Explanipedia

Comparison of Breathing Exercise Vs Walking in Chain Smokers to Improve Lung Volume in Adults Open

Nidhi Rawat, Saima Wajid, Pushpendra Yaduvanshi · 2025

- Tobacco smoking is one of the most important public health problems and while global smoking prevalence has fallen, it is still common in many countries and causes a significant health burden worldwide. More than 8 million deaths per yea…

In-vitro assessment of anti-breast cancer potential of pumpkin seed oil nanoemulsion with mechanistic insights into cytotoxicity and apoptosis Open

Rupali Ghosh, Noor Fatima, Abul Vafa, Syed Meraj Azhar Rizvi, Saima Wajid · 2025

Breast cancer is the most prevalent malignancy in women with 16% of all cancer deaths and current therapies frequently resulting in significant adverse consequences. Pumpkin seed oil (PSO) possesses antibacterial, antiviral, cytotoxic, and…

From Biosensors to Robotics: Pioneering Advances in Breast Cancer Management Open

Mohd. Rahil Hasan, Mohd Mughees, Shifa Shaikh, Furqan Choudhary, Anam Nizam , et al. · 2024

Breast cancer stands as the most prevalent form of cancer amongst females, constituting more than one-third of all cancer cases affecting women. It causes aberrant cell development, which can assault or spread to other sections of the body…

Secretome analysis of breast cancer cells to identify potential target proteins of Ipomoea turpethum extract-loaded nanoparticles in the tumor microenvironment Open

Sanskriti Swami, Mohd Mughees, Irengbam Rocky Mangangcha, Sana Kauser, Saima Wajid · 2023

Background: Breast cancer is the leading cause of frequent malignancy and morbidity among women across the globe, with an increment of 0.5% incidences every year. The deleterious effects of traditional treatment on off-target surrounding c…

Multiomics Approach Reveal Novel Insights in FUS Driven Juvenile Amyotrophic Lateral Sclerosis: A Family Quartet Analysis Open

Sagar Verma, Shiffali Khurana, Mandaville Gourie‐Devi, Ish Anand, Yuvraj Vats , et al. · 2023

Background Juvenile amyotrophic lateral sclerosis (JALS) is a rare and severe form of motor neuron disease characterized by progressive loss of upper and lower motor neurons with an early onset (<25 years). Purpose Due to complex etiology …

Secretome profiling of Artemisia absinthium extract-loaded polymeric nanoparticle-treated MCF-7 and MDA-MB-231 revealed perturbation in microtubule assembly and cell migration Open

Sana Kauser, Mohd Mughees, Irengbam Rocky Mangangcha, Sanskriti Swami, Saima Wajid · 2023

Introduction Artemisia absinthium (wormwood) exhibits anticancer properties by inhibiting proliferation and causing cell death in breast cancer. Targeted drug delivery of A. absinthium nanoformulation using N-isopropyl acrylamide, N-vinyl …

Pre-clinical toxicity assessment of Artemisia absinthium extract-loaded polymeric nanoparticles associated with their oral administration Open

Sana Kauser, Mohd Mughees, Sanskriti Swami, Saima Wajid · 2023

Background: This study was designed to quantify the composition of the ethanolic extract of Artemisia absinthium through gas chromatography–mass spectrometry analysis and ensure in vivo safety of A. absinthium extract-loaded polymeric nano…

Evaluation of acute oral toxicity of Ipomoea turpethum extract loaded polymeric nanoparticles in Wistar rats Open

Sanskriti Swami, Mohd Mughees, Sana Kauser, Saima Wajid · 2023

Introduction: The amalgamation of novel drug delivery techniques and potential drugs is considered the most promising tool for the treatment of diseases. In our study, we have employed N-isopropyl acrylamide, N-vinyl pyrrolidone, and acryl…

Systemic aftermaths of tobacco addiction on the physiological composite of human secretome and the prognostic potential of U2AF26 in oral cancers Open

Sapna Khowal, Seema Monga, Samar Husain Naqvi, Saima Wajid · 2022

Objectives: Tobacco chewing and smoking practices have been a common trend among human populations. Tobacco addiction is a commonly known etiology for oral cancers. The study showcases a clinical case (I_5; a 36y male) with a chronic infla…

Chemokines and cytokines: Axis and allies in prostate cancer pathogenesis Open

Mohd Mughees, Jyoti Kaushal, Gunjan Sharma, Saima Wajid, Surinder K. Batra , et al. · 2022

The potential role of U2AF1L4 cDNA 3’ stretch mutations in oral carcinogenesis Open

Sapna Khowal, Saima Wajid · 2022

Molecular winnowing, expressional analyses and interactome scrutiny of cellular proteomes of oral squamous cell carcinoma Open

Sapna Khowal, Seema Monga, Samar Husain Naqvi, Swatantra Kumar Jain, Saima Wajid · 2021

Elevated Expression of Cytosolic Phospholipase A2 Delta Is Associated with Lipid Metabolism Dysregulation during Hepatocellular Carcinoma Progression. Open

Maryam Ranjpour, Saima Wajid, Swatantra Kumar Jain · 2020

This study suggests that elevation in the expression of cytosolic phospholipase A2 delta is associated with progression of HCC.

Artemisia absinthium nanoparticles induce apoptosis in breast cancer cells via inhibiting vesicular trafficking related proteins Open

Mohd Mughees, Saima Wajid · 2019

Biophysical Characterization and Drug Delivery Potential of Exosomes from Human Wharton’s Jelly-Derived Mesenchymal Stem Cells Open

Neha Chopra, Brahamdutt Arya, Namrata G. Jain, Poonam Yadav, Saima Wajid , et al. · 2019

Cell-derived exosomes (30-200 nm) as biological "nanocarriers" have attracted a great deal of interest for therapeutic applications due to their ability to internalize in in vivo biological systems (i.e., cells). Although they can be harve…

Comparative analysis of homologous aminopeptidase PepN from pathogenic and non-pathogenic mycobacteria reveals divergent traits Open

Nishant Sharma, Suruchi Aggarwal, Saravanan Kumar, Rahul Sharma, Konika Choudhury , et al. · 2019

Mycobacterium tuberculosis (Mtb) secretes proteases and peptidases to subjugate its host. Out of its sixty plus proteases, atleast three are reported to reach host macrophages. In this study, we show that Mtb also delivers a lysyl alanine …

Mtb and Msm PepNs share high degree of sequence identity.pdf Open

Nishant Sharma, Suruchi Aggarwal, Saravanan Kumar, Rahul Sharma, Konika Choudhury , et al. · 2019

Mtb and Msm PepNs share high degree of sequence identity

Correction: Identification of protein targets and the mechanism of the cytotoxic action of <i>Ipomoea turpethum</i> extract loaded nanoparticles against breast cancer cells Open

Mohd Mughees, Mohd Samim, Yadhu Sharma, Saima Wajid · 2019

Correction for ‘Identification of protein targets and the mechanism of the cytotoxic action of Ipomoea turpethum extract loaded nanoparticles against breast cancer cells’ by Mohd Mughees et al., J. Mater. Chem. B, 2019, 7, 6048–6063.

Mtb and Msm PepNs share high degree of sequence identity.pdf Open

Nishant Sharma, Suruchi Aggarwal, Saravanan Kumar, Rahul Sharma, Konika Choudhury , et al. · 2019

Mtb and Msm PepNs share high degree of sequence identity

Lipase Precursor-Like Protein Promotes Miltefosine Tolerance in Leishmania donovani by Enhancing Parasite Infectivity and Eliciting Anti-inflammatory Responses in Host Macrophages Open

Deepak Kumar Deep, Ruchi Singh, Arpita Kulshrestha, Saima Wajid, Poonam Salotra · 2018

The oral drug miltefosine (MIL) was introduced in the Indian subcontinent in the year 2002 for the treatment of visceral leishmaniasis (VL). However, recent reports on its declining efficacy and increasing relapse rates pose a serious conc…

Artemisia absinthium extract loaded polymeric nanoparticles as the therapeutic remedy for breast cancer Open

Mohd Mughees, Mohd Samim, Saima Wajid · 2018

Increased miltefosine tolerance in clinical isolates of Leishmania donovani is associated with reduced drug accumulation, increased infectivity and resistance to oxidative stress Open

Deepak Kumar Deep, Ruchi Singh, Vasundhra Bhandari, Aditya Verma, Vanila Sharma , et al. · 2017

The present study highlights the parasitic factors and pathways responsible for miltefosine unresponsiveness in VL and PKDL.

Molecular Characterization of Insulin Gene in Diabetic Foot Ulcer Patients: A Pilot Study from Bengal Bay Coastal Origin Open

Ahmad Fazilat, Swarupa R. Didla, Myla S. Chakravarty, Saima Wajid · 2017

Objective: Many studies have showed that foot ulcer is the most frequent occurrence among diabetic patients in the south Indian origin. This study aimed to investigate on the hypothesis that in patients with diabetic foot ulcer in south In…

Engineered Production of Short Chain Fatty Acid in Escherichia coli Using Fatty Acid Synthesis Pathway Open

Kamran Jawed, Anu Jose Mattam, Zia Fatma, Saima Wajid, Malik Zainul Abdin , et al. · 2016

Short-chain fatty acids (SCFAs), such as butyric acid, have a broad range of applications in chemical and fuel industries. Worldwide demand of sustainable fuels and chemicals has encouraged researchers for microbial synthesis of SCFAs. In …

A Constitutive Expression System for Cellulase Secretion in Escherichia coli and Its Use in Bioethanol Production Open

Neha Munjal, Kamran Jawed, Saima Wajid, Syed Shams Yazdani · 2015

The production of biofuels from lignocellulosic biomass appears to be attractive and viable due to the abundance and availability of this biomass. The hydrolysis of this biomass, however, is challenging because of the complex lignocellulos…

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