
In the modern DAA era, transplantation of HCV NAT+ donor hearts is not associated with increased risk of CAV or adverse clinical outcomes over intermediate-term follow-up.
View article: Inflammation among kidney transplant donors with and without HIV: Multicenter HOPE in Action Consortium
Inflammation among kidney transplant donors with and without HIV: Multicenter HOPE in Action Consortium Open
View article: Phage Therapy for Urinary Tract Infections: Progress and Challenges Ahead
Phage Therapy for Urinary Tract Infections: Progress and Challenges Ahead Open
Introduction and Hypothesis Urinary tract infection (UTI) treatment is a growing public health concern owing to increasing antimicrobial resistance. Phage therapy, an alternative or adjunctive treatment to antibiotics, has the potential to…
View article: Kaposi Sarcoma–Associated Herpesvirus Risk and Disease in Kidney Donors and Transplant Recipients With Human Immunodeficiency Virus in the United States
Kaposi Sarcoma–Associated Herpesvirus Risk and Disease in Kidney Donors and Transplant Recipients With Human Immunodeficiency Virus in the United States Open
Background Due to high prevalence of Kaposi sarcoma–associated herpesvirus (KSHV) among people with human immunodeficiency virus (HIV), KSHV-associated disease (KAD) may be increased after kidney transplantation from donors with HIV (HIV D…
View article: Erratum for Aslam et al., “ <i>Pseudomonas aeruginosa</i> ventricular assist device infections: findings from ineffective phage therapies in five cases”
Erratum for Aslam et al., “ <i>Pseudomonas aeruginosa</i> ventricular assist device infections: findings from ineffective phage therapies in five cases” Open
View article: Safety of Kidney Transplantation from Donors with HIV
Safety of Kidney Transplantation from Donors with HIV Open
The primary objective of this study is to determine if an HIV-infected deceased kidney donor (HIVD+) transplant is safe with regard to major transplant-related and HIV-related complications.
View article: Proceedings of the 15 <sup>th</sup> International Newborn Brain Conference: Neuro-imaging studies
Proceedings of the 15 <sup>th</sup> International Newborn Brain Conference: Neuro-imaging studies Open
BACKGROUND: Hypoxic Ischemic Encephalopathy (HIE) is a signifi cant cause of perinatal encephalopathy, affecting a substantial number of neonates.Therapeutic hypothermia (TH) has become a standard treatment, signifi cantly reducing mortali…
View article: A Case of Persistent Intra-Abdominal <i>Stenotrophomonas maltophilia</i> Infection Despite Bacteriophage Therapy
A Case of Persistent Intra-Abdominal <i>Stenotrophomonas maltophilia</i> Infection Despite Bacteriophage Therapy Open
Multidrug resistant infections are a challenge in the health care setting and a cause of patient morbidity and mortality. Bacteriophages (phages) are viruses that target and kill bacteria and have been used in patients to treat bacterial i…
View article: Editorial Board
Editorial Board Open
View article: Low Mortality Associated with COVID-19 Infection in Lung Transplant Recipients at a Single Center
Low Mortality Associated with COVID-19 Infection in Lung Transplant Recipients at a Single Center Open
Lung Transplant Recipients (LTR) are particularly vulnerable to severe infection, hospitalization, and death due to community acquired respiratory viruses. As a result, the global SARS-Cov-2 pandemic poses a higher risk to this population.…
View article: A simple solid media assay for detection of synergy between bacteriophages and antibiotics
A simple solid media assay for detection of synergy between bacteriophages and antibiotics Open
The emergence of antibiotic-resistant bacteria (ARB) has necessitated the development of alternative therapies to deal with this global threat. Bacteriophages (viruses that target bacteria) that kill ARB are one such alternative. Although …
View article: <i>Pseudomonas aeruginosa</i> ventricular assist device infections: findings from ineffective phage therapies in five cases
<i>Pseudomonas aeruginosa</i> ventricular assist device infections: findings from ineffective phage therapies in five cases Open
Left ventricular assist devices (LVAD) are increasingly used for management of heart failure; infection remains a frequent complication. Phage therapy has been successful in a variety of antibiotic refractory infections and is of interest …
View article: Considerations for the Use of Phage Therapy in Clinical Practice
Considerations for the Use of Phage Therapy in Clinical Practice Open
Increasing antimicrobial resistance and medical device-related infections have led to a renewed interest in phage therapy as an alternative or adjunct to conventional antimicrobials. Expanded access and compassionate use cases have risen e…
View article: Difference in immunosuppressant dose requirement when transitioning to isavuconazole from other azoles in thoracic transplant recipients
Difference in immunosuppressant dose requirement when transitioning to isavuconazole from other azoles in thoracic transplant recipients Open
The triazole antifungal isavuconazole (ISAVU) is used for prevention and treatment of fungal infections in solid organ transplant (SOT). SOT recipients commonly need to transition from one azole to another due to breakthrough infection, to…
View article: Wait Time Advantage for Transplant Candidates With HIV Who Accept Kidneys From Donors With HIV Under the HOPE Act
Wait Time Advantage for Transplant Candidates With HIV Who Accept Kidneys From Donors With HIV Under the HOPE Act Open
Background. Kidney transplant (KT) candidates with HIV face higher mortality on the waitlist compared with candidates without HIV. Because the HIV Organ Policy Equity (HOPE) Act has expanded the donor pool to allow donors with HIV (D + ), …
View article: Post‐acute sequelae of COVID‐19 in solid organ transplant recipients
Post‐acute sequelae of COVID‐19 in solid organ transplant recipients Open
Background Post‐acute sequelae of coronavirus disease 2019 (COVID‐19) (PASC), defined as prolonged symptoms following an episode of COVID‐19, is not well‐characterized in solid organ transplant recipients (SOTR). In this study, we aimed to…
View article: Phage Therapy in Lung Transplantation: Current Status and Future Possibilities
Phage Therapy in Lung Transplantation: Current Status and Future Possibilities Open
Patients with chronic lung disease and lung transplantation have high rates of colonization and infection from multidrug-resistant (MDR) organisms. This article summarizes the current state of knowledge regarding phage therapy in the setti…
View article: Changing paradigm: Transplanting candidates with coronavirus disease 2019
Changing paradigm: Transplanting candidates with coronavirus disease 2019 Open
The coronavirus disease 2019 (COVID-19) pandemic continues to adversely affect solid organ transplant candidates. The initial guidance from transplant societies for waitlisted candidates testing positive for the severe acute respiratory sy…
View article: A simple solid media assay for detection of synergy between bacteriophages and antibiotics
A simple solid media assay for detection of synergy between bacteriophages and antibiotics Open
The emergence of antibiotic resistant bacteria (ARB) has necessitated the development of alternative therapies to deal with this global threat. Bacteriophages (viruses that target bacteria) that kill ARB are one such alternative. While pha…
View article: Risk factors for breakthrough COVID‐19 infections in solid organ transplant recipients receiving tixagevimab/cilgavimab for pre‐exposure prophylaxis
Risk factors for breakthrough COVID‐19 infections in solid organ transplant recipients receiving tixagevimab/cilgavimab for pre‐exposure prophylaxis Open
View article: Living kidney donors with HIV: experience and outcomes from a case series by the HOPE in Action Consortium
Living kidney donors with HIV: experience and outcomes from a case series by the HOPE in Action Consortium Open
National Institute of Allergy and Infectious Diseases, National Institutes of Health.
View article: HIV-Positive Liver Transplant Does not Alter the Latent Viral Reservoir in Recipients With Antiretroviral Therapy-Suppressed HIV
HIV-Positive Liver Transplant Does not Alter the Latent Viral Reservoir in Recipients With Antiretroviral Therapy-Suppressed HIV Open
The latent viral reservoir (LVR) remains a major barrier to HIV-1 curative strategies. It is unknown whether receiving a liver transplant from a donor with HIV might lead to an increase in the LVR because the liver is a large lymphoid orga…
View article: A Retrospective, Observational Study of 12 Cases of Expanded-Access Customized Phage Therapy: Production, Characteristics, and Clinical Outcomes
A Retrospective, Observational Study of 12 Cases of Expanded-Access Customized Phage Therapy: Production, Characteristics, and Clinical Outcomes Open
Background Antimicrobial resistance (AMR) is undermining modern medicine, a problem compounded by bacterial adaptation to antibiotic pressures. Phages are viruses that infect bacteria. Their diversity and evolvability offer the prospect of…
View article: The 2023 International Society for Heart and Lung Transplantation Guidelines for Mechanical Circulatory Support: A 10- Year Update
The 2023 International Society for Heart and Lung Transplantation Guidelines for Mechanical Circulatory Support: A 10- Year Update Open
Project Leaders: Diyar Saeed, MD, PhD; David Feldman, MD, PhD and David D'Alessandro, MD Task Force 1 Co-Chairs: Guy MacGowan, MD and Palak Shah, MD, MS Contributing Writers: Manreet Kanwar, MD, Antonio Loforte, MD, Feras Khaliel, MD, Salp…
View article: Therapeutic Potential of Intravenous Phage as Standalone Therapy for Recurrent Drug-Resistant Urinary Tract Infections
Therapeutic Potential of Intravenous Phage as Standalone Therapy for Recurrent Drug-Resistant Urinary Tract Infections Open
Recurrent urinary tract infections (rUTI) are common in kidney transplant recipients (KTR) and are associated with multidrug resistance and increased morbidity/mortality. Novel antibiotic alternatives to reduce UTI recurrence are criticall…
View article: Diversified Repertoire of Phage Defenses in Klebsiella pneumoniae: Bi-Directional Steering Effects Impacting Antibiotic Susceptibility
Diversified Repertoire of Phage Defenses in Klebsiella pneumoniae: Bi-Directional Steering Effects Impacting Antibiotic Susceptibility Open
View article: 783. Lung Transplantation for COVID-19-Associated Lung Injury (CALI): An International Registry
783. Lung Transplantation for COVID-19-Associated Lung Injury (CALI): An International Registry Open
Background SARS-CoV-2 can result in a range of infections from asymptomatic disease to progressive COVID-19 and death. In some pts with CALI, lung transplantation (LTx) may be lifesaving. Up to 10% of LTx in the US is currently for pts wit…
View article: Diversified repertoire of phage resistance in<i>Klebsiella pneumoniae</i>and bidirectional steering effects impacting antibiotic susceptibility
Diversified repertoire of phage resistance in<i>Klebsiella pneumoniae</i>and bidirectional steering effects impacting antibiotic susceptibility Open
Bacteriophage (phage) therapy is rising as a promising anti-infective option to combat antimicrobial resistance; however, its clinical utilization is severely hindered by the potential emergence of phage resistance. Fortunately, certain ph…
View article: The effect of induction immunosuppression for kidney transplant on the latent HIV reservoir
The effect of induction immunosuppression for kidney transplant on the latent HIV reservoir Open
The HIV latent viral reservoir (LVR) remains a major challenge in the effort to find a cure for HIV. There is interest in lymphocyte-depleting agents, used in solid organ and bone marrow transplantation to reduce the LVR. This study evalua…
View article: A Pilot Trial for Prevention of Hepatitis C Virus Transmission From Donor to Organ Transplant Recipient With Short-Course Glecaprevir/Pibrentasvir
A Pilot Trial for Prevention of Hepatitis C Virus Transmission From Donor to Organ Transplant Recipient With Short-Course Glecaprevir/Pibrentasvir Open
A 7-day course of glecaprevir/pibrentasvir started in the preoperative period prevented transmission of hepatitis C virus (HCV) from viremic donors to 10 HCV-negative recipients (2 heart, 1 lung, 6 kidney, 1 heart/kidney) with 100% sustain…