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View article: COVID-19 serological survey utilizing antenatal serum samples in British Columbia
COVID-19 serological survey utilizing antenatal serum samples in British Columbia Open
The COVID-19 pandemic, caused by SARS-CoV-2, highlighted the need for accurate and timely data on virus spread and immune responses at a population level. Serological surveys offer a comprehensive view of population-level immune response t…
View article: Effectiveness of VSV vectored SARS-CoV-2 spike when administered through intranasal, intramuscular or a combination of both
Effectiveness of VSV vectored SARS-CoV-2 spike when administered through intranasal, intramuscular or a combination of both Open
A critical feature of the VSV vector platform is the ability to pseudotype the virus with different glycoproteins from other viruses, thus altering cellular tropism of the recombinant virus. The route of administration is critical in trigg…
View article: Cross protection to SARS-CoV-2 variants in hamsters with naturally-acquired immunity
Cross protection to SARS-CoV-2 variants in hamsters with naturally-acquired immunity Open
Since SARS-CoV-2 was first reported in late 2019, multiple variations of the original virus have emerged. Each variant harbors accumulations of mutations, particularly within the spike glycoprotein, that are associated with increased viral…
View article: Arsenal of nanobodies shows broad-spectrum neutralization against SARS-CoV-2 variants of concern in vitro and in vivo in hamster models
Arsenal of nanobodies shows broad-spectrum neutralization against SARS-CoV-2 variants of concern in vitro and in vivo in hamster models Open
Nanobodies offer several potential advantages over mAbs for the control of SARS-CoV-2. Their ability to access cryptic epitopes conserved across SARS-CoV-2 variants of concern (VoCs) and feasibility to engineer modular, multimeric designs,…
View article: Arsenal of Nanobodies for Broad-Spectrum Countermeasures against Current and Future SARS-CoV-2 Variants of Concerns
Arsenal of Nanobodies for Broad-Spectrum Countermeasures against Current and Future SARS-CoV-2 Variants of Concerns Open
Nanobodies offer several potential advantages over mAbs for the control of SARS-CoV-2. Their ability to access cryptic epitopes conserved across SARS-CoV-2 variants of concern (VoCs) and feasibility to engineer modular, multimeric designs,…
View article: Decolonization of STEM in the Public Education System in Québec, Canada
Decolonization of STEM in the Public Education System in Québec, Canada Open
Indigenous representation in science, technology, engineering, and mathematics (STEM) is crucial for reconciliation, self-determination, and inclusive and equitable science policy. Indigenous people continue to be underrepresented in Canad…
View article: Artificial Intelligence Alongside Physicians in Canada: Reality and Risks
Artificial Intelligence Alongside Physicians in Canada: Reality and Risks Open
Artificial intelligence (AI) and machine learning (ML) have the potential to revolutionize the healthcare system with their immense potential to diagnose, personalize treatments, and reduce physician burnout. These technologies are highly …
View article: Differential Pressures of SERINC5 and IFITM3 on HIV-1 Envelope Glycoprotein over the Course of HIV-1 Infection
Differential Pressures of SERINC5 and IFITM3 on HIV-1 Envelope Glycoprotein over the Course of HIV-1 Infection Open
HIV-1 Env protein is exposed to the inhibition not only by humoral response, but also by host restriction factors, including serine incorporator 5 (SERINC5) and interferon-inducible transmembrane 3 (IFITM3). This study investigates how HIV…
View article: HIV-1 Envelope Glycoprotein at the Interface of Host Restriction and Virus Evasion
HIV-1 Envelope Glycoprotein at the Interface of Host Restriction and Virus Evasion Open
Without viral envelope proteins, viruses cannot enter cells to start infection. As the major viral proteins present on the surface of virions, viral envelope proteins are a prominent target of the host immune system in preventing and ultim…
View article: Effect of HIV-1 Env on SERINC5 Antagonism
Effect of HIV-1 Env on SERINC5 Antagonism Open
SERINC5 is able to restrict HIV-1 infection by drastically impairing the infectivity of viral particles. Studies have shown that the HIV-1 Nef protein counters SERINC5 through downregulating SERINC5 from the cell surface and preventing the…