Sakib Burza
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View article: Optimal anthropometric discharge criteria from treatment of wasting: meta-analysis of individual patient data from 34 studies
Optimal anthropometric discharge criteria from treatment of wasting: meta-analysis of individual patient data from 34 studies Open
View article: Referral of febrile children in resource-constrained community settings in Asia (Spot Sepsis) – a multi-country, prospective, cohort study
Referral of febrile children in resource-constrained community settings in Asia (Spot Sepsis) – a multi-country, prospective, cohort study Open
In resource-constrained community settings, distinguishing which febrile children require referral is a major unmet need. Current WHO danger signs lack accuracy, resulting in missed severe illness and unnecessary referrals. We developed an…
View article: Risk stratification of childhood infection using host markers of immune and endothelial activation in Asia (Spot Sepsis): a multi-country, prospective, cohort study
Risk stratification of childhood infection using host markers of immune and endothelial activation in Asia (Spot Sepsis): a multi-country, prospective, cohort study Open
For the Arabic and French translations of the abstract see Supplementary Materials section.
View article: Access to opioids for palliative care in humanitarian settings: two case studies of Médecins Sans Frontières (MSF) experience in India and Bangladesh
Access to opioids for palliative care in humanitarian settings: two case studies of Médecins Sans Frontières (MSF) experience in India and Bangladesh Open
View article: Risk stratification of childhood infection using host markers of immune and endothelial activation: a multi-country prospective cohort study in Asia (Spot Sepsis)
Risk stratification of childhood infection using host markers of immune and endothelial activation: a multi-country prospective cohort study in Asia (Spot Sepsis) Open
Background Circulating markers of immune and endothelial activation risk stratify infection syndromes agnostic to disease aetiology. However, their utility in children presenting from the community remains unclear. Methods This study recru…
View article: Derivation and validation of prognostic models for the risk stratification of childhood infection: a multi-country prospective cohort study in Asia (Spot-Sepsis)
Derivation and validation of prognostic models for the risk stratification of childhood infection: a multi-country prospective cohort study in Asia (Spot-Sepsis) Open
View article: Adaptation and validation of a light microscope for use in energy insecure settings: a proof-of-concept study
Adaptation and validation of a light microscope for use in energy insecure settings: a proof-of-concept study Open
View article: Visceral leishmaniasis in the hills of western Nepal: A transmission assessment
Visceral leishmaniasis in the hills of western Nepal: A transmission assessment Open
In Nepal, visceral leishmaniasis (VL) has been targeted for elimination as a public health problem by 2026. Recently, increasing numbers of VL cases have been reported from districts of doubtful endemicity including hills and mountains, th…
View article: Source Tracing of <i>Leishmania donovani</i> in Emerging Foci of Visceral Leishmaniasis, Western Nepal
Source Tracing of <i>Leishmania donovani</i> in Emerging Foci of Visceral Leishmaniasis, Western Nepal Open
We sequenced Leishmania donovani genomes in blood samples collected in emerging foci of visceral leishmaniasis in western Nepal. We detected lineages very different from the preelimination main parasite population, including a new lineage …
View article: Draft of WHO Pandemic Agreement plays down primary prevention
Draft of WHO Pandemic Agreement plays down primary prevention Open
View article: Correction: Doing our best and doing no harm: A focused ethnography of staff moral experiences of providing palliative care at a Médecins Sans Frontières pediatric hospital in Cox’s Bazar, Bangladesh
Correction: Doing our best and doing no harm: A focused ethnography of staff moral experiences of providing palliative care at a Médecins Sans Frontières pediatric hospital in Cox’s Bazar, Bangladesh Open
[This corrects the article DOI: 10.1371/journal.pone.0288938.].
View article: Extracorporeal life support and continuous renal replacement therapy in a patient with Enterovirus A71 associated cardiopulmonary failure: A case report
Extracorporeal life support and continuous renal replacement therapy in a patient with Enterovirus A71 associated cardiopulmonary failure: A case report Open
Rationale: Hand-foot-mouth disease (HFMD) caused by Enterovirus A71, complicated by cardiopulmonary failure, is associated with a high mortality rate despite intensive treatment. To date, there is a paucity of clinical management data, reg…
View article: Antibiotic susceptibility patterns of pathogens isolated from hospitalized patients with advanced HIV disease (AHD) in Bihar, India
Antibiotic susceptibility patterns of pathogens isolated from hospitalized patients with advanced HIV disease (AHD) in Bihar, India Open
Objectives To describe the prevalence of common bacterial pathogens and antibiotic susceptibility patterns amongst advanced HIV disease (AHD) patients admitted between May 2019 and March 2021 to a Médecins Sans Frontières (MSF)-supported A…
View article: Pediatric Profound Dengue Shock Syndrome and Use of Point-of-Care Ultrasound During Mechanical Ventilation to Guide Treatment: Single-Center Retrospective Study, 2013–2021
Pediatric Profound Dengue Shock Syndrome and Use of Point-of-Care Ultrasound During Mechanical Ventilation to Guide Treatment: Single-Center Retrospective Study, 2013–2021 Open
OBJECTIVES: Profound dengue shock syndrome (DSS) complicated by severe respiratory failure necessitating mechanical ventilation (MV) accounts for high case fatality rates among PICU-admitted patients. A major challenge to management is the…
View article: Source tracing of<i>Leishmania donovani</i>in emerging foci of visceral leishmaniasis in West Nepal
Source tracing of<i>Leishmania donovani</i>in emerging foci of visceral leishmaniasis in West Nepal Open
We sequenced Leishmania donovani genomes in blood samples collected in emerging foci of Visceral Leishmaniasis, in West Nepal. We detected lineages which are very different from pre-elimination main parasite population: a new lineage and a…
View article: Point-of-care prognostication in moderate Covid-19: Analytical validation and prognostic accuracy of a soluble urokinase plasminogen activator receptor (suPAR) rapid test
Point-of-care prognostication in moderate Covid-19: Analytical validation and prognostic accuracy of a soluble urokinase plasminogen activator receptor (suPAR) rapid test Open
The soluble urokinase plasminogen activator receptor (suPAR) has been proposed as a biomarker for risk stratification of patients presenting with acute infections. However, most studies evaluating suPAR have used platform-based assays, the…
View article: Doing our best and doing no harm: A focused ethnography of staff moral experiences of providing palliative care at a Médecins Sans Frontières pediatric hospital in Cox’s Bazar, Bangladesh
Doing our best and doing no harm: A focused ethnography of staff moral experiences of providing palliative care at a Médecins Sans Frontières pediatric hospital in Cox’s Bazar, Bangladesh Open
Introduction The Médecins Sans Frontières (MSF) Goyalmara Hospital in Cox’s Bazar, Bangladesh is a referral centre offering the highest level of care available in the Rohingya camps for pediatrics and neonatology. Efforts are underway to i…
View article: TUBERCULOSIS IN PATIENTS CO-INFECTED WITH VISCERAL LEISHMANIASIS AND HIV – A NEW DIAGNOSTIC AND MANAGEMENT CHALLENGE
TUBERCULOSIS IN PATIENTS CO-INFECTED WITH VISCERAL LEISHMANIASIS AND HIV – A NEW DIAGNOSTIC AND MANAGEMENT CHALLENGE Open
Intro: Between 6-10% of adults with Visceral Leishmaniasis (VL) are co-infected with HIV in Bihar, India. Although it is well known that VL-HIV patients commonly present with advanced HIV disease, there is minimal evidence on the prevalenc…
View article: Point-of-care ultrasound for tuberculosis diagnosis in children: a Médecins Sans Frontières cross-sectional study in Guinea-Bissau
Point-of-care ultrasound for tuberculosis diagnosis in children: a Médecins Sans Frontières cross-sectional study in Guinea-Bissau Open
Objective Description of tuberculosis (TB)-focused point-of-care ultrasound (POCUS) findings for children with presumptive TB. Design Cross-sectional study (July 2019 to April 2020). Setting Simão Mendes hospital in Bissau, a setting with …
View article: PREVALENCE OF ASYMPTOMATIC LEISHMANIA INFECTION IN PEOPLE LIVING WITH HIV AND PROGRESSION TO SYMPTOMATIC VISCERAL LEISHMANIASIS IN BIHAR, INDIA
PREVALENCE OF ASYMPTOMATIC LEISHMANIA INFECTION IN PEOPLE LIVING WITH HIV AND PROGRESSION TO SYMPTOMATIC VISCERAL LEISHMANIASIS IN BIHAR, INDIA Open
Intro: People living with HIV (PLHIV) have an increased risk of developing visceral leishmaniasis (VL) and poor outcomes compared to HIV-negative individuals. Here, we aim to establish the prevalence and determinants of asymptomatic Leishm…
View article: “We decide according to the protocol”: Humanitarian Healthcare Workers’ Moral Experiences of Palliative Care-Related Decision-Making in Cox’s Bazar, Bangladesh
“We decide according to the protocol”: Humanitarian Healthcare Workers’ Moral Experiences of Palliative Care-Related Decision-Making in Cox’s Bazar, Bangladesh Open
Introduction: 919,000 Rohingya refugees live in overcrowded camps in Cox’s Bazar, Bangladesh after fleeing violence in Myanmar. The Médecins Sans Frontières (MSF) Goyalmara Hospital offers the highest level of pediatric and neonatal care s…
View article: Perceptions of effective policy interventions and strategies to address antibiotic misuse within primary healthcare in India: A qualitative study
Perceptions of effective policy interventions and strategies to address antibiotic misuse within primary healthcare in India: A qualitative study Open
Objectives Antimicrobial resistance poses a major public health threat. Despite Indian retail sector antibiotic consumption per capita increasing by approximately 22% between 2008 and 2016, empirical studies that examine policy or behaviou…
View article: Point-of-care prognostication in moderate Covid-19: analytical validation and diagnostic accuracy of a soluble urokinase plasminogen activator receptor (suPAR) rapid test
Point-of-care prognostication in moderate Covid-19: analytical validation and diagnostic accuracy of a soluble urokinase plasminogen activator receptor (suPAR) rapid test Open
The soluble urokinase plasminogen activator receptor (suPAR) has been proposed as a biomarker for the risk stratification of patients presenting with acute infections. However, most studies evaluating suPAR have used platform-based assays,…
View article: Progression of asymptomatic<i>Leishmania</i>infection to visceral leishmaniasis in HIV-positive individuals in Bihar, India
Progression of asymptomatic<i>Leishmania</i>infection to visceral leishmaniasis in HIV-positive individuals in Bihar, India Open
There are no data on rate and risk factors for progression from asymptomatic Leishmania infection (ALI) to visceral leishmaniasis (VL) in people living with HIV (PLHIV) on the Indian subcontinent. In this prospective cohort study, we aim t…
View article: Host Biomarkers Reflect Prognosis in Patients Presenting With Moderate Coronavirus Disease 2019: A Prospective Cohort Study
Host Biomarkers Reflect Prognosis in Patients Presenting With Moderate Coronavirus Disease 2019: A Prospective Cohort Study Open
Efficient resource allocation is essential for effective pandemic response. We measured host biomarkers in 420 patients presenting with moderate coronavirus disease 2019 and found that different biomarkers predict distinct clinical outcome…
View article: Prevalence and determinants of asymptomatic Leishmania infection in HIV-infected individuals living within visceral leishmaniasis endemic areas of Bihar, India
Prevalence and determinants of asymptomatic Leishmania infection in HIV-infected individuals living within visceral leishmaniasis endemic areas of Bihar, India Open
People living with HIV (PLHIV) have an increased risk of developing visceral leishmaniasis (VL) and poor outcomes compared to HIV negative individuals. Here, we aim to establish the prevalence and determinants of asymptomatic Leishmania in…
View article: Practical Methods to Permit the Analysis of Host Biomarkers in Resource-Limited Settings
Practical Methods to Permit the Analysis of Host Biomarkers in Resource-Limited Settings Open
Host biomarker testing can be used as an adjunct to the clinical assessment of patients with infections and might be particularly impactful in resource-constrained settings. Research on the merits of this approach at peripheral levels of l…
View article: Facilitating Safe Discharge Through Predicting Disease Progression in Moderate Coronavirus Disease 2019 (COVID-19): A Prospective Cohort Study to Develop and Validate a Clinical Prediction Model in Resource-Limited Settings
Facilitating Safe Discharge Through Predicting Disease Progression in Moderate Coronavirus Disease 2019 (COVID-19): A Prospective Cohort Study to Develop and Validate a Clinical Prediction Model in Resource-Limited Settings Open
Background In locations where few people have received coronavirus disease 2019 (COVID-19) vaccines, health systems remain vulnerable to surges in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. Tools to identify p…
View article: AmBisome Monotherapy and Combination AmBisome–Miltefosine Therapy for the Treatment of Visceral Leishmaniasis in Patients Coinfected With Human Immunodeficiency Virus in India: A Randomized Open-Label, Parallel-Arm, Phase 3 Trial
AmBisome Monotherapy and Combination AmBisome–Miltefosine Therapy for the Treatment of Visceral Leishmaniasis in Patients Coinfected With Human Immunodeficiency Virus in India: A Randomized Open-Label, Parallel-Arm, Phase 3 Trial Open
Background Visceral leishmaniasis (VL) in patients with human immunodeficiency virus (HIV) presents an increasingly important patient cohort in areas where both infections are endemic. Evidence for treatment is sparce, with no high-quality…
View article: Facilitating safe discharge through predicting disease progression in moderate COVID-19: a prospective cohort study to develop and validate a clinical prediction model in resource-limited settings
Facilitating safe discharge through predicting disease progression in moderate COVID-19: a prospective cohort study to develop and validate a clinical prediction model in resource-limited settings Open
Background In locations where few people have received COVID-19 vaccines, health systems remain vulnerable to surges in SARS-CoV-2 infections. Tools to identify patients suitable for community-based management are urgently needed. Methods …