Saima Kausar
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View article: Assessment of urinary oxidative stress biomarkers associated with fine particulate matter (PM2.5) exposure in Chiang Mai, Thailand
Assessment of urinary oxidative stress biomarkers associated with fine particulate matter (PM2.5) exposure in Chiang Mai, Thailand Open
Background Exposure to fine particulate matter (PM2.5) is known to increase oxidative stress, impacting health adversely. This study examines the relationship between PM2.5 exposure and oxidative stress biomarkers in Chiang Mai, Thailand. …
View article: Impact of fine particulate matter (PM2.5) on ocular health among people living in Chiang Mai, Thailand
Impact of fine particulate matter (PM2.5) on ocular health among people living in Chiang Mai, Thailand Open
View article: REVIEWING ADVANCES IN UNDERSTANDING AND TARGETING THE MAPK SIGNALING PATHWAY IN HEPATOCELLULAR CARCINOMA PROGRESSION AND THERAPEUTICS
REVIEWING ADVANCES IN UNDERSTANDING AND TARGETING THE MAPK SIGNALING PATHWAY IN HEPATOCELLULAR CARCINOMA PROGRESSION AND THERAPEUTICS Open
Hepatocellular carcinoma (HCC) is a severe and increasingly prevalent health issue affecting individuals globally. Recent research endeavors in the clinical domains have lately focused more on the MAPK signaling pathway in HCC. Activating …
View article: MicroRNAs reshape the immunity of insects in response to bacterial infection
MicroRNAs reshape the immunity of insects in response to bacterial infection Open
The interaction between bacteria and insects can significantly impact a wide range of different areas because bacteria and insects are widely distributed around the globe. The bacterial-insect interactions have the potential to directly af…
View article: The Potential Biological Roles of Circular RNAs in the Immune Systems of Insects to Pathogen Invasion
The Potential Biological Roles of Circular RNAs in the Immune Systems of Insects to Pathogen Invasion Open
Circular RNAs (circRNAs) are a newly discovered class of endogenously expressed non-coding RNAs (ncRNAs). They are highly stable, covalently closed molecules that frequently exhibit tissue-specific expression in eukaryotes. A small number …
View article: Comparative Analysis of the Efficacies of the GeneXpert and Solid Culture Media Techniques in the Diagnosis of Mycobacterium Tuberculosis.
Comparative Analysis of the Efficacies of the GeneXpert and Solid Culture Media Techniques in the Diagnosis of Mycobacterium Tuberculosis. Open
Tuberculosis is one of the predominant infectious diseases causing significant deaths worldwide. Detection of Mycobacterium tuberculosis bacilli (MTB) using culture media was officially recognized by World Health Organization. Howev…
View article: Antheraea pernyi Suppressor of Cytokine Signaling 2 Negatively Modulates the JAK/STAT Pathway to Attenuate Microbial Infection
Antheraea pernyi Suppressor of Cytokine Signaling 2 Negatively Modulates the JAK/STAT Pathway to Attenuate Microbial Infection Open
The Janus kinase (JAK) signal transducer and activator of transcription (STAT) pathway has been shown to govern various physiological processes, including immune responses, hematopoiesis, cell growth, and differentiation. Recent studies sh…
View article: Integrins in the Immunity of Insects: A Review
Integrins in the Immunity of Insects: A Review Open
Integrins are a large group of cell-surface proteins that are classified as transmembrane proteins. Integrins are classified into different types based on sequence variations, leading to structural and functional diversity. They are broadl…
View article: Molecular Identification of Two DNA Methyltransferase Genes and Their Functional Characterization in the Anti-Bacterial Immunity of Antheraea pernyi
Molecular Identification of Two DNA Methyltransferase Genes and Their Functional Characterization in the Anti-Bacterial Immunity of Antheraea pernyi Open
Under different physiological conditions, such as microbial infection, epigenetic mechanisms regulate genes at the transcription level in living organisms. DNA methylation is a type of epigenetic mechanism in which DNA methyltransferases m…
View article: The Emerging Role of STING in Insect Innate Immune Responses and Pathogen Evasion Strategies
The Emerging Role of STING in Insect Innate Immune Responses and Pathogen Evasion Strategies Open
Emerging evidence reveals that the stimulator of the interferon genes (STING) signaling pathway in insects and other animal cells helps them to sense and effectively respond to infection caused by numerous types of microbial pathogens. Rec…
View article: Transcriptome Sequencing Highlights the Regulatory Role of DNA Methylation in Immune-Related Genes’ Expression of Chinese Oak Silkworm, Antheraea pernyi
Transcriptome Sequencing Highlights the Regulatory Role of DNA Methylation in Immune-Related Genes’ Expression of Chinese Oak Silkworm, Antheraea pernyi Open
Antheraea pernyi is an important lepidopteran used as a model insect species to investigate immune responses, development, and metabolism modulation. DNA methylation has recently been found to control various physiological processes throug…
View article: The mitochondrial genome of Smerinthus planus (Lepidoptera: Sphingidae) and its comparative analysis with other Lepidoptera species
The mitochondrial genome of Smerinthus planus (Lepidoptera: Sphingidae) and its comparative analysis with other Lepidoptera species Open
In the present study, the complete mitochondrial genome of Smerinthus planus Walker (Lepidoptera: Sphingidae) was sequenced and analyzed to add additional traits for expanding our knowledge on systematics and phylogenetics of world-wide st…
View article: Mitochondrial DNA: A Key Regulator of Anti-Microbial Innate Immunity
Mitochondrial DNA: A Key Regulator of Anti-Microbial Innate Immunity Open
During the last few years, mitochondrial DNA has attained much attention as a modulator of immune responses. Due to common evolutionary origin, mitochondrial DNA shares various characteristic features with DNA of bacteria, as it consists o…
View article: The Roles of Sirtuin Family Proteins in Cancer Progression
The Roles of Sirtuin Family Proteins in Cancer Progression Open
Sirtuin family members are characterized by either mono-ADP-ribosyltransferase or deacylase activity and are linked to various cancer-related biological pathways as regulators of transcriptional progression. Sirtuins play fundamental roles…
View article: Immune strategies of silkworm, Bombyx mori against microbial infections
Immune strategies of silkworm, Bombyx mori against microbial infections Open
The silkworm, Bombyx mori has great economic and scientific value, as it has long been exploited as a primary silk producer and as a model system for lepidopterans and arthropod studies. This species is highly susceptible to microbial dise…
View article: Biological Functions and Molecular Mechanisms of Antibiotic Tigecycline in the Treatment of Cancers
Biological Functions and Molecular Mechanisms of Antibiotic Tigecycline in the Treatment of Cancers Open
As an FDA-approved drug, glycylcycline tigecycline has been used to treat complicated microbial infections. However, recent studies in multiple hematologic and malignant solid tumors reveal that tigecycline treatment induces cell cycle arr…
View article: Advances in Targeting the Epidermal Growth Factor Receptor Pathway by Synthetic Products and Its Regulation by Epigenetic Modulators as a Therapy for Glioblastoma
Advances in Targeting the Epidermal Growth Factor Receptor Pathway by Synthetic Products and Its Regulation by Epigenetic Modulators as a Therapy for Glioblastoma Open
Glioma is the most common primary tumor of the nervous system, and approximately 50% of patients exhibit the most aggressive form of the cancer, glioblastoma. The biological function of epidermal growth factor receptor (EGFR) in tumorigene…
View article: The Role of Mitochondria in Reactive Oxygen Species Generation and Its Implications for Neurodegenerative Diseases
The Role of Mitochondria in Reactive Oxygen Species Generation and Its Implications for Neurodegenerative Diseases Open
Mitochondria are dynamic cellular organelles that consistently migrate, fuse, and divide to modulate their number, size, and shape. In addition, they produce ATP, reactive oxygen species, and also have a biological role in antioxidant acti…
View article: Interaction of simulated acid rain and seed gall nematode Anguina tritici on wheat
Interaction of simulated acid rain and seed gall nematode Anguina tritici on wheat Open
In the present study, Interaction of different doses of SAR (pH 3.0, 4.0 and 5.0) with different inoculum levels of A. tritici showed varied responses on wheat plant.Both SAR and A. tritici interacted antagonistically.The wheat plants inoc…
View article: Spider Diversity in Some Common Oilseed Crops in Central Punjab, Pakistan
Spider Diversity in Some Common Oilseed Crops in Central Punjab, Pakistan Open
Three commonly cultivated oilseed crops viz., soybean, sunflower and Indian mustard weresampled to compare density and diversity of spider at different developmental stages. This study wasconducted at Ayub Agriculture Research Institute, F…
View article: Characterization and functional analysis of the serpin-10 gene from oak silkworm, Antheraea pernyi (Lepidoptera: Saturniidae)
Characterization and functional analysis of the serpin-10 gene from oak silkworm, Antheraea pernyi (Lepidoptera: Saturniidae) Open
Serpin is a broadly distributed superfamily of proteins that have a crucial role in regulating various immune reactions. Herein we identified a serpin-10 gene from Antheraea pernyi that encodes a 1557 amino acid residue protein with a pred…
View article: Toxic Effects of Chlorpyrifos on 12th Day Desi Chick Embryo (Gallus gallusdomesticus)
Toxic Effects of Chlorpyrifos on 12th Day Desi Chick Embryo (Gallus gallusdomesticus) Open
The toxicity and lethal effects, on the survival and developmental stages of Gallus gallusdomesticus, of widely used insecticides on the ticks and mites (Arachnida) was investigated. Fertilized eggs of Desihen (Gallus gallusdomesticus) at …
View article: Comparative mitochondrial genome analysis of Daphnis nerii and other lepidopteran insects reveals conserved mitochondrial genome organization and phylogenetic relationships
Comparative mitochondrial genome analysis of Daphnis nerii and other lepidopteran insects reveals conserved mitochondrial genome organization and phylogenetic relationships Open
In the present study, the complete sequence of the mitochondrial genome (mitogenome) of Daphnis nerii (Lepidoptera: Sphingidae) is described. The mitogenome (15,247 bp) of D.nerii encodes13 protein-coding genes (PCGs), 22 transfer RNA gene…
View article: Nitrogen level affects growth and reactive oxygen scavenging of fenugreek irrigated with wastewater
Nitrogen level affects growth and reactive oxygen scavenging of fenugreek irrigated with wastewater Open
Today, due to the constraint in availability of the freshwater for irrigation, wastewater is being used for irrigation of agriculture fields.Wastewater contain plant nutrients that favour crop growth but leave a burden of heavy metals whic…
View article: Characterization of the complete mitochondrial genome of Spilarctia robusta (Lepidoptera: Noctuoidea: Erebidae) and its phylogenetic implications
Characterization of the complete mitochondrial genome of Spilarctia robusta (Lepidoptera: Noctuoidea: Erebidae) and its phylogenetic implications Open
The complete mitochondrial genome (mitogenome) of Spilarctia robusta (Lepidoptera: Noctuoidea: Erebidae) was sequenced and analyzed. The circular mitogenome is made up of 15,447 base pairs (bp). It contains a set of 37 genes, with the gene…
View article: Teratological Effects of Dimethoate on 12th Day Desi Chick Embryo (Gallus gallus domesticus)
Teratological Effects of Dimethoate on 12th Day Desi Chick Embryo (Gallus gallus domesticus) Open