Saketh R. Karamched
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View article: OS05.3.A AXONAL INJURY IS A TARGETABLE DRIVER OF GLIOBLASTOMA PROGRESSION
OS05.3.A AXONAL INJURY IS A TARGETABLE DRIVER OF GLIOBLASTOMA PROGRESSION Open
BACKGROUND Glioblastoma (GBM) is the commonest primary brain malignancy which, despite increasing understanding of advanced disease, remains incurable. A lack of relevant disease models has meant that the mechanisms driving earlier stages …
View article: Axonal injury is a targetable driver of glioblastoma progression
Axonal injury is a targetable driver of glioblastoma progression Open
View article: Detecting glioblastoma infiltration beyond conventional imaging tumour margins using MTE-NODDI
Detecting glioblastoma infiltration beyond conventional imaging tumour margins using MTE-NODDI Open
Glioblastoma (GBM) is the most common and aggressive brain tumour with stark resistance to available therapies, leading to relapse and a median survival of <15 months. A key cause of therapy resistance is diffuse infiltration of tumour …
View article: The incidence of movement disorder increases with age and contrasts with subtle and limited neuroimaging abnormalities in argininosuccinic aciduria
The incidence of movement disorder increases with age and contrasts with subtle and limited neuroimaging abnormalities in argininosuccinic aciduria Open
Argininosuccinate lyase (ASL) is integral to the urea cycle detoxifying neurotoxic ammonia and the nitric oxide (NO) biosynthesis cycle. Inherited ASL deficiency causes argininosuccinic aciduria (ASA), a rare disease with hyperammonemia an…
View article: Data-driven spatio-temporal modelling of glioblastoma
Data-driven spatio-temporal modelling of glioblastoma Open
Mathematical oncology provides unique and invaluable insights into tumour growth on both the microscopic and macroscopic levels. This review presents state-of-the-art modelling techniques and focuses on their role in understanding glioblas…
View article: Data-driven spatio-temporal modelling of glioblastoma
Data-driven spatio-temporal modelling of glioblastoma Open
Mathematical oncology provides unique and invaluable insights into tumour growth on both the microscopic and macroscopic levels. This review presents state-of-the-art modelling techniques and focuses on their role in understanding glioblas…
View article: Site-specific chelation therapy with EDTA-loaded albumin nanoparticles reverses arterial calcification in a rat model of chronic kidney disease
Site-specific chelation therapy with EDTA-loaded albumin nanoparticles reverses arterial calcification in a rat model of chronic kidney disease Open
View article: Targeted EDTA Chelation Therapy with Albumin Nanoparticles to Reverse Arterial Calcification and Restore Vascular Health in Chronic Kidney Disease
Targeted EDTA Chelation Therapy with Albumin Nanoparticles to Reverse Arterial Calcification and Restore Vascular Health in Chronic Kidney Disease Open
Cardiovascular diseases (CVDs) are the leading cause of death globally. An estimated 17.9 million people died from CVDs in 2016, with ~840,000 of them in the United States alone. Traditional risk factors, such as smoking, hypertension, and…
View article: Reversal of Vascular Calcification and Aneurysms in a Rat Model Using Dual Targeted Therapy with EDTA- and PGG-Loaded Nanoparticles
Reversal of Vascular Calcification and Aneurysms in a Rat Model Using Dual Targeted Therapy with EDTA- and PGG-Loaded Nanoparticles Open
Degeneration of elastic lamina and vascular calcification are common features of vascular pathology such as aortic aneurysms. We tested whether dual therapy with targeted nanoparticles (NPs) can remove mineral deposits (by delivery of a ch…