Sajad Jeddi
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View article: Sex- and Dose-Dependent Effect of L-Citrulline on Body Weight and Food Intake in Obese Type 2 Diabetic Rats
Sex- and Dose-Dependent Effect of L-Citrulline on Body Weight and Food Intake in Obese Type 2 Diabetic Rats Open
Background: Obesity and type 2 diabetes (T2D) are associated with nitric oxide (NO) deficiency. L-citrulline (Cit), a substrate for NO synthesis, has been suggested as a treatment for obesity and T2D. Objectives: This study aims to determi…
View article: Association of serum zinc concentration with multiple surrogates of insulin resistance in a population-based study
Association of serum zinc concentration with multiple surrogates of insulin resistance in a population-based study Open
View article: The Effect of Hyperoxia on Nitric Oxide Metabolism in the Skeletal Muscle of Male Type 2 Diabetic Rats
The Effect of Hyperoxia on Nitric Oxide Metabolism in the Skeletal Muscle of Male Type 2 Diabetic Rats Open
Introduction Hypoxia is involved in the pathophysiology of type 2 diabetes (T2D), and oxygen therapy (hyperoxia) has been proposed for managing T2D. As a side effect, hyperoxia increases nitric oxide (NO) metabolism and decreases NO bioava…
View article: The potential role of nitrate, a nitric oxide donor, in the prevention and treatment of diabetic osteoporosis
The potential role of nitrate, a nitric oxide donor, in the prevention and treatment of diabetic osteoporosis Open
Approximately 28% of individuals with diabetes have osteoporosis. Diabetoporosis, which refers to the diabetes-related decrease in bone quality and quantity, increases the risk of osteoporotic fractures by 600-700% in individuals with type…
View article: Long-term nitrate administration modulates sialin gene expression in the main tissues of male Wistar rats with type 2 diabetes
Long-term nitrate administration modulates sialin gene expression in the main tissues of male Wistar rats with type 2 diabetes Open
The increased sialin gene expression in the main tissues of diabetic rats is associated with decreased nitrate and nitrite levels, suggesting a counterregulatory response for reduced nitric oxide (NO) bioavailability. In this study, we hyp…
View article: Dose-dependent long-term effects of nitrate on lipid profile in male rats
Dose-dependent long-term effects of nitrate on lipid profile in male rats Open
Background. This study aims to investigate the long-term effects of different doses of nitrate on the lipid profile in male rats. Methods. Male Wistar rats (n = 60) were assigned to 6 groups (n = 10 per group). The control group received d…
View article: Impaired vascular relaxation in type 2 diabetes: A systematic review and meta-analysis
Impaired vascular relaxation in type 2 diabetes: A systematic review and meta-analysis Open
Type 2 diabetes (T2D) significantly increases the risk of vascular complications (12-32 %), which are a major cause of death (over 50 %) in T2D patients. In T2D, both endothelial (ET) and vascular smooth muscle (VSM) cells are impaired, wh…
View article: Effect of long-term inorganic nitrate administration on myocardial ischemia-reperfusion injury in ovariectomized rats
Effect of long-term inorganic nitrate administration on myocardial ischemia-reperfusion injury in ovariectomized rats Open
Introduction: Menopause is associated with reduced nitric oxide (NO) bioavailability and lower tolerance against myocardial ischemia-reperfusion (IR) injury. This study investigated whether long-term nitrate administration provides resista…
View article: Dissolving sodium hydrosulfide in drinking water is not a good source of hydrogen sulfide for animal studies
Dissolving sodium hydrosulfide in drinking water is not a good source of hydrogen sulfide for animal studies Open
Hydrogen sulfide (H 2 S) has many physiological and pathological roles in the human body. Sodium hydrosulfide (NaHS) is widely used as a pharmacological tool for assessing H 2 S effects in biological experiments. Although H 2 S loss from N…
View article: Myocardial infarct size is reduced by nitrite and nitrate administration: a systematic review and meta-analysis of animal studies
Myocardial infarct size is reduced by nitrite and nitrate administration: a systematic review and meta-analysis of animal studies Open
Ischemic heart disease (IHD) is the leading cause of mortality worldwide and can be complicated by myocardial infarction (MI), leading to cardiac failure. Inorganic nitrite and nitrate, which release nitric oxide (NO), can protect the hear…
View article: Long-term inorganic nitrate administration protects against myocardial ischemia-reperfusion injury in female rats
Long-term inorganic nitrate administration protects against myocardial ischemia-reperfusion injury in female rats Open
Background The favorable effects of nitrate against myocardial ischemia-reperfusion injury (MIRI) have primarily focused on male rats and in short term. Here we determine the impact of long-term nitrate intervention on baseline cardiac fun…
View article: Long-term Ovariectomy Reduces Tolerance of Rats to Myocardial Ischemia-reperfusion Injury
Long-term Ovariectomy Reduces Tolerance of Rats to Myocardial Ischemia-reperfusion Injury Open
Background: The harmful impact of ovariectomy on myocardial ischemia-reperfusion (M/IR) injury has been established in the short term. Objectives: In this study, we aimed to investigate the long-term effects of ovariectomy on M/IR injury. …
View article: Anti-oxidant effect of nitrite in the pancreatic islets of type 2 diabetic male rats.
Anti-oxidant effect of nitrite in the pancreatic islets of type 2 diabetic male rats. Open
Nitrite decreased oxidative stress in isolated pancreatic islets of rats with T2D by suppressing oxidants and augmenting anti-oxidants. These findings favor the notion that nitrite-induced insulin secretion is partially due to decreased ox…
View article: Altered sialin mRNA gene expression in type 2 diabetic male Wistar rats: implications for nitric oxide deficiency
Altered sialin mRNA gene expression in type 2 diabetic male Wistar rats: implications for nitric oxide deficiency Open
View article: The Impact of Early-Life Combined Exercise Modality on Creb Signaling Pathway and Hippocampus Neuroplasticity in Diabetic Adult Male Rats; the Study of Developmental Model
The Impact of Early-Life Combined Exercise Modality on Creb Signaling Pathway and Hippocampus Neuroplasticity in Diabetic Adult Male Rats; the Study of Developmental Model Open
View article: Streptozotocin as a tool for induction of rat models of diabetes: a practical guide
Streptozotocin as a tool for induction of rat models of diabetes: a practical guide Open
Streptozotocin (STZ) is the most used diabetogenic chemical for creating rat models of type 1 and type 2 diabetes. Despite ~60 years of using STZ in animal diabetes research, some prevailing views about STZ preparation and use are not supp…
View article: <b>The effect of ovariectomy on hemodynamic functions and the level of nitric oxide metabolites in the heart of rats</b>
<b>The effect of ovariectomy on hemodynamic functions and the level of nitric oxide metabolites in the heart of rats</b> Open
Background. A higher prevalence of cardiovascular disorders has been observed in women after menopause. This study aimed to determine the long-term effects of ovariectomy on hemodynamic functions and the level of nitric oxide metabolites (…
View article: Long-term inorganic nitrate administration protects against ovariectomy-induced osteoporosis in rats
Long-term inorganic nitrate administration protects against ovariectomy-induced osteoporosis in rats Open
The risk of osteoporotic fractures increases in women after menopause. This study aims at determining the effects of long-term inorganic nitrate administration against ovariectomy-induced osteoporosis in rats. Rats were divided into 4 grou…
View article: Association between serum hydrogen sulfide concentrations and dysglycemia: a population-based study
Association between serum hydrogen sulfide concentrations and dysglycemia: a population-based study Open
Background and aim Hydrogen sulfide (H 2 S), a signaling gasotransmitter, is involved in carbohydrate metabolism. Here, we aimed to assess the potential association between serum H 2 S and dysglycemia in the framework of a population-based…
View article: The laboratory rat: age and body weight matter
The laboratory rat: age and body weight matter Open
Animal experimentation helps us to understand human biology. Rodents and, in particular, rats are among the most common animals used in animal experiments. Reporting data on animal age, animal body weight, and animal postnatal developmenta…
View article: Effect of oral nitrite administration on gene expression of SNARE proteins involved in insulin secretion from pancreatic islets of male type 2 diabetic rats
Effect of oral nitrite administration on gene expression of SNARE proteins involved in insulin secretion from pancreatic islets of male type 2 diabetic rats Open
View article: Acidified Nitrite Accelerates Wound Healing in Type 2 Diabetic Male Rats: A Histological and Stereological Evaluation
Acidified Nitrite Accelerates Wound Healing in Type 2 Diabetic Male Rats: A Histological and Stereological Evaluation Open
Impaired skin nitric oxide production contributes to delayed wound healing in type 2 diabetes (T2D). This study aims to determine improved wound healing mechanisms by acidified nitrite (AN) in rats with T2D. Wistar rats were assigned to fo…
View article: Protective Role of Trans-chalcone against the Progression from Simple Steatosis to Non-alcoholic Steatohepatitis: Regulation of miR-122, 21, 34a, and 451
Protective Role of Trans-chalcone against the Progression from Simple Steatosis to Non-alcoholic Steatohepatitis: Regulation of miR-122, 21, 34a, and 451 Open
Purpose: Non-alcoholic steatohepatitis (NASH) is an inflammatory disorder and an aggressive form of fatty liver disease. Certain microRNAs, including miR-122, 21, 34a, and 451, are involved in the transition from steatosis to NASH. This st…
View article: Affective dimensions of pain and region -specific involvement of nitric oxide in the development of empathic hyperalgesia
Affective dimensions of pain and region -specific involvement of nitric oxide in the development of empathic hyperalgesia Open
Empathy for pain depends on the ability to feel, recognize, comprehend and share painful emotional conditions of others. In this study, we investigated the role of NO in a rat model of empathic pain. Pain was socially transferred from the …
View article: Inorganic nitrate, a natural anti-obesity agent: A systematic review and meta-analysis of animal studies
Inorganic nitrate, a natural anti-obesity agent: A systematic review and meta-analysis of animal studies Open
Evidence for potential effects of inorganic nitrate (NO3) on body weight is limited to inconsistent findings of animal experiments. In this systematic review and meta-analysis, we aimed to quantify the overall effect of inorganic NO3, admi…
View article: Dose-Dependent Effects of Long-Term Administration of Hydrogen Sulfide on Myocardial Ischemia–Reperfusion Injury in Male Wistar Rats: Modulation of RKIP, NF-κB, and Oxidative Stress
Dose-Dependent Effects of Long-Term Administration of Hydrogen Sulfide on Myocardial Ischemia–Reperfusion Injury in Male Wistar Rats: Modulation of RKIP, NF-κB, and Oxidative Stress Open
Decreased circulating levels of hydrogen sulfide (H2S) are associated with higher mortality following myocardial ischemia. This study aimed at determining the long-term dose-dependent effects of sodium hydrosulfide (NaSH) administration on…
View article: Ovariectomized rat model of osteoporosis: a practical guide.
Ovariectomized rat model of osteoporosis: a practical guide. Open
Osteoporosis affects about 200 million people worldwide and is a silent disease until a fracture occurs. Management of osteoporosis is still a challenge that warrants further studies for establishing new prevention strategies and more effe…
View article: Data Extraction from Graphs Using Adobe Photoshop: Applications for Meta-Analyses
Data Extraction from Graphs Using Adobe Photoshop: Applications for Meta-Analyses Open
Graphs, an effective form of data presentation, are used for summarizing complex information and making them easier to understand. Extracting numerical data from graphs, which is commonly required in systematic reviews and meta-analyses, i…
View article: Effects of Hydrogen Sulfide on Carbohydrate Metabolism in Obese Type 2 Diabetic Rats
Effects of Hydrogen Sulfide on Carbohydrate Metabolism in Obese Type 2 Diabetic Rats Open
Hydrogen sulfide (H2S) is involved in the pathophysiology of type 2 diabetes. Inhibition and stimulation of H2S synthesis has been suggested to be a potential therapeutic approach for type 2 diabetes. The aim of this study was therefore to…
View article: The Principles of Biomedical Scientific Writing: Introduction
The Principles of Biomedical Scientific Writing: Introduction Open
A well-written introduction of a scientific paper provides relevant background knowledge to convince the readers about the rationale, importance, and novelty of the research. The introduction should inform the readers about the "problem", …