Saisai Wei
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View article: Nuclear accumulation of YTHDF1 regulates mRNA splicing in the DNA damage response
Nuclear accumulation of YTHDF1 regulates mRNA splicing in the DNA damage response Open
YTH domain–containing family protein 1 (YTHDF1), a reader of N6-methyladenosine (m 6 A), has been implicated in regulating RNA metabolism in the cytosol. Here, we report a role of YTHDF1 within the nucleus in response to genotoxic stress. …
View article: Transcriptome-wide mapping of N3-methylcytidine modification at single-base resolution
Transcriptome-wide mapping of N3-methylcytidine modification at single-base resolution Open
3-Methylcytidine (m3C), a prevalent modification of transfer RNAs (tRNAs), was recently identified in eukaryotic messenger RNAs (mRNAs). However, its precise distribution and formation mechanisms in mRNAs remain elusive. Here, we develop a…
View article: <strong>Activation of METTL3 promotes white adipose tissue beiging and combats obesity</strong>
<strong>Activation of METTL3 promotes white adipose tissue beiging and combats obesity</strong> Open
The induction of beige adipocytes in white adipose tissue, also known as WAT beiging, improves glucose and lipid metabolism. However, the regulation of WAT beiging at the posttranscriptional level remains to be studied. Here, we report tha…
View article: Activation of METTL3 Promotes White Adipose Tissue Beiging and Combats Obesity
Activation of METTL3 Promotes White Adipose Tissue Beiging and Combats Obesity Open
The induction of beige adipocytes in white adipose tissue (WAT), also known as WAT beiging, improves glucose and lipid metabolism. However, the regulation of WAT beiging at the posttranscriptional level remains to be studied. Here, we repo…
View article: <strong>Activation of METTL3 promotes white adipose tissue beiging and combats obesity</strong>
<strong>Activation of METTL3 promotes white adipose tissue beiging and combats obesity</strong> Open
The induction of beige adipocytes in white adipose tissue, also known as WAT beiging, improves glucose and lipid metabolism. However, the regulation of WAT beiging at the posttranscriptional level remains to be studied. Here, we report tha…
View article: Adipocyte YTH N(6)-methyladenosine RNA-binding protein 1 protects against obesity by promoting white adipose tissue beiging in male mice
Adipocyte YTH N(6)-methyladenosine RNA-binding protein 1 protects against obesity by promoting white adipose tissue beiging in male mice Open
Obesity, one of the most serious public health issues, is caused by the imbalance of energy intake and energy expenditure. N(6)-methyladenosine (m 6 A) RNA modification has been recently identified as a key regulator of obesity, while the …
View article: Interplay between liver circadian rhythm and regeneration after PHx
Interplay between liver circadian rhythm and regeneration after PHx Open
Diurnal oscillations in gene expression are a hallmark of the liver internal clock and can be regulated by a variety of environmental stimuli. The circadian rhythm and liver regeneration (LR) are intimately linked. However, how they affect…
View article: Ribosome profiling reveals translatome remodeling in cancer cells in response to zinc oxide nanoparticles
Ribosome profiling reveals translatome remodeling in cancer cells in response to zinc oxide nanoparticles Open
The anticancer effect of zinc oxide nanoparticles (ZnO NPs) largely relies on cellular responses such as alteration of gene expression. Although ZnO NPs have been reported to induce transcriptional changes, the potential of ZnO NPs to affe…
View article: GSK923295 as a potential antihepatocellular carcinoma agent causing delay on liver regeneration after partial hepatectomy
GSK923295 as a potential antihepatocellular carcinoma agent causing delay on liver regeneration after partial hepatectomy Open
The anticancer drug GSK923295 causes a significant delay on HCC tumor growth and liver regeneration after PH in later stage.