Explanipedia

Insulin acts on astrocytes to shift their substrate preference to fatty acids Open

Bouchra Taïb, Pragney Deme, Sujasha Gupta, Seung Wan Yoo, Saja S. Khuder , et al. · 2025

FKBP51 Null Mice Are Resistant to Diet-Induced Obesity and the PPARγ Agonist Rosiglitazone Open

Lance A. Stechschulte, Bin Qiu, Manya Warrier, Terry D. Hinds, Man Zhang , et al. · 2024

FK506-binding protein-51 (FKBP51) is a molecular cochaperone recently shown to be a positive regulator of peroxisome proliferator-activated receptor (PPAR)γ, the master regulator of adipocyte differentiation and function. In cellular model…

Insulin Sensitivity Is Retained in Mice with Endothelial Loss of Carcinoembryonic Antigen Cell Adhesion Molecule 1 Open

Harrison T. Muturi, Saja S. Khuder, Hilda E. Ghadieh, Emily Esakov, Hye Lim Noh , et al. · 2021

CEACAM1 regulates endothelial barrier integrity. Because insulin signaling in extrahepatic target tissues is regulated by insulin transport through the endothelium, we aimed at investigating the metabolic role of endothelial CEACAM1. To th…

Inhibition of neutral sphingomyelinase 2 promotes remyelination Open

Seung-Wan Yoo, Amit Agarwal, Matthew D. Smith, Saja S. Khuder, Emily G. Baxi , et al. · 2020

Targeting a sphingomyelin hydrolase improves the structure of remyelinated fibers in a mouse model of multiple sclerosis.

Loss of Ceacam1 promotes prostate cancer progression in Pten haploinsufficient male mice Open

Jehnan Liu, Harrison T. Muturi, Saja S. Khuder, Raghd Abu Helal, Hilda E. Ghadieh , et al. · 2020

Loss of function variants in<i>PCYT1A</i>causing spondylometaphyseal dysplasia with cone/rod dystrophy have broad consequences on lipid metabolism, chondrocyte differentiation, and lipid droplet formation Open

Julie A. Jurgens, Suming Chen, Nara Sobreira, Sarah M. Robbins, Arianna F. Anzmann , et al. · 2019

Spondylometaphyseal dysplasia with cone-rod dystrophy (SMD-CRD) is a rare autosomal recessive disorder of the skeleton and the retina caused by biallelic variants in PCYT1A , encoding the nuclear enzyme CTP:phosphocholine cytidylyltransfer…

Inhibition of neutral sphingomyelinase-2 facilitates remyelination Open

Seung-Wan Yoo, Amit Agarwal, Matthew D. Smith, Saja S. Khuder, Emily G. Baxi , et al. · 2019

For reasons that are not completely understood, remyelination is often incomplete, producing thin myelin sheaths with disorganized structure. We investigated the cellular basis for this altered myelin structure, and found that the response…

SAT-174 Loss of CEACAM1 in Endothelial Cells Causes Hepatic Fibrogenesis Open

Harrison T. Muturi, Saja S. Khuder, Hilda E. Ghadieh, Raghd Abu Helal, Hannah Stankus , et al. · 2019

Carcinoembryonic Antigen-related Cell Adhesion Molecule 1 (CEACAM1) has been implicated in physiological processes in the metabolic as well as in the vascular systems, as supported by the cardiometabolic abnormalities associated with insul…

Impaired insulin sensitivity is associated with worsening cognition in HIV-infected patients Open

Saja S. Khuder, Suming Chen, Scott L. Letendre, Thomas D. Marcotte, Igor Grant , et al. · 2019

These findings suggest that hyperinsulinemia and impaired insulin sensitivity are associated with cognitive decline in antiretroviral therapy-treated HIV-infected patients.

Pharmacokinetics of Intranasal versus Subcutaneous Insulin in the Mouse Open

Michael T. Nedelcovych, Alexandra J. Gadiano, Ying Wu, Arena A. Manning, Ajit G. Thomas , et al. · 2017

Insulin delivery to the brain has emerged as an important therapeutic target for cognitive disorders associated with abnormal brain energy metabolism. Although insulin is transported across the blood-brain barrier, peripheral routes of adm…

Exenatide induces carcinoembryonic antigen‐related cell adhesion molecule 1 expression to prevent hepatic steatosis Open

Hilda E. Ghadieh, Harrison T. Muturi, Lucia Russo, Christopher C. Marino, Simona S. Ghanem , et al. · 2017

Exenatide, a glucagon‐like peptide‐1 receptor agonist, induces insulin secretion. Its role in insulin clearance has not been adequately examined. Carcinoembryonic antigen‐related cell adhesion molecule 1 (CEACAM1) promotes hepatic insulin …

FKBP51 Null Mice Are Resistant to Diet-Induced Obesity and the PPARγ Agonist Rosiglitazone Open

Lance A. Stechschulte, Bin Qiu, Manya Warrier, Terry D. Hinds, Man Zhang , et al. · 2016

FK506-binding protein-51 (FKBP51) is a molecular cochaperone recently shown to be a positive regulator of peroxisome proliferator-activated receptor (PPAR)γ, the master regulator of adipocyte differentiation and function. In cellular model…

Author Index Open

Simon L. Abdallah, Beatriz Álvarez, Matthew Andrusiak, B Bachovchin, Badu-Nkansah Akosua , et al. · 2016

PPARα (Peroxisome Proliferator-activated Receptor α) Activation Reduces Hepatic CEACAM1 Protein Expression to Regulate Fatty Acid Oxidation during Fasting-refeeding Transition Open

Sadeesh K. Ramakrishnan, Saja S. Khuder, Qusai Y. Al–Share, Lucia Russo, Simon L. Abdallah , et al. · 2016

Regulation of expression of CEACAM1 and functional correlation in metabolic diseases Open

Saja S. Khuder · 2016

Hepatic CEACAM1 Over-Expression Protects Against Diet-Induced Fibrosis and Inflammation in White Adipose Tissue Open

Sumona Ghosh Lester, Lucia Russo, Simona S. Ghanem, Saja S. Khuder, Anthony M. DeAngelis , et al. · 2015

CEACAM1 promotes insulin extraction, an event that occurs mainly in liver. Phenocopying global Ceacam1 null mice (Cc1(-/-) ), C57/BL6J mice fed a high-fat (HF) diet exhibited reduced hepatic CEACAM1 levels and impaired insulin clearance, f…

High-calorie diet exacerbates prostate neoplasia in mice with haploinsufficiency of Pten tumor suppressor gene Open

Jehnan Liu, Sadeesh K. Ramakrishnan, Saja S. Khuder, Meenakshi Kaw, Harrison T. Muturi , et al. · 2015

High-calorie diet promotes prostate cancer progression in the genetically susceptible Pten haploinsufficient mouse while preserving insulin sensitivity. This appears to be partly due to increased inflammatory response to high-caloric intak…

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