Explanipedia

HDM-FH treatment during static cold storage protects against ischaemic injury in a simulated kidney transplant model Open

Beth Gibson, Chloe Connelly, Samuel J Tingle, Grace Mallett, Harriet Denton , et al. · 2025

Precision-cut tumor slices for modeling hepatocellular carcinoma enable at-scale drug screening Open

Amy Collins, Keara Kirkness, Erik Ramon‐Gil, Eleni Tzortzopoulou, Daniel Geh , et al. · 2025

Background: Disease modeling is vital for our understanding of disease mechanisms and for developing new therapeutic strategies. Accurately modeling the intact tumor microenvironment (TME) is increasingly recognized as essential for gainin…

Evoked compound action potential (ECAP)-controlled closed-loop spinal cord stimulation in an experimental model of neuropathic pain in rats Open

Eline Versantvoort, Birte Dietz, Dave Mugan, Quoc C. Vuong, Saimir Luli , et al. · 2024

Background Preclinical models of spinal cord stimulation (SCS) are lacking objective measurements to inform translationally applicable SCS parameters. The evoked compound action potential (ECAP) represents a measure of dorsal column fiber …

Synthesis and preclinical evaluation of a 89Zr-labelled human single chain antibody for non-invasive detection of hepatic myofibroblasts in acute liver injury Open

Toni A. Pringle, Erik Ramon‐Gil, Jack Leslie, Fiona Oakley, Matthew C. Wright , et al. · 2024

Synaptophysin is expressed on fibrogenic hepatic myofibroblasts. C1–3 is a single chain human antibody (scAb) that binds specifically to synaptophysin on hepatic myofibroblasts, providing a targeting vector for novel in vivo imaging agents…

Synthesis and In Vitro Evaluation of a HER2-Specific ImmunoSCIFI Probe Open

Katie Gristwood, Saimir Luli, Kenneth S. Rankin, James C. Knight · 2023

Secondary Cerenkov-induced fluorescence imaging (SCIFI) is an emerging biomedical optical imaging modality that leverages Cerenkov luminescence, primarily generated by β-emitting radioisotopes, to excite fluorophores that offer near-infrar…

Assessing the potential application of bacteria-based self-healing cementitious materials for enhancing durability of wastewater treatment infrastructure Open

Manpreet Bagga, Ismael Justo-Reinoso, Charlotte Hamley‐Bennett, George Merces, Saimir Luli , et al. · 2023

Impact of retrotransposon protein L1 ORF1p expression on oncogenic pathways in hepatocellular carcinoma: the role of cytoplasmic PIN1 upregulation Open

Bassier Zadran, Praveen Dhondurao Sudhindar, Daniel Wainwright, Yvonne Bury, Saimir Luli , et al. · 2023

Background Molecular characterisation of hepatocellular carcinoma (HCC) is central to the development of novel therapeutic strategies for the disease. We have previously demonstrated mutagenic consequences of Long-Interspersed Nuclear Elem…

Table of Contents Open

Emily Essex, Martha B. Furie, Jin‐Yih Low, Minjeong Ko, Brian Hanratty , et al. · 2022

Claspin haploinsufficiency leads to defects in fertility, hyperplasia and an increased oncogenic potential Open

Suzanne Madgwick, Saimir Luli, Hélène Sellier, Jacqueline Butterworth, Jack Leslie , et al. · 2022

Claspin is an adaptor protein required for ATR-dependent phosphorylation of CHK1 during S-phase following DNA replication stress. Claspin expression is highly variable in cancer, with low levels frequently correlating with poor patient sur…

Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway Open

Jill V. Hunter, A. Campbell, Nicola Hannaway, Scott Kerridge, Saimir Luli , et al. · 2022

Previously, we discovered that deletion of c-Rel in the Eµ-Myc mouse model of lymphoma results in earlier onset of disease, a finding that contrasted with the expected function of this NF-κB subunit in B-cell malignancies. Here we report t…

Mutation of the RelA(p65) Thr505 phosphosite disrupts the DNA replication stress response leading to CHK1 inhibitor resistance Open

Jill V. Hunter, A. Campbell, Jacqueline Butterworth, Hélène Sellier, Nicola Hannaway , et al. · 2022

DNA replication stress resulting from the activity of oncogenes such as MYC, is a common feature of cancer cells. To cope with this challenge, tumours become addicted to ATR/CHK1 signalling, thus making these kinases attractive targets for…

Up-regulation of the PI3K/AKT and RHO/RAC/PAK signalling pathways in CHK1 inhibitor resistant Eµ-Myc lymphoma cells Open

Jill V. Hunter, A. Campbell, Scott Kerridge, Callum J. Fraser, Nicola Hannaway , et al. · 2022

The development of resistance and the activation of bypass pathway signalling represents a major problem for the clinical application of protein kinase inhibitors. While investigating the effect of either a c-Rel deletion or RelAT505A phos…

Anti–Cholestatic Therapy with Obeticholic Acid Improves Short-Term Memory in Bile Duct–Ligated Mice Open

Lucy Gee, Ben Barron‐Millar, Jack Leslie, Claire Richardson, Marco Y. W. Zaki , et al. · 2022

Synthesis and In Vivo Evaluation of a Site-specifically Labeled Radioimmunoconjugate for Dual-Modal (PET/NIRF) Imaging of MT1-MMP in Sarcomas Open

Toni A. Pringle, Corey D. Chan, Saimir Luli, Helen J. Blair, Kenneth S. Rankin , et al. · 2022

Bone sarcomas are devastating primary bone cancers that mostly affect children, young adults, and the elderly. These aggressive tumors are associated with poor survival, and surgery remains the mainstay of treatment. Surgical planning is i…

CXCR2 inhibition enables NASH-HCC immunotherapy Open

Jack Leslie, John B. G. Mackey, Thomas Jamieson, Erik Ramon‐Gil, Thomas M. Drake , et al. · 2022

Objective Hepatocellular carcinoma (HCC) is increasingly associated with non-alcoholic steatohepatitis (NASH). HCC immunotherapy offers great promise; however, recent data suggests NASH-HCC may be less sensitive to conventional immune chec…

Observations of root growth in stratified soils at the microscopic scale: Insights from micro-computed tomography Open

Sadegh Nadimi, Nina Kemp, Vasileios Angelidakis, Saimir Luli · 2022

Enhancing the overall resilience of vegetated slopes against shallow mass movement can be achieved by better understanding soil-root interaction.  To predict the behaviour of vegetated slopes during design, parameters rep…

CXCR2 inhibition enables NASH-HCC immunotherapy Open

Jack Leslie, John B. G. Mackey, Thomas Jamieson, Erik Ramon‐Gil, Thomas M. Drake , et al. · 2022

Objective Hepatocellular carcinoma (HCC) is increasingly associated with non-alcoholic steatohepatitis (NASH). HCC immunotherapy offers great promise; however, recent data suggests NASH-HCC may be less sensitive to conventional immune chec…

How Do Roots Interact with Layered Soils? Open

Nina Kemp, Vasileios Angelidakis, Saimir Luli, Sadegh Nadimi · 2022

Vegetation alters soil fabric by providing biological reinforcement and enhancing the overall mechanical behaviour of slopes, thereby controlling shallow mass movement. To predict the behaviour of vegetated slopes, parameters representing …

In situ excitation of BODIPY fluorophores by 89Zr-generated Cerenkov luminescence Open

Katie Gristwood, Saimir Luli, Kenneth S. Rankin, James C. Knight · 2022

Secondary Cerenkov-induced fluorescence imaging (SCIFI) is an emerging optical imaging modality that affords high signal-to-noise images. This report examines the utility of BODIPY fluorophores in SCIFI applications using 89 Zr-generated C…

Homodimeric Minimal Factor H: In Vivo Tracking and Extended Dosing Studies in Factor H Deficient Mice Open

Ola Kamala, Talat H. Malik, Thomas M Hallam, Thomas E. Cox, Yi Yang , et al. · 2021

C3 glomerulopathy (C3G) is associated with dysregulation of the alternative pathway (AP) of complement and treatment options remain inadequate. Factor H (FH) is a potent regulator of the AP. An in-depth analysis of FH-related protein dimer…

Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway Open

Jill V. Hunter, A. Campbell, Nicola Hannaway, Scott Kerridge, Saimir Luli , et al. · 2021

We previously discovered that deletion of c-Rel in the Eμ-Myc mouse model of lymphoma results in earlier onset of disease, a finding that contrasted with the expected function of this NF-κB subunit in B-cell malignancies. Here we report th…

Non-invasive synchronous monitoring of neutrophil migration using whole body near-infrared fluorescence-based imaging Open

Jack Leslie, Stuart Robinson, Fiona Oakley, Saimir Luli · 2021

Imaging the root–rhizosphere interface using micro computed tomography: quantifying void ratio and root volume ratio profiles Open

Tomás Lascurain, Vasileios Angelidakis, Saimir Luli, Sadegh Nadimi · 2021

Root growth alters soil fabric and consequently its mechanical and physical properties. Recent studies show that roots induce compaction of soil in their immediate vicinity, a region that is central for plant health. However, high quality …

Author Correction: c-Rel orchestrates energy-dependent epithelial and macrophage reprogramming in fibrosis Open

Jack Leslie, Marina García‐Macía, Saimir Luli, Julie C. Worrell, William J. Reilly , et al. · 2020

c-Rel orchestrates energy-dependent epithelial and macrophage reprogramming in fibrosis Open

Jack Leslie, Marina García‐Macía, Saimir Luli, Julie C. Worrell, William J. Reilly , et al. · 2020

FPR-1 is an important regulator of neutrophil recruitment and a tissue-specific driver of pulmonary fibrosis Open

Jack Leslie, Ben Millar, Alicia del Carpio Pons, Rachel A. Burgoyne, Joseph D. Frost , et al. · 2020

Neutrophils are the most abundant inflammatory cells at the earliest stages of wound healing and play important roles in wound repair and fibrosis. Formyl peptide receptor 1 (FPR-1) is abundantly expressed on neutrophils and has been shown…

Loss of Endothelial Endoglin Promotes High-Output Heart Failure Through Peripheral Arteriovenous Shunting Driven by VEGF Signaling Open

Simon Tual‐Chalot, Maria Garcia-Collado, Rachael E. Redgrave, Esha Singh, Benjamin Davison , et al. · 2019

Rationale: ENG (endoglin) is a coreceptor for BMP (bone morphogenetic protein) 9/10 and is strongly expressed in endothelial cells. Mutations in ENG lead to the inherited vascular disorder hereditary hemorrhagic telangiectasia characterize…

Fibrogenic Activity of MECP2 Is Regulated by Phosphorylation in Hepatic Stellate Cells Open

Eva Morán‐Salvador, Marina García‐Macía, Ashwin Sivaharan, Laura Sabater, Marco Y. W. Zaki , et al. · 2019

Regulation of checkpoint kinase signalling and tumorigenesis by the NF-κB regulated gene, CLSPN Open

Jill V. Hunter, Jacqueline Butterworth, Hélène Sellier, Saimir Luli, Achilleas Floudas , et al. · 2018

Inhibition of the tumour promoting activities of NF-κB by cell signalling pathways has been proposed as a natural mechanism to limit the development of cancer. However, there has been a lack of evidence for these effects in vivo . Here we …

A Proof-of-Concept for Epigenetic Therapy of Tissue Fibrosis: Inhibition of Liver Fibrosis Progression by 3-Deazaneplanocin A Open

Müjdat Zeybel, Saimir Luli, Laura Sabater, Timothy Hardy, Fiona Oakley , et al. · 2017

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